Works (49)
Updated: September 27th, 2023 05:00
2023 journal article
The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis
FRONTIERS IN IMMUNOLOGY, 14.
co-author countries:
United States of America 🇺🇸
author keywords: mast cell (MC); anaphylaxis; KIT; exon skipping; mast cell depletion
MeSH headings : Mice; Animals; Mast Cells; Anaphylaxis / genetics; Anaphylaxis / therapy; Mastocytosis; Allergens
www.frontiersin.org (publisher PDF)
Sources: Web Of Science, ORCID
Added: March 6, 2023
2022 article
Identification of redundancy between human Fc epsilon RI beta and MS4A6A proteins points toward additional complex mechanisms for Fc epsilon RI trafficking and signaling
Bitting, K., Hedgespeth, B., Ehrhardt-Humbert, L. C., Arthur, G. K., Schubert, A. G., Bradding, P., … Cruse, G. (2022, December 7). ALLERGY, Vol. 12.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: asthma; IgE; mast cells
MeSH headings : Animals; Humans; Mice; Basophils / metabolism; Cell Degranulation; Exons; Hypersensitivity / metabolism; Mast Cells / metabolism; Receptors, IgE / genetics; Receptors, IgE / metabolism; Signal Transduction
Sources: ORCID, Web Of Science
Added: November 25, 2022
2022 journal article
Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis
FRONTIERS IN ALLERGY, 3.
co-author countries:
United States of America 🇺🇸
author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
Sources: Web Of Science, ORCID
Added: September 25, 2023
2022 journal article
Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by Fc epsilon RI beta and the Potential Impact of Fc epsilon RI beta Splicing in Allergic Inflammation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(2).
co-author countries:
United States of America 🇺🇸
author keywords: mast cell; IgE receptor; Fc epsilon RI beta; antisense therapy; allergy; asthma; exon skipping
MeSH headings : Alternative Splicing; Animals; Biomarkers; Cell Degranulation / genetics; Cell Degranulation / immunology; Disease Susceptibility; Gene Expression Regulation; Humans; Hypersensitivity / diagnosis; Hypersensitivity / etiology; Hypersensitivity / metabolism; Hypersensitivity / therapy; Mast Cells / immunology; Mast Cells / metabolism; RNA Splicing; Receptors, IgE / chemistry; Receptors, IgE / genetics; Receptors, IgE / metabolism; Signal Transduction; Structure-Activity Relationship
Sources: Web Of Science, ORCID
Added: February 7, 2022
2022 journal article
Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms
MOLECULAR THERAPY, 30(1), 295–310.
co-author countries:
United States of America 🇺🇸
MeSH headings : Humans; Mast Cells / metabolism; Mast Cells / pathology; Mastocytosis / genetics; Mastocytosis / pathology; Mastocytosis / therapy; Proto-Oncogene Proteins c-kit / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptor Protein-Tyrosine Kinases / metabolism
Sources: Web Of Science, ORCID
Added: February 7, 2022
2021 journal article
Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation
TISSUE ENGINEERING PART A, 27(15-16), 1008–1022.
co-author countries:
United States of America 🇺🇸
author keywords: extracellular matrix; mast cell; allergy; metabolism
MeSH headings : Animals; Cell Differentiation; Collagen; Extracellular Matrix; Humans; Hydrogels; Mast Cells; Swine
Sources: Web Of Science, ORCID
Added: December 11, 2020
2021 journal article
Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness
JCI INSIGHT, 6(21).
co-author countries:
China 🇨🇳 United States of America 🇺🇸
MeSH headings : Adenosine Triphosphate / metabolism; Animals; Bronchial Hyperreactivity / metabolism; Female; Humans; Mast Cells / metabolism; Mice; Ozone / adverse effects
Sources: Web Of Science, ORCID
Added: January 31, 2022
2021 journal article
Mast Cell-Biomaterial Interactions and Tissue Repair
TISSUE ENGINEERING PART B-REVIEWS, 27(6), 590–603.
co-author countries:
United States of America 🇺🇸
author keywords: mast cells; biomaterials; inflammation; tissue repair; foreign body response; wound healing
MeSH headings : Biocompatible Materials; Cell Communication; Fibrosis; Humans; Mast Cells / pathology; Tissue Engineering
Sources: Web Of Science, ORCID
Added: March 8, 2021
2020 journal article
Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609.
