Douglas John Kojetin

Works (9)

Updated: July 5th, 2023 15:59

2007 article

NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC

Kojetin, D. J., McLaughlin, P. D., Thompson, R. J., Venters, R. A., Rance, M., & Cavanagh, J. (2007, September 5). Biomolecular NMR Assignments.

By: D. Kojetin*, P. McLaughlin n, R. Thompson n, R. Venters *, M. Rance * & J. Cavanagh n

author keywords: ClpC; Bacillus subtilis; N-domain; genetic competence; HSP100/AAA+
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Connexins / chemistry; Heat-Shock Proteins / chemistry; Magnetic Resonance Spectroscopy / methods; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid
topics (OpenAlex): Bacterial Genetics and Biotechnology; Protein Structure and Dynamics; RNA and protein synthesis mechanisms
TL;DR: The backbone and side-chain assignments of the N-terminal repeat domain (residues 1–145) of ClpC from Bacillus subtilis are presented. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D-28K

Douglas John Kojetin; David Ronald Kordys; Richele J. Thompson; John Cavanagh

topics (OpenAlex):
Source: NC State University Libraries
Added: August 6, 2018

2005 article

(4,2)D Projection−Reconstruction Experiments for Protein Backbone Assignment:  Application to Human Carbonic Anhydrase II and Calbindin D28K

Venters, R. A., Coggins, B. E., Kojetin, D., Cavanagh, J., & Zhou, P. (2005, May 25). Journal of the American Chemical Society.

By: R. Venters  n, B. Coggins  n, D. Kojetin n, J. Cavanagh n & P. Zhou  n

MeSH headings : Calbindins; Carbonic Anhydrase II / chemistry; Humans; Nuclear Magnetic Resonance, Biomolecular / methods; S100 Calcium Binding Protein G / chemistry
topics (OpenAlex): Protein Structure and Dynamics; Mass Spectrometry Techniques and Applications; Advanced NMR Techniques and Applications
TL;DR: This work shows that projection-reconstruction NMR techniques can be extended to larger protonated and perdeuterated proteins and presents a suite of (4,2)D triple-resonance experiments for protein backbone assignment and a Hybrid Backprojection/Lower-Value algorithm for reconstructing data with relatively weak signal-to-noise ratios. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 article

Solution Structure and Dynamics of LuxU from Vibrio harveyi, a Phosphotransferase Protein Involved in Bacterial Quorum Sensing

Ulrich, D. L., Kojetin, D., Bassler, B. L., Cavanagh, J., & Loria, J. P. (2005, February 1). Journal of Molecular Biology.

By: D. Ulrich*, D. Kojetin n, B. Bassler *, J. Cavanagh n & J. Loria *

author keywords: quorum-sensing; NMR; solution structure; LuxU; bioluminescence
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Binding Sites; Models, Molecular; Molecular Sequence Data; Phosphoproteins / chemistry; Phosphoproteins / genetics; Phosphoproteins / metabolism; Protein Structure, Tertiary; Sequence Alignment; Sequence Homology, Amino Acid; Vibrio / metabolism
topics (OpenAlex): Bacterial biofilms and quorum sensing; Bacterial Genetics and Biotechnology; Bacteriophages and microbial interactions
TL;DR: The studies described here represent the first structural characterization of an isolated, monomeric bacterial phosphotransferase protein, LuxU, which acts to shuttle the phosphate from the membrane-bound proteins, LuxN and LuxQ, to LuxO. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 article

Structural Analysis of Divalent Metals Binding to the Bacillus subtilis Response Regulator Spo0F: The Possibility for In Vitro Metalloregulation in the Initiation of Sporulation

Kojetin, D. J., Thompson, R. J., Benson, L. M., Naylor, S., Waterman, J., Davies, K. G., … Cavanagh, J. (2005, October 1). BioMetals.

By: D. Kojetin n, R. Thompson n, L. Benson*, S. Naylor *, J. Waterman  n, K. Davies *, C. Opperman n, K. Stephenson*, J. Hoch*, J. Cavanagh n

author keywords: metal binding; NMR spectroscopy; response regulator; sporulation; two-component signal transduction
MeSH headings : Amino Acid Sequence; Bacillus subtilis / chemistry; Bacillus subtilis / physiology; Bacterial Proteins / chemistry; Bacterial Proteins / drug effects; Calcium / chemistry; Calcium / pharmacology; Copper / chemistry; Copper / pharmacology; Crystallography, X-Ray; In Vitro Techniques; Magnesium / chemistry; Magnesium / pharmacology; Magnetic Resonance Spectroscopy / methods; Magnetic Resonance Spectroscopy / standards; Manganese / chemistry; Manganese / pharmacology; Models, Molecular; Molecular Sequence Data; Phosphorylation / drug effects; Protein Binding; Protein Conformation; Protein Kinases / chemistry; Protein Kinases / drug effects; Reference Standards; Signal Transduction / drug effects; Signal Transduction / physiology; Spectrometry, Mass, Electrospray Ionization / methods; Spores, Bacterial / metabolism; Structure-Activity Relationship
topics (OpenAlex): Microbial bioremediation and biosurfactants; Bacterial Genetics and Biotechnology; Mass Spectrometry Techniques and Applications
TL;DR: Metal binding studies of the Bacillus subtilis response regulator Spo0F using NMR and μESI-MS show that the divalent metals Ca2+, Mg2+ and Mn2+ primarily bind, as expected, in the Asp pocket phosphorylation site, while Cu2+ fails to support KinA phosphotransfer. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 article

