Leandi Kruger

Works (2)

Updated: July 7th, 2023 21:17

2020 journal article

Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 318(4), G613–G623.

By: L. Kruger n, T. Pridgen n, E. Taylor n, K. Garman * & A. Blikslager n 

author keywords: ClC-2; esophagus; injury; lubiprostone; repair
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Bumetanide / pharmacology; Chloride Channel Agonists / pharmacology; Chloride Channels / genetics; Chloride Channels / metabolism; Chlorides / pharmacology; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Dose-Response Relationship, Drug; Esophageal Mucosa / drug effects; Female; Gene Expression Regulation / drug effects; Hydrochloric Acid / pharmacology; Lubiprostone / pharmacology; Male; Occludin / metabolism; Swine; Time Factors; Zinc Compounds / pharmacology
TL;DR: It is concluded that ClC-2 contributes to esophageal protection from acid exposure, potentially offering a new therapeutic target. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2017 journal article

Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair

American Journal of Physiology-Gastrointestinal and Liver Physiology, 313(3), G180–G191.

By: L. Krüger n, L. Gonzalez n , T. Pridgen n, S. McCall *, R. Furstenberg* , I. Harnden*, G. Carnighan n, A. Cox n ...

author keywords: esophagus; injury; repair; esophageal submucosal gland; proliferation
MeSH headings : Active Transport, Cell Nucleus; Animals; Cell Proliferation / physiology; Esophageal Diseases / pathology; Esophagus / cytology; Esophagus / injuries; Female; Gene Expression Regulation / physiology; Humans; Male; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Staining and Labeling; Swine
TL;DR: A novel porcine model of injury and repair using radiofrequency ablation has been developed, allowing for reproducible injury to the esophagus to study repair in an animal model with esophageal submucosal glands, a key anatomical feature and missing in rodent models but possibly harboring progenitor cells. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

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