Adam James Moeser

Works (44)

Updated: April 5th, 2024 02:47

2022 article

Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective

Mackey, E., & Moeser, A. J. (2022, July 11). Cold Spring Harbor Perspectives in Biology.

By: E. Mackey n & A. Moeser*

MeSH headings : Animals; Female; Humans; Longevity; Male; Mast Cells; Sex Characteristics
topics (OpenAlex): Mast cells and histamine; Asthma and respiratory diseases; Urticaria and Related Conditions
TL;DR: Sex differences in human mast cell-associated diseases and animal models are reviewed and the underlying biological mechanisms driving these sex differences are reviewed, which include adult gonadal sex hormones as well the emerging organizational role of perinatal gonadal hormones on mast cell activity and development. (via Semantic Scholar)
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Source: Web Of Science
Added: October 17, 2022

2020 article

Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood

Mackey, E., Thelen, K. M., Bali, V., Fardisi, M., Trowbridge, M., Jordan, C. L., & Moeser, A. J. (2020, September 11). Proceedings of the National Academy of Sciences.

By: E. Mackey n, K. Thelen *, V. Bali*, M. Fardisi *, M. Trowbridge *, C. Jordan*, A. Moeser*

author keywords: mast cell; sex differences; immune; inflammation; histamine
MeSH headings : Anaphylaxis; Androgens / pharmacology; Animals; Disease Models, Animal; Female; Inflammation; Male; Mast Cells / drug effects; Mast Cells / physiology; Mice; Mice, Transgenic; Sex Factors; Testis / cytology; Testis / drug effects
topics (OpenAlex): Mast cells and histamine; Food Allergy and Anaphylaxis Research; Dermatology and Skin Diseases
TL;DR: It is shown that perinatal, but not adult gonadal, androgens play a protective role in MC-mediated anaphylaxis severity into adulthood, and proposed thatPerinatal androgens mediate their protective effects via programming of bone marrow MC precursors to exhibit reduced granule histamine and release. (via Semantic Scholar)
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Source: Web Of Science
Added: October 26, 2020

2018 article

Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability

D'Costa, S., Ayyadurai, S., Gibson, A. J., Mackey, E., Rajput, M., Sommerville, L. J., … Moeser, A. J. (2018, November 12). Journal of Allergy and Clinical Immunology.

By: S. D'Costa *, S. Ayyadurai, A. Gibson, E. Mackey n, M. Rajput, L. Sommerville *, N. Wilson, Y. Li* ...

author keywords: Mast cell; corticotropin-releasing factor receptor; stress; anaphylaxis; allergy; intestinal permeability
MeSH headings : Anaphylaxis / immunology; Animals; Cell Degranulation; Cell Line; Disease Models, Animal; Female; Histamine Release / genetics; Humans; Immunoglobulin E / metabolism; Intestinal Mucosa / metabolism; Mast Cells / physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; Receptors, Corticotropin-Releasing Hormone / genetics; Receptors, Corticotropin-Releasing Hormone / metabolism; Stress, Psychological / immunology; Tight Junctions / metabolism
topics (OpenAlex): Dermatology and Skin Diseases; Asthma and respiratory diseases; Food Allergy and Anaphylaxis Research
TL;DR: MC CRF2 is a negative global modulator of stimuli‐induced MC degranulation and limits the severity of IgE‐mediated anaphylaxis and stress‐related disease pathogenesis. (via Semantic Scholar)
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Source: Web Of Science
Added: April 20, 2020

2015 article

MARCKS‐dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging

Muthusamy, N., Sommerville, L. J., Moeser, A. J., Stumpo, D. J., Sannes, P., Adler, K., … Ghashghaei, H. T. (2015, May 25). Aging Cell.

By: N. Muthusamy n, L. Sommerville n, A. Moeser n, D. Stumpo *, P. Sannes n, K. Adler n, P. Blackshear *, J. Weimer *, H. Ghashghaei n

author keywords: aging; barrier function; Clca3; cerebral cortex; ependymal cells; lipid droplets; mucin; oxidative stress
MeSH headings : Aging / metabolism; Animals; Ependyma / cytology; Ependyma / metabolism; Homeostasis; Intracellular Signaling Peptides and Proteins / deficiency; Intracellular Signaling Peptides and Proteins / metabolism; Lipid Metabolism; Membrane Proteins / deficiency; Membrane Proteins / metabolism; Mice; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oxidative Stress; Prosencephalon / metabolism
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Barrier Structure and Function Studies; Alzheimer's disease research and treatments
TL;DR: It is demonstrated that metabolic and barrier functions in ECs decline significantly during aging in mice, and this work constitutes a conceptually new paradigm in the potential role of ECs in the initiation of various conditions and diseases in the aging brain. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 article

Impact of dietary organic acids and botanicals on intestinal integrity and inflammation in weaned pigs

Grilli, E., Tugnoli, B., Passey, J. L., Stahl, C. H., Piva, A., & Moeser, A. J. (2015, April 15). BMC Veterinary Research.

By: E. Grilli *, B. Tugnoli *, J. Passey  n, C. Stahl  n, A. Piva * & A. Moeser n

author keywords: Organic acids; Pure botanicals; Weaning piglet; Inflammatory cytokines; Intestinal barrier
MeSH headings : Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Benzaldehydes / administration & dosage; Benzaldehydes / pharmacology; Caco-2 Cells; Citric Acid / administration & dosage; Citric Acid / pharmacology; Cytokines / genetics; Cytokines / metabolism; Diet / veterinary; Gene Expression Regulation / drug effects; Humans; Inflammation / prevention & control; Inflammation / veterinary; Intestines / drug effects; Sorbic Acid / administration & dosage; Sorbic Acid / pharmacology; Swine; Thymol / administration & dosage; Thymol / pharmacology
topics (OpenAlex): Animal Nutrition and Physiology; Meat and Animal Product Quality; Essential Oils and Antimicrobial Activity
TL;DR: Overall, considering the results from both experiments, OA + PB improved the maturation of the intestinal mucosa by modulating the local and systemic inflammatory pressure ultimately resulting in a less permeable intestine, and eventually improving the growth of piglets prematurely weaned. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research

American Journal of Physiology-Gastrointestinal and Liver Physiology, 308(2), G63–G75.

