Works (55)
Updated: April 3rd, 2024 17:44
2024 review
How Sex Hormones Affect Migraine: An Interdisciplinary Preclinical Research Panel Review
[Review of ]. JOURNAL OF PERSONALIZED MEDICINE, 14(2).
author keywords: sex hormones; migraine; estrogen; oxytocin; progesterone; testosterone; prolactin; vasopressin
TL;DR:
The conclusion was that progress in the preclinical study of hormones on the nervous system has been challenging and slow, that there remain substantial gaps in the authors' understanding of the complex roles sex hormones play in migraine, and that opportunities remain for improved or novel therapeutic agents.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024
2024 journal article
Sex steroid hormones, the estrous cycle, and rapid modulation of glutamatergic synapse properties in the striatal brain regions with a focus on 17β -estradiol and the nucleus accumbens
STEROIDS, 201.
author keywords: Estradiol; Sex differences; Estrous cycle; Nucleus accumbens; Estrogen receptors
TL;DR:
There is strong evidence regarding estradiol action upon glutamatergic synapse function in female NAcs MSNs and call for more research regarding other hormones and striatal regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 8, 2024
2023 article
A nonparametric test of group distributional differences for hierarchically clustered functional data
Long, A. S., Reich, B. J., Staicu, A.-M., & Meitzen, J. (2023, March 13). BIOMETRICS, Vol. 3.
author keywords: bivariate functional data; functional data analysis; hierarchically clustered data; multivariate testing
TL;DR:
This paper proposes a method to test for differences in the electrophysiological properties across estrous cycle phase without first defining a metric of interest by modeling membrane potential data in the frequency domain as realizations of a bivariate process by adopting existing methods for longitudinal functional data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 27, 2023
2023 article
ER alpha stimulation rapidly modulates excitatory synapse properties in female rat nucleus accumbens core
Miller, C. K., Krentzel, A. A., & Meitzen, J. (2023, February 6). NEUROENDOCRINOLOGY, Vol. 2.
TL;DR:
Findings extend the understanding of the neuroendocrinology of the NAcc and implicate ERα as a primary target for future studies and provide evidence that activation of ERα is sufficient for inducing changes in mEPSC frequency and is a likely candidate underlying the estradiol-induced changes observed during the estrous cycle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023
2023 article
Estrous cycle impacts on dendritic spine plasticity in rat nucleus accumbens core and shell and caudate-putamen
Beeson, A. L. S., & Meitzen, J. (2023, February 9). JOURNAL OF COMPARATIVE NEUROLOGY, Vol. 2.
author keywords: caudate-putamen; dendritic spine; estradiol; estrous cycle; nucleus accumbens; sex differences
MeSH headings : Humans; Rats; Female; Male; Animals; Nucleus Accumbens; Dendritic Spines / physiology; Rats, Sprague-Dawley; Putamen; Estrous Cycle; Estradiol
TL;DR:
It is indicated, for the first time, that estrous cycle phase impacts dendritic spine plasticity in striatal regions, providing a neuroanatomical avenue by which sex‐specific hormone fluctuations can impact striatal function and disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023
2023 journal article
Neurosteroids and the mesocorticolimbic system
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 153.
author keywords: Androgen receptor; Aromatase; Brain; 178-estradiol; Set shifting; Testosterone
TL;DR:
Evidence that cells in multiple nodes of the mesocorticolimbic system produce neurosteroids, neuroestrogens, and androgen and estrogen receptors and steroids produced in the gonads and locally in the brain modulate higher-order cognition and executive functions is summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023
2023 journal article
No detectable changes in anxiety-related and locomotor behaviors in adult ovariectomized female rats exposed to estradiol, the ER beta agonist DPN or the ER alpha agonist PPT
HORMONES AND BEHAVIOR, 152.
author keywords: Estradiol; Sex; Locomotion; Anxiety; Estrogen receptor
MeSH headings : Rats; Female; Animals; Humans; Estradiol / pharmacology; Estradiol / physiology; Receptors, Estrogen; Estrogen Receptor beta / agonists; Estrogen Receptor alpha / agonists; Anxiety / drug therapy; Nitriles; Ovariectomy
TL;DR:
Two experiments are tested in which the hypothesis that anxiety-related behaviors would decrease after ERβ activation and locomotor behaviors would increase after ERα activation are tested, and the persistence of these behavioral effects are assessed by varying the timing of behavioral testing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023
2023 journal article
Simultaneous, Real-Time Detection of Glutamate and Dopamine in Rat Striatum Using Fast-Scan Cyclic Voltammetry
ACS SENSORS, 8(11), 4091–4100.
author keywords: FSCV; biosensor; carbon-fiber microelectrode; excitatory amino acid transporter; dl-threo-beta-benzyloxyaspartic acid; dl-TBOA
TL;DR:
A novel glutamate microbiosensor fabricated on a carbon-fiber microelectrode substrate and coupled with fast-scan cyclic voltammetry (FSCV) to enable the simultaneous quantification of glutamate and DA at single recording sites in the brain, which is impossible when using typical amperometric approaches.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023
2022 article
The estrous cycle and 17 beta-estradiol modulate the electrophysiological properties of rat nucleus accumbens core medium spiny neurons
Krentzel, A. A., Proano, S. B., Dorris, D. M., Setzer, B., & Meitzen, J. (2022, April 2). JOURNAL OF NEUROENDOCRINOLOGY, Vol. 4.
