M Umar Qureshi

Works (8)

Updated: July 18th, 2023 21:14

2022 article

Numerical predictions of shear stress and cyclic stretch in pulmonary hypertension due to left heart failure

Bartolo, M. A., Qureshi, M. U., Colebank, M. J., Chesler, N. C., & Olufsen, M. S. (2022, January 17). Biomechanics and Modeling in Mechanobiology, Vol. 1.

By: M. Bartolo n, M. Qureshi n, M. Colebank* , N. Chesler * & M. Olufsen n

author keywords: Pulmonary hypertension; Micro-circulation; Wall shear stress; Cyclic stretch; Left heart disease; Computational modeling; Pulse wave propagation
MeSH headings : Blood Pressure; Heart Failure / complications; Hemodynamics; Humans; Hypertension, Pulmonary; Pulmonary Artery
topics (OpenAlex): Pulmonary Hypertension Research and Treatments; Cardiovascular Function and Risk Factors; Cardiac Valve Diseases and Treatments
TL;DR: Using a computational fluid dynamics model of the human pulmonary arteries, arterioles, venules, and veins, this model predicts pressure, flow, shear stress, and cyclic stretch that providing a way to analyze and investigate hypotheses related to disease progression in the pulmonary circulation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 17, 2022

2021 article

A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension

Colebank, M. J., Qureshi, M. U., Rajagopal, S., Krasuski, R. A., & Olufsen, M. S. (2021, February 12). ArXiv (Cornell University), Vol. 6.

By: M. Colebank n , M. Qureshi n, S. Rajagopal *, R. Krasuski * & M. Olufsen n

author keywords: hemodynamics; mathematical modeling; pulmonary circulation; pulmonary hypertension; wave propagation
MeSH headings : Angioplasty, Balloon; Chronic Disease; Hemodynamics; Humans; Hypertension, Pulmonary / diagnostic imaging; Hypertension, Pulmonary / etiology; Hypertension, Pulmonary / physiopathology; Hypertension, Pulmonary / therapy; Models, Cardiovascular; Models, Theoretical; Pulmonary Artery / diagnostic imaging; Pulmonary Artery / physiopathology; Pulmonary Embolism / complications; Pulmonary Embolism / diagnostic imaging; Pulmonary Embolism / physiopathology; Pulmonary Embolism / therapy
topics (OpenAlex): Pulmonary Hypertension Research and Treatments; Cardiovascular Disease and Adiposity; Hemodynamic Monitoring and Therapy
TL;DR: A multiscale, image-to-hemodynamics pipeline for BPA therapy planning for inoperable CTEPH patients is provided, providing an integrative, holistic tool for identifying optimal target lesions for treatment. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 28, 2021

2020 article

Structural and hemodynamic properties of murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension

Chambers, M. J., Colebank, M. J., Qureshi, M. U., Clipp, R., & Olufsen, M. S. (2020, July 28). Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, Vol. 234, pp. 1312–1329.

By: M. Chambers n, M. Colebank n , M. Qureshi n, R. Clipp * & M. Olufsen n

author keywords: Pulmonary hypertension; fractal networks; image segmentation; center line extraction; one-dimensional fluid dynamics; Navier-Stokes equations
MeSH headings : Animals; Hemodynamics; Humans; Hypertension, Pulmonary / diagnostic imaging; Hypoxia; Mice; Models, Cardiovascular; Pulmonary Artery / diagnostic imaging; X-Ray Microtomography
topics (OpenAlex): Pulmonary Hypertension Research and Treatments; Cardiovascular Function and Risk Factors; Cardiovascular Health and Disease Prevention
TL;DR: This study demonstrates how to combine imaging data from microcomputed tomography images with hemodynamic pressure and flow waveforms from control and hypertensive mice to generate subject-specific arterial networks in which one-dimensional fluid dynamics modeling is used to predict blood Pressure and flow. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 31, 2020

2019 article

Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries

Colebank, M. J., Paun, L. M., Qureshi, M. U., Chesler, N., Husmeier, D., Olufsen, M. S., & Fix, L. E. (2019, October 2). Journal of The Royal Society Interface, Vol. 16, p. 20190284.

By: M. Colebank n , L. Paun*, M. Qureshi n, N. Chesler*, D. Husmeier *, M. Olufsen n, L. Fix *

author keywords: haemodynamics; fluid dynamics; pulmonary circulation; uncertainty quantification; image segmentation
MeSH headings : Algorithms; Animals; Computer Simulation; Hemodynamics; Hypertension, Pulmonary / diagnostic imaging; Hypertension, Pulmonary / physiopathology; Male; Mice; Models, Cardiovascular; Pulmonary Artery / diagnostic imaging; Pulmonary Artery / physiopathology; X-Ray Microtomography
topics (OpenAlex): Pulmonary Hypertension Research and Treatments; Cardiovascular Function and Risk Factors; Cardiovascular Disease and Adiposity; Inhalation and Respiratory Drug Delivery; Medical Image Segmentation Techniques
TL;DR: This study quantifies the variability of one-dimensional CFD predictions by propagating the uncertainty of network geometry and connectivity to blood pressure and flow predictions using multiple segmentations of a single, excised mouse lung. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 3, 2020

2019 article

Sensitivity analysis and uncertainty quantification of 1‐D models of pulmonary hemodynamics in mice under control and hypertensive conditions

Colebank, M. J., Qureshi, M. U., & Olufsen, M. S. (2019, July 29). International Journal for Numerical Methods in Biomedical Engineering, Vol. 37.

