Emily Michelle Childress

Works (4)

Updated: July 18th, 2023 21:18

2013 journal article

Computationally Efficient Particle Release Map Determination for Direct Tumor-Targeting in a Representative Hepatic Artery System

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 136(1).

By: E. Childress n & C. Kleinstreuer n

author keywords: drug-particle transport; tumor-targeting; computational efficiency
MeSH headings : Antineoplastic Agents / administration & dosage; Computer Simulation; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Hepatic Artery / physiology; Humans; Infusions, Intra-Arterial; Microspheres; Models, Cardiovascular; Pulsatile Flow
TL;DR: While the best steady PRMs provide a qualitative guide for best catheter placement, the final injection position could be adjusted in vivo using biodegradable mock-spheres to ensure that patient-specific optimal tumor-targeting is achieved. (via Semantic Scholar)
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Added: August 6, 2018

2013 journal article

Impact of Fluid-Structure Interaction on Direct Tumor-Targeting in a Representative Hepatic Artery System

ANNALS OF BIOMEDICAL ENGINEERING, 42(3), 461–474.

By: E. Childress n & C. Kleinstreuer n

author keywords: Optimal tumor-targeting; Drug particles; Fluid-particle dynamics; Fluid-structure interaction; Rigid-wall assumption
MeSH headings : Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Computer Simulation; Drug Delivery Systems; Hemorheology; Hepatic Artery / physiopathology; Humans; Liver Neoplasms / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / physiopathology; Models, Cardiovascular
TL;DR: The impact of fluid–structure interaction on direct drug-targeting is evaluated, using a representative hepatic artery system with liver tumor as a test bed and it was found that the best rigid geometry is the physiological one that occurs during the diastolic targeting interval. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Experimental Microsphere Targeting in a Representative Hepatic Artery System

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 59(1), 198–204.

By: A. Richards n, C. Kleinstreuer n, A. Kennedy, E. Childress n & G. Buckner n

author keywords: Computational fluid-particle dynamics; hepatic artery (HA); liver tumor; radioembolization (RE)
MeSH headings : Animals; Blood Flow Velocity / physiology; Blood Physiological Phenomena; Brachytherapy / instrumentation; Computer Simulation; Drug Carriers / chemistry; Hepatic Artery / physiopathology; Humans; Microspheres; Models, Cardiovascular; Motion; Radiopharmaceuticals / chemistry; Rheology / methods
TL;DR: The experimental results validate the simulation methodology for achieving targeted microsphere distributions in a known geometry under constant flow conditions and exhibited a clear dependence on injection location that correlated very strongly with the computationally predicted results. (via Semantic Scholar)
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Added: August 6, 2018

2010 journal article

Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System

ANNALS OF BIOMEDICAL ENGINEERING, 38(5), 1862–1879.

By: C. Basciano n, C. Kleinstreuer n, A. Kennedy *, W. Dezarn* & E. Childress n

author keywords: Computational fluid-particle dynamics; Yttrium-90 particle transport; Transient particle-hemodynamics; Non-Newtonian fluid; Drug-targeting methodology
MeSH headings : Animals; Computer Simulation; Drug Delivery Systems / methods; Hemodynamics / physiology; Hepatic Artery / physiology; Liver / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / radiotherapy; Microspheres; Yttrium / adverse effects
TL;DR: Results begin paving the way towards directing 100% of the released microspheres to specific daughter vessels under transient flow conditions in realistic geometries via a novel drug-particle targeting methodology. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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