author keywords: estradiol; estrogen receptors; estrous cycle; nucleus accumbens; sex differences
MeSH headings : Animals; Estradiol / pharmacology; Estrous Cycle; Female; Male; Mammals; Neurons / physiology; Nucleus Accumbens / physiology; Rats; Sex Characteristics
TL;DR:
Recent insights demonstrate the strong impact of sex‐specific estradiol action upon nucleus accumbens core neuron electrophysiology, which mirror the natural changes seen across estrous cycle phases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022
2021 journal article
Estrogen receptor alpha, G-protein coupled estrogen receptor 1, and aromatase: Developmental, sex, and region-specific differences across the rat caudate-putamen, nucleus accumbens core and shell
JOURNAL OF COMPARATIVE NEUROLOGY, 529(4), 786–801.
author keywords: aromatase; estrogen receptor; rat; RRID AB_1141090; RRID AB_310305; RRID AB_566942; sex differences; striatum
MeSH headings : Animals; Caudate Nucleus / chemistry; Caudate Nucleus / growth & development; Caudate Nucleus / metabolism; Estrogen Receptor alpha / analysis; Estrogen Receptor alpha / biosynthesis; Female; Male; Nucleus Accumbens / chemistry; Nucleus Accumbens / growth & development; Nucleus Accumbens / metabolism; Putamen / chemistry; Putamen / growth & development; Putamen / metabolism; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled / analysis; Receptors, G-Protein-Coupled / biosynthesis; Sex Characteristics
TL;DR:
The hypothesis that ERα, GPER1, and aromatase exhibits sex, region, and age‐specific differences, including nuclear expression is tested, indicating that developmental period exerts critical sex‐specific influences on striatal cellular estrogenic mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 17, 2020
2021 journal article
FireMaster (R) 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster
HORMONES AND BEHAVIOR, 134.
author keywords: Vole; Electrophysiology; Nucleus accumbens; Flame retardants; Endocrine disruptors; Neurodevelopment; Endocrine disrupting chemical
MeSH headings : Animals; Arvicolinae; Electrophysiology; Female; Grassland; Male; Neurons; Nucleus Accumbens; Organophosphates; Pair Bond; Polybrominated Biphenyls; Pregnancy; Social Behavior; Zebrafish
TL;DR:
The hypothesis that developmental exposure to FM 550 impacts attachment behaviors is supported and a novel FM 550 effect on neural electrophysiology is demonstrated.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021
2021 journal article
Interactions of the estrous cycle, novelty, and light on female and male rat open field locomotor and anxiety-related behaviors
PHYSIOLOGY & BEHAVIOR, 228.
author keywords: Estrous cycle; Locomotor and anxiety-related behavior; Open-field; Novelty; Light; Sex differences
MeSH headings : Animals; Anxiety; Behavior, Animal; Estrous Cycle; Estrus; Female; Light; Male; Rats
TL;DR:
The open field test is used to disassociate differences in behavior resulting from each of these factors by testing the hypothesis that locomotor and anxiety-related behaviors differ between estrous cycle phases in female rats and that novelty and light exposure concurrently influence these behaviors in both female and male rats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021
2021 journal article
Perinatal activation of ER alpha and ER beta but not GPER-1 masculinizes female rat caudate-putamen medium spiny neuron electrophysiological properties
JOURNAL OF NEUROPHYSIOLOGY, 125(6), 2322–2338.
author keywords: < em > caudate putamen <; em >; < em > dorsal striatum <; em >; < em > electrophysiology <; em >; < em > estradiol <; em >; < em > estrogen receptor <; em >
MeSH headings : Animals; Animals, Newborn; Caudate Nucleus / drug effects; Electrophysiological Phenomena / drug effects; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / drug effects; Estrogen Receptor beta / agonists; Estrogen Receptor beta / drug effects; Estrogens / administration & dosage; Estrogens / pharmacology; Female; GABAergic Neurons / drug effects; Male; Patch-Clamp Techniques; Putamen / drug effects; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled / drug effects; Sex Characteristics
TL;DR:
It is indicated that perinatal estradiol exposure masculinizes MSN electrophysiological phenotype via activation of ERα and ERβ.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021
2020 journal article
Differential and synergistic roles of 17 beta-estradiol and progesterone in modulating adult female rat nucleus accumbens core medium spiny neuron electrophysiology
JOURNAL OF NEUROPHYSIOLOGY, 123(6), 2390–2405.
author keywords: electrophysiology; estradiol; nucleus accumbens; progesterone; sex differences
MeSH headings : Animals; Estradiol / physiology; Estrous Cycle / metabolism; Estrous Cycle / physiology; Excitatory Postsynaptic Potentials / physiology; Female; Membrane Potentials / physiology; Neurons / metabolism; Neurons / physiology; Nucleus Accumbens / metabolism; Nucleus Accumbens / physiology; Progesterone / physiology; Rats; Rats, Sprague-Dawley
TL;DR:
Data indicate that circulating levels of estradiol and progesterone alone or in combination interact with specific MSN electrophysiological properties, indicating differential and synergistic roles of these hormones.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020
2020 journal article
Estradiol decreases medium spiny neuron excitability in female rat nucleus accumbens core
JOURNAL OF NEUROPHYSIOLOGY, 123(6), 2465–2475.
author keywords: estradiol; estrous cycle; excitability; nucleus accumbens; sex differences
MeSH headings : Animals; Electrophysiological Phenomena / physiology; Estradiol / metabolism; Estradiol / physiology; Estrous Cycle / physiology; Female; Membrane Potentials / physiology; Neurons / physiology; Nucleus Accumbens / metabolism; Nucleus Accumbens / physiology; Ovariectomy; Rats; Rats, Sprague-Dawley
TL;DR:
These data are the first to demonstrate that an estrous cycle relevant estradiol exposure modulates MSN electrophysiology, providing evidence of the fundamental neuroendocrine mechanisms regulating the AcbC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020
2020 journal article
Metabotropic glutamate receptor subtype 5 (mGlu(5)) is necessary for estradiol mitigation of light-induced anxiety behavior in female rats
PHYSIOLOGY & BEHAVIOR, 214.
