Works (3)

Updated: July 5th, 2023 15:43

2015 journal article

Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion

PLOS ONE, 10(9), e0138174.

By: M. Nighot n, P. Nighot n, T. Ma*, D. Malinowska*, G. Shull*, J. Cuppoletti*, A. Blikslager n

Contributors: M. Nighot n, P. Nighot n, T. Ma*, D. Malinowska*, G. Shull*, J. Cuppoletti*, A. Blikslager n

Ed(s): A. Guerrero-Hernandez

MeSH headings : Animals; Biological Transport; CLC-2 Chloride Channels; Cell Count; Chloride Channels / genetics; Cytoplasmic Vesicles / metabolism; Digestion / genetics; Digestion / physiology; Fluorescent Antibody Technique; Gastric Acid / metabolism; H(+)-K(+)-Exchanging ATPase / biosynthesis; H(+)-K(+)-Exchanging ATPase / metabolism; Mice; Mice, Knockout; Microscopy, Electron; Parietal Cells, Gastric / metabolism; Parietal Cells, Gastric / ultrastructure; Pepsinogen A / metabolism
TL;DR: Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase, reduced tubulovesicles and reduced stimulated acid secretion. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis

Inflammatory Bowel Diseases, 19(13), 2867–2877.

Contributors: P. Nighot n, K. Young n, M. Nighot n, M. Rawat*, E. Sung n, N. Maharshak*, S. Plevy*, T. Ma*, A. Blikslager n

author keywords: inflammatory bowel disease; barrier function; tight junction
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Caco-2 Cells; Chloride Channels / physiology; Colitis / chemically induced; Colitis / metabolism; Colitis / pathology; Cytokines / metabolism; Dextran Sulfate / toxicity; Disease Models, Animal; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa / injuries; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions / metabolism; Tight Junctions / pathology
TL;DR: ClC-2 plays a critical role in experimental colitis in that its absence increases disease activity, reduces barrier function and recovery, and perturbs TJs. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

journal article

Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa

Nighot, M., Moeser, A., Ueno, R., & Blikslager, A. World Journal of Gastroenterology, 18(34), 4684–4692.

By: M. Nighot, A. Moeser, R. Ueno & A. Blikslager

Source: NC State University Libraries
Added: August 6, 2018

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