Stephanie Proano

Works (7)

Updated: April 23rd, 2025 21:15

2023 article

Sex steroid hormones, the estrous cycle, and rapid modulation of glutamatergic synapse properties in the striatal brain regions with a focus on 17β-estradiol and the nucleus accumbens

Proaño, S. B., Miller, C. K., Krentzel, A. A., Dorris, D. M., & Meitzen, J. (2023, November 17). Steroids, Vol. 201.

By: S. Proaño n, C. Miller n, A. Krentzel n, D. Dorris n & J. Meitzen n 

author keywords: Estradiol; Sex differences; Estrous cycle; Nucleus accumbens; Estrogen receptors
MeSH headings : Female; Humans; Male; Brain; Estradiol / pharmacology; Estrous Cycle; Glutamates; Nucleus Accumbens / physiology; Progesterone; Putamen / chemistry; Synapses; Testosterone; Caudate Nucleus / chemistry; Caudate Nucleus / physiology
topics (OpenAlex): Neuroendocrine regulation and behavior; Neuroscience and Neuropharmacology Research; Stress Responses and Cortisol
TL;DR: There is strong evidence regarding estradiol action upon glutamatergic synapse function in female NAcs MSNs and call for more research regarding other hormones and striatal regions. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 8, 2024

2022 journal article

The estrous cycle and 17β‐estradiol modulate the electrophysiological properties of rat nucleus accumbens core medium spiny neurons

Journal of Neuroendocrinology, 34(6).

By: A. Krentzel n, S. Proaño*, D. Dorris n, B. Setzer * & J. Meitzen n 

author keywords: estradiol; estrogen receptors; estrous cycle; nucleus accumbens; sex differences
MeSH headings : Animals; Estradiol / pharmacology; Estrous Cycle; Female; Male; Mammals; Neurons / physiology; Nucleus Accumbens / physiology; Rats; Sex Characteristics
topics (OpenAlex): Stress Responses and Cortisol; Neuroendocrine regulation and behavior; Neuroscience and Neuropharmacology Research
TL;DR: Recent insights demonstrate the strong impact of sex‐specific estradiol action upon nucleus accumbens core neuron electrophysiology, which mirror the natural changes seen across estrous cycle phases. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 18, 2022

2020 article

Differential and synergistic roles of 17β-estradiol and progesterone in modulating adult female rat nucleus accumbens core medium spiny neuron electrophysiology

Proaño, S. B., Krentzel, A. A., & Meitzen, J. (2020, May 13). Journal of Neurophysiology, Vol. 123, pp. 2390–2405.

By: S. Proaño n, A. Krentzel n & J. Meitzen n 

author keywords: electrophysiology; estradiol; nucleus accumbens; progesterone; sex differences
MeSH headings : Animals; Estradiol / physiology; Estrous Cycle / metabolism; Estrous Cycle / physiology; Excitatory Postsynaptic Potentials / physiology; Female; Membrane Potentials / physiology; Neurons / metabolism; Neurons / physiology; Nucleus Accumbens / metabolism; Nucleus Accumbens / physiology; Progesterone / physiology; Rats; Rats, Sprague-Dawley
topics (OpenAlex): Neuroscience and Neuropharmacology Research; Neuroendocrine regulation and behavior; Stress Responses and Cortisol
TL;DR: Data indicate that circulating levels of estradiol and progesterone alone or in combination interact with specific MSN electrophysiological properties, indicating differential and synergistic roles of these hormones. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020

2020 article

Estradiol decreases medium spiny neuron excitability in female rat nucleus accumbens core

Proaño, S. B., & Meitzen, J. (2020, May 20). Journal of Neurophysiology, Vol. 123, pp. 2465–2475.

