Madison Davidson

Works (4)

Updated: April 25th, 2025 17:54

2024 article

Poly-γ-glutamylation of biomolecules

Bashiri, G., Bulloch, E. M. M., Bramley, W. R., Davidson, M., Stuteley, S. M., Young, P. G., … Squire, C. J. (2024, February 12). Nature Communications, Vol. 15.

By: G. Bashiri *, E. Bulloch *, W. Bramley*, M. Davidson n, S. Stuteley *, P. Young *, P. Harris *, M. Naqvi* ...

MeSH headings : Humans; Glutamic Acid; Folic Acid; Peptide Synthases / metabolism; Bacteria / metabolism; Protein Processing, Post-Translational
topics (OpenAlex): Cancer Research and Treatments; Biopolymer Synthesis and Applications; Enzyme Structure and Function
TL;DR: It is discovered that folylpolyglutamate synthase and γ-glutamyl ligase enzymes add successive L -glutamates to the termini of the growing γ-glutamyl chain in a processive mechanism. (via Semantic Scholar)
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Added: March 25, 2024

2020 article

Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

Cha, L., Milikisiyants, S., Davidson, M., Xue, S., Smirnova, T., Smirnov, A., … Chang, W.-chen. (2020, May 13). Biochemistry, Vol. 59, pp. 1961–1965.

By: L. Cha n , S. Milikisiyants n, M. Davidson n, S. Xue *, T. Smirnova n , A. Smirnov n , Y. Guo *, W. Chang n 

Contributors: L. Cha n , S. Milikisiyants n, M. Davidson n, S. Xue *, T. Smirnova n , A. Smirnov n , Y. Guo *, W. Chang n 

MeSH headings : Alkenes / chemistry; Alkenes / metabolism; Leucine / chemistry; Leucine / metabolism; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Molecular Conformation; Nostoc / enzymology; Substrate Specificity
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Metalloenzymes and iron-sulfur proteins; ATP Synthase and ATPases Research
TL;DR: It is demonstrated that the activity of an Fe/2OG enzyme can be redirected when changing the targeted carbon hybridization from sp3 to sp2 and the resulting epoxide subsequently undergoes intramolecular cyclization to form the substituted piperidine, 2S,5S-hydroxypipecolic acid. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 22, 2020

2019 article

Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance

Davidson, M., McNamee, M., Fan, R., Guo, Y., & Chang, W.-chen. (2019, February 13). Journal of the American Chemical Society, Vol. 141, pp. 3419–3423.

By: M. Davidson n, M. McNamee n, R. Fan *, Y. Guo * & W. Chang n 

Contributors: M. Davidson n, M. McNamee n, R. Fan *, Y. Guo * & W. Chang n 

topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Metalloenzymes and iron-sulfur proteins; Microbial metabolism and enzyme function
TL;DR: It is demonstrated that these enzymes can accommodate leucine isomers and catalyze regiospecific hydroxylation and can catalyze non-native nitrile group installation when an azido group is introduced. (via Semantic Scholar)
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Added: March 25, 2019

2018 article

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non‐Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

Liao, H. J., Li, J., Huang, J. L., Davidson, M., Kurnikov, I., Lin, T. S., … Chang, W. (2018, January 3). Angewandte Chemie International Edition, Vol. 57, pp. 1831–1835.

By: H. Liao*, J. Li *, J. Huang  n, M. Davidson n, I. Kurnikov *, T. Lin *, J. Lee *, M. Kurnikova * ...

Contributors: H. Liao*, J. Li *, J. Huang  n, M. Davidson n, I. Kurnikov *, T. Lin *, J. Lee *, M. Kurnikova * ...

author keywords: carbocations; C-C bond formation; desaturation; enzyme mechanisms; viridicatin
MeSH headings : Aspergillus nidulans / enzymology; Biocatalysis; Catalytic Domain; Cytochrome P-450 Enzyme System / metabolism; Epoxy Compounds / chemistry; Epoxy Compounds / metabolism; Ferric Compounds / chemistry; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Ketoglutaric Acids / chemistry; Ketoglutaric Acids / metabolism; Molecular Dynamics Simulation; Peptides / chemistry; Peptides / metabolism; Quantum Theory; Stereoisomerism
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Photosynthetic Processes and Mechanisms; Metalloenzymes and iron-sulfur proteins
TL;DR: Findings suggest that a pathway involving hydrogen atom abstraction at the C10 position of the substrate by a short-lived FeIV -oxo species and the subsequent formation of a carbocation or a hydroxylated intermediate is preferred during AsqJ-catalyzed desaturation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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