Christophe Guilluy

Works (27)

Updated: April 5th, 2024 11:16

2023 journal article

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

ELIFE, 12.

By: D. Buglak*, P. Bougaran*, M. Kulikauskas*, Z. Liu*, E. Monaghan-Benson n, A. Gold*, A. Marvin*, A. Burciu* ...

author keywords: endothelial cells; nuclear LINC complex; SUN1; microtubules; adherens junctions; blood vessels; GEF-H1; Nesprin-1; angiogenesis; Rho; contractility; Endothelial cell; Mouse; Zebrafish
MeSH headings : Animals; Mice; Microtubule-Associated Proteins / metabolism; Endothelial Cells / metabolism; Zebrafish / metabolism; Nuclear Proteins / metabolism; Microtubules / metabolism; Intercellular Junctions / metabolism
TL;DR: It is shown that the nuclear-localized LINC complex protein SUN1 regulates vascular sprouting and barrier function via effects on endothelial cell-cell junction morphology and function and long-range communication from the nucleus to the cell periphery is important for vascular development and function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: May 1, 2023

2022 journal article

SUN2 regulates mitotic duration in response to extracellular matrix rigidity

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(45).

author keywords: mitosis; nucleus; LINC; mechanotransduction; matrix
MeSH headings : Nuclear Matrix / metabolism; Cytoskeleton / metabolism; Microtubules / metabolism; Mitosis; Extracellular Matrix; Spindle Apparatus; Anaphase
TL;DR: It is found that cells divide more rapidly when cultured on substrates with increasing rigidity, and this mechanism involves the nuclear protein SUN2, whose expression is up-regulated by matrix rigidity and in turn accelerates mitosis by promoting metaphase-to-anaphase transition. (via Semantic Scholar)
Source: Web Of Science
Added: January 30, 2023

2017 journal article

Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System

Cellular and Molecular Gastroenterology and Hepatology, 5(1), 31–49.

By: E. Duchalais*, C. Guilluy*, S. Nedellec*, M. Touvron*, A. Bessard*, Y. Touchefeu*, C. Bossard*, H. Boudin* ...

author keywords: Colorectal Cancer; Enteric Neurons; Adhesion; Migration
TL;DR: The data show that the enteric neuronal network guides tumor cell migration, partly via L1CAM and N-cadherin. (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2017 journal article

Lysyl oxidase like-2 (LOXL2) regulates endothelial mechanotransduction and 3D vascular morphogenesis through scaffolding of basement membrane

Archives of Cardiovascular Diseases Supplements, 9(2), 164.

By: M. Marchand, C. Umana, C. Pichol-Thievend, R. Salza, S. Ricard-Blum, C. Monnot, C. Guilluy*, L. Muller, S. Germain

Source: Crossref
Added: February 21, 2020

2017 journal article

Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface

Current Opinion in Cell Biology, 44, 59–67.

By: J. Aureille*, N. Belaadi* & C. Guilluy*

MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Cell Movement; Cell Nucleus / metabolism; Cytoskeleton / metabolism; Humans; Mechanotransduction, Cellular; Nuclear Envelope / chemistry; Nuclear Envelope / metabolism; Organelle Shape
TL;DR: These nuclear mechanosensitive mechanisms exist in the nucleus and regulate its structure and function in response to mechanical force are reviewed and their functional homology with those located at the cell surface is highlighted. (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2016 journal article

Focal adhesions, stress fibers and mechanical tension

Experimental Cell Research, 343(1), 14–20.

By: K. Burridge* & C. Guilluy*

author keywords: Myosin II; RhoA; Integrins; Substratum rigidity
MeSH headings : Animals; Focal Adhesions / physiology; Humans; Models, Biological; Stress Fibers / physiology; Stress, Mechanical
TL;DR: The evidence for and against the role of mechanical tension in driving the assembly of stress fibers and focal adhesions are discussed, and how their assembly is influenced by the rigidity of the substratum to which cells are adhering is considered. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2016 journal article

Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells

Methods, 94, 19–26.

By: R. Marjoram*, C. Guilluy* & K. Burridge*

author keywords: Mechanotransduction; Tension; VE-cadherin; Endothelial cell
MeSH headings : Antigens, CD / physiology; Cadherins / physiology; Electron Spin Resonance Spectroscopy; Human Umbilical Vein Endothelial Cells / physiology; Humans; Magnetic Phenomena; Mechanotransduction, Cellular; Phosphorylation; Protein Processing, Post-Translational; rho GTP-Binding Proteins / physiology
TL;DR: The methods for analyzing mechanotransduction through VE-cadherin on endothelial cells using both permanent magnets and magnetic tweezers are demonstrated. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Nuclear mechanotransduction: Forcing the nucleus to respond

Nucleus, 6(1), 19–22.