By: L. Gonzalez n , A. Moeser n & A. Blikslager n 

Contributors: L. Gonzalez n , A. Moeser n & A. Blikslager n 

author keywords: animal model; intestine; ischemia; mucosal injury; reperfusion
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / injuries; Intestines / pathology; Ischemia / complications; Ischemia / pathology; Oxygen / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Reperfusion Injury / pathology; Translational Research, Biomedical / methods
topics (OpenAlex): Cardiac Ischemia and Reperfusion; Organ Transplantation Techniques and Outcomes; Anesthesia and Neurotoxicity Research
TL;DR: This review assesses animal models of ischemia-reperfusion injury as well as the knowledge that has been derived from each to aid selection of appropriate research models. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets

World Journal of Gastroenterology, 19(31), 5094–5102.

By: S. Jacobi n, A. Moeser, A. Blikslager , J. Rhoads, B. Corl, R. Harrell, J. Odle 

Contributors: S. Jacobi n, A. Moeser, A. Blikslager , J. Rhoads, B. Corl, R. Harrell, J. Odle 

author keywords: Rotavirus gastroenteritis; Kwashiorkor; Occludin; Ussing chamber; Villus
MeSH headings : Animals; Animals, Newborn; Diarrhea / metabolism; Diarrhea / virology; Disease Models, Animal; Electric Impedance; Humans; Infant Formula / metabolism; Infant, Newborn; Intestinal Absorption; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / virology; Mannitol / metabolism; Occludin / metabolism; Permeability; Protein-Energy Malnutrition / metabolism; Protein-Energy Malnutrition / pathology; Protein-Energy Malnutrition / virology; Rotavirus Infections / metabolism; Rotavirus Infections / pathology; Rotavirus Infections / virology; Swine; Tight Junctions / metabolism; Tight Junctions / virology; Time Factors; Weight Loss
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Trace Elements in Health; Iron Metabolism and Disorders
TL;DR: Overall, malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 article

Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10−/− Mice

Lennon, E. M., Maharshak, N., Elloumi, H., Borst, L., Plevy, S. E., & Moeser, A. J. (2013, February 27). Inflammatory Bowel Diseases, Vol. 19, pp. 712–719.

By: E. Lennon n, N. Maharshak *, H. Elloumi*, L. Borst n , S. Plevy* & A. Moeser n

author keywords: psychological stress; neonatal maternal separation; inflammatory bowel disease; colitis; animal models of IBD; barrier function
MeSH headings : Animals; Animals, Newborn; Cell Membrane Permeability; Cells, Cultured; Colitis / etiology; Colitis / pathology; Colon / metabolism; Colon / pathology; Cytokines / metabolism; Female; Interleukin-10 / physiology; Mast Cells / metabolism; Mast Cells / pathology; Maternal Deprivation; Mice; Mice, Inbred C57BL; Mice, Knockout; Stress, Psychological / complications
topics (OpenAlex): Microscopic Colitis; Gastrointestinal motility and disorders; Gut microbiota and health
TL;DR: It is demonstrated that colitis in IL-10−/− mice can be exacerbated by NMS stress, and the precise mechanisms of enhanced colitis severity in NMS IL10− /− mice are unclear but persistent defects in intestinal barrier function likely play a contributing role. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli Challenge and Exacerbates Intestinal Injury and Clinical Disease

McLamb, B. L., Gibson, A. J., Overman, E. L., Stahl, C., & Moeser, A. J. (2013, April 24). PLoS ONE.

By: B. McLamb n, A. Gibson n, E. Overman n, C. Stahl  n & A. Moeser n

MeSH headings : Animals; Animals, Newborn; Cytokines / immunology; Cytokines / metabolism; Dextrans / metabolism; Enterotoxigenic Escherichia coli / immunology; Enterotoxigenic Escherichia coli / pathogenicity; Escherichia coli Infections / veterinary; Ileum / immunology; Ileum / metabolism; Ileum / microbiology; Ileum / pathology; Immunity, Innate; Immunity, Mucosal; Inflammation Mediators / immunology; Inflammation Mediators / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Mast Cells / immunology; Mast Cells / pathology; Neutrophils / immunology; Neutrophils / pathology; Permeability; Stress, Physiological / immunology; Swine; Swine Diseases / immunology; Weaning
topics (OpenAlex): Gut microbiota and health; Viral gastroenteritis research and epidemiology; Stress Responses and Cortisol
TL;DR: The early weaning stress can profoundly alter subsequent immune and physiology responses and clinical outcomes to subsequent infectious pathogen challenge, as demonstrated in pigs weaned from their dam. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets

Cabrera, R. A., Usry, J. L., Arrellano, C., Nogueira, E. T., Kutschenko, M., Moeser, A. J., & Odle, J. (2013, August 3). Journal of Animal Science and Biotechnology/Journal of Animal Science and Biotechnology, Vol. 4.

By: R. Cabrera n, J. Usry*, C. Arrellano n, E. Nogueira, M. Kutschenko, A. Moeser n, J. Odle n 

Contributors: R. Cabrera n, J. Usry*, C. Arrellano n, E. Nogueira, M. Kutschenko, A. Moeser n, J. Odle n 

author keywords: Creep feeding; Glutamine; Growth performance; Intestinal health; SEM; Villi
topics (OpenAlex): Animal Nutrition and Physiology; Rabbits: Nutrition, Reproduction, Health; Animal Behavior and Welfare Studies
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 article

Effects of quaternary benzo(c)phenanthridine alkaloids on growth performance, shedding of organisms, and gastrointestinal tract integrity in pigs inoculated with multidrug-resistant Salmonella spp

Robbins, R. C., Artuso-Ponte, V. C., Moeser, A. J., Morrow, W. E. M., Spears, J. W., & Gebreyes, W. A. (2013, November 25). American Journal of Veterinary Research.

