Zhe Zhang

Works (32)

Updated: July 12th, 2023 21:19

2014 conference paper

Estimating trust from agents' interactions via commitments

21st european conference on artificial intelligence (ecai 2014), 263, 1043–1044.

By: A. Kalia, Z. Zhang & M. Singh 

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Shin: Generalized Trust Propagation with Limited Evidence

COMPUTER, 46(3), 78–85.

By: C. Hang n, Z. Zhang n & M. Singh n 

Contributors: C. Hang n, Z. Zhang n & M. Singh n 

TL;DR: Shin incorporates a probabilistic method for revising trust estimates in trustees, yielding higher prediction accuracy than traditional approaches that base trust exclusively on a series of referrals culminating with the trustee. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Vapor deposition during cigarette smoke inhalation in a subject-specific human airway model

JOURNAL OF AEROSOL SCIENCE, 53, 40–60.

By: Z. Zhang n, C. Kleinstreuer n & Y. Feng n

author keywords: Cigarette smoke; Respiratory vapor mass transfer and deposition; Transient puffing and inhalation; Subject-specific human upper airways; Computational analysis; Quantitative data sets for toxicologists
TL;DR: Results show that vapor deposition is strongly influenced by its property values as well as inhalation waveform, i.e., puffing behavior, and a correction factor has been proposed, considering vapor transport delay, in order to calculate efficiently actual deposition fraction values under transient puffing condition. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model

JOURNAL OF AEROSOL SCIENCE, 46, 34–52.

By: Z. Zhang n, C. Kleinstreuer n & S. Hyun*

author keywords: Respiratory deposition; Cigarette smoke particles; Subject-specific human upper airways; Computational analysis; Potential reduced exposure tobacco products
TL;DR: It is demonstrated that changes in cigarette composition significantly influence the hygroscopic growth of CSPs and is helpful for quantitatively evaluating the dose-exposure and subsequent health effects of both conventional and potentially less-harmful cigarettes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 journal article

Optimal Drug-Aerosol Delivery to Predetermined Lung Sites

JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, 133(1).

By: C. Kleinstreuer n & Z. Zhang n

author keywords: subject-specific lung airways; air-particle flow; computer simulation results; inhaler devices; optimal drug-aerosol targeting; smart inhaler system
TL;DR: This review summarizes computer simulation methodologies of air-particle flow, results of drug-aerosol transport/deposition in models of the human respiratory system, as well as aspects ofdrug-aerOSol targeting and associated inhalation devices. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

Airflow and Particle Transport in the Human Respiratory System

ANNUAL REVIEW OF FLUID MECHANICS, Vol. 42, pp. 301–334.

By: C. Kleinstreuer n & Z. Zhang n

author keywords: human respiratory air-way models; experimental observations and computer simulations; laminar/turbulent airflow structures; dilute suspensions of nanomaterial; solid particles or droplets; inhaled/exhaled aerosol transport and deposition
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Source: Web Of Science
Added: August 6, 2018

2009 journal article

Improving Data Availability for Better Access Performance: A Study on Caching Scientific Data on Distributed Desktop Workstations

JOURNAL OF GRID COMPUTING, 7(4), 419–438.

By: X. Ma n, S. Vazhkudai * & Z. Zhang n

author keywords: Desktop grids; Storage scavenging; Scientific data
TL;DR: This article proposes a novel combination of prefix caching, collective download, and remote partial data recovery (RPDR), to deal with optimal cache space consumption and storage node volatility, and indicates that prefix caching can significantly improve the cache hit rate andpartial data recovery is better than (or comparable to) many persistent-data availability techniques. (via Semantic Scholar)
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7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A new methodology for targeting drug-aerosols in the human respiratory system

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 51(23-24), 5578–5589.

By: C. Kleinstreuer n, Z. Zhang n, Z. Li  n, W. Roberts n & C. Rojas*

author keywords: Drug-aerosol inhalers; Targeted drug-aerosol delivery; Methodology for smart inhaler system; Experimental verification of new methodology
TL;DR: The new methodology introduces the idea of a controlled air-particle stream which provides maximum, patient-specific drug-aerosol deposition based on optimal particle diameter and density, inhalation waveform, and particle-release position. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Airflow and Nanoparticle Deposition in a 16-Generation Tracheobronchial Airway Model

