Works (48)

2023 journal article

The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis

FRONTIERS IN IMMUNOLOGY, 14.

By: B. Hedgespeth, D. Snider, K. Bitting & G. Cruse

author keywords: mast cell (MC); anaphylaxis; KIT; exon skipping; mast cell depletion
Sources: Web Of Science, ORCID
Added: March 6, 2023

2022 article

Identification of redundancy between human Fc epsilon RI beta and MS4A6A proteins points toward additional complex mechanisms for Fc epsilon RI trafficking and signaling

Bitting, K., Hedgespeth, B., Ehrhardt-Humbert, L. C., Arthur, G. K., Schubert, A. G., Bradding, P., … Cruse, G. (2022, December 7). ALLERGY, Vol. 12.

By: K. Bitting n, B. Hedgespeth, L. Ehrhardt-Humbert n, G. Arthur, A. Schubert, P. Bradding*, S. Tilley*, G. Cruse

author keywords: asthma; IgE; mast cells
Sources: ORCID, Web Of Science
Added: November 25, 2022

2022 journal article

Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by Fc epsilon RI beta and the Potential Impact of Fc epsilon RI beta Splicing in Allergic Inflammation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(2).

By: G. Arthur & G. Cruse

author keywords: mast cell; IgE receptor; Fc epsilon RI beta; antisense therapy; allergy; asthma; exon skipping
Sources: Web Of Science, ORCID
Added: February 7, 2022

2022 journal article

Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms

MOLECULAR THERAPY, 30(1), 295–310.

By: D. Snider, G. Arthur, G. Falduto*, A. Olivera*, L. Ehrhardt-Humbert n, E. Smith n, C. Smith, D. Metcalfe*, G. Cruse

Sources: Web Of Science, ORCID
Added: February 7, 2022

2021 journal article

Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation

TISSUE ENGINEERING PART A, 27(15-16), 1008–1022.

By: E. Ozpinar, A. Frey*, G. Arthur, C. Mora-Navarro n, A. Biehl n, D. Snider n, G. Cruse, D. Freytes

author keywords: extracellular matrix; mast cell; allergy; metabolism
Sources: Web Of Science, ORCID
Added: December 11, 2020

2021 journal article

Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness

JCI INSIGHT, 6(21).

By: X. Kong*, W. Bennett*, C. Jania*, K. Chason*, Z. German*, J. Adouli*, S. Budney*, B. Oby* ...

Sources: Web Of Science, ORCID
Added: January 31, 2022

2021 journal article

Mast Cell-Biomaterial Interactions and Tissue Repair

TISSUE ENGINEERING PART B-REVIEWS, 27(6), 590–603.

By: E. Ozpinar, A. Frey n, G. Cruse & D. Freytes

author keywords: mast cells; biomaterials; inflammation; tissue repair; foreign body response; wound healing
Sources: Web Of Science, ORCID
Added: March 8, 2021

2020 journal article

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609.

By: E. Chee, S. Nandi, K. Nellenbach, E. Mihalko, D. Snider n, L. Morrill n, A. Bond n, E. Sproul n ...

author keywords: antimicrobial; microgels; nanosilver; platelet-mimetic; wound healing
Sources: Web Of Science, ORCID
Added: March 16, 2020

2020 journal article

Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch

CELL REPORTS, 31(1).

By: S. Mishra, J. Wheeler, S. Pitake n, H. Ding*, C. Jiang*, T. Fukuyama, J. Paps, P. Ralph n ...

Sources: Web Of Science, ORCID
Added: April 27, 2020

2020 journal article

The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells

Cellular Signalling, 71, 109617.

By: G. Arthur n, L. Ehrhardt-Humbert n, D. Snider n, C. Jania*, S. Tilley*, D. Metcalfe*, G. Cruse

author keywords: Mast cell; IgE receptor; MS4A; Allergy; Orai1
Source: ORCID
Added: April 10, 2020

2018 article

Exon Skipping of Fc epsilon RI beta for Allergic Diseases

EXON SKIPPING AND INCLUSION THERAPIES: METHODS AND PROTOCOLS, Vol. 1828, pp. 503–518.