By: S. Proaño n & J. Meitzen n 

author keywords: estradiol; estrous cycle; excitability; nucleus accumbens; sex differences
MeSH headings : Animals; Electrophysiological Phenomena / physiology; Estradiol / metabolism; Estradiol / physiology; Estrous Cycle / physiology; Female; Membrane Potentials / physiology; Neurons / physiology; Nucleus Accumbens / metabolism; Nucleus Accumbens / physiology; Ovariectomy; Rats; Rats, Sprague-Dawley
topics (OpenAlex): Neuroendocrine regulation and behavior; Stress Responses and Cortisol; Neuroscience and Neuropharmacology Research
TL;DR: These data are the first to demonstrate that an estrous cycle relevant estradiol exposure modulates MSN electrophysiology, providing evidence of the fundamental neuroendocrine mechanisms regulating the AcbC. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020

2020 article

Temporal and bidirectional influences of estradiol on voluntary wheel running in adult female and male rats

Krentzel, A. A., Proaño, S., Patisaul, H. B., & Meitzen, J. (2020, January 27). Hormones and Behavior, Vol. 120.

By: A. Krentzel n, S. Proaño n, H. Patisaul n  & J. Meitzen n 

author keywords: Estradiol; Sex differences; Voluntary wheel running; Locomotion; Motivation
MeSH headings : Animals; Behavior, Animal / drug effects; Estradiol / analogs & derivatives; Estradiol / pharmacology; Female; Male; Motivation / drug effects; Motor Activity / drug effects; Rats; Rats, Sprague-Dawley; Running / physiology; Sex Characteristics; Time Factors
topics (OpenAlex): Neurobiology and Insect Physiology Research; Genetics and Physical Performance; Behavioral Health and Interventions
TL;DR: Findings indicate that estradiol rapidly, non-rapidly, and bidirectionally modulates wheel running in a sex-responsive manner, and that rapid est radiol action is modulated by non-Rapid Estradiol action. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2018 article

Estrous cycle-induced sex differences in medium spiny neuron excitatory synaptic transmission and intrinsic excitability in adult rat nucleus accumbens core

Proaño, S. B., Morris, H. J., Kunz, L. M., Dorris, D. M., & Meitzen, J. (2018, June 27). Journal of Neurophysiology, Vol. 120, pp. 1356–1373.

By: S. Proaño n, H. Morris n, L. Kunz n, D. Dorris n & J. Meitzen n 

author keywords: estrous cycle; excitability; medium spiny neurons; nucleus accumbens; sex steroid hormones
MeSH headings : Action Potentials; Animals; Castration; Estrous Cycle; Excitatory Postsynaptic Potentials; Female; Male; Neurons / physiology; Nucleus Accumbens / physiology; Rats, Sprague-Dawley; Sex Characteristics
topics (OpenAlex): Neuroendocrine regulation and behavior; Neuroscience and Neuropharmacology Research; Neurotransmitter Receptor Influence on Behavior
TL;DR: It is the first demonstration that medium spiny neuron electrophysiological properties change across adult female hormone cycle phases in any striatal region and indicates that adultFemale hormone cycles are an important factor for neurophysiology. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 5, 2018

2017 article

Problems and Progress regarding Sex Bias and Omission in Neuroscience Research

Will, T. R., Proaño, S. B., Thomas, A. M., Kunz, L. M., Thompson, K. C., Ginnari, L. A., … Meitzen, J. (2017, November 1). ENeuro, Vol. 4.

By: T. Will n, S. Proaño n, A. Thomas n, L. Kunz n, K. Thompson n, L. Ginnari n, C. Jones n, S. Lucas n ...

author keywords: Animal models; journals; neuroscience; sex bias; sex omission
MeSH headings : Animals; Female; Male; Mice; Neurosciences; Rats; Sexism / statistics & numerical data; Sexism / trends
topics (OpenAlex): Sex and Gender in Healthcare; Animal testing and alternatives
TL;DR: The largest-ever number of neuroscience articles for sex bias and omission is analyzed: 6636 articles using mice or rats in 6 journals published from 2010 to 2014, finding sex bias remains present and sex omission is declining, as increasing numbers of articles report sex. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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