By: R. Robbins*, V. Artuso-Ponte*, A. Moeser n, W. Morrow n, J. Spears n & W. Gebreyes *

MeSH headings : Animals; Bacterial Shedding / drug effects; Benzophenanthridines / pharmacology; Chlortetracycline / pharmacology; Drug Resistance, Multiple; Feces / microbiology; Gastrointestinal Tract / drug effects; Growth and Development / drug effects; Microbial Sensitivity Tests; Salmonella Infections, Animal / drug therapy; Swine; Swine Diseases / drug therapy; Swine Diseases / microbiology
topics (OpenAlex): Antibiotic Resistance in Bacteria; Berberine and alkaloids research; Plant Pathogenic Bacteria Studies
TL;DR: QBAs and chlortetracycline decreased Salmonella spp shedding but did not differ with regard to growth performance and Gastrointestinal tract integrity was better, albeit not significantly, in pigs fed diets containing QBAs. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2013 article

Infection with feline immunodeficiency virus alters intestinal epithelial transport and mucosal immune responses to probiotics

Stoeker, L. L., Overman, E. L., Nordone, S. K., Moeser, A. J., Simões, R. D., & Dean, G. A. (2013, February 8). Veterinary Immunology and Immunopathology.

By: L. Stoeker n, E. Overman n, S. Nordone n, A. Moeser n, R. Simões n & G. Dean *

author keywords: HIV; FIV; Lactobacillus; Mucosal immune system
MeSH headings : Animals; Biological Transport; Cats; Electric Impedance; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / metabolism; Immunity, Mucosal / drug effects; Intestinal Mucosa / metabolism; Probiotics / pharmacology
topics (OpenAlex): HIV Research and Treatment; Gut microbiota and health; HIV/AIDS oral health manifestations
TL;DR: A novel role for FIV in upregulating transcellular transport across the gastrointestinal epithelial barrier is suggested and the potential therapeutic use of probiotic bacteria to restore intestinal homeostasis is demonstrated. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNF-α

Overman, E. L., Rivier, J. E., & Moeser, A. J. (2012, June 29). PLoS ONE.

By: E. Overman n, J. Rivier* & A. Moeser n

MeSH headings : Animals; Cell Degranulation / drug effects; Corticotropin-Releasing Hormone / pharmacology; Dextrans; Enteric Nervous System / drug effects; Enteric Nervous System / pathology; Fluorescein-5-isothiocyanate / analogs & derivatives; Ileum / drug effects; Ileum / pathology; Ileum / physiopathology; In Vitro Techniques; Intestinal Mucosa / drug effects; Intestinal Mucosa / injuries; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Mast Cells / drug effects; Mast Cells / enzymology; Mast Cells / physiology; Molecular Weight; Neutralization Tests; Occludin / metabolism; Peptide Fragments / pharmacology; Peptide Hydrolases / metabolism; Permeability / drug effects; Protease Inhibitors / pharmacology; Protein Transport / drug effects; Rats; Sus scrofa; Tumor Necrosis Factor-alpha / antagonists & inhibitors; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Gastrointestinal motility and disorders; Dermatology and Skin Diseases; Acupuncture Treatment Research Studies
TL;DR: Investigating the mechanisms by which CRF mediates intestinal epithelial barrier disturbances demonstrated that CRF triggers increases in intestinal paracellular permeability via mast cell dependent release of TNF-α and proteases, hallmarks of IBS and IBD. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Carbon Monoxide and Heme Oxygenase-1 Prevent Intestinal Inflammation in Mice by Promoting Bacterial Clearance

Onyiah, J. C., Sheikh, S. Z., Maharshak, N., Steinbach, E. C., Russo, S. M., Kobayashi, T., … Plevy, S. E. (2012, December 22). Gastroenterology, Vol. 144, pp. 789–798.

By: J. Onyiah*, S. Sheikh *, N. Maharshak *, E. Steinbach *, S. Russo*, T. Kobayashi *, L. Mackey *, J. Hansen* ...

author keywords: Mouse Model; IBD; Ulcerative Colitis; Anti-Inflammatory Agent
MeSH headings : Animals; Bacterial Translocation / drug effects; Bacterial Translocation / physiology; Blotting, Western; Carbon Monoxide / pharmacology; Colitis / drug therapy; Colitis / microbiology; Colitis / prevention & control; Disease Models, Animal; Escherichia coli / pathogenicity; Gentamicins / pharmacology; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / metabolism; Macrophages / cytology; Macrophages / physiology; Metagenome; Mice; Mice, Inbred C57BL; Random Allocation; Real-Time Polymerase Chain Reaction; Salmonella typhimurium / physiology
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Neonatal Health and Biochemistry; Optimism, Hope, and Well-being
TL;DR: Colonic HO-1 prevents colonic inflammation in mice and its homeostatic function is mediated, in part, by promoting bactericidal activities of macrophages. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Defects in small intestinal epithelial barrier function and morphology associated with peri-weaning failure to thrive syndrome (PFTS) in swine

Moeser, A. J., Borst, L. B., Overman, B. L., & Pittman, J. S. (2012, January 31). Research in Veterinary Science, Vol. 93, pp. 975–982.

By: A. Moeser n, L. Borst n , B. Overman n & J. Pittman*

author keywords: Pigs; Weaning; Intestine; Barrier function; Failure-to-thrive
MeSH headings : Animals; Dextrans; Failure to Thrive / pathology; Failure to Thrive / veterinary; Female; Fluorescein-5-isothiocyanate / analogs & derivatives; Intestinal Mucosa / pathology; Intestine, Small / pathology; Swine; Swine Diseases / pathology; Weaning
topics (OpenAlex): Animal Nutrition and Physiology; Meat and Animal Product Quality; Gastrointestinal motility and disorders
TL;DR: It is demonstrated that PFTS is associated with profound disturbances in intestinal epithelial barrier function and alterations in mucosal and epithelial morphology in which anorexia is not the sole factor. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Dietary Long-Chain PUFA Enhance Acute Repair of Ischemia-Injured Intestine of Suckling Pigs

The Journal of Nutrition, 142(7), 1266–1271.