author keywords: Estradiol; Metabotropic glutamate receptor 5; Female; Anxiety; Estrogen
MeSH headings : Animals; Anxiety / prevention & control; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Excitatory Amino Acid Antagonists / pharmacology; Female; Light; Locomotion / drug effects; Ovariectomy; Pyridines / pharmacology; Rats; Receptor, Metabotropic Glutamate 5 / metabolism
TL;DR:
Novel findings indicate that mGlu5 activation is necessary for estradiol mitigation of anxiety-related behaviors induced by an acute stressor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 10, 2020
2020 review
Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding
[Review of ]. FRONTIERS IN NEUROENDOCRINOLOGY, 57.
author keywords: Sex bias; Sex omission; Sex reporting; Sex difference; Women's health; Male; Female; Neuroscience
MeSH headings : Animals; Biomedical Research / economics; Biomedical Research / statistics & numerical data; Disease Models, Animal; Female; Humans; Male; National Institutes of Health (U.S.); Neurosciences / statistics & numerical data; Research Support as Topic; Serial Publications / statistics & numerical data; Sexism / statistics & numerical data; United States
TL;DR:
The status of sex bias and omission in neuroscience research published across six different journals in 2017 was analyzed and differed across research models, but not by reported NIH funding status.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2020 journal article
Temporal and bidirectional influences of estradiol on voluntary wheel running in adult female and male rats
HORMONES AND BEHAVIOR, 120.
author keywords: Estradiol; Sex differences; Voluntary wheel running; Locomotion; Motivation
MeSH headings : Animals; Behavior, Animal / drug effects; Estradiol / analogs & derivatives; Estradiol / pharmacology; Female; Male; Motivation / drug effects; Motor Activity / drug effects; Rats; Rats, Sprague-Dawley; Running / physiology; Sex Characteristics; Time Factors
TL;DR:
Findings indicate that estradiol rapidly, non-rapidly, and bidirectionally modulates wheel running in a sex-responsive manner, and that rapid est radiol action is modulated by non-Rapid Estradiol action.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020
2020 journal article
The estrous cycle modulates rat caudate-putamen medium spiny neuron physiology
EUROPEAN JOURNAL OF NEUROSCIENCE, 52(1), 2737–2755.
author keywords: caudate-putamen; electrophysiology; estrous cycle; excitability; medium spiny neuron; sex differences
MeSH headings : Action Potentials; Animals; Estrous Cycle; Female; Male; Neurons; Nucleus Accumbens; Putamen; Rats
TL;DR:
Recordings indicate that female caudate–putamen MSNs are sensitive to the estrous cycle, and the importance of considering neuroendocrine state in studies of neuron physiology is considered.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019
2019 journal article
Electrophysiological Properties of Medium Spiny Neuron Subtypes in the Caudate-Putamen of Prepubertal Male and Female Drd1a-tdTomato Line 6 BAC Transgenic Mice
ENEURO, 6(2).
author keywords: caudate putamen; electrophysiology; intrinsic excitability; medium spiny neurons; rodent; sex differences
MeSH headings : Animals; Corpus Striatum / cytology; Corpus Striatum / physiology; Electrophysiology; Female; Male; Mice; Mice, Transgenic; Neurons / cytology; Neurons / physiology; Organ Culture Techniques; Sex Characteristics; Synaptic Potentials / physiology
TL;DR:
A comprehensive evaluation of mouse caudate-putamen MSN subtype electrophysiological properties across females and males is provided, both confirming and extending previous studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 28, 2019
2019 journal article
Estradiol rapidly modulates excitatory synapse properties in a sex- and region-specific manner in rat nucleus accumbens core and caudate-putamen
JOURNAL OF NEUROPHYSIOLOGY, 122(3), 1213–1225.
author keywords: caudate-putamen; estradiol; medium spiny neuron; miniature excitatory postsynaptic currents; nucleus accumbens; striatum
MeSH headings : Animals; Caudate Nucleus / drug effects; Caudate Nucleus / physiology; Estradiol / pharmacology; Estradiol / physiology; Excitatory Postsynaptic Potentials / drug effects; Excitatory Postsynaptic Potentials / physiology; Female; GABAergic Neurons / drug effects; GABAergic Neurons / physiology; Male; Nucleus Accumbens / drug effects; Nucleus Accumbens / physiology; Patch-Clamp Techniques; Putamen / drug effects; Putamen / physiology; Rats; Rats, Sprague-Dawley
TL;DR:
This demonstration of sex and striatal region-specific acuteEstradiol neuromodulation revises the understanding of sex hormone action on striatal physiology and resulting behaviors and first demonstration of acute estradiol action on MSN excitatory synapse function is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 4, 2019
2019 article
The expression of select genes necessary for membrane-associated estrogen receptor signaling differ by sex in adult rat hippocampus
Meitzen, J., Britson, K. A., Tuomela, K., & Mermelstein, P. G. (2019, February). STEROIDS, Vol. 142, pp. 21–27.
