Works (4)

Updated: March 29th, 2024 05:04

2024 journal article

Poly-γ-glutamylation of biomolecules

NATURE COMMUNICATIONS, 15(1).

By: G. Bashiri*, E. Bulloch*, W. Bramley*, M. Davidson n, S. Stuteley*, P. Young*, P. Harris*, M. Naqvi* ...

TL;DR: It is discovered that folylpolyglutamate synthase and γ-glutamyl ligase enzymes add successive L -glutamates to the termini of the growing γ-glutamyl chain in a processive mechanism. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2020 journal article

Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

BIOCHEMISTRY, 59(21), 1961–1965.

Contributors: L. Cha n, S. Milikisiyants n, M. Davidson n, S. Xue*, T. Smirnova n, A. Smirnov n, Y. Guo*, W. Chang n

MeSH headings : Alkenes / chemistry; Alkenes / metabolism; Leucine / chemistry; Leucine / metabolism; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Molecular Conformation; Nostoc / enzymology; Substrate Specificity
TL;DR: It is demonstrated that the activity of an Fe/2OG enzyme can be redirected when changing the targeted carbon hybridization from sp3 to sp2 and the resulting epoxide subsequently undergoes intramolecular cyclization to form the substituted piperidine, 2S,5S-hydroxypipecolic acid. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 22, 2020

2019 journal article

Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(8), 3419–3423.

By: M. Davidson n, M. McNamee n, R. Fan*, Y. Guo* & W. Chang n

Contributors: M. Davidson n, M. McNamee n, R. Fan*, Y. Guo* & W. Chang n

TL;DR: It is demonstrated that these enzymes can accommodate leucine isomers and catalyze regiospecific hydroxylation and can catalyze non-native nitrile group installation when an azido group is introduced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 25, 2019

2018 journal article

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57(7), 1831–1835.

By: H. Liao*, J. Li*, J. Huang n, M. Davidson n, I. Kurnikov*, T. Lin*, J. Lee*, M. Kurnikova* ...

Contributors: H. Liao*, J. Li*, J. Huang n, M. Davidson n, I. Kurnikov*, T. Lin*, J. Lee*, M. Kurnikova* ...

author keywords: carbocations; C-C bond formation; desaturation; enzyme mechanisms; viridicatin
MeSH headings : Aspergillus nidulans / enzymology; Biocatalysis; Catalytic Domain; Cytochrome P-450 Enzyme System / metabolism; Epoxy Compounds / chemistry; Epoxy Compounds / metabolism; Ferric Compounds / chemistry; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Ketoglutaric Acids / chemistry; Ketoglutaric Acids / metabolism; Molecular Dynamics Simulation; Peptides / chemistry; Peptides / metabolism; Quantum Theory; Stereoisomerism
TL;DR: Findings suggest that a pathway involving hydrogen atom abstraction at the C10 position of the substrate by a short-lived FeIV -oxo species and the subsequent formation of a carbocation or a hydroxylated intermediate is preferred during AsqJ-catalyzed desaturation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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