2010 journal article

Photocleavable Polyethylene Glycol for the Light-Regulation of Protein Function


By: W. Georgianna n, H. Lusic n, A. Mclver & A. Deiters n

MeSH headings : Crystallography, X-Ray; Models, Molecular; Molecular Structure; Muramidase / chemistry; Muramidase / metabolism; Photochemical Processes; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Stereoisomerism; Ultraviolet Rays
TL;DR: The synthesis of a photocleavable PEG reagent (PhotoPEG) and its application to the light-regulation of enzyme activity is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Reversible light switching of cell signalling by genetically encoded protein dimerization

Chembiochem, 11(3), 301–303.

By: W. Georgianna n & A. Deiters n

MeSH headings : Animals; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Cell Membrane / chemistry; Cell Membrane / metabolism; Light; Luminescent Proteins / chemistry; Luminescent Proteins / metabolism; Mice; NIH 3T3 Cells; Phycobilins / chemistry; Phycocyanin / chemistry; Phytochrome B / chemistry; Phytochrome B / genetics; Phytochrome B / metabolism; Protein Multimerization; Protein Structure, Tertiary; Signal Transduction
TL;DR: This work has shown that a light-switchable transcriptional activator was constructed from a protein–protein interaction module in the phytochrome signalling network of the plant Arabidopsis thaliana, which enables the application of light toward the genetically encoded, reversible photoregulation of a cellular event. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: NC State University Libraries
Added: August 6, 2018

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