By: S. Jacobi n, A. Moeser n, B. Corl n, R. Harrell n, A. Blikslager n  & J. Odle n 

Contributors: S. Jacobi n, A. Moeser n, B. Corl n, R. Harrell n, A. Blikslager n  & J. Odle n 

MeSH headings : Animals; Constriction; Diet; Dietary Fats / pharmacology; Dietary Supplements; Eicosapentaenoic Acid / pharmacology; Electric Impedance; Ileal Diseases / drug therapy; Ileal Diseases / pathology; Ileal Diseases / physiopathology; Ileum / drug effects; Ileum / pathology; Ileum / physiopathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / blood; Ischemia / drug therapy; Ischemia / pathology; Ischemia / physiopathology; Mannitol / blood; Mesentery / blood supply; Swine; Wound Healing / drug effects
topics (OpenAlex): Clinical Nutrition and Gastroenterology; Infant Nutrition and Health; Fatty Acid Research and Health
TL;DR: It is demonstrated that feeding elevated levels of long-chain PUFA enhances acute recovery of ischemia-injured porcine ileum, and a histological evaluation of ischemic ilea from piglets fed the 5% ARA showed reduced histological lesions after ischemIA compared with the other dietary groups. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

Spray-Dried Porcine Plasma Influences Intestinal Barrier Function, Inflammation,and Diarrhea in Weaned Pigs

Peace, R. M., Campbell, J., Polo, J., Crenshaw, J., Russell, L., & Moeser, A. (2011, May 26). Journal of Nutrition.

By: R. Peace*, J. Campbell, J. Polo, J. Crenshaw, L. Russell & A. Moeser n

MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Cytokines / metabolism; Diarrhea / prevention & control; Diarrhea / veterinary; Dietary Supplements; Gastroenteritis / prevention & control; Gastroenteritis / veterinary; Intestinal Mucosa / metabolism; Intestines / physiology; Models, Animal; Plasma / physiology; Sus scrofa / blood; Sus scrofa / physiology; Swine; Swine Diseases / prevention & control; Weaning
topics (OpenAlex): Barrier Structure and Function Studies; Nutritional Studies and Diet; Gut microbiota and health
TL;DR: It is demonstrated that dietary inclusion of SDPP had beneficial effects on intestinal barrier function, inflammation, and diarrhea in weaned pigs. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 article

The Fecal Virome of Pigs on a High-Density Farm

Shan, T., Li, L., Simmonds, P., Wang, C., Moeser, A., & Delwart, E. (2011, September 8). Journal of Virology.

By: T. Shan *, L. Li *, P. Simmonds *, C. Wang, A. Moeser n & E. Delwart *

MeSH headings : Animals; Animals, Domestic / virology; Biodiversity; Diarrhea / veterinary; Diarrhea / virology; Feces / virology; Humans; Metagenome; Molecular Sequence Data; Sequence Analysis, DNA; Swine / virology; Swine Diseases / virology; Viruses / classification; Viruses / genetics; Viruses / isolation & purification
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Animal Virus Infections Studies; Virus-based gene therapy research
TL;DR: An unbiased survey of viruses in the feces of intensely farmed animals revealed frequent coinfections with a highly diverse set of viruses providing favorable conditions for viral recombination. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 journal article

Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression

Virology, 401(2), 146–154.

By: P. Nighot n, A. Moeser n, R. Ali n, A. Blikslager n  & M. Koci n 

Contributors: P. Nighot n, A. Moeser n, R. Ali n, A. Blikslager n  & M. Koci n 

author keywords: Astrovirus; Viral enteritis; Malabsorption diarrhea; Sodium/hydrogen exchanger; Intestinal electrophysiology; Turkey
MeSH headings : Actins / metabolism; Animals; Astroviridae Infections / pathology; Astroviridae Infections / veterinary; Avastrovirus / pathogenicity; Cell Membrane / chemistry; Cytoplasm / chemistry; Gene Expression; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Poultry Diseases / pathology; Poultry Diseases / virology; Sodium / metabolism; Sodium-Hydrogen Exchangers / analysis; Turkeys
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Animal Virus Infections Studies; Virus-based gene therapy research
TL;DR: Data suggest astrovirus infection induces sodium malabsorption, possibly through redistribution of specific sodium transporters, which results in the development of an osmotic diarrhoea in infants and the immunocompromised. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2010 article

High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves

Hansen, S. L., Ashwell, M. S., Moeser, A. J., Fry, R. S., Knutson, M. D., & Spears, J. W. (2010, February 1). Journal of Dairy Science, Vol. 93, pp. 656–665.

By: S. Hansen n, M. Ashwell n , A. Moeser n, R. Fry n, M. Knutson * & J. Spears n

author keywords: cattle; iron; manganese; metal transporter
MeSH headings : Animals; Body Weight / physiology; Cattle / metabolism; Cattle / physiology; Diet / veterinary; Duodenum / chemistry; Duodenum / drug effects; Gene Expression Regulation / drug effects; Heart / drug effects; Iron / analysis; Iron / blood; Iron / metabolism; Iron, Dietary / metabolism; Iron, Dietary / pharmacology; Liver / drug effects; Liver / metabolism; Male; Manganese / analysis; Manganese / blood; Manganese / metabolism; Membrane Transport Proteins / metabolism; Myocardium / chemistry; Oxidative Stress / drug effects
topics (OpenAlex): Iron Metabolism and Disorders; Plant Micronutrient Interactions and Effects; Trace Elements in Health
TL;DR: Feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Early weaning stress impairs development of mucosal barrier function in the porcine intestine

American Journal of Physiology-Gastrointestinal and Liver Physiology, 298(3), G352–G363.

By: F. Smith n, J. Clark n, B. Overman n, C. Tozel n, J. Huang  n, J. Rivier*, A. Blisklager n , A. Moeser n

author keywords: weaning age; mast cells; corticotropin releasing factor
MeSH headings : Animals; Animals, Newborn; Barium Compounds / pharmacology; Cell Count; Chlorides / pharmacology; Corticotropin-Releasing Hormone / blood; Corticotropin-Releasing Hormone / metabolism; Corticotropin-Releasing Hormone / pharmacology; Cromolyn Sodium / pharmacology; Electric Impedance; Electrophysiological Phenomena / drug effects; Electrophysiological Phenomena / physiology; Female; Hydrocortisone / blood; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / metabolism; Ion Transport / physiology; Jejunum / drug effects; Jejunum / metabolism; Jejunum / pathology; Jejunum / physiopathology; Male; Mannitol / metabolism; Mast Cells / drug effects; Mast Cells / metabolism; Mast Cells / pathology; Permeability; Potassium / metabolism; Potassium Channel Blockers / pharmacology; Protease Inhibitors / pharmacology; Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors; Receptors, Corticotropin-Releasing Hormone / metabolism; Receptors, Glucocorticoid / metabolism; Stress, Physiological / physiology; Sus scrofa; Tryptases / metabolism; Weaning
topics (OpenAlex): Dermatology and Skin Diseases; Gastrointestinal motility and disorders; Stress Responses and Cortisol
TL;DR: It is shown that stress associated with early weaning in pigs leads to impaired mucosal barrier function, and activation of mast cells ex vivo with c48/80 and corticotrophin-releasing factor induced barrier dysfunction and elevations in short-circuit current that were inhibited with mast cell protease inhibitors. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2009 article

Iron Transporters Are Differentially Regulated by Dietary Iron, and Modifications Are Associated with Changes in Manganese Metabolism in Young Pigs

Hansen, S. L., Trakooljul, N., Liu, H.-C., Moeser, A. J., & Spears, J. W. (2009, June 18). Journal of Nutrition.

