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Works (10)
Updated: November 23rd, 2024 05:02
2023 journal article
Enteric glial cell network function is required for epithelial barrier restitution following intestinal ischemic injury in the early postnatal period
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 326(3), G228–G246.
author keywords: enteric glia; epithelial restitution; intestinal barrier; intestinal ischemia; restitution
TL;DR:
A neonatal phenotype characterized by a complete lack of coordinated reparative signaling in the mucosal microenvironment is confirmed and important evidence is reported that the subepithelial EGC network changes significantly over the early postnatal period and that proximity of a specific functional population of EGC to wounded intestinal epithelium contributes to intestinal barrier restitution following ischemic injury.
(via Semantic Scholar)
open access via www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 12, 2024
2022 journal article
Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis
FRONTIERS IN ALLERGY, 3.
author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
TL;DR:
Swine is established as a relevant large animal model for translational biomedical research in EoE with the potential to facilitate development of therapeutics and it is demonstrated that the sensitization and oral challenge protocol not only induces the underlying immune markers but also the micro- and macro-pathological hallmarks of human EiE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023
2021 journal article
Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions
PLOS ONE, 16(4).
MeSH headings : Animals; Disease Models, Animal; Female; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Ischemia / drug therapy; Ischemia / metabolism; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Male; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability / drug effects; Swine; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR:
It is concluded that LA stimulates repair of ischemic-injured epithelium at the level of the tight junctions, at an optimal dose of 1 μM LA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 journal article
Steroid Eluting Esophageal-Targeted Drug Delivery Devices for Treatment of Eosinophilic Esophagitis
POLYMERS, 13(4).
author keywords: eosinophilic esophagitis (EoE); esophageal drug delivery systems; drug-eluting string; 3D printing; photopolymerizable resins; Drug loading strategies; steroids; fluticasone
TL;DR:
Two novel esophageal-specific drug delivery platforms are reported, including a fluticasone-eluting string that could be swallowed similar to the string test “entero-test” and used for overnight treatment, and a 3D printed ring for local and sustained release of flutic asone in the esophagus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 18, 2021
2020 article
A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia
Sheridan, A., Pridgen, T., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
It is hypothesized that EGC inhibition in juveniles will block epithelial barrier repair after ischemic injury mimicking the neonatal phenotype, and the development of glial‐epithelial crosstalk in barrier repair will ultimately guide novel clinical solutions to improve outcomes in neonatal patients affected by intestinal injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020
2020 journal article
Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model
TISSUE BARRIERS, 8(4).
author keywords: Intestinal barrier; ischemia; stress; pig model; tight junctions
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / physiopathology; Ischemia / physiopathology; Permeability; Swine
TL;DR:
The effects of a period of environmental acclimation versus acute transport stress on mucosal barrier repair after intestinal ischemic injury and recovery are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 27, 2020
2020 journal article
Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 318(4), G613–G623.
author keywords: ClC-2; esophagus; injury; lubiprostone; repair
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Bumetanide / pharmacology; Chloride Channel Agonists / pharmacology; Chloride Channels / genetics; Chloride Channels / metabolism; Chlorides / pharmacology; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Dose-Response Relationship, Drug; Esophageal Mucosa / drug effects; Female; Gene Expression Regulation / drug effects; Hydrochloric Acid / pharmacology; Lubiprostone / pharmacology; Male; Occludin / metabolism; Swine; Time Factors; Zinc Compounds / pharmacology
TL;DR:
It is concluded that ClC-2 contributes to esophageal protection from acid exposure, potentially offering a new therapeutic target.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020
2018 journal article
Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair
PLOS ONE, 13(8), e0200674.
Contributors: A. Ziegler n , n, J. Mills n, L. Gonzalez n , L. Van Landeghem n, J. Odle n , A. Blikslager n
Ed(s): J. Karhausen
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
TL;DR:
Findings support the hypothesis that a defect in mucosal repair in neonates is due to immature repair mechanisms within the mucosal compartment, and ex vivo exogenous application of injured juvenile mucosal homogenate produced a significant increase in TEER and enhanced histological restitution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: October 16, 2018
2017 journal article
Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair
American Journal of Physiology-Gastrointestinal and Liver Physiology, 313(3), G180–G191.
author keywords: esophagus; injury; repair; esophageal submucosal gland; proliferation
MeSH headings : Active Transport, Cell Nucleus; Animals; Cell Proliferation / physiology; Esophageal Diseases / pathology; Esophagus / cytology; Esophagus / injuries; Female; Gene Expression Regulation / physiology; Humans; Male; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Staining and Labeling; Swine
TL;DR:
A novel porcine model of injury and repair using radiofrequency ablation has been developed, allowing for reproducible injury to the esophagus to study repair in an animal model with esophageal submucosal glands, a key anatomical feature and missing in rodent models but possibly harboring progenitor cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis
Inflammatory Bowel Diseases, 21(12), 2747–2757.
Contributors: Y. Jin n , n & A. Blikslager n
author keywords: ClC-2 chloride channel; lubiprostone; tight junctions; inflammatory bowel diseases; intestinal barrier function
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Chloride Channel Agonists / pharmacology; Chloride Channels / deficiency; Chloride Channels / drug effects; Colitis / chemically induced; Colitis / drug therapy; Colitis / genetics; Dextran Sulfate; Fluorescent Antibody Technique; Intestinal Mucosa / metabolism; Intestines / drug effects; Lubiprostone / pharmacology; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Permeability / drug effects; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism; Trinitrobenzenes
TL;DR:
A central role for ClC-2 in restoration of barrier function and tight junction architecture in experimental murine colitis is suggested, which can be therapeutically targeted with lubiprostone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
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