Zachary Martin Slifer

College of Veterinary Medicine

Works (3)

Updated: July 5th, 2023 14:46

2021 journal article

Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions

PLOS ONE, 16(4).

By: Z. Slifer n, L. Hernandez  n, T. Pridgen n, A. Carlson n, K. Messenger n, J. Madan, B. Krishnan, S. Laumas, A. Blikslager n 

MeSH headings : Animals; Disease Models, Animal; Female; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Ischemia / drug therapy; Ischemia / metabolism; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Male; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability / drug effects; Swine; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR: It is concluded that LA stimulates repair of ischemic-injured epithelium at the level of the tight junctions, at an optimal dose of 1 μM LA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: June 10, 2021

2021 review

Larazotide acetate: a pharmacological peptide approach to tight junction regulation

[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 320(6), G983–G989.

By: Z. Slifer n, B. Krishnan, J. Madan & A. Blikslager n 

author keywords: barrier function; celiac disease; tight junction
MeSH headings : Animals; Celiac Disease / drug therapy; Celiac Disease / metabolism; Humans; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR: Small and large animal studies have been conducted that demonstrate the importance of LA as a tight junction regulatory peptide in conditions other than celiac disease, including collagen-induced arthritis in mice and intestinal ischemic injury in pigs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 7, 2021

2020 journal article

Updating the Clinical Picture of Facioscapulohumeral Muscular Dystrophy: Ramifications for Drug Development With Potential Solutions

THERAPEUTIC INNOVATION & REGULATORY SCIENCE, 54(1), 144–150.

By: R. Huml *, O. Uspenskaya-Cadoz*, J. Dawson * & Z. Slifer n

author keywords: facioscapulohumeral muscular dystrophy (FSHD); drug development; misconceptions; muscle weakness; respiratory; animal; model
MeSH headings : Animals; Clinical Trials as Topic; Drug Development; Humans; Muscle, Skeletal / pathology; Muscular Dystrophy, Facioscapulohumeral / drug therapy
TL;DR: Four major topics with potential clinical manifestations for patients with FSHD will be discussed related to muscle weakness, respiratory issues, animal models and prevalence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 20, 2020

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