author keywords: Caveolin; DHHC; Palmitoylation; Estrogen receptor; Sex; Hippocampus
MeSH headings : Animals; Cell Membrane / metabolism; Female; Hippocampus / metabolism; Male; Receptors, Estrogen / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Signal Transduction / genetics
TL;DR:
Select genes differ by sex at specific developmental stages, arguing for a more nuanced model than simple widespread perinatal emergence of sex differences in all genes enabling sex‐specific estradiol action.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2019
2018 journal article
Biological Sex, Estradiol and Striatal Medium Spiny Neuron Physiology: A Mini-Review
Frontiers in Cellular Neuroscience, 12, 492.
author keywords: female; estradiol; estrous cycle; spiny projection neurons; caudate-putamen; dorsal striatum; nucleus accumbens; aromatase
TL;DR:
This mini-review describes sex differences in the electrophysiological properties of the MSNs in prepubertal rats and discusses specific examples of how the human menstrual and rat estrous cycles induce differences in striatal-relevant behaviors and neural substrate, including how female rat MSN electrophYSiology is influenced by the estrous cycle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 31, 2018
2018 journal article
Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice
JOURNAL OF NEUROPHYSIOLOGY, 120(4), 1712–1727.
author keywords: medium spiny neuron; mice; nucleus accumbens; sex; ventral striatum
MeSH headings : Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Male; Mice; Mice, Inbred C57BL; Miniature Postsynaptic Potentials; Neurons / physiology; Nucleus Accumbens / growth & development; Nucleus Accumbens / physiology; Sex Factors
TL;DR:
This research provides the most comprehensive assessment of medium spiny neuron subtype electrophysiological properties to date in a critical brain region, the nucleus accumbens core, and represents the first evaluation of whether mouse medium sp Tiny neuron sub type electrophYSiological properties differ by sex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 10, 2018
2018 journal article
Estrous cycle-induced sex differences in medium spiny neuron excitatory synaptic transmission and intrinsic excitability in adult rat nucleus accumbens core
JOURNAL OF NEUROPHYSIOLOGY, 120(3), 1356–1373.
author keywords: estrous cycle; excitability; medium spiny neurons; nucleus accumbens; sex steroid hormones
MeSH headings : Action Potentials; Animals; Castration; Estrous Cycle; Excitatory Postsynaptic Potentials; Female; Male; Neurons / physiology; Nucleus Accumbens / physiology; Rats, Sprague-Dawley; Sex Characteristics
TL;DR:
It is the first demonstration that medium spiny neuron electrophysiological properties change across adult female hormone cycle phases in any striatal region and indicates that adultFemale hormone cycles are an important factor for neurophysiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 5, 2018
2018 journal article
Nucleus accumbens core medium spiny neuron electrophysiological properties and partner preference behavior in the adult male prairie vole, Microtus ochrogaster
Journal of Neurophysiology, 119(4), 1576–1588.
author keywords: electrophysiology; medium spiny neuron; nucleus accumbens; rat; vole
MeSH headings : Action Potentials / physiology; Animals; Arvicolinae / physiology; Excitatory Postsynaptic Potentials / physiology; Male; Mating Preference, Animal / physiology; Neurons / physiology; Nucleus Accumbens / physiology; Patch-Clamp Techniques; Social Behavior
TL;DR:
It is found that decreases in miniature excitatory postsynaptic current amplitude and the slope of the evoked action potential firing rate to depolarizing current injection weakly associated with increased preference for the partnered female, suggests that exciteatory synaptic strength and neuronal excitability may be decreased in MSNs in males exhibiting stronger preference for a partnered female.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2018 journal article
Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors
JOURNAL OF BIOLOGICAL CHEMISTRY, 293(41), 15901–15911.
author keywords: estrogen receptor; post-translational modification (PTM); protein palmitoylation; caveolin; membrane protein; DHHC
MeSH headings : Acetyltransferases; Acyltransferases / genetics; Acyltransferases / metabolism; Animals; Caveolin 1 / metabolism; Cyclic AMP Response Element-Binding Protein / metabolism; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Lipoylation; Protein Processing, Post-Translational; Rats, Sprague-Dawley
TL;DR:
Findings provide additional information about the overall influence of palmitoylation on the membrane-initiated estrogen signaling pathway and highlight the importance of considering the influence ofPalmitoylated proteins on other CAV1-dependent processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 29, 2018
2018 review
Sex Differences in Medium Spiny neuron excitability and Glutamatergic Synaptic input: Heterogeneity Across Striatal Regions and evidence for Estradiol-Dependent Sexual Differentiation
[Review of ]. FRONTIERS IN ENDOCRINOLOGY, 9.
author keywords: sex; estradiol; hormones; striatum; medium spiny neuron; nucleus accumbens; caudate-putamen; electrophysiology
TL;DR:
Sex differences in rat MSN glutamatergic synaptic input and intrinsic excitability across striatal regions are reviewed, including evidence for estradiol-mediated sexual differentiation in the nucleus AcbC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 review
Sex differences and the effects of estradiol on striatal function
[Review of ]. CURRENT OPINION IN BEHAVIORAL SCIENCES, 23, 42–48.
TL;DR:
A brief review of the recent literature reporting on sex differences and effects of the estrogenic hormone 17β-estradiol on behavioral and neural function across all three striatal regions, focusing upon the most prominent striatal neuron type, the medium spiny neuron.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018
2017 journal article
Interviewing neuroscientists for an undergraduate honors project
Journal of Undergraduate Neuroscience Education, 16(1), A89–A94.
