Jocsa Cortes

College of Veterinary Medicine

Works (4)

Updated: July 5th, 2023 15:02

2022 journal article

Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells

GUT MICROBES, 14(1).

By: B. Sheahan n , C. Theriot n, J. Cortes n & C. Dekaney n

author keywords: Microbiota; intestinal stem cells; doxorubicin; antibiotics; antimicrobials; DNA damage; germ free; injury; small intestine
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Gastrointestinal Microbiome / drug effects; Germ-Free Life; Humans; Jejunum / cytology; Jejunum / drug effects; Jejunum / microbiology; Mice; Mice, Inbred C57BL; Mucositis / microbiology; Mucositis / prevention & control; Stem Cells / cytology; Stem Cells / drug effects; Time Factors
TL;DR: Pro-survival signaling from microbiota in AMBx-treated mice to the aISCs is suggested, and that this signaling maintains aISC retention in the face of chemotherapeutic injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022

2021 journal article

Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(6), G668–G681.

By: M. Shanahan *, M. Kanke *, O. Oyesola *, Y. Hung *, K. Koch-Laskowski *, A. Singh *, B. Peck *, M. Biraud n ...

author keywords: intestinal epithelium; marker; microRNA; Paneth; tuft
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage; Cell Separation; Cells, Cultured; Computational Biology; Dogs; Epithelial Cells / metabolism; Female; Flow Cytometry; Gene Expression Profiling; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestine, Small / cytology; Intestine, Small / metabolism; Male; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs / genetics; MicroRNAs / metabolism; Organoids; RNA-Seq; Single-Cell Analysis; Transcriptome
TL;DR: Comprehensive microRNA profiling in all major cell types of the mouse SI epithelium revealed highly enriched microRNA markers for almost every major cell type, and observed that the two most-enriched microRNAs in secretory progenitors are miR-1224 andMiR-672, the latter of which is deleted in hominin species. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2020 journal article

Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers

SCIENTIFIC REPORTS, 10(1).

By: P. Cray n, B. Sheahan n , J. Cortes n & C. Dekaney n

MeSH headings : Animals; Cell Line; Cell Membrane Permeability / drug effects; Doxorubicin / metabolism; Doxorubicin / pharmacology; Duodenum / metabolism; Epithelium / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestine, Small / drug effects; Intestine, Small / metabolism; Jejunum / metabolism; Male; Mice; Mice, Inbred C57BL; Permeability / drug effects; Tight Junctions / metabolism
TL;DR: DXR increases paracellular transit of small macromolecules, including bacterial products, through the epithelium, by altering expression of tight junctional components and dynamic loosening of cellular tight junctions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021

2019 journal article

Mist1 Expression Is Required for Paneth Cell Maturation

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 8(4), 549–560.

By: C. Dekaney n, S. King  n, B. Sheahan n  & J. Cortes n

author keywords: MIST1; Paneth Cells; Intermediate Cells
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / biosynthesis; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Cell Differentiation / physiology; Cell Division / physiology; Cell Lineage; Endoplasmic Reticulum Stress; Endoplasmic Reticulum, Rough / physiology; Epithelium / metabolism; Female; Intestinal Mucosa / metabolism; Intestine, Small / physiology; Intestines / physiology; Mice; Mice, Knockout; Paneth Cells / metabolism; Paneth Cells / physiology; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Transcriptome
TL;DR: MIST1 plays an important role in organization of the Paneth cell secretory apparatus and managing endoplasmic reticulum stress, which occurs downstream ofPaneth cell lineage allocation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 16, 2019

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