Chathuri De Alwis

College of Sciences

Works (2)

Updated: April 25th, 2025 17:45

2023 article

Exploiting Microelectrode Geometry for Comprehensive Detection of Individual Exocytosis Events at Single Cells

Alwis, A. C. D., Denison, J. D., Shah, R., McCarty, G. S., & Sombers, L. A. (2023, August 8). ACS Sensors, Vol. 8.

By: A. Alwis n, J. Denison n, R. Shah  n, G. McCarty n  & L. Sombers n 

author keywords: voltammetry; amperometry; chromaffincell; diffusion; catecholamine; dense corevesicle; carbon fiber microelectrode
MeSH headings : Microelectrodes; Carbon Fiber; Exocytosis / physiology; Catecholamines; Chromaffin Cells
topics (OpenAlex): Neuroscience and Neural Engineering; Cellular transport and secretion; Advanced Memory and Neural Computing
TL;DR: This work demonstrates how electrode geometry can be exploited for improved detection of exocytosis events by addressing diffusional loss─an often-overlooked source of inaccuracy in single-cell measurements. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

Untapped Potential: Real-Time Measurements of Opioid Exocytosis at Single Cells

Denison, J. D., Alwis, A. C. D., Shah, R., McCarty, G. S., & Sombers, L. A. (2023, October 19). Journal of the American Chemical Society, Vol. 145, pp. 24071–24080.

By: J. Denison n, A. Alwis n, R. Shah  n, G. McCarty n  & L. Sombers n 

MeSH headings : Analgesics, Opioid / pharmacology; Chromaffin Cells / metabolism; Catecholamines; Neuropeptides / metabolism; Neuropeptides / pharmacology; Exocytosis / physiology
topics (OpenAlex): Receptor Mechanisms and Signaling; Neuroscience and Neuropharmacology Research; Lipid Membrane Structure and Behavior
TL;DR: Comparing the results collected at the two potentials reveals unique kinetics for these two neurochemical classes at the single-vesicle level, providing unprecedented insight into key differences between catecholamine and opioid neuropeptide release from isolated chromaffin cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023

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