By: S. Hansen n, N. Trakooljul n, H. Liu n, A. Moeser n & J. Spears n

MeSH headings : Animals; Antimicrobial Cationic Peptides / metabolism; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Copper / metabolism; Dietary Supplements; Duodenum / metabolism; Gene Expression; Hemoglobins / metabolism; Hepcidins; Ion Transport / drug effects; Iron / metabolism; Iron, Dietary / pharmacology; Liver / metabolism; Male; Manganese / metabolism; Swine; Trace Elements / pharmacology; Weight Gain / drug effects
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Plant Micronutrient Interactions and Effects
TL;DR: Fe deficiency in pigs increased gene expression of duodenal metal transporters and supplementation with H-Fe reduced expression of DMT1 and ZIP14, which may have decreased absorption of Mn. (via Semantic Scholar)
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Added: August 6, 2018

2008 journal article

Arginine Activates Intestinal p70S6k and Protein Synthesis in Piglet Rotavirus Enteritis

The Journal of Nutrition, 138(1), 24–29.

By: B. Corl n, J. Odle n , X. Niu*, A. Moeser*, L. Gatlin n, O. Phillips n, A. Blikslager* , J. Rhoads*

MeSH headings : Animals; Arginine / pharmacology; Dietary Supplements; Enteritis / blood; Enteritis / metabolism; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / virology; Jejunum / pathology; Protein Biosynthesis / drug effects; Ribosomal Protein S6 Kinases, 70-kDa / metabolism; Rotavirus Infections / enzymology; Rotavirus Infections / metabolism; Sirolimus / pharmacology; Swine / metabolism; Swine / virology
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Animal Virus Infections Studies; Virus-based gene therapy research
TL;DR: It is concluded that, early in rotavirus enteritis, Arg has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation, while improving intestinal permeability via a mammalian target of rapamycin/p70( S6k)-independent mechanism. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum

Experimental Cell Research, 315(1), 110–118.

By: P. Nighot n, A. Moeser n, K. Ryan n, T. Ghashghaei n & A. Blikslager n 

Contributors: P. Nighot n, A. Moeser n, K. Ryan n, T. Ghashghaei n & A. Blikslager n 

author keywords: Tight junction; Intestinal permeability; Ischemia; ClC-2
MeSH headings : Animals; CLC-2 Chloride Channels; Cell Membrane / metabolism; Chloride Channels / deficiency; Chloride Channels / metabolism; Epithelium / metabolism; Epithelium / pathology; Epithelium / ultrastructure; Fluorescent Antibody Technique; Immunoprecipitation; Ischemia / metabolism; Ischemia / physiopathology; Jejunum / blood supply; Jejunum / pathology; Jejunum / ultrastructure; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Protein Transport; Tight Junctions / metabolism; Tight Junctions / ultrastructure; Wound Healing
topics (OpenAlex): Barrier Structure and Function Studies; Connexins and lens biology; Neurological Disease Mechanisms and Treatments
TL;DR: A pivotal role is demonstrated in recovery of the intestinal epithelium barrier by anchoring assembly of tight junctions following ischemic injury in ClC-2(-/-) mice. (via Semantic Scholar)
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Added: August 6, 2018

2008 journal article

Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine

World Journal of Gastroenterology, 14(39), 6012.

By: A. Moeser n, P. Nighot*, B. Roerig, R. Ueno & A. Blikslager n 

Contributors: A. Moeser n, P. Nighot*, B. Roerig, R. Ueno & A. Blikslager n 

author keywords: Intestinal ischemia; Barrier function; Permeability; Laxative; Polyethylene Glycol
MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Animals; Cell Membrane Permeability / drug effects; Cell Membrane Permeability / physiology; Chloride Channel Agonists; Disease Models, Animal; Epithelial Cells / drug effects; Epithelial Cells / physiology; Female; Ileum / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / metabolism; Laxatives / pharmacology; Lubiprostone; Male; Mannitol / metabolism; Polyethylene Glycols / pharmacology; Recovery of Function / drug effects; Reperfusion Injury / pathology; Reperfusion Injury / physiopathology; Swine
topics (OpenAlex): Gastrointestinal motility and disorders; Gastroesophageal reflux and treatments; Barrier Structure and Function Studies
TL;DR: Results suggest that, unlike osmotic laxatives, lubiprostone stimulates repair of the injured intestinal barrier, whereas the PEG laxative had deleterious effects on mucosal repair. (via Semantic Scholar)
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Added: August 6, 2018

2008 journal article

Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function

American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4), G791–G797.

By: A. Moeser*, P. Nighot n, K. Ryan n, J. Simpson*, L. Clarke * & A. Blikslager n 

Contributors: A. Moeser*, P. Nighot n, K. Ryan n, J. Simpson*, L. Clarke * & A. Blikslager n 

author keywords: tight junction; intestinal permeability; ischemia; Na(+)/H(+) exchange
MeSH headings : Animals; Claudin-1; Intestinal Mucosa / physiopathology; Intestine, Small / blood supply; Ischemia / physiopathology; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Permeability; Phosphorylation; Sodium-Hydrogen Exchangers / genetics; Sodium-Hydrogen Exchangers / physiology; Tight Junctions / metabolism; Tight Junctions / ultrastructure
topics (OpenAlex): Barrier Structure and Function Studies; Ion Transport and Channel Regulation; Gastrointestinal motility and disorders
TL;DR: Recovery of barrier function was assessed in wild-type (NHE2(+/+)) and NHE2(-/-) mice in vivo and in vitro and pharmacological inhibition of N HE2 in postischemic tissues from wild- type mice also resulted in significant reductions in TER. (via Semantic Scholar)
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Added: August 6, 2018

2007 journal article

Determination of minimum alveolar concentration of sevoflurane in juvenile swine

Research in Veterinary Science, 84(2), 283–285.