ANNALS OF BIOMEDICAL ENGINEERING, 36(12), 2095–2110.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

author keywords: Human tracheobronchial region; Computational analysis; Airflow; Nanoparticle deposition; Deposition efficiencies; Deposition correlations
MeSH headings : Algorithms; Bronchi / physiology; Computer Simulation; Humans; Models, Biological; Nanoparticles; Particle Size; Pulmonary Ventilation; Reproducibility of Results; Trachea / physiology
TL;DR: It was found that fully developed flow and uniform nanoparticle concentrations can be assumed beyond generation G12 and the deposition efficiencies at each individual bifurcation in the TB region can be well correlated as a function of an effective diffusion parameter. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

Comparison of analytical and CFD models with regard to micron particle deposition in a human 16-generation tracheobronchial airway model

JOURNAL OF AEROSOL SCIENCE, 40(1), 16–28.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

author keywords: Human tracheobronchial airways; Computational analysis; Micron particle deposition; Deposition efficiency; Deposition fraction
TL;DR: Surprisingly, simulated inspiratory deposition fractions for the entire tracheobronchial region with repeated TBUs in parallel and in series agree rather well with those calculated using analytical/semi-empirical expressions, however, the predicted particle-deposition fractions based on such analytical formulas differ greatly from the present simulation results. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 review

Modeling airflow and particle transport/deposition in pulmonary airways

[Review of ]. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 163(1-3), 128–138.

By: C. Kleinstreuer n, Z. Zhang n & Z. Li n

author keywords: Pulmonary airways; Deposition enhancement factor; Tracheobronchial airways
MeSH headings : Aerosols; Computer Simulation; Humans; Models, Biological; Particle Size; Pulmonary Ventilation / physiology; Respiratory Transport / physiology
TL;DR: A review of research papers is presented, pertinent to computer modeling of airflow as well as nano- and micron-size particle deposition in pulmonary airway replicas, and optimal parameters for mechanical drug-aerosol targeting of predetermined lung areas can be computed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Targeted drug-aerosol delivery in the human respiratory system

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, Vol. 10, pp. 195–220.

By: C. Kleinstreuer n, Z. Zhang n & J. Donohue *

author keywords: nasal and lung airways; nano- and micro-size aerosols; transport/deposition; present and proposed inhaler devices; methodology of optimal drug-aerosol targeting; computer simulations; experimental evidence
MeSH headings : Aerosols / administration & dosage; Aerosols / pharmacokinetics; Animals; Computer Simulation; Drug Delivery Systems / methods; Humans; Models, Biological; Pharmaceutical Preparations / administration & dosage; Pharmacokinetics; Respiratory System / metabolism
TL;DR: Experimental measurements and computer models of particle transport and deposition in nasal and lung airway models are presented and the underlying methodology and performance of pressurized metered dose inhalers as well as new smart inhaler systems are discussed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Combined inertial and gravitational deposition of microparticles in small model airways of a human respiratory system

JOURNAL OF AEROSOL SCIENCE, 38(10), 1047–1061.

By: C. Kleinstreuer n, Z. Zhang n & C. Kim*

author keywords: inertial impaction; gravitational sedimentation; micron particle deposition; small human airways; computational analysis; deposition efficiency; stokes number; fronde number; sedimentation parameter; deposition correlations
TL;DR: More prudent is the use of curve-fitted correlations generated from experimentally validated computer simulation results as a function of Stokes number and sedimentation parameter for predicting gravitational deposition in local bronchial airway segments. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 20(3), 294–309.

By: C. Kleinstreuer n, H. Shi* & Z. Zhang n

author keywords: computer simulation; droplet spray formation; pMDI performance; droplet transport/deposition; human upper airways; controlled air-particle stream; targeted drug-aerosol transport/deposition
MeSH headings : Aerosol Propellants / chemistry; Aerosols; Anti-Asthmatic Agents / administration & dosage; Anti-Asthmatic Agents / chemistry; Computer Simulation; Drug Delivery Systems / instrumentation; Equipment Design; Humans; Hydrocarbons, Fluorinated / chemistry; Inhalation Spacers; Metered Dose Inhalers; Models, Biological; Motion; Particle Size; Pressure; Reproducibility of Results; Respiratory System / anatomy & histology
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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness

JOURNAL OF AEROSOL SCIENCE, 38(4), 398–419.

