Cierra Smith

Works (1)

Updated: June 18th, 2023 21:46

2021 article

Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms

Snider, D. B., Arthur, G. K., Falduto, G. H., Olivera, A., Ehrhardt-Humbert, L. C., Smith, E., … Cruse, G. (2021, August 8). Molecular Therapy, Vol. 1, pp. 295–310.

By: D. Snider n, G. Arthur n, G. Falduto *, A. Olivera *, L. Ehrhardt-Humbert n, E. Smith n, C. Smith n, D. Metcalfe *, G. Cruse n 

Contributors: D. Snider n, G. Arthur n, G. Falduto *, A. Olivera *, L. Ehrhardt-Humbert n, E. Smith n, C. Smith n, D. Metcalfe *, G. Cruse n 

MeSH headings : Humans; Mast Cells / metabolism; Mast Cells / pathology; Mastocytosis / genetics; Mastocytosis / pathology; Mastocytosis / therapy; Proto-Oncogene Proteins c-kit / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptor Protein-Tyrosine Kinases / metabolism
topics (OpenAlex): Mast cells and histamine; Polyamine Metabolism and Applications; Eosinophilic Disorders and Syndromes; Monoclonal and Polyclonal Antibodies Research
TL;DR: It is proposed that the innovative approach, which employs well-tolerated, chemically stable oligonucleotides to target KIT expression through unconventional pathways, has potential as a KIT-targeted therapeutic alone, or in combination with agents thattarget KIT signaling, in the treatment of K IT-associated malignancies. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 7, 2022

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