By: M. Colebank n , M. Qureshi n & M. Olufsen n

author keywords: computational fluid dynamics; network models; pulmonary hypertension; sensitivity analysis; uncertainty quantification
MeSH headings : Animals; Bayes Theorem; Hemodynamics; Mice; Pulmonary Artery; Uncertainty; X-Ray Microtomography
topics (OpenAlex): Hemodynamic Monitoring and Therapy; Probabilistic and Robust Engineering Design; Cardiovascular Function and Risk Factors; Pulmonary Hypertension Research and Treatments; Cardiovascular Health and Disease Prevention
TL;DR: Results show that MPA pressure predictions are most sensitive to distal vascular resistance and that parameter influence changes with increasing network complexity, and suggest that PH leads to increased vascular stiffness and decreased peripheral compliance, congruent with clinical observations. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 30, 2019

2018 journal article

Hemodynamic assessment of pulmonary hypertension in mice: a model-based analysis of the disease mechanism

Biomechanics and Modeling in Mechanobiology, 18(1), 219–243.

By: M. Qureshi n, M. Colebank n , L. Paun *, L. Ellwein Fix *, N. Chesler *, M. Haider n , N. Hill *, D. Husmeier *, M. Olufsen n

author keywords: Pulmonary hypertension; 1D fluid dynamics model; Linear and nonlinear wall model; Parameter estimation; Statistical model selection; Wave intensity analysis; Impedance analysis
MeSH headings : Animals; Electric Impedance; Hemodynamics; Hypertension, Pulmonary / diagnostic imaging; Hypertension, Pulmonary / physiopathology; Male; Mice, Inbred C57BL; Models, Biological; Nonlinear Dynamics; Pressure; X-Ray Microtomography
topics (OpenAlex): Pulmonary Hypertension Research and Treatments; Cardiovascular Function and Risk Factors; Cardiomyopathy and Myosin Studies
TL;DR: Results show that pulmonary hypertension is associated with stiffer and less compliant proximal and distal vasculature with augmented wave reflections, and that elastic nonlinearities are insignificant in the hypertensive animal. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: February 25, 2019

2017 journal article

Characteristic impedance: frequency or time domain approach?

Physiological Measurement, 39(1), 014004.

By: M. Qureshi n, M. Colebank n , D. Schreier*, D. Tabima *, M. Haider n , N. Chesler *, M. Olufsen n

author keywords: characteristic impedance; blood pressure and flow; pulse wave analysis; impedance analysis; time domain analysis; Fourier methods; large arteries
MeSH headings : Animals; Blood Pressure; Dogs; Electric Impedance; Heart / physiology; Hemodynamics; Humans; Mice; Pulse Wave Analysis; Signal-To-Noise Ratio; Time Factors
topics (OpenAlex): Cardiovascular Health and Disease Prevention; Hemodynamic Monitoring and Therapy; Heart Rate Variability and Autonomic Control
TL;DR: It is shown that the frequency and time domain estimates of Zc are not equally sensitive to certain characteristics of hemodynamic signals including phase lag between pressure and flow, signal to noise ratio and the end of systole retrograde flow. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2016 article

Heterogeneous mechanics of the mouse pulmonary arterial network

Lee, P., Carlson, B. E., Chesler, N., Olufsen, M. S., Qureshi, M. U., Smith, N. P., … Beard, D. A. (2016, January 20). Biomechanics and Modeling in Mechanobiology.

By: P. Lee*, B. Carlson *, N. Chesler *, M. Olufsen n, M. Qureshi n, N. Smith *, T. Sochi*, D. Beard *

author keywords: Arterial blood flow; Vessel mechanics; Heterogeneity; Pulmonary arterial network; Pressure-radius relationship; Wave intensity analysis
MeSH headings : Animals; Biomechanical Phenomena; Blood Flow Velocity / physiology; Mice; Nonlinear Dynamics; Numerical Analysis, Computer-Assisted; Pressure; Pulmonary Artery / physiology; Reproducibility of Results; Stress, Mechanical
topics (OpenAlex): Elasticity and Material Modeling; Cardiovascular Function and Risk Factors; Cardiovascular Health and Disease Prevention
TL;DR: Simulations were conducted to investigate the role of linear versus nonlinear formulations of wall elasticity and homogeneous versus heterogeneous treatments of vessel wall properties, and Accounting for heterogeneity, by parameterizing the pressure/distention equation of state individually for each vessel segment was found to have little effect on the predicted pressure profiles and wave propagation. (via Semantic Scholar)
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Added: August 6, 2018

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