Tae-Hyung Kim

Works (1)

Updated: July 5th, 2023 15:48

2010 journal article

Overexpression of Transcription Factor Sp2 Inhibits Epidermal Differentiation and Increases Susceptibility to Wound- and Carcinogen-Induced Tumorigenesis

CANCER RESEARCH, 70(21), 8507–8516.

By: T. Kim n, S. Chiera n, K. Linder n, C. Trempus n, R. Smart n  & J. Horowitz n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Blotting, Western; COS Cells; Carcinogens / toxicity; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cattle; Cell Differentiation; Chlorocebus aethiops; Disease Susceptibility; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Female; Humans; Immunoenzyme Techniques; Keratin-5 / genetics; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Sp2 Transcription Factor / physiology; Wounds and Injuries
TL;DR: It is reported that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas, and this results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
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Added: August 6, 2018

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