co-author countries:
United States of America 🇺🇸
Contributors: E. Chee n, S. Nandi n, K. Nellenbach n, E. Mihalko n, D. Snider n, L. Morrill n, A. Bond n, E. Sproul n
author keywords: antimicrobial; microgels; nanosilver; platelet-mimetic; wound healing
MeSH headings : Acrylic Resins / chemistry; Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Blood Platelets; Clot Retraction; Colony-Forming Units Assay; Fibrin / chemistry; Fibrin / immunology; Gels; Hemorrhage / drug therapy; Hemostasis / drug effects; Liver / injuries; Male; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Microgels; Silver / administration & dosage; Silver / chemistry; Wound Healing
Sources: Web Of Science, ORCID
Added: March 16, 2020
2020 journal article
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
CELL REPORTS, 31(1).
co-author countries:
Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dogs; Female; Hypersensitivity / physiopathology; Integrin alpha5 / metabolism; Integrin beta3 / metabolism; Integrins / metabolism; Keratinocytes / metabolism; Male; Mice; Primates; Pruritus / metabolism; Pruritus / pathology; Sensory Receptor Cells / metabolism; Skin / metabolism
Sources: Web Of Science, ORCID
Added: April 27, 2020
2020 journal article
The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells
Cellular Signalling, 71, 109617.
co-author countries:
United States of America 🇺🇸
author keywords: Mast cell; IgE receptor; MS4A; Allergy; Orai1
MeSH headings : Calcium / metabolism; Calcium Signaling; Cell Degranulation; Cell Line; Cholesterol / metabolism; Fetal Blood / metabolism; Humans; Mast Cells / metabolism; Mast Cells / physiology; Membrane Microdomains / metabolism; Membrane Proteins / metabolism; ORAI1 Protein / metabolism; Phospholipase C gamma / metabolism; Proto-Oncogene Proteins c-kit / metabolism; Receptors, IgE / metabolism; Sequence Homology, Amino Acid; Signal Transduction
Source: ORCID
Added: April 10, 2020
2018 article
Exon Skipping of Fc epsilon RI beta for Allergic Diseases
EXON SKIPPING AND INCLUSION THERAPIES: METHODS AND PROTOCOLS, Vol. 1828, pp. 503–518.
co-author countries:
United States of America 🇺🇸
Contributors: G. Arthur n & n
author keywords: Mast cell; Allergic diseases; Allergic inflammation; Fc epsilon RI; Exon skipping
MeSH headings : Anaphylaxis; Animals; Calcium / metabolism; Calcium Signaling; Cell Degranulation / immunology; Exons; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Hypersensitivity / genetics; Hypersensitivity / immunology; Mast Cells / immunology; Mast Cells / metabolism; Mice; Oligonucleotides, Antisense / administration & dosage; Oligonucleotides, Antisense / genetics; RNA Splicing; Receptors, IgE / genetics; Transfection
Sources: Web Of Science, ORCID
Added: March 4, 2019
2016 journal article
Constitutive KIT Activity and IL-6 Production in Mast Cells Alters Levels of Reactive Oxygen Species (ROS) and the Scavenger Protein DJ-1 in Mastocytosis
Journal of Allergy and Clinical Immunology, 137(2), AB281.
co-author countries:
United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 25, 2020
2016 journal article
Exon skipping of Fc epsilon RI beta eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(49), 14115–14120.
co-author countries:
United States of America 🇺🇸
Contributors: n , Y. Yin *, T. Fukuyama n, A. Desai*, G. Arthur n, W. Bäumer n, M. Beaven*, D. Metcalfe *
author keywords: mast cell; allergy; IgE receptor; oligonucleotides; dermatitis
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Cytokines / biosynthesis; Dermatitis, Allergic Contact / therapy; Disease Models, Animal; Female; Humans; Mast Cells / drug effects; Mast Cells / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotides, Antisense / pharmacology; Oligonucleotides, Antisense / therapeutic use; Passive Cutaneous Anaphylaxis / genetics; RNA Splicing / drug effects; Receptors, IgE / genetics; Receptors, IgE / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Immunophenotypic and ultrastructural analysis of mast cells in hermansky-pudlak syndrome type-1: A possible connection to pulmonary fibrosis
PLoS ONE, 11(7).
