Daniel C. Whitehead

Works (2)

Updated: April 25th, 2025 15:04

2015 article

Gold Nanoparticles to Improve HIV Drug Delivery

Garrido, C., Simpson, C. A., Dahl, N. P., Bresee, J., Whitehead, D. C., Lindsey, E. A., … Margolis, D. M. (2015, July 1). Future Medicinal Chemistry.

By: C. Garrido *, C. Simpson*, N. Dahl*, J. Bresee*, D. Whitehead n, E. Lindsey n, T. Harris n, C. Smith * ...

MeSH headings : Animals; Anti-HIV Agents / administration & dosage; Anti-HIV Agents / chemical synthesis; Anti-HIV Agents / chemistry; Brain / metabolism; Drug Carriers / chemistry; Endothelial Cells / cytology; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Female; Gold / chemistry; HIV Core Protein p24 / antagonists & inhibitors; HIV Core Protein p24 / metabolism; HIV Infections / drug therapy; HIV-1 / physiology; Humans; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Mice; Mice, Inbred BALB C; Raltegravir Potassium / administration & dosage; Raltegravir Potassium / chemical synthesis; Raltegravir Potassium / chemistry; Tissue Distribution; Virus Replication / drug effects
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Gold and Silver Nanoparticles Synthesis and Applications; Nanoparticles: synthesis and applications
TL;DR: Gold nanoparticles prove to be a promising tool to use in HIV therapy by showing entry into different cell types, antiviral activity of an HIV integrase inhibitor conjugated in a gold nanoparticle and penetration into the brain in vivo without toxicity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 article

Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents

Rogers, S. A., Lindsey, E. A., Whitehead, D. C., Mullikin, T., & Melander, C. (2010, December 23). Bioorganic & Medicinal Chemistry Letters.

By: S. Rogers n, E. Lindsey n, D. Whitehead n, T. Mullikin n & C. Melander n

author keywords: Biofilms; Anti-biofilm; Antibiotic; 2-Aminoimidazole; Menthyl carbamate
MeSH headings : Animals; Anti-Infective Agents / chemical synthesis; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Biofilms / drug effects; Carbamates / chemistry; Erythrocytes / drug effects; Hemolysis; Imidazoles / chemistry; Microbial Sensitivity Tests; Sheep
topics (OpenAlex): Antimicrobial Peptides and Activities; Bacterial biofilms and quorum sensing; Antimicrobial agents and applications
TL;DR: The successful marriage of structural features from 2-aminoimidazole and menthyl carbamate classes of anti-biofilm agents has resulted in the development of a novel hybrid scaffold of biofilm modulators. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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