By: G. Arthur & G. Cruse

author keywords: Mast cell; Allergic diseases; Allergic inflammation; Fc epsilon RI; Exon skipping
Sources: Web Of Science, ORCID
Added: March 4, 2019

2016 journal article

Constitutive KIT Activity and IL-6 Production in Mast Cells Alters Levels of Reactive Oxygen Species (ROS) and the Scavenger Protein DJ-1 in Mastocytosis

Journal of Allergy and Clinical Immunology, 137(2), AB281.

Sources: Crossref, ORCID
Added: January 25, 2020

2016 journal article

Exon skipping of Fc epsilon RI beta eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(49), 14115–14120.

By: G. Cruse, Y. Yin*, T. Fukuyama, A. Desai*, G. Arthur, W. Baumer n, M. Beaven*, D. Metcalfe*

author keywords: mast cell; allergy; IgE receptor; oligonucleotides; dermatitis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Immunophenotypic and ultrastructural analysis of mast cells in hermansky-pudlak syndrome type-1: A possible connection to pulmonary fibrosis

PLoS ONE, 11(7).

Source: ORCID
Added: February 11, 2019

2016 journal article

Mast cells in airway diseases and interstitial lung disease

European Journal of Pharmacology, 778, 125–138.

By: G. Cruse & P. Bradding*

author keywords: Mast cell; Asthma; Airway diseases; Interstitial lung disease
Source: ORCID
Added: February 11, 2019

2016 journal article

Vibratory urticaria associated with a missense variant in ADGRE2

New England Journal of Medicine, 374(7), 656–663.

By: S. Boyden, A. Desai*, G. Cruse, M. Young*, H. Bolan*, L. Scott, A. Robin Eisch, R. Daniel Long ...

Source: ORCID
Added: February 11, 2019

2015 journal article

Constitutively Activated KIT in Mastocytosis Patients Is Associated with Decreased Levels of the Scavenger Protein DJ1 and Reciprocal Increases in Reactive Oxygen Species

Journal of Allergy and Clinical Immunology, 135(2), AB389.

Sources: Crossref, ORCID
Added: January 25, 2020

2015 book

Flow cytometry-based monitoring of mast cell activation

In Methods in Molecular Biology (Vol. 1220, pp. 365–379).

By: G. Cruse, A. Gilfillan* & D. Smrz*

author keywords: Mast cell; Signaling; Protein phosphorylation; Calcium signal; Actin polymerization/depolymerization; Degranulation; Flow cytometry
Source: ORCID
Added: February 11, 2019

2015 journal article

Mast Cells Expressing the Germline HPS1 16-Bp Duplication (c.1470_1486dup16, Hermansky-Pudlak Syndrome-1) Defect Produce Extracellular Matrix Components

Journal of Allergy and Clinical Immunology, 135(2), AB172.

By: A. Kirshenbaum*, G. Bandara*, A. Desai*, E. Fischer*, M. Leerkes*, D. Metcalfe*, G. Cruse

Sources: Crossref, ORCID
Added: January 25, 2020

2015 journal article

The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling

Molecular Biology of the Cell, 26(9), 1711–1727.

By: G. Cruse, M. Beaven*, S. Music*, P. Bradding*, A. Gilfillan* & D. Metcalfe*

Source: ORCID
Added: February 11, 2019

2015 journal article

The Fcεriβ Homologue, MS4A4, Promotes Fcεri-Dependent Human Mast Cell Degranulation By Facilitating PLCγ1 Signaling

Journal of Allergy and Clinical Immunology, 135(2), AB240.

By: G. Cruse, M. Beaven*, S. Music*, P. Bradding* & D. Metcalfe*

Sources: Crossref, ORCID
Added: January 25, 2020

2014 journal article

Functional deregulation of KIT: Link to mast cell proliferative diseases and other neoplasms

Immunology and Allergy Clinics of North America, 34(2), 219–237.

By: G. Cruse, D. Metcalfe* & A. Olivera*

author keywords: Mastocytosis; KIT mutations; KIT signaling; KIT trafficking; KIT inhibitors
Source: ORCID
Added: February 11, 2019

2014 journal article

Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation

Journal of Immunology, 193(12), 5924–5932.

By: D. Smrz*, G. Cruse, M. Beaven*, A. Kirshenbaum*, D. Metcalfe* & A. Gilfillan*

Source: ORCID
Added: February 11, 2019

2013 journal article

A Truncated Splice-Variant of the FcεRIβ Receptor Subunit Is Critical for Microtubule Formation and Degranulation in Mast Cells

Immunity, 38(5), 906–917.