Contributors: A. Kirshenbaum*, * , A. Desai*, G. Bandara*, M. Leerkes*, C. Lee*, E. Fischer *, . K.J. O'Brien
MeSH headings : Adult; Biomarkers; Case-Control Studies; Cell Line; Cells, Cultured; Chemotaxis; Cluster Analysis; Extracellular Matrix / metabolism; Female; Gene Expression Profiling; Hermanski-Pudlak Syndrome / diagnosis; Hermanski-Pudlak Syndrome / genetics; Hermanski-Pudlak Syndrome / metabolism; Humans; Imatinib Mesylate / pharmacology; Immunophenotyping; Lung / metabolism; Lung / pathology; Male; Mast Cells / drug effects; Mast Cells / metabolism; Mast Cells / ultrastructure; Membrane Proteins / genetics; Middle Aged; Mutation; Phenotype; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / pathology; Pulmonary Fibrosis / etiology; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Young Adult
Source: ORCID
Added: February 11, 2019
2016 journal article
Mast cells in airway diseases and interstitial lung disease
European Journal of Pharmacology, 778, 125–138.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Contributors: * & P. Bradding *
author keywords: Mast cell; Asthma; Airway diseases; Interstitial lung disease
MeSH headings : Animals; Cell Proliferation; Humans; Lung Diseases, Interstitial / immunology; Lung Diseases, Interstitial / microbiology; Mast Cells / microbiology; Mast Cells / pathology
Source: ORCID
Added: February 11, 2019
2016 journal article
Vibratory urticaria associated with a missense variant in ADGRE2
New England Journal of Medicine, 374(7), 656–663.
co-author countries:
France 🇫🇷 Lebanon 🇱🇧 Malaysia 🇲🇾 United States of America 🇺🇸
MeSH headings : Biopsy; Cell Degranulation / genetics; Female; Histamine / blood; Humans; Lebanon; Male; Mast Cells / physiology; Middle Aged; Mutation, Missense; Pedigree; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Skin / pathology; Urticaria / blood; Urticaria / etiology; Urticaria / genetics; Vibration / adverse effects
Source: ORCID
Added: February 11, 2019
2015 journal article
Constitutively Activated KIT in Mastocytosis Patients Is Associated with Decreased Levels of the Scavenger Protein DJ1 and Reciprocal Increases in Reactive Oxygen Species
Journal of Allergy and Clinical Immunology, 135(2), AB389.
co-author countries:
Poland 🇵🇱 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 25, 2020
2015 book
Flow cytometry-based monitoring of mast cell activation
In Methods in Molecular Biology (Vol. 1220, pp. 365–379).
co-author countries:
Czechia 🇨🇿 United States of America 🇺🇸
Contributors: * , A. Gilfillan* & D. Smrz *
author keywords: Mast cell; Signaling; Protein phosphorylation; Calcium signal; Actin polymerization/depolymerization; Degranulation; Flow cytometry
Source: ORCID
Added: February 11, 2019
2015 journal article
Mast Cells Expressing the Germline HPS1 16-Bp Duplication (c.1470_1486dup16, Hermansky-Pudlak Syndrome-1) Defect Produce Extracellular Matrix Components
Journal of Allergy and Clinical Immunology, 135(2), AB172.
co-author countries:
United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 25, 2020
2015 journal article
The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling
Molecular Biology of the Cell, 26(9), 1711–1727.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Contributors: * , M. Beaven*, S. Music*, P. Bradding *, A. Gilfillan* & D. Metcalfe *
MeSH headings : Antigens, CD20 / physiology; Cell Line; Cell Membrane / metabolism; Clathrin / metabolism; Endocytosis; Endosomes / metabolism; Gene Expression; Humans; Mast Cells / metabolism; Membrane Proteins / physiology; Phospholipase C gamma / metabolism; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-kit / metabolism; Signal Transduction; rab5 GTP-Binding Proteins / metabolism
Source: ORCID
Added: February 11, 2019
2015 journal article
The Fcεriβ Homologue, MS4A4, Promotes Fcεri-Dependent Human Mast Cell Degranulation By Facilitating PLCγ1 Signaling
Journal of Allergy and Clinical Immunology, 135(2), AB240.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 25, 2020
2014 journal article
Functional deregulation of KIT: Link to mast cell proliferative diseases and other neoplasms
Immunology and Allergy Clinics of North America, 34(2), 219–237.