By: A. Moeser n, A. Blikslager n  & C. Swanson n

Contributors: A. Moeser n, A. Blikslager n  & C. Swanson n

MeSH headings : Anesthesia, Inhalation / veterinary; Anesthetics, Inhalation / pharmacokinetics; Animals; Methyl Ethers / pharmacokinetics; Pulmonary Alveoli; Sevoflurane; Swine / metabolism
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Sedative Agents; Cardiac Ischemia and Reperfusion
TL;DR: The sevoflurane MAC value was determined to be 3.5+/-0.1% which is notably higher than values reported in the literature for pigs, which may represent changes in anesthetic requirements between different age groups of pigs and differences in the type of stimulus used to determine MAC. (via Semantic Scholar)
Sources: NC State University Libraries, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum

American Journal of Veterinary Research, 68(6), 614–624.

By: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & A. Blikslager* 

Contributors: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & A. Blikslager* 

MeSH headings : Animals; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Horse Diseases / drug therapy; Horses; Intestinal Diseases / drug therapy; Intestinal Diseases / veterinary; Ischemia / veterinary; Jejunum / injuries; Meloxicam; Thiazines / pharmacokinetics; Thiazines / therapeutic use; Thiazoles / pharmacokinetics; Thiazoles / therapeutic use
topics (OpenAlex): Veterinary Equine Medical Research; Inflammatory mediators and NSAID effects; Veterinary Pharmacology and Anesthesia
TL;DR: It is suggested that IV administration of meloxicam may be a useful alternative to flunixin meglumine for postoperative treatment of horses with colic. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs

American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(2), G413–G421.

By: A. Moeser n, K. Ryan n, P. Nighot* & A. Blikslager n 

Contributors: A. Moeser n, K. Ryan n, P. Nighot* & A. Blikslager n 

author keywords: stress; barrier function; corticotropin releasing factor; tryptase
MeSH headings : Aging / metabolism; Animals; Cell Degranulation / drug effects; Colon, Ascending / drug effects; Colon, Ascending / metabolism; Corticotropin-Releasing Hormone / blood; Cromolyn Sodium / pharmacology; Cromolyn Sodium / therapeutic use; Electric Impedance; Gastrointestinal Agents / pharmacology; Gastrointestinal Agents / therapeutic use; Gastrointestinal Diseases / enzymology; Gastrointestinal Diseases / metabolism; Gastrointestinal Diseases / prevention & control; Gastrointestinal Diseases / psychology; Hydrocortisone / blood; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Secretions / metabolism; Jejunum / drug effects; Jejunum / metabolism; Mannitol / metabolism; Mast Cells / drug effects; Mast Cells / enzymology; Mast Cells / metabolism; Permeability; Receptors, Corticotropin-Releasing Hormone / metabolism; Stress, Psychological / complications; Stress, Psychological / enzymology; Stress, Psychological / metabolism; Swine; Time Factors; Tryptases / metabolism; Up-Regulation; Weaning
topics (OpenAlex): Gastrointestinal motility and disorders; Dermatology and Skin Diseases; Regulation of Appetite and Obesity
TL;DR: The results indicate that early-weaning stress induces mucosal dysfunction mediated by intestinal mast cell activation and can be prevented by delaying weaning. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Mechanisms of porcine diarrheal disease

Journal of the American Veterinary Medical Association, 231(1), 56–67.

By: A. Moeser n & A. Blikslager n 

Contributors: A. Moeser n & A. Blikslager n 

MeSH headings : Animals; Diarrhea / microbiology; Diarrhea / physiopathology; Diarrhea / veterinary; Intestinal Absorption / physiology; Intestinal Mucosa / metabolism; Species Specificity; Swine; Swine Diseases / microbiology; Swine Diseases / physiopathology
topics (OpenAlex): Veterinary medicine and infectious diseases; Clostridium difficile and Clostridium perfringens research; Viral gastroenteritis research and epidemiology
TL;DR: The objective of this report was to review the current understanding of the basic mechanisms of diarrheal diseases in swine, with particular emphasis on the ability of specific enteric pathogens to alter intestinal ion transport and fluid movement across intestinal epithelium. (via Semantic Scholar)
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Added: August 6, 2018

2007 article

Nutritional value for swine of extruded corn and corn fractions obtained after dry milling1,2

Muley, N. S., Heugten, E., Moeser, A. J., Rausch, K. D., & Kempen, T. A. T. G. (2007, June 16). Journal of Animal Science, Vol. 85, pp. 1695–1701.

By: N. Muley n, E. Heugten n , A. Moeser n, K. Rausch  n & T. Kempen n 

author keywords: amino acid; corn; dry matter; ileal digestibility; phosphorus; swine
MeSH headings : Amino Acids / analysis; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Dietary Proteins / analysis; Digestion; Food Handling / methods; Male; Nutritional Requirements; Nutritive Value; Particle Size; Swine / growth & development; Swine / metabolism; Zea mays / chemistry
topics (OpenAlex): Food composition and properties; Animal Nutrition and Physiology; Phytase and its Applications
TL;DR: In conclusion, germ and hulls have a low ileal DM digestibility; germ also has low AA and P digestibility. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Restoration of Barrier Function in Injured Intestinal Mucosa

Physiological Reviews, 87(2), 545–564.

By: A. Blikslager n , A. Moeser n, J. Gookin n , S. Jones n  & J. Odle n 

Contributors: A. Blikslager n , A. Moeser n, J. Gookin n , S. Jones n  & J. Odle n 

MeSH headings : Animals; Epithelial Cells / physiology; Humans; Inflammation / pathology; Intestinal Diseases / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Mucous Membrane / cytology; Mucous Membrane / physiology
topics (OpenAlex): Barrier Structure and Function Studies; Wound Healing and Treatments; S100 Proteins and Annexins
TL;DR: Ex vivo studies of mammalian small intestine have revealed the importance of closure of the interepithelial tight junctions and the paracellular space, which underscores the critical role of tight junction closure in measures of barrier function such as transepithelial electrical resistance. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2006 journal article

Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis

American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(3), G913–G922.

