Works (4)
Updated: March 29th, 2024 05:04
2024 journal article
Poly-γ-glutamylation of biomolecules
NATURE COMMUNICATIONS, 15(1).
TL;DR:
It is discovered that folylpolyglutamate synthase and γ-glutamyl ligase enzymes add successive L -glutamates to the termini of the growing γ-glutamyl chain in a processive mechanism.
(via Semantic Scholar)
open access via www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024
2020 journal article
Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring
BIOCHEMISTRY, 59(21), 1961–1965.
Contributors: L. Cha n , S. Milikisiyants n, n, S. Xue *, T. Smirnova n , A. Smirnov n , Y. Guo *, W. Chang n
MeSH headings : Alkenes / chemistry; Alkenes / metabolism; Leucine / chemistry; Leucine / metabolism; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Molecular Conformation; Nostoc / enzymology; Substrate Specificity
TL;DR:
It is demonstrated that the activity of an Fe/2OG enzyme can be redirected when changing the targeted carbon hybridization from sp3 to sp2 and the resulting epoxide subsequently undergoes intramolecular cyclization to form the substituted piperidine, 2S,5S-hydroxypipecolic acid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 22, 2020
2019 journal article
Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(8), 3419–3423.
TL;DR:
It is demonstrated that these enzymes can accommodate leucine isomers and catalyze regiospecific hydroxylation and can catalyze non-native nitrile group installation when an azido group is introduced.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 25, 2019
2018 journal article
Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57(7), 1831–1835.
Contributors: H. Liao*, J. Li *, J. Huang n, n, I. Kurnikov *, T. Lin *, J. Lee *, M. Kurnikova *
author keywords: carbocations; C-C bond formation; desaturation; enzyme mechanisms; viridicatin
MeSH headings : Aspergillus nidulans / enzymology; Biocatalysis; Catalytic Domain; Cytochrome P-450 Enzyme System / metabolism; Epoxy Compounds / chemistry; Epoxy Compounds / metabolism; Ferric Compounds / chemistry; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Ketoglutaric Acids / chemistry; Ketoglutaric Acids / metabolism; Molecular Dynamics Simulation; Peptides / chemistry; Peptides / metabolism; Quantum Theory; Stereoisomerism
TL;DR:
Findings suggest that a pathway involving hydrogen atom abstraction at the C10 position of the substrate by a short-lived FeIV -oxo species and the subsequent formation of a carbocation or a hydroxylated intermediate is preferred during AsqJ-catalyzed desaturation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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