co-author countries:
United States of America 🇺🇸
Contributors: * , D. Metcalfe * & A. Olivera*
author keywords: Mastocytosis; KIT mutations; KIT signaling; KIT trafficking; KIT inhibitors
MeSH headings : Bone Marrow / drug effects; Bone Marrow / metabolism; Bone Marrow / pathology; Cell Proliferation; Exons; Gene Expression Regulation, Neoplastic; Hematologic Neoplasms / diagnosis; Hematologic Neoplasms / drug therapy; Hematologic Neoplasms / genetics; Hematologic Neoplasms / pathology; Humans; Mast Cells / drug effects; Mast Cells / metabolism; Mast Cells / pathology; Mastocytosis / diagnosis; Mastocytosis / drug therapy; Mastocytosis / genetics; Mastocytosis / pathology; Mutation; Protein Kinase Inhibitors / therapeutic use; Protein Structure, Tertiary; Protein Transport; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / metabolism; Signal Transduction / genetics; Stem Cell Factor / genetics; Stem Cell Factor / metabolism
Source: ORCID
Added: February 11, 2019
2014 journal article
Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation
Journal of Immunology, 193(12), 5924–5932.
co-author countries:
United States of America 🇺🇸
Contributors: D. Smrz *, * , M. Beaven*, A. Kirshenbaum*, D. Metcalfe * & A. Gilfillan*
MeSH headings : Actins / metabolism; Calcium Signaling; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Degranulation / genetics; Cell Degranulation / immunology; Cell Line; Enzyme Activation; Gene Knockdown Techniques; Humans; Mast Cells / immunology; Mast Cells / metabolism; Protein Aggregates; Protein Transport; RNA Interference; Rapamycin-Insensitive Companion of mTOR Protein; Receptors, IgE / metabolism; Signal Transduction; TOR Serine-Threonine Kinases / metabolism
Source: ORCID
Added: February 11, 2019
2013 journal article
A Truncated Splice-Variant of the FcεRIβ Receptor Subunit Is Critical for Microtubule Formation and Degranulation in Mast Cells
Immunity, 38(5), 906–917.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Contributors: * , M. Beaven*, I. Ashmole*, P. Bradding *, A. Gilfillan* & D. Metcalfe *
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Calcium / metabolism; Calcium Signaling / immunology; Calmodulin-Binding Proteins / genetics; Calmodulin-Binding Proteins / immunology; Cell Degranulation / immunology; Golgi Apparatus / metabolism; Humans; Hypersensitivity / immunology; Immunoglobulin E / immunology; Interleukin-8 / metabolism; Mast Cells / immunology; Mast Cells / metabolism; Microtubules / metabolism; Prostaglandin D2 / biosynthesis; Prostaglandin D2 / immunology; Protein Isoforms / immunology; RNA Interference; RNA Splicing; RNA, Messenger; RNA, Small Interfering; Receptors, IgE / genetics; Receptors, IgE / metabolism
Source: ORCID
Added: February 11, 2019
2013 journal article
Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation
Journal of Allergy and Clinical Immunology, 132(6).
MeSH headings : Adolescent; Adult; Aged; Animals; Cell Degranulation / genetics; Cells, Cultured; Child; Child, Preschool; Dermatitis, Atopic / genetics; Dermatitis, Atopic / immunology; Female; Food Hypersensitivity / epidemiology; Food Hypersensitivity / genetics; Food Hypersensitivity / immunology; Humans; Immunoglobulin E / metabolism; Incidence; Infant; Job Syndrome / epidemiology; Job Syndrome / genetics; Job Syndrome / immunology; Male; Mast Cells / immunology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mutation / genetics; STAT3 Transcription Factor / genetics; STAT3 Transcription Factor / physiology; Signal Transduction / genetics; Transgenes / genetics; Young Adult
Source: ORCID
Added: February 11, 2019
2013 journal article
Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation
Journal of Allergy and Clinical Immunology, 132(6), 1388–1396.e3.