By: C. Guilluy* & K. Burridge*

author keywords: nucleoskeleton; nuclear lamins; emerin; nesprin; mechanotransduction
MeSH headings : Animals; Cell Nucleus / metabolism; Cytoskeleton / metabolism; Humans; Mechanotransduction, Cellular; Stress, Mechanical
TL;DR: Recent evidence shows that mechanotransduction mechanisms occur in the nucleus, allowing dynamic regulation of the nucleoskeleton in response to mechanical stress, and its impact on both nuclear structure and function is discussed. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2014 journal article

Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells

Nature Communications, 5(1).

By: C. Collins*, L. Osborne*, C. Guilluy*, Z. Chen*, E. O’Brien*, J. Reader*, K. Burridge*, R. Superfine*, E. Tzima*

MeSH headings : Animals; Aorta / cytology; Aorta / enzymology; Aorta / metabolism; Aorta / physiology; Cyclic AMP-Dependent Protein Kinases / metabolism; Endothelium, Vascular / cytology; Endothelium, Vascular / enzymology; Endothelium, Vascular / metabolism; Endothelium, Vascular / physiology; Extracellular Matrix / enzymology; Extracellular Matrix / metabolism; Extracellular Matrix / physiology; Focal Adhesions; Hemodynamics; Male; Mice; Mice, Inbred C57BL; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism; rhoA GTP-Binding Protein / metabolism
TL;DR: It is shown that the interaction of extracellular matrix proteins with adhesion molecules on the endothelial cell surface determines cellular stiffness and sensitivity to mechanical forces. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2014 journal article

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

Nature Cell Biology, 16(4), 376–381.

By: C. Guilluy*, L. Osborne*, L. Van Landeghem*, L. Sharek*, R. Superfine*, R. Garcia-Mata*, K. Burridge*

MeSH headings : Cell Line; Cell Nucleus / genetics; Cell Nucleus / physiology; Chromatin / metabolism; Cytoskeletal Proteins; Cytoskeleton / metabolism; DNA / metabolism; Focal Adhesion Kinase 1 / antagonists & inhibitors; HeLa Cells; Histone Deacetylase Inhibitors / pharmacology; Humans; Hydroxamic Acids / pharmacology; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Mechanotransduction, Cellular / physiology; Membrane Proteins / genetics; Membrane Proteins / metabolism; Microtubule-Associated Proteins / genetics; Microtubule-Associated Proteins / metabolism; Nerve Tissue Proteins / metabolism; Nuclear Lamina / physiology; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phosphorylation; Proto-Oncogene Proteins c-abl / antagonists & inhibitors; RNA Interference; RNA, Small Interfering; Stress, Mechanical
TL;DR: The results demonstrate that mechanotransduction is not restricted to cell surface receptors and adhesions but can occur in the nucleus, and applying force on nesprin-1 triggers nuclear stiffening that does not involve chromatin or nuclear actin, but requires an intact nuclear lamina and emerin, a protein of the inner nuclear membrane. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2014 journal article

Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions

The Journal of Cell Biology, 205(2), 251–263.

By: J. Bays*, X. Peng*, C. Tolbert*, C. Guilluy*, A. Angell*, Y. Pan*, R. Superfine*, K. Burridge*, K. DeMali*

MeSH headings : Cadherins / genetics; Cadherins / metabolism; Cell Adhesion / physiology; Cell Communication / physiology; Cell Line, Tumor; Extracellular Matrix / genetics; Extracellular Matrix / metabolism; Humans; Mechanotransduction, Cellular / physiology; Phosphorylation / physiology; Proto-Oncogene Proteins c-abl / genetics; Proto-Oncogene Proteins c-abl / metabolism; Vinculin / genetics; Vinculin / metabolism
TL;DR: Vinculin phosphorylation on residue Y822 is necessary for cell stiffening in response to tension on cadherins but not integrins. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2013 journal article

Mechanically activated fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells

STEM CELLS, 31(11), 2528–2537.