Source: NC State University Libraries
Added: November 7, 2020
2017 journal article
Problems and Progress regarding Sex Bias and Omission in Neuroscience Research
ENEURO, 4(6).
author keywords: Animal models; journals; neuroscience; sex bias; sex omission
MeSH headings : Animals; Female; Male; Mice; Neurosciences; Rats; Sexism / statistics & numerical data; Sexism / trends
TL;DR:
The largest-ever number of neuroscience articles for sex bias and omission is analyzed: 6636 articles using mice or rats in 6 journals published from 2010 to 2014, finding sex bias remains present and sex omission is declining, as increasing numbers of articles report sex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Genetic sex and the volumes of the caudate-putamen, nucleus accumbens core and shell: original data and a review
BRAIN STRUCTURE & FUNCTION, 221(8), 4257–4267.
author keywords: Striatum; Caudate-putamen; Dorsal striatum; Ventral striatum; Volume; Nucleus accumbens; Sex; Hemisphere; Lateralization
MeSH headings : Animals; Caudate Nucleus / anatomy & histology; Caudate Nucleus / physiology; Female; Male; Nucleus Accumbens / anatomy & histology; Nucleus Accumbens / physiology; Preoptic Area / anatomy & histology; Preoptic Area / physiology; Putamen / anatomy & histology; Putamen / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR:
Findings complement previous reports of lateralized nucleus accumbens volume in humans, and suggest that this may possibly be driven via hemispheric differences in nucleus Accumbens core volume.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core
ENDOCRINOLOGY, 157(8), 3181–3196.
MeSH headings : Animals; Animals, Newborn; Estradiol / pharmacology; Excitatory Postsynaptic Potentials / drug effects; Excitatory Postsynaptic Potentials / physiology; Female; Feminization / chemically induced; Feminization / pathology; Feminization / physiopathology; Male; Nucleus Accumbens / cytology; Nucleus Accumbens / drug effects; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sexual Maturation / drug effects; Sexual Maturation / physiology; Synaptic Transmission / drug effects; Synaptic Transmission / physiology
TL;DR:
It is concluded that excitatory synaptic input onto AcbC MSNs is organized long before adulthood via steroid sex hormone action, providing new insight into a mechanism by which sex differences in motivated behavior and other AbcC functions may be generated or compromised.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
No Evidence for Sex Differences in the Electrophysiological Properties and Excitatory Synaptic Input onto Nucleus Accumbens Shell Medium Spiny Neurons
ENEURO, 3(1).
author keywords: genetic sex; intrinsic electrophysiological properties; male and female rats; medium spiny neuron; mEPSC; striatum
MeSH headings : Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Interneurons / physiology; Male; Membrane Potentials; Miniature Postsynaptic Potentials; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR:
Overall, it appears that sex differences in striatal function, including motivated behavior and reward, are likely mediated by other factors and striatal regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons
JOURNAL OF NEUROPHYSIOLOGY, 113(3), 720–729.
author keywords: intrinsic excitability; sex differences; medium spiny neuron; dorsal striatum; mEPSC
MeSH headings : Action Potentials; Animals; Corpus Striatum / cytology; Corpus Striatum / growth & development; Corpus Striatum / physiology; Female; Male; Neurons / physiology; Rats; Rats, Sprague-Dawley; Sex Factors
TL;DR:
It is indicated that MSN excitability is increased in prepubertal females compared with males, providing a new mechanism that potentially contributes to generating sex differences in striatal-mediated processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Using Tinbergen’s four questions as the framework for a neuroscience capstone course
Journal of Undergraduate Neuroscience Education, 14(1), A46–A55.
Source: NC State University Libraries
Added: November 7, 2020
2014 journal article
An aerator for brain slice experiments in individual cell culture plate wells
JOURNAL OF NEUROSCIENCE METHODS, 238, 1–10.
author keywords: Brain slices; Aerator; Bubbler; 24-Well culture plate; Oxygenation; Dorsal striatum; beta-Adrenergic receptor; Caudate putamen
MeSH headings : Animals; Brain / drug effects; Brain / physiology; Cell Culture Techniques / instrumentation; Equipment Design; G-Protein-Coupled Receptor Kinase 2 / metabolism; Gene Expression / drug effects; Gene Expression / physiology; Immunohistochemistry; Neurons / drug effects; Neurons / physiology; Organ Culture Techniques / instrumentation; Oxygen / administration & dosage; Patch-Clamp Techniques / instrumentation; RNA, Messenger / metabolism; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Spectrum Analysis
TL;DR:
Key differences include enhanced control over gas delivery to individual wells containing brain slices, decreased necessary volume, a sample restraint to reduce movement artifacts, the potential to be sterilized, the avoidance of materials that absorb water and small biological molecules, minimal production costs, and increased experimental throughput.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Enhanced Striatal beta 1-Adrenergic Receptor Expression Following Hormone Loss in Adulthood Is Programmed by Both Early Sexual Differentiation and Puberty: A Study of Humans and Rats
ENDOCRINOLOGY, 154(5), 1820–1831.
MeSH headings : Adolescent; Adult; Aging / genetics; Aging / metabolism; Aging / physiology; Animals; Corpus Striatum / growth & development; Corpus Striatum / metabolism; Estradiol / deficiency; Estradiol / pharmacology; Female; Gene Expression Regulation, Developmental / physiology; Hormones / deficiency; Hormones / pharmacology; Humans; Male; Ovariectomy; Puberty / genetics; Puberty / metabolism; Puberty / physiology; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1 / genetics; Receptors, Adrenergic, beta-1 / metabolism; Sex Differentiation / drug effects; Sex Differentiation / genetics; Sex Differentiation / physiology; Time Factors; Up-Regulation / genetics; Up-Regulation / physiology
TL;DR:
It is demonstrated that critical periods early in life and at puberty program adult gene responsiveness to hormone loss after gonadectomy and potentially reproductive senescence, indicating the necessity of pubertal development and adult ovariectomy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Palmitoylation of Estrogen Receptors Is Essential for Neuronal Membrane Signaling
ENDOCRINOLOGY, 154(11), 4293–4304.
