Works (4)
Updated: July 18th, 2023 21:18
2014 journal article
Computationally Efficient Particle Release Map Determination for Direct Tumor-Targeting in a Representative Hepatic Artery System
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 136(1).
author keywords: drug-particle transport; tumor-targeting; computational efficiency
MeSH headings : Antineoplastic Agents / administration & dosage; Computer Simulation; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Hepatic Artery / physiology; Humans; Infusions, Intra-Arterial; Microspheres; Models, Cardiovascular; Pulsatile Flow
TL;DR:
While the best steady PRMs provide a qualitative guide for best catheter placement, the final injection position could be adjusted in vivo using biodegradable mock-spheres to ensure that patient-specific optimal tumor-targeting is achieved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Impact of Fluid-Structure Interaction on Direct Tumor-Targeting in a Representative Hepatic Artery System
ANNALS OF BIOMEDICAL ENGINEERING, 42(3), 461–474.
author keywords: Optimal tumor-targeting; Drug particles; Fluid-particle dynamics; Fluid-structure interaction; Rigid-wall assumption
MeSH headings : Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Computer Simulation; Drug Delivery Systems; Hemorheology; Hepatic Artery / physiopathology; Humans; Liver Neoplasms / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / physiopathology; Models, Cardiovascular
TL;DR:
The impact of fluid–structure interaction on direct drug-targeting is evaluated, using a representative hepatic artery system with liver tumor as a test bed and it was found that the best rigid geometry is the physiological one that occurs during the diastolic targeting interval.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Experimental Microsphere Targeting in a Representative Hepatic Artery System
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 59(1), 198–204.
author keywords: Computational fluid-particle dynamics; hepatic artery (HA); liver tumor; radioembolization (RE)
MeSH headings : Animals; Blood Flow Velocity / physiology; Blood Physiological Phenomena; Brachytherapy / instrumentation; Computer Simulation; Drug Carriers / chemistry; Hepatic Artery / physiopathology; Humans; Microspheres; Models, Cardiovascular; Motion; Radiopharmaceuticals / chemistry; Rheology / methods
TL;DR:
The experimental results validate the simulation methodology for achieving targeted microsphere distributions in a known geometry under constant flow conditions and exhibited a clear dependence on injection location that correlated very strongly with the computationally predicted results.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System
ANNALS OF BIOMEDICAL ENGINEERING, 38(5), 1862–1879.
author keywords: Computational fluid-particle dynamics; Yttrium-90 particle transport; Transient particle-hemodynamics; Non-Newtonian fluid; Drug-targeting methodology
MeSH headings : Animals; Computer Simulation; Drug Delivery Systems / methods; Hemodynamics / physiology; Hepatic Artery / physiology; Liver / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / radiotherapy; Microspheres; Yttrium / adverse effects
TL;DR:
Results begin paving the way towards directing 100% of the released microspheres to specific daughter vessels under transient flow conditions in realistic geometries via a novel drug-particle targeting methodology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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