By: W. Thompson*, C. Guilluy*, Z. Xie*, B. Sen*, K. Brobst*, S. Yen*, G. Uzer*, M. Styner* ...

author keywords: Src; Fyn; FAK; RhoA; Mesenchymal stem cells; Adipogenesis
MeSH headings : Adipogenesis / physiology; Cell Culture Techniques; Humans; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 2; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Multiprotein Complexes / genetics; Multiprotein Complexes / metabolism; Phosphorylation; Proto-Oncogene Proteins c-fyn / genetics; Proto-Oncogene Proteins c-fyn / metabolism; Signal Transduction; TOR Serine-Threonine Kinases / genetics; TOR Serine-Threonine Kinases / metabolism; Transfection; rhoA GTP-Binding Protein / metabolism
TL;DR: Fyn expression in mdMSCs contributes to basal cytoskeletal architecture and, when associated with FAs, functions as a proximal mechanical effector for environmental signals that influence MSC lineage allocation. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

From Mechanical Force to RhoA Activation

Biochemistry, 51(38), 7420–7432.

By: E. Lessey*, C. Guilluy* & K. Burridge*

MeSH headings : Cell Adhesion Molecules / chemistry; Extracellular Matrix / chemistry; Focal Adhesions; Gene Expression; Humans; Neoplasms / pathology; rhoA GTP-Binding Protein / chemistry
TL;DR: This review focuses on the pathways by which mechanical force leads to RhoA regulation, especially when force is transmitted via cell adhesion molecules that mediate either cell-matrix or cell-cell interactions. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway

Current Biology, 22(22), 2087–2094.

By: C. Collins*, C. Guilluy*, C. Welch*, E. O’Brien*, K. Hahn*, R. Superfine*, K. Burridge*, E. Tzima*

MeSH headings : Animals; Biomechanical Phenomena; Cattle; Cell Adhesion / physiology; Cells, Cultured; Endothelial Cells / physiology; Gene Expression Regulation / physiology; Integrins / genetics; Integrins / metabolism; Magnetics; Mechanotransduction, Cellular / physiology; Platelet Endothelial Cell Adhesion Molecule-1 / physiology; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism
TL;DR: This work provides the first evidence of a global signaling event in response to a localized mechanical stress, and provides a possible mechanism for the differential stiffness of vessels exposed to distinct hemodynamic force patterns in vivo. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2011 journal article

Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus

Nature Protocols, 6(12), 2050–2060.

By: C. Guilluy*, A. Dubash* & R. García-Mata*

MeSH headings : Cell Fractionation / methods; Cell Nucleus / metabolism; Guanine Nucleotide Exchange Factors / analysis; Guanine Nucleotide Exchange Factors / metabolism; HEK293 Cells; Humans; Rho Guanine Nucleotide Exchange Factors; Subcellular Fractions / metabolism; rhoA GTP-Binding Protein / analysis; rhoA GTP-Binding Protein / metabolism
TL;DR: This protocol can be also used for other Rho GTPases and Rho GEFs, which have also been found in the nucleus, and has been shown that the nuclear guanine nucleotide exchange factor (GEF) Net1 has a role in the regulation of its activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2011 journal article

Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells

STEM CELLS, 29(11), 1829–1836.

author keywords: Akt; Adipocyte; Focal adhesion; Mechanical force
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Animals; Cells, Cultured; Focal Adhesions / metabolism; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mice; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Stress, Mechanical
TL;DR: It is demonstrated that reapplication of cyclic strain within a 24‐hour period leads to amplification of both Akt activation and its subsequent inhibition of GSK3β, such that total cycle number can be reduced while still inhibiting adipogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Source: Crossref
Added: August 28, 2020

2011 journal article

Rho protein crosstalk: another social network?

Trends in Cell Biology, 21(12), 718–726.

By: C. Guilluy*, R. Garcia-Mata* & K. Burridge*

MeSH headings : Animals; Cell Movement; Feedback, Physiological; GTPase-Activating Proteins / metabolism; Guanine Nucleotide Dissociation Inhibitors / metabolism; Guanine Nucleotide Exchange Factors / metabolism; Humans; rho GTP-Binding Proteins / metabolism; rho-Associated Kinases / metabolism
TL;DR: The main mechanisms of Rho protein crosstalk are described, which can occur at three different levels of the pathway: (i) throughregulation of activity, (ii) through regulation of protein expression and stability, and (iii)through regulation of downstream signaling pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Crossref
Added: August 28, 2020

2011 journal article

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

Nature Cell Biology, 13(6), 722–727.