By: G. Cruse, M. Beaven*, I. Ashmole*, P. Bradding*, A. Gilfillan* & D. Metcalfe*

Source: ORCID
Added: February 11, 2019

2013 journal article

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation

Journal of Allergy and Clinical Immunology, 132(6).

Source: ORCID
Added: February 11, 2019

2013 journal article

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation

Journal of Allergy and Clinical Immunology, 132(6), 1388–1396.e3.

By: A. Siegel*, K. Stone*, G. Cruse, M. Lawrence*, A. Olivera*, M. Jung*, J. Barber*, A. Freeman* ...

author keywords: Autosomal dominant hyper-IgE syndrome; Job syndrome; signal transducer and activator of transcription 3; mast cell; degranulation
Sources: Crossref, ORCID
Added: February 5, 2020

2013 journal article

Establishment of the Hermansky Pudlak Mastocyte (HPM) Cell Line Which Has the HPS1 16-Bp Duplication (c.1470_1486dup16)

Journal of Allergy and Clinical Immunology, 131(2), AB115.

By: A. Kirshenbaum*, A. Desai*, G. Bandara*, G. Cruse, E. Fischer*, A. Gilfillan*, W. Gahl*, D. Metcalfe*

Sources: Crossref, ORCID
Added: February 5, 2020

2012 journal article

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions

New England Journal of Medicine, 366(4), 330–338.

By: M. Ombrello*, E. Remmers, G. Sun, A. Freeman, S. Datta, P. Torabi-Parizi, N. Subramanian, T. Bunney ...

Source: ORCID
Added: February 11, 2019

2011 journal article

Functional KCa3.1 K+ channels are required for human fibrocyte migration

Journal of Allergy and Clinical Immunology, 128(6).

author keywords: Pulmonary fibrosis; asthma; fibrocyte; cell migration; ion channel; K(Ca)3.1; patch clamp electrophysiology
Source: ORCID
Added: February 11, 2019

2010 journal article

A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival

FASEB Journal, 24(10), 4047–4057.

By: G. Cruse, D. Kaur*, M. Leyland* & P. Bradding*

author keywords: MS4A2; IgE receptor; cell cycle; G2 phase; cell membrane
Source: ORCID
Added: February 11, 2019

2010 journal article

Activation of human mast cells through the platelet-activating factor receptor

Journal of Allergy and Clinical Immunology, 125(5).

By: N. Kajiwara*, T. Sasaki*, P. Bradding*, G. Cruse, H. Sagara*, K. Ohmori*, H. Saito*, C. Ra*, Y. Okayama*

author keywords: Anaphylaxis; histamine; human lung mast cells; human peripheral blood-derived mast cells; human skin mast cells; platelet-activating factor receptor
Source: ORCID
Added: February 11, 2019

2010 journal article

Airway smooth muscle proliferation and survival is not modulated by mast cells

Clinical and Experimental Allergy, 40(2), 279–288.

By: D. Kaur*, F. Hollins*, R. Saunders*, L. Woodman*, A. Sutcliffe*, G. Cruse, P. Bradding*, C. Brightling*

author keywords: airway smooth muscle; apoptosis; asthma; mast cells; necrosis; proliferation; survival
Source: ORCID
Added: February 11, 2019

2010 journal article

Counterregulation of β2-adrenoceptor function in human mast cells by stem cell factor

Journal of Allergy and Clinical Immunology, 125(1-3).

By: G. Cruse, W. Yang*, S. Duffy*, L. Chachi*, M. Leyland*, Y. Amrani*, P. Bradding*

author keywords: beta(2)-Adrenoceptor; albuterol; asthma; mast cell; desensitization
Source: ORCID
Added: February 11, 2019

2010 journal article

Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin

Journal of Immunology, 184(12), 7108–7115.

By: G. Cruse, V. Fernandes*, J. De Salort*, D. Pankhania*, M. Marinas*, H. Brewin*, P. Andrew*, P. Bradding*, A. Kadioglu*

Source: ORCID
Added: February 11, 2019

2009 journal article

Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis

Allergy: European Journal of Allergy and Clinical Immunology, 64(6), 951–958.