By: J. Rhoads *, B. Corl  n, R. Harrell n, X. Niu*, L. Gatlin n, O. Phillips n, A. Blikslager n , A. Moeser n ...

Contributors: J. Rhoads *, B. Corl  n, R. Harrell n, X. Niu*, L. Gatlin n, O. Phillips n, A. Blikslager n , A. Moeser n, G. Wu *, J. Odle n 

author keywords: mammalian target of rapamycin; diarrhea; virus; malnutrition
MeSH headings : Amino Acids / blood; Animals; Animals, Newborn; Antigens, Viral / analysis; Body Weight; Diarrhea / metabolism; Diarrhea / pathology; Energy Intake; Enteritis / blood; Enteritis / metabolism; Enteritis / virology; Enterocytes / chemistry; Enterocytes / metabolism; Feces / chemistry; Intestinal Mucosa / chemistry; Intestinal Mucosa / metabolism; Jejunum / chemistry; Jejunum / metabolism; Lactase / metabolism; Malnutrition / metabolism; Malnutrition / physiopathology; Muscle, Skeletal / metabolism; Muscle, Smooth / metabolism; Phosphorylation; Protein Kinases / physiology; Ribosomal Protein S6 Kinases, 70-kDa / analysis; Ribosomal Protein S6 Kinases, 70-kDa / metabolism; Rotavirus Infections / blood; Rotavirus Infections / metabolism; Signal Transduction / physiology; Sus scrofa; TOR Serine-Threonine Kinases
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Animal Virus Infections Studies; Virus-based gene therapy research
TL;DR: In conclusion, intestinal activation of p70(S6K) was not inhibited by malnutrition but was strongly activated during an active state of mucosal regeneration, mainly in the crypt. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine

American Journal of Physiology-Gastrointestinal and Liver Physiology, 291(5), G885–G894.

By: A. Moeser n, P. Nighot*, K. Ryan*, J. Wooten* & A. Blikslager* 

Contributors: A. Moeser n, P. Nighot*, K. Ryan*, J. Wooten* & A. Blikslager* 

author keywords: tight junction; restitution; Na+/H+ exchange
MeSH headings : Animals; Blotting, Western; Diffusion Chambers, Culture; Electric Impedance; Electrophoresis, Polyacrylamide Gel; Female; Guanidines / pharmacology; Ileum / blood supply; Ileum / metabolism; Immunohistochemistry; Immunoprecipitation; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestines / blood supply; Intestines / pathology; Ischemia / pathology; Male; Methacrylates / pharmacology; Prostaglandins / pharmacology; Regional Blood Flow / drug effects; Regional Blood Flow / physiology; Sodium / metabolism; Sodium-Hydrogen Exchangers / antagonists & inhibitors; Sulfones / pharmacology; Swine
topics (OpenAlex): Ion Transport and Channel Regulation; Gastrointestinal motility and disorders; Ion channel regulation and function
TL;DR: Selective inhibition of NHE2, and not NHE3, induces recovery of barrier function in the ischemia-injured intestine. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone

American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2), G647–G656.

By: A. Moeser n, P. Nighot*, K. Engelke, R. Ueno & A. Blikslager n 

Contributors: A. Moeser n, P. Nighot*, K. Engelke, R. Ueno & A. Blikslager n 

author keywords: ischemia; type 2 chloride channels; repair
MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Alprostadil / therapeutic use; Animals; Bumetanide / pharmacology; CLC-2 Chloride Channels; Chloride Channel Agonists; Chloride Channels / antagonists & inhibitors; Chlorides / pharmacology; Colon / blood supply; Colon / drug effects; Colon / physiopathology; Cystic Fibrosis Transmembrane Conductance Regulator / antagonists & inhibitors; Dinoprostone / pharmacology; Electric Impedance; Electrophysiology; Fatty Acids / pharmacology; Fatty Acids / therapeutic use; Female; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Indomethacin / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Ischemia / metabolism; Ischemia / physiopathology; Lubiprostone; Male; Mannitol / metabolism; Membrane Proteins / metabolism; Occludin; Permeability; Recovery of Function / drug effects; Sus scrofa; Urea / analogs & derivatives; Urea / pharmacology; Zinc Compounds / pharmacology
topics (OpenAlex): Gastrointestinal motility and disorders; Helicobacter pylori-related gastroenterology studies; Ion Transport and Channel Regulation
TL;DR: Prostones such as lubiprostone may provide a selective and novel pharmacological mechanism of accelerating recovery of acutely injured intestine compared with the nonselective action of prostaglandins such as PGE(2). (via Semantic Scholar)
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Added: August 6, 2018

2006 article

Selecting soybean meal characteristics preferred for swine nutrition1

Kempen, T. A. T. G., Heugten, E., Moeser, A. J., Muley, N. S., & Sewalt, V. J. H. (2006, June 1). Journal of Animal Science, Vol. 84, pp. 1387–1395.

By: T. Kempen n , E. Heugten n , A. Moeser n, N. Muley n & V. Sewalt  n

author keywords: ammonia; digestibility; odor; soybean meal; swine
MeSH headings : Ammonia; Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Diet; Digestion; Feces / chemistry; Female; Ileum / metabolism; Male; Odorants; Soybeans / chemistry; Soybeans / metabolism; Swine / metabolism
topics (OpenAlex): Animal Nutrition and Physiology; Agriculture Sustainability and Environmental Impact; Ruminant Nutrition and Digestive Physiology
TL;DR: In conclusion, nutritionally relevant variability exists in soy varieties and low stachyose content is important for maximizing ileal energy digestibility of soybean meal. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig

American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G173–G181.

By: A. Moeser*, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

Contributors: A. Moeser*, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

author keywords: barrier function; secretion
MeSH headings : Animals; Colon / physiopathology; Disease Models, Animal; Female; Jejunum / physiopathology; Male; Maternal Behavior; Muscle, Smooth / physiopathology; Signal Transduction; Stress, Psychological / physiopathology; Swine; Weaning
topics (OpenAlex): Gastrointestinal motility and disorders; Diet and metabolism studies; Stress Responses and Cortisol
TL;DR: The results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2004 article

ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum

Moeser, A. J., Haskell, M. M., Shifflett, D. E., Little, D., Schultz, B. D., & Blikslager, A. T. (2004, September 1). Gastroenterology, Vol. 127, pp. 802–815.