MeSH headings : Acyltransferases / genetics; Acyltransferases / metabolism; Animals; Cell Membrane / physiology; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; Endoplasmic Reticulum; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Gene Expression Regulation / physiology; Gene Knockdown Techniques; Lipoylation; Mutation; Neurons / cytology; Neurons / physiology; Phosphorylation / physiology; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / metabolism; Receptors, Metabotropic Glutamate / genetics; Receptors, Metabotropic Glutamate / metabolism; Signal Transduction / physiology
TL;DR:
In hippocampal neurons, pharmacological inhibition of palmitoylation eliminated 17β-estradiol-mediated phosphorylation of cAMP response element-binding protein, a process dependent on surface membrane ERs, and data collectively suggest discrete mechanisms that regulate specific isoform or global membrane ER signaling in neurons separate from mGluR activity or nuclear ER function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Seasonal Changes in Patterns of Gene Expression in Avian Song Control Brain Regions
PLoS ONE, 7(4), e35119.
Ed(s): S. Yamazaki
MeSH headings : Animals; Brain / metabolism; Breeding; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Hormones / blood; Male; Molecular Sequence Annotation; Molecular Sequence Data; Reproducibility of Results; Seasons; Sparrows / genetics; Telencephalon / metabolism; Vocalization, Animal
TL;DR:
Changing the hormonal and photoperiodic conditions in seasonally-breeding Gambel's white-crowned sparrows and extracting RNA from the telencephalic song control nuclei reveals categorical differences in the kinds of genes regulated in HVC and RA, and provides insights into the complex molecular pathways that underlie adult neural plasticity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
The Organizational and Aromatization Hypotheses Apply to Rapid, Nonclassical Hormone Action: Neonatal Masculinization Eliminates Rapid Estradiol Action in Female Hippocampal Neurons
Endocrinology, 153(10), 4616–4621.
MeSH headings : Animals; Aromatase / metabolism; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / metabolism; Dihydrotestosterone / metabolism; Dihydrotestosterone / pharmacology; Estradiol / metabolism; Estradiol / pharmacology; Female; Hippocampus / cytology; Hippocampus / drug effects; Hippocampus / metabolism; Neurons / cytology; Neurons / drug effects; Neurons / metabolism; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate / metabolism; Signal Transduction / drug effects; Testosterone / metabolism; Testosterone / pharmacology
TL;DR:
Findings indicate that testosterone aromatization to estradiol leads to a masculinization/defeminization process whereby hippocampal neurons fail to exhibit rapidEstradiol signaling to CREB, extending the organizational and aromatized hypotheses to rapid, nonclassical hormone action.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
Corticotropin Releasing Factor-Induced CREB Activation in Striatal Neurons Occurs via a Novel Gβγ Signaling Pathway
PLoS ONE, 6(3), e18114.
Ed(s): V. Degtyar
MeSH headings : Adenylyl Cyclases / metabolism; Animals; Calcium / metabolism; Corticotropin-Releasing Hormone / pharmacology; Cyclic AMP / metabolism; Cyclic AMP Response Element-Binding Protein / metabolism; Cyclic AMP-Dependent Protein Kinases / metabolism; GTP-Binding Protein alpha Subunits, Gs / metabolism; GTP-Binding Protein beta Subunits / metabolism; GTP-Binding Protein gamma Subunits / metabolism; MAP Kinase Signaling System / drug effects; Models, Biological; Neostriatum / cytology; Neurons / drug effects; Neurons / enzymology; Neurons / metabolism; Phosphorylation / drug effects; Rats; Receptors, Corticotropin-Releasing Hormone / metabolism; Signal Transduction / drug effects
TL;DR:
A novel neuronal signaling pathway whereby CRF leads to a rapid Gβγ- and MEK-dependent increase in CREB phosphorylation in neurons is described, which is the first descriptions of CRF leading to activation of a G βγ-dependent signaling pathway in neurons, as well as the first description of Gβαγ activation leading to downstream CREBosphorylated in any cellular system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons
European Journal of Neuroscience, 34(5), 671–681.
author keywords: corticotropin-releasing factor receptor; G-protein coupled receptor; mitogen-activated protein kinase (MAPK); rat; stress
MeSH headings : Animals; Cells, Cultured; Corticotropin-Releasing Hormone / pharmacology; Cyclic AMP / metabolism; Cyclic AMP Response Element-Binding Protein / metabolism; Cyclic AMP-Dependent Protein Kinases / metabolism; GTP-Binding Protein alpha Subunits, Gs / metabolism; GTP-Binding Protein beta Subunits / metabolism; GTP-Binding Protein gamma Subunits / metabolism; Hippocampus / cytology; Hippocampus / physiology; Mitogen-Activated Protein Kinase Kinases / metabolism; Pyramidal Cells / cytology; Pyramidal Cells / drug effects; Pyramidal Cells / physiology; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors; Receptors, Corticotropin-Releasing Hormone / metabolism; Signal Transduction / physiology; Stress, Physiological; Urocortins / pharmacology
TL;DR:
Novel molecular mechanisms by which stress can directly impact hippocampal neurons are suggested, and an emerging role for Gβγ signaling in mediating the effects of stress peptides in extrahypothalamic stress‐responsive brain regions is highlighted.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathways
Journal of Chemical Neuroanatomy, 42(4), 236–241.
