Michael David O'Connell

Works (2)

Updated: July 5th, 2023 15:35

2017 journal article

A facilitated diffusion mechanism establishes the Drosophila Dorsal gradient

DEVELOPMENT, 144(23), 4450–4461.

By: S. Carrell n, . Michael D. O'Connell n, T. Jacobsen n, A. Pomeroy  n, S. Hayes n & G. Reeves n

author keywords: Morphogen; Tissue patterning; Mathematical modeling; Dorsal; Cactus; Shuttling
MeSH headings : Animals; Animals, Genetically Modified; Biophysical Phenomena; Body Patterning / genetics; Body Patterning / physiology; Computer Simulation; DNA-Binding Proteins / genetics; DNA-Binding Proteins / physiology; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / embryology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Facilitated Diffusion; Female; Models, Biological; Nuclear Proteins / genetics; Nuclear Proteins / physiology; Phosphoproteins / genetics; Phosphoproteins / physiology; Signal Transduction; Toll-Like Receptors / genetics; Toll-Like Receptors / physiology; Transcription Factors / genetics; Transcription Factors / physiology
TL;DR: Dorsal, a transcription factor that patterns the Drosophila dorsal-ventral axis, accumulates at the embryo ventral midline, and model-guided experiments show that the inhibitor Cactus shuttles Dorsal to the ventral side. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

The presence of nuclear cactus in the early Drosophila embryo may extend the dynamic range of the dorsal gradient

PLoS Computational Biology, 11(4).

By: M. O'Connell & G. Reeves

Source: NC State University Libraries
Added: August 6, 2018

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