By: C. Guilluy*, V. Swaminathan*, R. Garcia-Mata*, E. Timothy O’Brien*, R. Superfine* & K. Burridge*

MeSH headings : Animals; Cell Line; Fibroblasts / cytology; Fibroblasts / metabolism; Guanine Nucleotide Exchange Factors / genetics; Guanine Nucleotide Exchange Factors / metabolism; Integrins / metabolism; Mechanical Phenomena; Mice; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Rho Guanine Nucleotide Exchange Factors
TL;DR: Two guanine nucleotide exchange factors, LARG and GEF-H1, are identified as key molecules that regulate the cellular adaptation to force and stimulation of integrins with tensional force triggers activation of these two GEFs and their recruitment to adhesion complexes. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2011 journal article

The Vinculin C-terminal Hairpin Mediates F-actin Bundle Formation, Focal Adhesion, and Cell Mechanical Properties

Journal of Biological Chemistry, 286(52), 45103–45115.

MeSH headings : Actins / genetics; Actins / metabolism; Animals; Avian Proteins / genetics; Avian Proteins / metabolism; Cells, Cultured; Chickens; Fibroblasts / cytology; Fibroblasts / metabolism; Focal Adhesions / genetics; Focal Adhesions / metabolism; Mice; Mice, Knockout; Protein Binding; Protein Multimerization / physiology; Protein Structure, Tertiary; Vinculin / genetics; Vinculin / metabolism
TL;DR: Results from this study provide additional support for actin-induced Vt self-association and appear distinct from the dimer formed in the absence of actin, which has been proposed to induce formation of a Vt dimer that is necessary for cross-linking actin filaments. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

Nature Cell Biology, 12(5), 477–483.

MeSH headings : Cell Line; Guanine Nucleotide Dissociation Inhibitors / metabolism; Guanine Nucleotide Dissociation Inhibitors / physiology; Homeostasis; Humans; Protein Binding; Protein Folding; Protein Prenylation; Protein Stability; Receptor Cross-Talk; rho GTP-Binding Proteins / metabolism; rho-Specific Guanine Nucleotide Dissociation Inhibitors
TL;DR: It is found that depletion of RhoGDI1 promotes misfolding and degradation of the cytosolic geranylgeranylated pool of R Ho GTPases while activating the remaining membrane-bound fraction, raising important questions about the conclusions drawn from studies that manipulate Rho protein levels. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

Nature Medicine, 16(2), 183–190.

By: C. Guilluy*, J. Brégeon, G. Toumaniantz, M. Rolli-Derkinderen, K. Retailleau, L. Loufrani, D. Henrion, E. Scalbert ...

MeSH headings : Angiotensin II / physiology; Animals; Blood Pressure / physiology; Guanine Nucleotide Exchange Factors / chemistry; Guanine Nucleotide Exchange Factors / metabolism; Guanine Nucleotide Exchange Factors / physiology; Hypertension / etiology; Hypertension / physiopathology; Janus Kinase 2 / metabolism; Mice; Mice, Knockout; Muscle, Smooth, Vascular / cytology; Muscle, Smooth, Vascular / physiology; Phosphorylation; Proto-Oncogene Proteins / chemistry; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins / physiology; Rho Guanine Nucleotide Exchange Factors; Signal Transduction; Tyrosine / metabolism
TL;DR: Evidence is provided that Arhgef1 is the RhoA guanine exchange factor specifically responsible for angiotensin II–induced activation of RHoA signaling in arterial smooth muscle cells and identifies Arh gef1 as a potential target for the treatment of hypertension. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2009 journal article

Activation de Rho kinase par sérotonylation intracellulaire de la petite protéine G RhoA dans l’hypertension artérielle pulmonaire

La Revue De Médecine Interne, 30, S373.

By: C. Agard*, C. Guilluy*, S. Eddahibi*, C. Guignabert*, M. Izikki*, L. Tu*, L. Savale*, M. Humbert* ...

Source: Crossref
Added: August 28, 2020

2009 journal article

I025 Smooth muscle specific deletion of the RhoA exchange factor Arhgef1 protects against Ang II-dependent hypertension

Archives of Cardiovascular Diseases, 102, S95–S96.

By: J. Bregeon*, C. Guilluy*, G. Toumaniantz*, M. Rolliderkinderen*, K. Retailleau*, L. Loufrani*, D. Henrion*, E. Scalbert* ...

TL;DR: It is shown that Arhgef1 activation and its downstream RhoA/Rho kinase signaling are central to the development of Ang IIdependent hypertension. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2006 journal article

Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation

Cardiovascular Research, 72(2), 339–348.