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

author keywords: human nasal cavity; inertial particle decomposition; computer analysis; wall roughness
TL;DR: Considering drug–aerosol targeting, an optimal impaction parameter value exists which generates for normal inlet conditions the largest deposition in desired areas, e.g., the middle meatus, inferior meatus and olfactory regions, however, the absolute deposition efficiencies are very small because particles hardly reach those regions due to the complex nasal geometric structures. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Particle deposition in the human tracheobronchial airways due to transient inspiratory flow patterns

JOURNAL OF AEROSOL SCIENCE, 38(6), 625–644.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

author keywords: transient inhalation; laminar flow; turbulent flow; local flow pattern; micro-particle deposition; deposition fraction; drug-aerosol targeting
TL;DR: It is shown that the relation between particle-release positions at the trachea inlet and particle depositions at specific lung sites are greatly influenced by the complex airway geometry and the flow-rate magnitude. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part I: Airflow patterns

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 26(5), 632–649.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

author keywords: asymmetric upper airways; transient 3-D airflow simulations; parabolic and realistic velocity inlet conditions; local velocity distributions
TL;DR: The main results can be summarized as follows: Considering two acceleration and deceleration time levels during transient inhalation as well as steady-state inhalation generating the same inlet Reynolds number, Re in - mean = 1201 , the airflow patterns are quite similar. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part II: Particle transport and deposition

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 26(5), 650–668.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

author keywords: asymmetric upper airways; matching inlet Reynolds number; 3-D microparticle transport simulations; particle depositions and segmental correlations
TL;DR: Based on current research results, the out-of-plane model with tracheal rings and realistic inlet condition is recommended for future work and significant differences were recorded when comparing DFs in some branches of the present realistic model and the Weibel Type A model. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 journal article

Isotonic and hypertonic saline droplet deposition in a human upper airway model

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 19(2), 184–198.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

author keywords: aerosol deposition; computational fluid-particle dynamics; droplet vaporization and hygroscopicity; isotonic and hypertonic saline droplets
MeSH headings : Administration, Inhalation; Humans; Humidity; Isotonic Solutions / pharmacokinetics; Lung / physiology; Models, Anatomic; Models, Biological; Particle Size; Respiratory Mechanics; Saline Solution, Hypertonic / pharmacokinetics; Thermodynamics; Volatilization; Wettability
TL;DR: The validated computer simulation results indicate that the increase of NaCl-solute concentration, increase of inlet relative humidity, or decrease of inlets air temperature may reduce water evaporation and increase water condensation at saline droplet surfaces, resulting in higher droplet depositions due to the increasing particle diameter and density. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Laminar airflow and nanoparticle or vapor deposition in a human nasal cavity model

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 128(5), 697–706.

By: H. Shi  n, C. Kleinstreuer n & Z. Zhang n

MeSH headings : Absorption; Aerosols / pharmacokinetics; Air Movements; Computer Simulation; Gases / pharmacokinetics; Humans; Male; Middle Aged; Models, Biological; Nanoparticles; Nasal Cavity / metabolism; Tissue Distribution
TL;DR: An equation for a matching steady-state inhalation flow rate was developed that generates the same deposition results as cyclic inhalation in the olfactory region where the narrow channel surfaces receive only about one-half of a percent of the inhaled nanoparticles. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 journal article

Water vapor transport and its effects on the deposition of hygroscopic droplets in a human upper airway model

AEROSOL SCIENCE AND TECHNOLOGY, 40(1), 1–16.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

TL;DR: The fundamentals of 3-D airflow as well as heat and water vapor transport and droplet vaporization (or hygroscopicity) and deposition of isotonic saline droplets have been described and the effects of inhalation flow rates and thermodynamic air properties are discussed. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Airflow structures and nano-particle deposition in a human upper airway model

JOURNAL OF COMPUTATIONAL PHYSICS, 198(1), 178–210.

By: Z. Zhang n & C. Kleinstreuer n

author keywords: inspiratory flow; nano-size particle deposition; human airways; computational fluid-particle dynamics simulation
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

Comparison of micro- and nano-size particle depositions in a human upper airway model

JOURNAL OF AEROSOL SCIENCE, 36(2), 211–233.

By: Z. Zhang n, C. Kleinstreuer n, J. Donohue * & C. Kim*

author keywords: microparticle deposition; nanoparticle deposition; human upper airways; computational fluid-particle dynamics
TL;DR: Simulation results of microparticle and nanoparticle deposition patterns, local concentrations, and segmental averages are contrasted for a human upper airway model starting from the mouth to planar airway generation G3 under different inspiratory flow conditions to demonstrate uniformly deposited nanoparticles of similar concentrations may have greater toxicity effects when compared to microparticles of the same material. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions

PHYSICS OF FLUIDS, 16(7), 2199–2213.

