Glenn Paul Cruse

Comparison of histochemical methods for the analysis of eosinophils and mast cells using a porcine model of eosinophilic esophagitis

Snider, D. B., Meyerholz, D. K., Dellon, E. S., Cortes, L. M., Karri, A., Blikslager, A. T., … Cruse, G. (2025, March 19). Frontiers in Veterinary Science, Vol. 12.

Corrigendum to ‘Round Window Membrane Extracellular Vesicles Facilitate Inner Ear Drug Delivery’ [Journal of Controlled Release 387 (2025) 114153].

Holdsclaw, S., Silkstone, D., Moazzam, F., Jeanneret, H., Tehsin, N., Norris, E., … Moatti, A. (2025, October 17). Journal of Controlled Release.

Evolution of mast cell research associated with the Laboratory of Allergic Diseases, 1985-2022: Summary of the 2023 NIAID Symposium

Komarow, H. D., Nilsson, G., Okayama, Y., Mekori, Y., Olivera, A., Valent, P., … Carter, M. C. (2025, July 7). Journal of Allergy and Clinical Immunology, Vol. 156, pp. 579–589.

Round window membrane extracellular vesicles facilitate inner ear drug delivery

Holdsclaw, S., Silkstone, D., Moazzam, F., Jeanneret, H., Tehsin, N., Norris, E., … Moatti, A. (2025, August 21). Journal of Controlled Release.

Antihistamine Medication Blunts Localized-Vibration-Induced Increases in Popliteal Blood Flow

Needs, D., Blotter, J., Fellingham, G. W., Cruse, G., Gifford, J. R., Johnson, A. W., & Feland, J. B. (2024, March 29). Vibration, Vol. 7, pp. 351–361.

Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice

Journal of Controlled Release, 359, 287–301.

The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis

Hedgespeth, B. A., Snider, D. B., Bitting, K. J., & Cruse, G. (2023, January 31). Frontiers in Immunology, Vol. 14.

Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling

Bitting, K., Hedgespeth, B., Ehrhardt‐Humbert, L. C., Arthur, G. K., Schubert, A. G., Bradding, P., … Cruse, G. (2022, November 25). Allergy, Vol. 12, pp. 1204–1217.

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis

Cortes, L. M., Brodsky, D., Chen, C., Pridgen, T., Odle, J., Snider, D. B., … Käser, T. (2022, November 14). Frontiers in Allergy, Vol. 3.

Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by FcεRIβ and the Potential Impact of FcεRIβ Splicing in Allergic Inflammation

Arthur, G. K., & Cruse, G. (2022, January 12). International Journal of Molecular Sciences, Vol. 1.

Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness

Kong, X., Bennett, W. C., Jania, C. M., Chason, K. D., German, Z., Adouli, J., … Tilley, S. L. (2021, September 22). JCI Insight, Vol. 11.

Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms

Snider, D. B., Arthur, G. K., Falduto, G. H., Olivera, A., Ehrhardt-Humbert, L. C., Smith, E., … Cruse, G. (2021, August 8). Molecular Therapy, Vol. 1, pp. 295–310.

Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation

Tissue Engineering Part A, 27(15-16), 1008–1022.

Mast Cell–Biomaterial Interactions and Tissue Repair

Tissue Engineering Part B: Reviews, 27(6), 590–603.

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet‐like particles

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(6), 2599–2609.

Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch

Mishra, S. K., Wheeler, J. J., Pitake, S., Ding, H., Jiang, C., Fukuyama, T., … Olivry, T. (2020, April 1). Cell Reports, Vol. 31.

The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells

Arthur, G. K., Ehrhardt-Humbert, L. C., Snider, D. B., Jania, C., Tilley, S. L., Metcalfe, D. D., & Cruse, G. (2020, March 30). Cellular Signalling, Vol. 71, p. 109617.

The Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch

Mishra, S. K., Wheeler, J., Pitake, S., Ding, H., Jiang, C., Fukuyama, T., … Olivry, T. (2019, January 1). SSRN Electronic Journal.

Exon Skipping of FcεRIβ for Allergic Diseases

Arthur, G. K., & Cruse, G. (2018, January 1). Methods in Molecular Biology, Vol. 1828, pp. 503–518.

Constitutive KIT Activity and IL-6 Production in Mast Cells Alters Levels of Reactive Oxygen Species (ROS) and the Scavenger Protein DJ-1 in Mastocytosis

Journal of Allergy and Clinical Immunology, 137(2), AB281.

Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

Cruse, G., Yin, Y., Fukuyama, T., Desai, A., Arthur, G. K., Bäumer, W., … Metcalfe, D. D. (2016, November 21). Proceedings of the National Academy of Sciences, Vol. 113, pp. 14115–14120.

Immunophenotypic and Ultrastructural Analysis of Mast Cells in Hermansky-Pudlak Syndrome Type-1: A Possible Connection to Pulmonary Fibrosis

Kirshenbaum, A. S., Cruse, G., Desai, A., Bandara, G., Leerkes, M., Lee, C.-C. R., … Metcalfe, D. D. (2016, July 26). PLoS ONE, Vol. 11.

Vibratory Urticaria Associated with a Missense Variant inADGRE2

Boyden, S. E., Desai, A., Cruse, G., Young, M. L., Bolan, H. C., Scott, L. M., … Komarow, H. D. (2016, February 3). New England Journal of Medicine, Vol. 374, pp. 656–663.

Constitutively Activated KIT in Mastocytosis Patients Is Associated with Decreased Levels of the Scavenger Protein DJ1 and Reciprocal Increases in Reactive Oxygen Species

Journal of Allergy and Clinical Immunology, 135(2), AB389.

Mast Cells Expressing the Germline HPS1 16-Bp Duplication (c.1470_1486dup16, Hermansky-Pudlak Syndrome-1) Defect Produce Extracellular Matrix Components

Journal of Allergy and Clinical Immunology, 135(2), AB172.

Mast cells in airway diseases and interstitial lung disease

Cruse, G., & Bradding, P. (2015, May 8). European Journal of Pharmacology, Vol. 778, pp. 125–138.

The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling

Cruse, G., Beaven, M. A., Music, S. C., Bradding, P., Gilfillan, A. M., & Metcalfe, D. D. (2015, February 26). Molecular Biology of the Cell, Vol. 26, pp. 1711–1727.

The Fcεriβ Homologue, MS4A4, Promotes Fcεri-Dependent Human Mast Cell Degranulation By Facilitating PLCγ1 Signaling

Journal of Allergy and Clinical Immunology, 135(2), AB240.

Flow Cytometry-Based Monitoring of Mast Cell Activation

Cruse, G., Gilfillan, A. M., & Smrz, D. (2014, September 12). Methods in Molecular Biology, Vol. 1220, pp. 365–379.

Functional Deregulation of KIT

Cruse, G., Metcalfe, D. D., & Olivera, A. (2014, March 15). Immunology and Allergy Clinics of North America, Vol. 34, pp. 219–237.

Rictor Negatively Regulates High-Affinity Receptors for IgE-Induced Mast Cell Degranulation

Smrz, D., Cruse, G., Beaven, M. A., Kirshenbaum, A., Metcalfe, D. D., & Gilfillan, A. M. (2014, November 7). The Journal of Immunology, Vol. 193, pp. 5924–5932.

A Truncated Splice-Variant of the FcεRIβ Receptor Subunit Is Critical for Microtubule Formation and Degranulation in Mast Cells

Cruse, G., Beaven, M. A., Ashmole, I., Bradding, P., Gilfillan, A. M., & Metcalfe, D. D. (2013, May 1). Immunity, Vol. 38, pp. 906–917.

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation

Journal of Allergy and Clinical Immunology, Vol. 132.

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation

Journal of Allergy and Clinical Immunology, 132(6), 1388–1396.e3.

Establishment of the Hermansky Pudlak Mastocyte (HPM) Cell Line Which Has the HPS1 16-Bp Duplication (c.1470_1486dup16)

Journal of Allergy and Clinical Immunology, 131(2), AB115.

Cold Urticaria, Immunodeficiency, and Autoimmunity Related toPLCG2Deletions

Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., … Milner, J. D. (2012, January 11). New England Journal of Medicine, Vol. 366, pp. 330–338.

Functional KCa3.1 K+ channels are required for human fibrocyte migration

Cruse, G., Singh, S. R., Duffy, S. M., Doe, C., Saunders, R., Brightling, C. E., & Bradding, P. (2011, August 29). Journal of Allergy and Clinical Immunology, Vol. 128.

A novel FcεRIβ‐chain truncation regulates human mast cell proliferation and survival

Cruse, G., Kaur, D., Leyland, M., & Bradding, P. (2010, June 16). The FASEB Journal, Vol. 24, pp. 4047–4057.

Activation of human mast cells through the platelet-activating factor receptor

Kajiwara, N., Sasaki, T., Bradding, P., Cruse, G., Sagara, H., Ohmori, K., … Okayama, Y. (2010, April 15). Journal of Allergy and Clinical Immunology, Vol. 125.