Corrigendum to: Sub‐classification of response regulators using the surface characteristics of their receiver domains (FEBS 27785)

Kojetin, D. J., Thompson, R. J., & Cavanagh, J. (2004, February 4). FEBS Letters.

By: D. Kojetin n, R. Thompson n & J. Cavanagh n

topics (OpenAlex): Insect Pheromone Research and Control; Hearing, Cochlea, Tinnitus, Genetics; Hydraulic flow and structures
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Source: Web Of Science
Added: August 6, 2018

2003 article

Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy

Lutz, W., Frank, E. M., Craig, T. A., Thompson, R., Venters, R. A., Kojetin, D., … Kumar, R. (2003, April 1). Biochemical and Biophysical Research Communications.

By: W. Lutz, E. Frank*, T. Craig*, R. Thompson n, R. Venters *, D. Kojetin n, J. Cavanagh n, R. Kumar *

MeSH headings : Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Binding Sites; Calbindins; Cytoskeletal Proteins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nuclear Proteins / chemistry; Nuclear Proteins / metabolism; Precipitin Tests; Protein Structure, Tertiary; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / metabolism; ran GTP-Binding Protein / chemistry; ran GTP-Binding Protein / metabolism
topics (OpenAlex): Mitochondrial Function and Pathology; Microtubule and mitosis dynamics; Protein Structure and Dynamics
TL;DR: Using NMR methods, a peptide, LASIKNR, derived from Ran-binding protein M, interacts with several regions of the calcium-loaded calbindin D(28K) including the amino terminus and two other regions that exhibit conformational exchange on the NMR timescale. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 article

Sub‐classification of response regulators using the surface characteristics of their receiver domains

Kojetin, D. J., Thompson, R. J., & Cavanagh, J. (2003, October 21). FEBS Letters.

By: D. Kojetin n, R. Thompson n & J. Cavanagh n

author keywords: OmpR sub-families; homology modeling
MeSH headings : Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / classification; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Escherichia coli / chemistry; Escherichia coli / metabolism; Genes, Regulator; Histidine Kinase; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Protein Kinases / genetics; Protein Kinases / metabolism; Protein Structure, Secondary; Protein Structure, Tertiary; Structural Homology, Protein; Trans-Activators / chemistry; Trans-Activators / classification; Trans-Activators / genetics
topics (OpenAlex): Bacterial Genetics and Biotechnology; RNA and protein synthesis mechanisms; Genomics and Phylogenetic Studies
TL;DR: Comparison based homology modeling of the receiver domains of the OmpR sub‐family of response regulators in Bacillus subtilis and Escherichia coli suggests further sub‐classification is possible. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 article

Alternative Splicing of a β4Subunit Proline-Rich Motif Regulates Voltage-Dependent Gating and Toxin Block of Cav2.1 Ca2+Channels

Helton, T. D., Kojetin, D. J., Cavanagh, J., & Horne, W. A. (2002, November 1). Journal of Neuroscience.

By: T. Helton*, D. Kojetin n, J. Cavanagh n & W. Horne*

MeSH headings : Alternative Splicing / physiology; Amino Acid Motifs / physiology; Animals; Brain / metabolism; Calcium Channel Blockers / pharmacology; Calcium Channels, N-Type / drug effects; Calcium Channels, N-Type / genetics; Calcium Channels, N-Type / metabolism; Humans; Ion Channel Gating / drug effects; Ion Channel Gating / physiology; Membrane Potentials / physiology; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins / genetics; Oocytes / metabolism; Organ Specificity; Patch-Clamp Techniques; Protein Structure, Tertiary / physiology; Protein Subunits / drug effects; Protein Subunits / genetics; Protein Subunits / metabolism; RNA, Messenger / metabolism; Sequence Deletion; Sequence Homology, Amino Acid; Spinal Cord / metabolism; Structure-Activity Relationship; Xenopus laevis; omega-Conotoxins / pharmacology
topics (OpenAlex): Ion channel regulation and function; Cardiac electrophysiology and arrhythmias; Neuroscience and Neuropharmacology Research
TL;DR: The models reveal that alternative splicing of the β4 N terminus results in dramatic differences in surface charge distribution and localize the proline-rich motif of β4b to an extended arm structure that flanks what would be the equivalent of a highly modified PSD-95 carboxylate binding loop. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

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