By: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & A. Blikslager n 

Contributors: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & A. Blikslager n 

MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channels / metabolism; Chlorides / metabolism; Dinoprostone / pharmacology; Electric Impedance; Female; Ileum / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiopathology; Ischemia / metabolism; Ischemia / physiopathology; Male; Models, Animal; Permeability / drug effects; Prostaglandins / pharmacology; Recovery of Function / drug effects; Recovery of Function / physiology; Swine
topics (OpenAlex): Barrier Structure and Function Studies; Neuroscience and Neuropharmacology Research; Ion Transport and Channel Regulation
TL;DR: ClC-2-mediated intestinal Cl - secretion restores TER in ischemia-injured intestine and may provide the basis for targeted pharmacologic therapy for diseases associated with impaired barrier function. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 286(6), G906–G913.

By: D. Shifflett n, S. Jones* , A. Moeser* & A. Blikslager* 

Contributors: D. Shifflett n, S. Jones* , A. Moeser* & A. Blikslager* 

author keywords: intestine; prostaglandin; transepithelial electrical resistance; cyclooxygenase 2
MeSH headings : Animals; Cyclooxygenase 2; Electric Impedance; Enzyme Activation; Enzyme Inhibitors / pharmacology; Female; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Prostaglandin-Endoperoxide Synthases / metabolism; Recovery of Function; Swine; p38 Mitogen-Activated Protein Kinases
topics (OpenAlex): Barrier Structure and Function Studies; Melanoma and MAPK Pathways; Biological Stains and Phytochemicals
TL;DR: COX-2 expression appears to be positively and negatively regulated by the p38 MAPK and the JNK pathways, respectively, and ERK1/2 appear to be involved in COX- 2-independent reparative events that remain to be defined. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1β- and COX-2-dependent mechanism

American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(1), G50–G57.

By: D. Shifflett n, F. Bottone, K. Young*, A. Moeser*, S. Jones*  & A. Blikslager* 

Contributors: D. Shifflett n, F. Bottone Jr., K. Young*, A. Moeser*, S. Jones*  & A. Blikslager* 

author keywords: intestine; prostaglandin; transepithelial electrical resistance; tight junction
MeSH headings : Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Electric Impedance; Female; Ileum / blood supply; Ileum / physiopathology; Interleukin-1 / administration & dosage; Interleukin-1 / metabolism; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; Male; Neutrophils; Prostaglandin-Endoperoxide Synthases / metabolism; Swine
topics (OpenAlex): S100 Proteins and Annexins; Intensive Care Unit Cognitive Disorders; Immune Response and Inflammation
TL;DR: PMNs augment recovery of TER in ischemia-injured ileal mucosa via IL-1beta-dependent upregulation of COX-2, and this action was inhibited by pretreatment with the nonselective cyclooxygenase (COX) inhibitor indomethacin. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2003 article

Diet and evaluators affect perception of swine waste odor: An educational demonstration

Moeser, A. J., See, M. T., Heugten, E., Morrow, W. E. M., & Kempen, T. A. T. G. (2003, December 1). Journal of Animal Science, Vol. 81, pp. 3211–3215.

By: A. Moeser n, M. See n , E. Heugten n , W. Morrow n & T. Kempen n 

MeSH headings : Air Pollutants / analysis; Animal Feed / adverse effects; Animal Feed / analysis; Animal Husbandry / education; Animal Husbandry / methods; Animals; Diet / veterinary; Education, Continuing; Education, Graduate; Faculty; Manure / analysis; Odorants / analysis; Odorants / prevention & control; Swine / growth & development; Swine / metabolism
topics (OpenAlex): Odor and Emission Control Technologies; Composting and Vermicomposting Techniques; Turfgrass Adaptation and Management
TL;DR: Differences in odor are achievable through altering diet composition, and that the response to swine odor depends on individual odor perception. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018

2002 article

Dietary fibre level and enzyme inclusion affect nutrient digestibility and excreta characteristics in grower pigs

Moeser, A. J., & Kempen, T. A. T. G. (2002, September 25). Journal of the Science of Food and Agriculture, Vol. 82, pp. 1606–1613.

By: A. Moeser n & T. Kempen n 

author keywords: fibre; digestibility; feed enzymes; grower pigs
topics (OpenAlex): Animal Nutrition and Physiology; Odor and Emission Control Technologies; Agriculture Sustainability and Environmental Impact
TL;DR: Lowering the dietary NDF level or inclusion of fibre-degrading enzymes in high-fibre diets may offer relatively practical and easy methods for reducing waste production in pigs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

The nutritional value of degermed, dehulled corn for pigs and its impact on the gastrointestinal tract and nutrient excretion

Moeser, A. J., Kim, I. B., Heugten, E., & Kempen, T. A. T. G. (2002, January 1). Journal of Animal Science, Vol. 80, pp. 2629–2638.

By: A. Moeser n, I. Kim*, E. Heugten n  & T. Kempen n 

MeSH headings : Animal Feed / standards; Animal Nutritional Physiological Phenomena; Animals; Digestion; Digestive System Physiological Phenomena; Eating; Energy Metabolism; Feces / chemistry; Ileum / metabolism; Male; Nitrogen / metabolism; Nutritive Value; Random Allocation; Swine / growth & development; Swine / metabolism; Swine / physiology; Zea mays
topics (OpenAlex): Animal Nutrition and Physiology; Agriculture Sustainability and Environmental Impact; Meat and Animal Product Quality
TL;DR: Results from these trials suggest that corn processed to remove poorly digestible fiber fractions provides more digestible nutrients than corn grain, thus providing a means to reduce nutrient excretion in degermed, dehulled corn. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

journal article

Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa

Nighot, M., Moeser, A., Ueno, R., & Blikslager, A. World Journal of Gastroenterology, 18(34), 4684–4692.

By: M. Nighot, A. Moeser, R. Ueno & A. Blikslager 

Source: NC State University Libraries
Added: August 6, 2018

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