Airway smooth muscle proliferation and survival is not modulated by mast cells

Kaur, D., Hollins, F., Saunders, R., Woodman, L., Sutcliffe, A., Cruse, G., … Brightling, C. (2010, January 11). Clinical & Experimental Allergy, Vol. 40, pp. 279–288.

Human Lung Mast Cells Mediate Pneumococcal Cell Death in Response to Activation by Pneumolysin

Cruse, G., Fernandes, V. E., Salort, J., Pankhania, D., Marinas, M. S., Brewin, H., … Kadioglu, A. (2010, May 11). The Journal of Immunology, Vol. 184, pp. 7108–7115.

Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis

Siddiqui, S., Gupta, S., Cruse, G., Haldar, P., Entwisle, J., Mcdonald, S., … Brightling, C. (2009, February 11). Allergy, Vol. 64, pp. 951–958.

Counterregulation of β2-adrenoceptor function in human mast cells by stem cell factor

Cruse, G., Yang, W., Duffy, S. M., Chachi, L., Leyland, M., Amrani, Y., & Bradding, P. (2009, October 28). Journal of Allergy and Clinical Immunology, Vol. 125.

IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis

Siddiqui, S., Cruse, G., Mckenna, S., Monteiro, W., Mistry, V., Wardlaw, A., & Brightling, C. (2009, July 14). BMC Pulmonary Medicine, Vol. 9.

Engagement of the EP₂ prostanoid receptor closes the K⁺ channel K_Ca3.1 in human lung mast cells and attenuates their migration

Duffy, S. M., Cruse, G., Cockerill, S. L., Brightling, C. E., & Bradding, P. (2008, September 1). European Journal of Immunology, Vol. 38, pp. 2548–2556.

Human Airway Smooth Muscle Promotes Human Lung Mast Cell Survival, Proliferation, and Constitutive Activation: Cooperative Roles for CADM1, Stem Cell Factor, and IL-6

Hollins, F., Kaur, D., Yang, W., Cruse, G., Saunders, R., Sutcliffe, A., … Bradding, P. (2008, August 15). The Journal of Immunology, Vol. 181, pp. 2772–2780.

IgE alone promotes human lung mast cell survival through the autocrine production of IL-6

Cruse, G., Cockerill, S., & Bradding, P. (2008, January 1). BMC Immunology, Vol. 9.

Mast Cells: Biological Properties and Role in Health and Allergic Diseases

Bradding, P., & Cruse, G. (2008, July 25). Allergy and Allergic Diseases, Second Edition, Vol. 1, pp. 217–257.

Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-β1

Journal of Immunology, 181(7), 5001–5007. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149280835&partnerID=MN8TOARS

Adenosine closes the K⁺ channel K_Ca3.1 in human lung mast cells and inhibits their migration via the adenosine A_2A receptor

Duffy, S. M., Cruse, G., Brightling, C. E., & Bradding, P. (2007, May 2). European Journal of Immunology, Vol. 37, pp. 1653–1662.

K_Ca3.1 Ca²⁺Activated K⁺ Channels Regulate Human Airway Smooth Muscle Proliferation

Shepherd, M. C., Duffy, S. M., Harris, T., Cruse, G., Schuliga, M., Brightling, C. E., … Stewart, A. G. (2007, June 22). American Journal of Respiratory Cell and Molecular Biology, Vol. 37, pp. 525–531.

Functional KCa3.1 K+ channels are required for human lung mast cell migration

Cruse, G., Duffy, S. M., Brightling, C. E., & Bradding, P. (2006, June 30). Thorax, Vol. 61, pp. 880–885.

Activation of human lung mast cells by monomeric immunoglobulin E

Cruse, G., Kaur, D., Yang, W., Duffy, S. M., Brightling, C. E., & Bradding, P. (2005, April 29). European Respiratory Journal, Vol. 25, pp. 858–863.

Activation of human lung mast cells by monomeric immunoglobulin E: Table. 1—

Hart, S. P., Dransfield, I., Bradding, P., & Cruse, G. (2005, October 1). European Respiratory Journal, Vol. 26, pp. 744–746.

β ₂ ‐Adrenoceptor regulation of the K ⁺ channel iK _Ca 1 in human mast cells

Duffy, S. M., Cruse, G., Lawley, W. J., & Bradding, P. (2005, April 7). The FASEB Journal, Vol. 19, pp. 1006–1008.

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells

Duffy, S. M., Berger, P., Cruse, G., Yang, W., Bolton, S. J., & Bradding, P. (2004, July 1). Journal of Allergy and Clinical Immunology, Vol. 114, pp. 66–72.