co-author countries:
United States of America 🇺🇸
author keywords: Autosomal dominant hyper-IgE syndrome; Job syndrome; signal transducer and activator of transcription 3; mast cell; degranulation
MeSH headings : Adolescent; Adult; Aged; Animals; Cell Degranulation / genetics; Cells, Cultured; Child; Child, Preschool; Dermatitis, Atopic / genetics; Dermatitis, Atopic / immunology; Female; Food Hypersensitivity / epidemiology; Food Hypersensitivity / genetics; Food Hypersensitivity / immunology; Humans; Immunoglobulin E / metabolism; Incidence; Infant; Job Syndrome / epidemiology; Job Syndrome / genetics; Job Syndrome / immunology; Male; Mast Cells / immunology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mutation / genetics; STAT3 Transcription Factor / genetics; STAT3 Transcription Factor / physiology; Signal Transduction / genetics; Transgenes / genetics; Young Adult
Sources: Crossref, ORCID
Added: February 5, 2020
2013 journal article
Establishment of the Hermansky Pudlak Mastocyte (HPM) Cell Line Which Has the HPS1 16-Bp Duplication (c.1470_1486dup16)
Journal of Allergy and Clinical Immunology, 131(2), AB115.
co-author countries:
United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 5, 2020
2012 journal article
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions
New England Journal of Medicine, 366(4), 330–338.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 Korea (Republic of) 🇰🇷 United States of America 🇺🇸
Contributors: M. Ombrello *, E. Remmers*, G. Sun*, A. Freeman *, S. Datta*, P. Torabi-Parizi *, N. Subramanian*, T. Bunney *
MeSH headings : Autoimmune Diseases / genetics; Cold Temperature / adverse effects; Cryopyrin-Associated Periodic Syndromes / genetics; DNA, Complementary / analysis; DNA, Complementary / isolation & purification; Female; Humans; Immunologic Deficiency Syndromes / genetics; Male; Pedigree; Phenotype; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Sequence Deletion
Source: ORCID
Added: February 11, 2019
2011 journal article
Functional KCa3.1 K+ channels are required for human fibrocyte migration
Journal of Allergy and Clinical Immunology, 128(6).
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: * , S. Singh *, S. Duffy*, C. Doe*, R. Saunders *, C. Brightling *, P. Bradding *
author keywords: Pulmonary fibrosis; asthma; fibrocyte; cell migration; ion channel; K(Ca)3.1; patch clamp electrophysiology
MeSH headings : Airway Remodeling / physiology; Asthma / metabolism; Asthma / pathology; Blotting, Western; Cell Differentiation / physiology; Cell Movement; Connective Tissue Cells / cytology; Connective Tissue Cells / metabolism; Fibrosis / metabolism; Fibrosis / pathology; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels / metabolism; Patch-Clamp Techniques; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction
Source: ORCID
Added: February 11, 2019
2010 journal article
A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival
FASEB Journal, 24(10), 4047–4057.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: * , D. Kaur *, M. Leyland* & P. Bradding *
author keywords: MS4A2; IgE receptor; cell cycle; G2 phase; cell membrane
MeSH headings : Amino Acid Sequence; Apoptosis; Base Sequence; Blotting, Western; Cell Cycle; Cell Proliferation; Cell Survival / physiology; DNA; DNA Primers; Electrophoresis, Polyacrylamide Gel; Humans; Mast Cells / cytology; Molecular Sequence Data; Receptors, IgE / chemistry; Receptors, IgE / physiology; Reverse Transcriptase Polymerase Chain Reaction
Source: ORCID
Added: February 11, 2019
2010 journal article
Activation of human mast cells through the platelet-activating factor receptor
Journal of Allergy and Clinical Immunology, 125(5).
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 Japan 🇯🇵
Contributors: N. Kajiwara*, T. Sasaki*, P. Bradding *, * , H. Sagara *, K. Ohmori*, H. Saito *, C. Ra *, Y. Okayama*
author keywords: Anaphylaxis; histamine; human lung mast cells; human peripheral blood-derived mast cells; human skin mast cells; platelet-activating factor receptor
MeSH headings : Anaphylaxis / immunology; Anaphylaxis / physiopathology; Cells, Cultured; Histamine Release; Humans; Lung / cytology; Mast Cells / cytology; Mast Cells / immunology; Mast Cells / metabolism; Platelet Activating Factor / metabolism; Platelet Membrane Glycoproteins / metabolism; Receptors, G-Protein-Coupled / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin / cytology
Source: ORCID
Added: February 11, 2019
2010 journal article
Airway smooth muscle proliferation and survival is not modulated by mast cells
Clinical and Experimental Allergy, 40(2), 279–288.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: D. Kaur *, F. Hollins*, R. Saunders *, L. Woodman*, A. Sutcliffe*, * , P. Bradding *, C. Brightling *
author keywords: airway smooth muscle; apoptosis; asthma; mast cells; necrosis; proliferation; survival
MeSH headings : Aged; Apoptosis; Asthma / immunology; Asthma / pathology; Cell Proliferation; Cell Survival; Cells, Cultured; Coculture Techniques; Female; Humans; Immunoglobulin E / immunology; Male; Mast Cells / immunology; Mast Cells / physiology; Middle Aged; Muscle, Smooth / metabolism; Muscle, Smooth / pathology
Source: ORCID
Added: February 11, 2019
2010 journal article
Counterregulation of β2-adrenoceptor function in human mast cells by stem cell factor
Journal of Allergy and Clinical Immunology, 125(1-3).