By: S. Siddiqui*, S. Gupta*, G. Cruse, P. Haldar*, J. Entwisle*, S. McDonald*, P. Whithers*, S. Hainsworth*, H. Coxson*, C. Brightling*

author keywords: airway hyperresponsiveness; asthma; computed tomography; eosinophilic bronchitis; geometry
Source: ORCID
Added: February 11, 2019

2009 journal article

IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis

BMC Pulmonary Medicine, 9.

By: S. Siddiqui*, G. Cruse, S. Mckenna*, W. Monteiro*, V. Mistry*, A. Wardlaw*, C. Brightling*

Source: ORCID
Added: February 11, 2019

2009 book

Mast Cells: Biological Properties and Role in Health and Allergic Diseases

In Allergy and Allergic Diseases, Second Edition (Vol. 1, pp. 217–257).

By: P. Bradding* & G. Cruse

Source: ORCID
Added: February 11, 2019

2008 journal article

Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration

European Journal of Immunology, 38(9), 2548–2556.

By: S. Duffy*, G. Cruse, S. Cockerill*, C. Brightling* & P. Bradding*

author keywords: chemotaxis; ion channel; K(Ca)3.1; mast cell; prostaglandin E-2
Source: ORCID
Added: February 11, 2019

2008 journal article

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: Cooperative roles for CADM1, stem cell factor, and IL-6

Journal of Immunology, 181(4), 2772–2780.

Source: ORCID
Added: February 11, 2019

2008 journal article

IgE alone promotes human lung mast cell survival through the autocrine production of IL-6

BMC Immunology, 9.

By: G. Cruse, S. Cockerill* & P. Bradding*

Source: ORCID
Added: February 11, 2019

2008 journal article

Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-β1

Journal of Immunology, 181(7), 5001–5007. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149280835&partnerID=MN8TOARS

By: L. Woodman, S. Siddiqui, G. Cruse, A. Sutcliffe, R. Saunders, D. Kaur, P. Bradding, C. Brightling

Source: ORCID
Added: February 11, 2019

2007 journal article

Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor

European Journal of Immunology, 37(6), 1653–1662.

author keywords: adenosine; chemotaxis; ion channel K(Ca)3.1; mast cell
Source: ORCID
Added: February 11, 2019

2007 journal article

KCa3.1 Ca2+-activated K+ channels regulate human airway smooth muscle proliferation

American Journal of Respiratory Cell and Molecular Biology, 37(5), 525–531.

By: M. Shepherd*, S. Duffy, T. Harris, G. Cruse, M. Schuliga, C. Brightling, C. Neylon, P. Bradding, A. Stewart

author keywords: asthma; ion channels; cell cycle
Source: ORCID
Added: February 11, 2019

2006 journal article

Functional KCa3.1 K+ channels are required for human lung mast cell migration

Thorax, 61(10), 880–885.

By: G. Cruse, S. Duffy*, C. Brightling* & P. Bradding*

Source: ORCID
Added: February 11, 2019

2005 journal article

Activation of human lung mast cells by monomeric immunoglobulin E

European Respiratory Journal, 25(5), 858–863.

By: G. Cruse, D. Kaur, W. Yang, S. Duffy, C. Brightling & P. Bradding

author keywords: asthma; calcium; human; mast cell; mediators; monomeric immunoglobulin E
Source: ORCID
Added: February 11, 2019

2005 journal article

Activation of human lung mast cells by monomeric immunoglobulin E (multiple letters) [2]

European Respiratory Journal, 26(4), 744–746.

By: S. Hart, I. Dransfield, P. Bradding & G. Cruse

Source: ORCID
Added: February 11, 2019

2005 journal article

β2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells

FASEB Journal, 19(8), 1006–1008.

By: S. Duffy*, G. Cruse, W. Lawley* & P. Bradding*

author keywords: salbutamol; ICI 118551; K(Ca)3.1; lung; G protein
Source: ORCID
Added: February 11, 2019

2004 journal article

The K + channel iK CA1 potentiates Ca 2+ influx and degranulation in human lung mast cells

Journal of Allergy and Clinical Immunology, 114(1), 66–72.

By: S. Mark Duffy, P. Berger*, G. Cruse, W. Yang*, S. Bolton* & P. Bradding*

author keywords: mast cell; human; K+; ion channel; Ca2+; histamine
Source: ORCID
Added: February 11, 2019

Employment

2016 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Molecular Biomedical Sciences