By: Y. Goueffic*, C. Guilluy*, P. Guerin*, P. Patra*, P. Pacaud* & G. Loirand*

author keywords: smooth muscle; extracellular matrix; signal transduction; receptors; G-proteins
MeSH headings : Actins / metabolism; Amides / pharmacology; Animals; Antibodies, Monoclonal / pharmacology; Aorta; Bacterial Toxins / pharmacology; Cell Movement / drug effects; Cells, Cultured; Chromones / pharmacology; Complement C3 / genetics; Cytoskeleton / metabolism; Dose-Response Relationship, Drug; Enterotoxins / pharmacology; Escherichia coli Proteins / pharmacology; Extracellular Matrix Proteins / metabolism; Genes, tat; Hyaluronan Receptors / immunology; Hyaluronan Receptors / metabolism; Hyaluronic Acid / pharmacology; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Morpholines / pharmacology; Muscle, Smooth, Vascular / cytology; Muscle, Smooth, Vascular / drug effects; Muscle, Smooth, Vascular / metabolism; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases / antagonists & inhibitors; Pyridines / pharmacology; RNA Interference; RNA, Small Interfering / pharmacology; Rats; Recombinant Fusion Proteins / pharmacology; Signal Transduction; Simvastatin / pharmacology; Stimulation, Chemical; rac GTP-Binding Proteins / antagonists & inhibitors; rac GTP-Binding Proteins / genetics; rac GTP-Binding Proteins / metabolism; rho-Associated Kinases; rhoA GTP-Binding Protein / antagonists & inhibitors; rhoA GTP-Binding Protein / metabolism
TL;DR: High-molecular weight HA independently activates RhoA and Rac through CD44 and RHAMM, respectively, and depends exclusively on RHAMm-mediated PI3K-dependent Rac activation. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2006 journal article

Regulation of Rho Proteins by Phosphorylation in the Cardiovascular System

Trends in Cardiovascular Medicine, 16(6), 199–204.

By: G. Loirand*, C. Guilluy* & P. Pacaud*

MeSH headings : Animals; Cardiovascular Diseases / metabolism; Cardiovascular Diseases / pathology; Cardiovascular Diseases / physiopathology; Cardiovascular System / metabolism; Cardiovascular System / pathology; Cardiovascular System / physiopathology; Humans; Phosphorylation; Signal Transduction; rho GTP-Binding Proteins / classification; rho GTP-Binding Proteins / metabolism; rho GTP-Binding Proteins / physiology
TL;DR: The small G protein Rho signaling pathways are recognized as major regulators of cardiovascular functions, and activation of Rho proteins appears to be a common component for the pathogenesis of hypertension and vascular proliferative disorders. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2006 journal article

Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells

Journal of Biological Chemistry, 282(5), 2918–2928.

MeSH headings : Animals; Aorta; Cell Hypoxia; DNA Primers; Enzyme Activation; Hypertension / physiopathology; Hypoxia / physiopathology; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular / drug effects; Muscle, Smooth, Vascular / enzymology; Muscle, Smooth, Vascular / physiology; Pulmonary Artery / drug effects; Pulmonary Artery / enzymology; Pulmonary Artery / physiology; RNA, Small Interfering / genetics; Rats; Serotonin / pharmacology; Transglutaminases / deficiency; Transglutaminases / genetics; Transglutaminases / metabolism; rhoA GTP-Binding Protein / metabolism
TL;DR: Evidence is provided that 5-HT, internalized through the 5- HT transporter, is transamidated to RhoA by transglutaminase, which in turn is responsible for Akt activation and contraction inhibition in arterial smooth muscle. (via Semantic Scholar)
Source: Crossref
Added: December 29, 2020

2005 journal article

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

British Journal of Pharmacology, 146(7), 1010–1018.

author keywords: Rho proteins; signal transduction; phosphodiesterase; smooth muscle
MeSH headings : 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / analogs & derivatives; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / therapeutic use; Actins / metabolism; Animals; Carrier Proteins / metabolism; Chronic Disease; Cytoskeleton / drug effects; Guanine Nucleotide Dissociation Inhibitors / physiology; Hypertension, Pulmonary / drug therapy; Hypertension, Pulmonary / enzymology; Hypertension, Pulmonary / etiology; Hypoxia / complications; Male; Phosphodiesterase Inhibitors / pharmacology; Phosphoprotein Phosphatases / metabolism; Phosphorylation; Piperazines / pharmacology; Piperazines / therapeutic use; Protein Phosphatase 1; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; rhoA GTP-Binding Protein / antagonists & inhibitors
TL;DR: It is proposed that sildenafil inhibits RhoA/Rho kinase‐dependent functions in pulmonary artery through enhanced RHoA phosphorylation and cytosolic sequestration by GDI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

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