author keywords: Estradiol; mGluR; Hypothalamus; Arcuate Nucleus; Caveolin; Hippocampus; Striatum
MeSH headings : Animals; Brain Chemistry / physiology; Humans; Receptors, Estrogen / chemistry; Receptors, Estrogen / physiology; Receptors, Metabotropic Glutamate / chemistry; Receptors, Metabotropic Glutamate / metabolism; Receptors, Metabotropic Glutamate / physiology; Signal Transduction / physiology; Time Factors
TL;DR:
It is becoming clear that ER signaling through mGluRs is one important mechanism by which estrogens can modulate neuron and glial physiology, ultimately impacting various aspects of nervous system function.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
Measurements of neuron soma size and density in rat dorsal striatum, nucleus accumbens core and nucleus accumbens shell: Differences between striatal region and brain hemisphere, but not sex
Neuroscience Letters, 487(2), 177–181.
author keywords: Striatum; Sexual dimorphism; Rat; Nucleus accumbens; Lateralization; Morphometry
MeSH headings : Animals; Cell Count / methods; Cell Size; Corpus Striatum / cytology; Corpus Striatum / growth & development; Female; Male; Neurons / cytology; Neurons / physiology; Nucleus Accumbens / cytology; Nucleus Accumbens / growth & development; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR:
Results provide the first evidence that hemispheric bias in the striatum and striatal-mediated behaviors can be attributed to a lateralization in neuronal density within the CPu.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons
Journal of Neurochemistry, 116(6), 984–995.
author keywords: adrenergic receptor; cyclic AMP response element binding protein; noradrenaline; norepinephrine; nucleus accumbens; striatum
MeSH headings : Adrenergic Agents / pharmacology; Animals; Animals, Newborn; CREB-Binding Protein / genetics; CREB-Binding Protein / metabolism; Cells, Cultured; Chelating Agents / pharmacology; Corpus Striatum / cytology; Cyclic AMP / pharmacology; Egtazic Acid / analogs & derivatives; Egtazic Acid / pharmacology; Enzyme Inhibitors / pharmacology; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Microtubule-Associated Proteins / genetics; Microtubule-Associated Proteins / metabolism; Neurons / drug effects; Neurons / physiology; Norepinephrine / pharmacology; Phosphorylation / drug effects; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases / genetics; Receptor Protein-Tyrosine Kinases / metabolism; Receptors, Adrenergic, beta-1 / genetics; Receptors, Adrenergic, beta-1 / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2009 journal article
Plastic and Stable Electrophysiological Properties of Adult Avian Forebrain Song-Control Neurons across Changing Breeding Conditions
Journal of Neuroscience, 29(20), 6558–6567.
MeSH headings : Action Potentials / drug effects; Action Potentials / physiology; Analysis of Variance; Androgens / blood; Androgens / pharmacology; Animals; Biophysics; Electric Stimulation; Male; Neural Pathways / drug effects; Neural Pathways / physiology; Neuronal Plasticity / drug effects; Neuronal Plasticity / physiology; Neurons / classification; Neurons / drug effects; Neurons / physiology; Patch-Clamp Techniques / methods; Photoperiod; Prosencephalon / cytology; Radioimmunoassay / methods; Sparrows / physiology; Testosterone / blood; Testosterone / pharmacology; Time Factors; Vocalization, Animal / physiology
TL;DR:
Test the hypothesis that passive and active neuronal properties in the forebrain song-control nuclei HVC and RA change across breeding conditions and finds that RA projection neuron membrane time constant, capacitance, and evoked and spontaneous firing rates were all increased in the breeding condition.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2009 journal article
Time course of changes in Gambel's white-crowned sparrow song behavior following transitions in breeding condition
Hormones and Behavior, 55(1), 217–227.
author keywords: Gambel's white-crowned sparrow; Zonotrichia leucophrys gambelii; Testosterone; Birdsong; Songbird; Seasonal plasticity; Photoperiod
MeSH headings : Analysis of Variance; Animals; Cues; Male; Photoperiod; Radioimmunoassay; Seasons; Sexual Behavior, Animal / drug effects; Sparrows / physiology; Stereotyped Behavior / drug effects; Testosterone / administration & dosage; Testosterone / blood; Vocalization, Animal / drug effects
TL;DR:
It is suggested that while song rate changes quickly, song phonology changes more slowly, generally following or in parallel with previously investigated changes in the neural substrate.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2008 journal article
Seasonal-like growth and regression of the avian song control system: Neural and behavioral plasticity in adult male Gambel’s white-crowned sparrows
General and Comparative Endocrinology, 157(3), 259–265.
author keywords: testosterone; estrogen; androgen; seasonal plasticity; regression; growth; song control system; photoperiod
MeSH headings : Animals; Birds / physiology; Brain / anatomy & histology; Brain / physiology; Male; Seasons; Sparrows / physiology; Vocalization, Animal / physiology
TL;DR:
This mini-review discusses the steroidal and cellular mechanisms underlying seasonal-like growth and regression of the song control system in adult male Gambel's white-crowned sparrows, and its impact on song behavior.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2007 journal article
Seasonal changes in intrinsic electrophysiological activity of song control neurons in wild song sparrows
Journal of Comparative Physiology A, 193(6), 677–683.
