Emily Michelle Childress

Works (4)

Updated: July 18th, 2023 21:18

2013 article

Computationally Efficient Particle Release Map Determination for Direct Tumor-Targeting in a Representative Hepatic Artery System

Childress, E. M., & Kleinstreuer, C. (2013, November 4). Journal of Biomechanical Engineering.

By: E. Childress n & C. Kleinstreuer n

author keywords: drug-particle transport; tumor-targeting; computational efficiency
MeSH headings : Antineoplastic Agents / administration & dosage; Computer Simulation; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Hepatic Artery / physiology; Humans; Infusions, Intra-Arterial; Microspheres; Models, Cardiovascular; Pulsatile Flow
topics (OpenAlex): Hepatocellular Carcinoma Treatment and Prognosis; Nanoparticle-Based Drug Delivery; Liver physiology and pathology
TL;DR: While the best steady PRMs provide a qualitative guide for best catheter placement, the final injection position could be adjusted in vivo using biodegradable mock-spheres to ensure that patient-specific optimal tumor-targeting is achieved. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

Impact of Fluid–Structure Interaction on Direct Tumor-Targeting in a Representative Hepatic Artery System

Childress, E. M., & Kleinstreuer, C. (2013, September 18). Annals of Biomedical Engineering.

By: E. Childress n & C. Kleinstreuer n

author keywords: Optimal tumor-targeting; Drug particles; Fluid-particle dynamics; Fluid-structure interaction; Rigid-wall assumption
MeSH headings : Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Computer Simulation; Drug Delivery Systems; Hemorheology; Hepatic Artery / physiopathology; Humans; Liver Neoplasms / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / physiopathology; Models, Cardiovascular
topics (OpenAlex): Elasticity and Material Modeling; Fluid Dynamics Simulations and Interactions; Computational Fluid Dynamics and Aerodynamics
TL;DR: The impact of fluid–structure interaction on direct drug-targeting is evaluated, using a representative hepatic artery system with liver tumor as a test bed and it was found that the best rigid geometry is the physiological one that occurs during the diastolic targeting interval. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 article

Experimental Microsphere Targeting in a Representative Hepatic Artery System

Richards, A. L., Kleinstreuer, C., Kennedy, A. S., Childress, E., & Buckner, G. D. (2011, October 5). IEEE Transactions on Biomedical Engineering.

By: A. Richards n, C. Kleinstreuer n, A. Kennedy, E. Childress n & G. Buckner n

author keywords: Computational fluid-particle dynamics; hepatic artery (HA); liver tumor; radioembolization (RE)
MeSH headings : Animals; Blood Flow Velocity / physiology; Blood Physiological Phenomena; Brachytherapy / instrumentation; Computer Simulation; Drug Carriers / chemistry; Hepatic Artery / physiopathology; Humans; Microspheres; Models, Cardiovascular; Motion; Radiopharmaceuticals / chemistry; Rheology / methods
topics (OpenAlex): Hepatocellular Carcinoma Treatment and Prognosis; Liver physiology and pathology; Cyclone Separators and Fluid Dynamics
TL;DR: The experimental results validate the simulation methodology for achieving targeted microsphere distributions in a known geometry under constant flow conditions and exhibited a clear dependence on injection location that correlated very strongly with the computationally predicted results. (via Semantic Scholar)
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Added: August 6, 2018

2010 article

Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System

Basciano, C. A., Kleinstreuer, C., Kennedy, A. S., Dezarn, W. A., & Childress, E. (2010, February 16). Annals of Biomedical Engineering.

By: C. Basciano n, C. Kleinstreuer n, A. Kennedy *, W. Dezarn* & E. Childress n

author keywords: Computational fluid-particle dynamics; Yttrium-90 particle transport; Transient particle-hemodynamics; Non-Newtonian fluid; Drug-targeting methodology
MeSH headings : Animals; Computer Simulation; Drug Delivery Systems / methods; Hemodynamics / physiology; Hepatic Artery / physiology; Liver / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / radiotherapy; Microspheres; Yttrium / adverse effects
topics (OpenAlex): Cyclone Separators and Fluid Dynamics; Hepatocellular Carcinoma Treatment and Prognosis; Gas Dynamics and Kinetic Theory
TL;DR: Results begin paving the way towards directing 100% of the released microspheres to specific daughter vessels under transient flow conditions in realistic geometries via a novel drug-particle targeting methodology. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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