Madison Davidson

Works (4)

Updated: March 29th, 2024 05:04

2024 journal article

Poly-γ-glutamylation of biomolecules

NATURE COMMUNICATIONS, 15(1).

By: G. Bashiri *, E. Bulloch *, W. Bramley*, M. Davidson n, S. Stuteley *, P. Young *, P. Harris*, M. Naqvi* ...

TL;DR: It is discovered that folylpolyglutamate synthase and γ-glutamyl ligase enzymes add successive L -glutamates to the termini of the growing γ-glutamyl chain in a processive mechanism. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2020 journal article

Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

BIOCHEMISTRY, 59(21), 1961–1965.

By: L. Cha n , S. Milikisiyants n, M. Davidson n, S. Xue *, T. Smirnova n , A. Smirnov  n, Y. Guo *, W. Chang n 

Contributors: L. Cha n , S. Milikisiyants n, M. Davidson n, S. Xue *, T. Smirnova n , A. Smirnov n , Y. Guo *, W. Chang n 

MeSH headings : Alkenes / chemistry; Alkenes / metabolism; Leucine / chemistry; Leucine / metabolism; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Molecular Conformation; Nostoc / enzymology; Substrate Specificity
TL;DR: It is demonstrated that the activity of an Fe/2OG enzyme can be redirected when changing the targeted carbon hybridization from sp3 to sp2 and the resulting epoxide subsequently undergoes intramolecular cyclization to form the substituted piperidine, 2S,5S-hydroxypipecolic acid. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 22, 2020

2019 journal article

Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(8), 3419–3423.

By: M. Davidson n, M. McNamee n, R. Fan *, Y. Guo * & W. Chang n 

Contributors: M. Davidson n, M. McNamee n, R. Fan *, Y. Guo * & W. Chang n 

TL;DR: It is demonstrated that these enzymes can accommodate leucine isomers and catalyze regiospecific hydroxylation and can catalyze non-native nitrile group installation when an azido group is introduced. (via Semantic Scholar)
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Added: March 25, 2019

2018 journal article

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57(7), 1831–1835.

By: H. Liao*, J. Li *, J. Huang n, M. Davidson n, I. Kurnikov *, T. Lin *, J. Lee *, M. Kurnikova * ...

Contributors: H. Liao*, J. Li *, J. Huang n, M. Davidson n, I. Kurnikov *, T. Lin *, J. Lee *, M. Kurnikova * ...

author keywords: carbocations; C-C bond formation; desaturation; enzyme mechanisms; viridicatin
MeSH headings : Aspergillus nidulans / enzymology; Biocatalysis; Catalytic Domain; Cytochrome P-450 Enzyme System / metabolism; Epoxy Compounds / chemistry; Epoxy Compounds / metabolism; Ferric Compounds / chemistry; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Ketoglutaric Acids / chemistry; Ketoglutaric Acids / metabolism; Molecular Dynamics Simulation; Peptides / chemistry; Peptides / metabolism; Quantum Theory; Stereoisomerism
TL;DR: Findings suggest that a pathway involving hydrogen atom abstraction at the C10 position of the substrate by a short-lived FeIV -oxo species and the subsequent formation of a carbocation or a hydroxylated intermediate is preferred during AsqJ-catalyzed desaturation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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