Zachary Martin Slifer

College of Veterinary Medicine

Works (3)

Updated: July 5th, 2023 14:46

2021 journal article

Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions

PLOS ONE, 16(4).

By: Z. Slifer n, L. Hernandez n, T. Pridgen n, A. Carlson  n, K. Messenger n, J. Madan, B. Krishnan, S. Laumas, A. Blikslager n 

MeSH headings : Animals; Disease Models, Animal; Female; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Ischemia / drug therapy; Ischemia / metabolism; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Male; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability / drug effects; Swine; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR: It is concluded that LA stimulates repair of ischemic-injured epithelium at the level of the tight junctions, at an optimal dose of 1 μM LA. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 review

Larazotide acetate: a pharmacological peptide approach to tight junction regulation

[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 320(6), G983–G989.

By: Z. Slifer n, B. Krishnan, J. Madan & A. Blikslager n 

author keywords: barrier function; celiac disease; tight junction
MeSH headings : Animals; Celiac Disease / drug therapy; Celiac Disease / metabolism; Humans; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR: Small and large animal studies have been conducted that demonstrate the importance of LA as a tight junction regulatory peptide in conditions other than celiac disease, including collagen-induced arthritis in mice and intestinal ischemic injury in pigs. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2020 journal article

Updating the Clinical Picture of Facioscapulohumeral Muscular Dystrophy: Ramifications for Drug Development With Potential Solutions

THERAPEUTIC INNOVATION & REGULATORY SCIENCE, 54(1), 144–150.

By: R. Huml *, O. Uspenskaya-Cadoz*, J. Dawson * & Z. Slifer n

author keywords: facioscapulohumeral muscular dystrophy (FSHD); drug development; misconceptions; muscle weakness; respiratory; animal; model
MeSH headings : Animals; Clinical Trials as Topic; Drug Development; Humans; Muscle, Skeletal / pathology; Muscular Dystrophy, Facioscapulohumeral / drug therapy
TL;DR: Four major topics with potential clinical manifestations for patients with FSHD will be discussed related to muscle weakness, respiratory issues, animal models and prevalence. (via Semantic Scholar)
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Source: Web Of Science
Added: April 20, 2020

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