author keywords: beta(2)-Adrenoceptor; albuterol; asthma; mast cell; desensitization
MeSH headings : Albuterol / metabolism; Albuterol / pharmacology; Asthma / drug therapy; Asthma / metabolism; Asthma / physiopathology; Cell Line; Histamine Release; Humans; Lung / cytology; Lung / drug effects; Mast Cells / drug effects; Mast Cells / immunology; Mast Cells / metabolism; Potassium Channels, Calcium-Activated / metabolism; Receptors, Adrenergic, beta-2 / drug effects; Receptors, Adrenergic, beta-2 / metabolism; Stem Cell Factor / metabolism; Stem Cell Factor / pharmacology
Source: ORCID
Added: February 11, 2019
2010 journal article
Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin
Journal of Immunology, 184(12), 7108–7115.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: * , V. Fernandes *, J. De Salort*, D. Pankhania*, M. Marinas*, H. Brewin*, P. Andrew *, P. Bradding *, A. Kadioglu *
MeSH headings : Bacterial Proteins / immunology; Cell Degranulation / immunology; Cells, Cultured; Coculture Techniques; Humans; Lung / cytology; Lung / immunology; Mast Cells / immunology; Mast Cells / microbiology; Pneumococcal Infections / immunology; Streptococcus pneumoniae / immunology; Streptolysins / immunology
Source: ORCID
Added: February 11, 2019
2009 journal article
Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis
Allergy: European Journal of Allergy and Clinical Immunology, 64(6), 951–958.
co-author countries:
Canada 🇨🇦 United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: S. Siddiqui *, S. Gupta *, * , P. Haldar *, J. Entwisle*, S. McDonald, P. Whithers, S. Hainsworth*, H. Coxson*, C. Brightling *
author keywords: airway hyperresponsiveness; asthma; computed tomography; eosinophilic bronchitis; geometry
MeSH headings : Adult; Aged; Asthma / pathology; Bronchi / pathology; Bronchial Hyperreactivity / pathology; Bronchitis / pathology; Eosinophilia / pathology; Female; Humans; Male; Middle Aged; Tomography, X-Ray Computed
Source: ORCID
Added: February 11, 2019
2009 journal article
IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis
BMC Pulmonary Medicine, 9.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: S. Siddiqui *, * , S. Mckenna*, W. Monteiro*, V. Mistry *, A. Wardlaw*, C. Brightling *
MeSH headings : Adult; Asthma / blood; Asthma / pathology; Bronchitis / blood; Bronchitis / pathology; Case-Control Studies; Eosinophils / metabolism; Eosinophils / pathology; Female; Humans; Interleukin-13 / blood; Leukocytes, Mononuclear / metabolism; Leukocytes, Mononuclear / pathology; Male; Middle Aged; T-Lymphocytes / metabolism; T-Lymphocytes / pathology; Up-Regulation
Source: ORCID
Added: February 11, 2019
2009 book
Mast Cells: Biological Properties and Role in Health and Allergic Diseases
In Allergy and Allergic Diseases, Second Edition (Vol. 1, pp. 217–257).