author keywords: spontaneous activity; song sparrow; electrophysiology; songbird; seasonal plasticity
MeSH headings : Animals; Brain / anatomy & histology; Brain / physiology; Data Interpretation, Statistical; Electrophysiology; Hormones / physiology; In Vitro Techniques; Lateral Thalamic Nuclei / physiology; Male; Neurons / physiology; Neurons / ultrastructure; Photoperiod; Seasons; Sparrows / physiology; Testosterone / blood; Vocalization, Animal / physiology
TL;DR:
It is concluded that environmental cues are sufficient to induce seasonal changes in electrophysiological properties of song control neurons, and that changes in these properties may underlie seasonally changes in song behavior.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2007 journal article
Steroid Hormones Act Transsynaptically within the Forebrain to Regulate Neuronal Phenotype and Song Stereotypy
Journal of Neuroscience, 27(44), 12045–12057.
author keywords: androgen; estrogen; testosterone; electrophysiology; birdsong; seasonal plasticity
MeSH headings : Analysis of Variance; Animals; Gonadal Steroid Hormones / administration & dosage; Gonadal Steroid Hormones / blood; In Vitro Techniques; Male; Membrane Potentials / drug effects; Membrane Potentials / physiology; Membrane Potentials / radiation effects; Neuronal Plasticity / drug effects; Neuronal Plasticity / physiology; Patch-Clamp Techniques / methods; Photoperiod; Prosencephalon / drug effects; Radioimmunoassay / methods; Sparrows / physiology; Stereotyped Behavior / drug effects; Stereotyped Behavior / physiology; Time Factors; Vocalization, Animal / drug effects; Vocalization, Animal / physiology
TL;DR:
It is found that ARs and ERs in the song-control nucleus HVC mediate systemic testosterone-induced changes in song stereotypy but not rate, part of a concerted change in key premotor nuclei, enabling stereotyped song.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 journal article
Differing Roles of Inhibition in Hierarchical Processing of Species-Specific Calls in Auditory Brainstem Nuclei
Journal of Neurophysiology, 94(6), 4019–4037.
MeSH headings : Acoustic Stimulation / methods; Action Potentials / drug effects; Action Potentials / physiology; Animals; Auditory Pathways / physiology; Bicuculline / pharmacology; Brain Stem / cytology; Brain Stem / physiology; Cell Count / methods; Chiroptera; Dose-Response Relationship, Radiation; Drug Interactions; Echolocation / drug effects; Echolocation / physiology; Electrodes; Functional Laterality; GABA Antagonists / pharmacology; Glycine Agents / pharmacology; Neural Inhibition / drug effects; Neural Inhibition / physiology; Neurons / classification; Neurons / drug effects; Neurons / physiology; Sound Localization; Species Specificity; Strychnine / pharmacology; gamma-Aminobutyric Acid / pharmacology
TL;DR:
It is shown that inhibition plays only limited roles in the DNLL and INLL but dominates in the IC, where the various patterns of inhibition sculpt a wide variety of emergent response properties from the backdrop of more expansive and far less specific excitatory innervation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 journal article
Electrophysiological Properties of Neurons in the Basal Ganglia of the Domestic Chick: Conservation and Divergence in the Evolution of the Avian Basal Ganglia
Journal of Neurophysiology, 94(1), 454–467.
MeSH headings : Age Factors; Animals; Animals, Newborn; Basal Ganglia / cytology; Basal Ganglia / growth & development; Chickens; Choline O-Acetyltransferase / metabolism; Dose-Response Relationship, Radiation; Electric Stimulation / methods; Electrophysiology; Immunohistochemistry / methods; In Vitro Techniques; Lysine / analogs & derivatives; Lysine / metabolism; Membrane Potentials / drug effects; Membrane Potentials / physiology; Membrane Potentials / radiation effects; Neurons / classification; Neurons / physiology; Patch-Clamp Techniques / methods
TL;DR:
It is discovered that spiny neurons, the most common cell type in the striatum of all amniotes, possess a diverse set of physiological properties in chicks that distinguish them from both mammals and songbirds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 journal article
Seasonal-like plasticity of spontaneous firing rate in a songbird pre-motor nucleus
Journal of Neurobiology, 64(2), 181–191.
author keywords: androgen; estrogen; testosterone; electrophysiology; birdsong
MeSH headings : Action Potentials / drug effects; Action Potentials / physiology; Analysis of Variance; Animals; Brain / cytology; Brain / drug effects; Brain / physiology; Dihydrotestosterone / blood; Dihydrotestosterone / pharmacology; Drug Interactions; Estradiol / blood; Estradiol / pharmacology; In Vitro Techniques; Male; Neural Pathways / drug effects; Neural Pathways / physiology; Neuronal Plasticity / drug effects; Neuronal Plasticity / physiology; Neurons / drug effects; Neurons / physiology; Photoperiod; Seasons; Songbirds; Statistics as Topic; Testosterone / blood; Testosterone / pharmacology; Time Factors; Vocalization, Animal / drug effects; Vocalization, Animal / physiology
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2002 journal article
Response Selectivity for Species-Specific Calls in the Inferior Colliculus of Mexican Free-Tailed Bats is Generated by Inhibition
Journal of Neurophysiology, 88(4), 1941–1954.
MeSH headings : Acoustic Stimulation; Animals; Bicuculline / pharmacology; Chiroptera / physiology; Discrimination Learning / drug effects; Discrimination Learning / physiology; GABA Antagonists / pharmacology; Inferior Colliculi / cytology; Inferior Colliculi / physiology; Neural Inhibition / drug effects; Neural Inhibition / physiology; Neurons / physiology; Pitch Perception / drug effects; Pitch Perception / physiology; Species Specificity; Vocalization, Animal / physiology
TL;DR:
The inhibition evoked by each call can shape a unique pattern of activity in the IC population and that pattern may be important for both the identification of a particular call and for discriminating it from other calls and other signals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
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