By: H. Shi  n, C. Kleinstreuer n, Z. Zhang n & C. Kim*

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Source: Web Of Science
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2004 journal article

Vaporizing microdroplet inhalation, transport, and deposition in a human upper airway model

AEROSOL SCIENCE AND TECHNOLOGY, 38(1), 36–49.

By: Z. Zhang*, C. Kleinstreuer*, C. Kim & Y. Cheng

Source: Web Of Science
Added: August 6, 2018

2003 article

Computational thermodynamics analysis of vaporizing fuel droplets in the human upper airways

Zhang, Z., & Kleinstreuer, C. (2003, November). JSME INTERNATIONAL JOURNAL SERIES B-FLUIDS AND THERMAL ENGINEERING, Vol. 46, pp. 563–571.

By: Z. Zhang n & C. Kleinstreuer n

author keywords: liquid aerosol transport and deposition; JP-8 fuel; human airways; heat and mass transfer
TL;DR: Focusing on highly toxic JP-8 fuel aerosols, 3-D airflow and fluid-particle thermodynamics in a human upper airway model, the computational results show that the thermal effect on vapor deposition is minor, but it may greatly affect droplet deposition in human airways. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Laminar-to-turbulent fluid-particle flows in a human airway model

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW, 29(2), 271–289.

By: C. Kleinstreuer n & Z. Zhang n

author keywords: computational gas-solid two-phase flow; internal laminar-to-turbulent flow modeling; micro-particle distributions; human oral airway
TL;DR: The laminar-to-turbulent suspension flow problem was solved for a human airway model using a commercial software with user-supplied pre- and post-processing programs and the methodology outlined can be readily applied to other two-phase flows undergoing changing flow regimes in complex tubular systems. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Low-Reynolds-number turbulent flows in locally constricted conduits: A comparison study

AIAA JOURNAL, 41(5), 831–840.

By: Z. Zhang n & C. Kleinstreuer n

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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Species heat and mass transfer in a human upper airway model

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 46(25), 4755–4768.

By: Z. Zhang n & C. Kleinstreuer n

TL;DR: Steady 3-D airflow and scalar transport of ultrafine particles, d p Q in, ambient temperature variations influence the local velocity fields and vapor concentrations, but the total and segmental deposition fractions of fuel vapor in the upper airway are essentially unaffected. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 125(2), 197–206.

By: C. Kleinstreuer n & Z. Zhang n

MeSH headings : Administration, Inhalation; Adsorption; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Aerosols / therapeutic use; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiopathology; Bronchial Neoplasms / drug therapy; Bronchial Neoplasms / metabolism; Bronchial Neoplasms / physiopathology; Computer Simulation; Drug Delivery Systems / methods; Drug Therapy, Computer-Assisted / methods; Finite Element Analysis; Lung / drug effects; Lung / metabolism; Lung / physiopathology; Models, Biological; Particle Size; Pulsatile Flow; Rheology / methods; Sensitivity and Specificity
TL;DR: The concept of "controlled particle release and targeting" is introduced and results are discussed for a representative model of bronchial lung airways afflicted with hemispherical tumors of different sizes and locations, using a validated commercial finite-volume code with user-enhanced programs on a high-end engineering workstation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Aerosol transport and deposition in a triple bifurcation bronchial airway model with local tumors

INHALATION TOXICOLOGY, 14(11), 1111–1133.

By: Z. Zhang*, C. Kleinstreuer*, C. Kim * & A. Hickey *

MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Airway Obstruction / pathology; Airway Obstruction / physiopathology; Biological Availability; Bronchi / metabolism; Computer Simulation; Humans; Models, Anatomic; Models, Biological; Neoplasms / metabolism; Neoplasms / pathology; Particle Size; Pulmonary Ventilation
TL;DR: The results show that enhanced deposition occurs in the carina region at each bifurcation, and deposition increases with increasing Stokes and Reynolds number as expected from earlier studies, and there exists a maximum particle deposition fraction for a protruding tumor that occludes the lumen. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 journal article

Micro-particle transport and deposition in a human oral airway model

JOURNAL OF AEROSOL SCIENCE, 33(12), 1635–1652.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

author keywords: human oral airway; laminar-to-turbulent airflow; particle deposition; computational fluid-particle dynamics simulations
TL;DR: The present model may serve as the “entryway” for simulating and analyzing airflow and particle deposition in the lung, and exhibit the main features of laminar-transitional-turbulent particle suspension flows in actual human oral airways. (via Semantic Scholar)
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