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: P. Bradding * & *
Source: ORCID
Added: February 11, 2019
2008 journal article
Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration
European Journal of Immunology, 38(9), 2548–2556.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: S. Duffy*, * , S. Cockerill*, C. Brightling * & P. Bradding *
author keywords: chemotaxis; ion channel; K(Ca)3.1; mast cell; prostaglandin E-2
MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Benzimidazoles / pharmacology; Calcium Channel Agonists / pharmacology; Cell Movement / drug effects; Chemotaxis; Dinoprostone / metabolism; Histamine Release; Humans; Mast Cells / drug effects; Mast Cells / immunology; Mast Cells / physiology; Potassium Channels / immunology; Potassium Channels / metabolism; Prostaglandin Antagonists / pharmacology; Receptors, Prostaglandin E / agonists; Receptors, Prostaglandin E / antagonists & inhibitors; Receptors, Prostaglandin E / metabolism; Receptors, Prostaglandin E, EP2 Subtype; Xanthones / pharmacology
Source: ORCID
Added: February 11, 2019
2008 journal article
Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: Cooperative roles for CADM1, stem cell factor, and IL-6
Journal of Immunology, 181(4), 2772–2780.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧 Japan 🇯🇵
Contributors: F. Hollins*, D. Kaur *, W. Yang*, * , R. Saunders *, A. Sutcliffe*, P. Berger *, A. Ito *, C. Brightling *, P. Bradding *
MeSH headings : Cell Adhesion / immunology; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Cell Communication / immunology; Cell Movement / immunology; Cell Proliferation; Cell Survival / immunology; Cells, Cultured; Coculture Techniques; Humans; Immunoglobulins / physiology; Interleukin-6 / physiology; Mast Cells / cytology; Mast Cells / immunology; Mast Cells / metabolism; Membrane Proteins / physiology; Muscle, Smooth / cytology; Muscle, Smooth / immunology; Respiratory Mucosa / cytology; Respiratory Mucosa / immunology; Respiratory Mucosa / metabolism; Stem Cell Factor / physiology; Tumor Suppressor Proteins / physiology
Source: ORCID
Added: February 11, 2019
2008 journal article
IgE alone promotes human lung mast cell survival through the autocrine production of IL-6
BMC Immunology, 9.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: * , S. Cockerill* & P. Bradding *
MeSH headings : Autocrine Communication; Benzothiazoles; Cell Separation; Cell Survival; Cells, Cultured; Diamines; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Humans; Immunoglobulin E / immunology; Interleukin-6 / biosynthesis; Interleukin-6 / genetics; Interleukin-6 / immunology; Interleukin-6 / metabolism; Lung / cytology; Lung / immunology; Mast Cells / cytology; Mast Cells / immunology; Nucleic Acid Denaturation; Organic Chemicals; Quinolines; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Subcellular Fractions; Transcription, Genetic
Source: ORCID
Added: February 11, 2019
2008 journal article
Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-β1
Journal of Immunology, 181(7), 5001–5007. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149280835&partnerID=MN8TOARS
Source: ORCID
Added: February 11, 2019
2007 journal article
Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor
European Journal of Immunology, 37(6), 1653–1662.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: S. Duffy*, * , C. Brightling * & P. Bradding *
author keywords: adenosine; chemotaxis; ion channel K(Ca)3.1; mast cell
MeSH headings : Adenosine / analogs & derivatives; Adenosine / pharmacology; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Benzimidazoles / pharmacology; Calcium Channel Agonists / pharmacology; Cations / metabolism; Cell Movement / drug effects; Culture Media, Conditioned / pharmacology; Electric Stimulation; Electrophysiology; Histamine / metabolism; Humans; Immunoglobulin E / pharmacology; Intermediate-Conductance Calcium-Activated Potassium Channels / metabolism; Lung / cytology; Mast Cells / drug effects; Mast Cells / metabolism; Mast Cells / physiology; Phenethylamines / pharmacology; Receptor, Adenosine A2A / metabolism; Receptor, Adenosine A2B / metabolism; Triazines / pharmacology; Triazoles / pharmacology
Source: ORCID
Added: February 11, 2019
2007 journal article
KCa3.1 Ca2+-activated K+ channels regulate human airway smooth muscle proliferation
American Journal of Respiratory Cell and Molecular Biology, 37(5), 525–531.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
author keywords: asthma; ion channels; cell cycle
MeSH headings : Calcium / physiology; Cell Proliferation; Cells, Cultured; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels / biosynthesis; Intermediate-Conductance Calcium-Activated Potassium Channels / genetics; Intermediate-Conductance Calcium-Activated Potassium Channels / physiology; Muscle, Smooth / cytology; Muscle, Smooth / metabolism; Potassium / metabolism; RNA, Messenger / metabolism; Respiratory System / cytology; Respiratory System / metabolism; Transforming Growth Factor beta / physiology; Up-Regulation / physiology
Source: ORCID
Added: February 11, 2019
2006 journal article
Functional KCa3.1 K+ channels are required for human lung mast cell migration
Thorax, 61(10), 880–885.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: * , S. Duffy*, C. Brightling * & P. Bradding *
MeSH headings : Asthma / metabolism; Asthma / pathology; Calcium Channel Blockers / pharmacology; Carcinoma, Bronchogenic / pathology; Cell Proliferation; Cells, Cultured; Chemotaxis / physiology; Clotrimazole / pharmacology; Cytokines / pharmacology; Humans; Lung / cytology; Lung / metabolism; Mast Cells / cytology; Mast Cells / metabolism; Potassium Channels, Calcium-Activated / metabolism
Source: ORCID
Added: February 11, 2019
2005 journal article
Activation of human lung mast cells by monomeric immunoglobulin E
European Respiratory Journal, 25(5), 858–863.
author keywords: asthma; calcium; human; mast cell; mediators; monomeric immunoglobulin E
MeSH headings : Calcium / metabolism; Cells, Cultured; Culture Media, Conditioned; Histamine / metabolism; Humans; Immunoglobulin E / metabolism; Interleukin-8 / metabolism; Leukotriene C4 / metabolism; Lung / cytology; Lung / immunology; Mast Cells / immunology; Mast Cells / metabolism; Reference Values; Stem Cell Factor
Source: ORCID
Added: February 11, 2019
2005 journal article
Activation of human lung mast cells by monomeric immunoglobulin E (multiple letters) [2]
European Respiratory Journal, 26(4), 744–746.
MeSH headings : Centrifugation; Chromatography; Humans; Immunoglobulin E / chemistry; Immunoglobulin E / immunology; Immunoglobulin E / pharmacology; Immunologic Factors / chemistry; Immunologic Factors / immunology; Immunologic Factors / pharmacology; Lung / immunology; Mast Cells / drug effects; Mast Cells / immunology
Source: ORCID
Added: February 11, 2019
2005 journal article
β2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells
FASEB Journal, 19(8), 1006–1008.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: S. Duffy*, * , W. Lawley* & P. Bradding *
author keywords: salbutamol; ICI 118551; K(Ca)3.1; lung; G protein
MeSH headings : Adrenergic beta-Agonists / pharmacology; Albuterol / pharmacology; Antibodies / pharmacology; Benzimidazoles / pharmacology; Cells, Cultured; Electric Conductivity; GTP-Binding Protein alpha Subunits, Gs; Humans; Immunoglobulin E / immunology; Immunoglobulin E / physiology; Intermediate-Conductance Calcium-Activated Potassium Channels / drug effects; Intermediate-Conductance Calcium-Activated Potassium Channels / physiology; Ion Channel Gating / drug effects; Lung / cytology; Mast Cells / chemistry; Mast Cells / drug effects; Mast Cells / physiology; Propanolamines / pharmacology; Receptors, Adrenergic, beta-2 / physiology
Source: ORCID
Added: February 11, 2019
2004 journal article
The K + channel iK CA1 potentiates Ca 2+ influx and degranulation in human lung mast cells
Journal of Allergy and Clinical Immunology, 114(1), 66–72.
co-author countries:
United Kingdom of Great Britain and Northern Ireland 🇬🇧
Contributors: S. Mark Duffy*, P. Berger *, * , W. Yang*, S. Bolton* & P. Bradding *
author keywords: mast cell; human; K+; ion channel; Ca2+; histamine
MeSH headings : Benzimidazoles / pharmacology; Calcium / metabolism; Calcium Channel Agonists / pharmacology; Calcium Channel Blockers / pharmacology; Cell Degranulation / drug effects; Cell Degranulation / immunology; Cells, Cultured; Clotrimazole / pharmacology; Histamine / immunology; Humans; Immunoglobulin E / immunology; Intermediate-Conductance Calcium-Activated Potassium Channels; Lung / cytology; Lung / immunology; Mast Cells / drug effects; Mast Cells / immunology; Patch-Clamp Techniques; Potassium Channels / drug effects; Potassium Channels / metabolism; Pyrazoles / pharmacology
Source: ORCID
Added: February 11, 2019
Employment
Updated: August 24th, 2018 09:56
2016 - present
North Carolina State University Raleigh, NC, US
Assistant Professor
Molecular Biomedical Sciences
