Robin M. Sternberg
Works (7)
Updated: July 14th, 2023 21:16
2010 review
Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs
[Review of ]. ECOTOXICOLOGY, 19(1), 4–23.
author keywords: Mollusk; Endocrinology; Tributyltin; Imposex; Retinoid X-receptor
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Female; Male; Models, Biological; Photoperiod; Retinoid X Receptors / metabolism; Sex Characteristics; Sex Differentiation / drug effects; Signal Transduction / drug effects; Snails / drug effects; Snails / physiology; Temperature; Tretinoin / metabolism; Trialkyltin Compounds / metabolism; Trialkyltin Compounds / toxicity
TL;DR:
A cohesive model is provided for the environmental-endocrine regulation of reproduction in gastropods and it is proposed that TBT causes imposex through the inappropriate activation of this signaling pathway.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Environmental cues trigger seasonal regression of primary and accessory sex organs of the mud snail, Ilyanassa obsoleta
JOURNAL OF MOLLUSCAN STUDIES, 74, 301–303.
TL;DR:
Whether the seasonal onset of regression in mud snails is controlled by two environmental cues, photoperiod or temperature is investigated, which is an accurate predictor of changing seasons.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Synchronized expression of retinoid X receptor mRNA with reproductive tract recrudescence in an imposex-susceptible mollusc
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 42(4), 1345–1351.
MeSH headings : Amino Acid Sequence; Animals; Female; Male; Molecular Sequence Data; Mollusca / anatomy & histology; Phylogeny; RNA, Messenger / genetics; Reproduction; Retinoid X Receptors / chemistry; Retinoid X Receptors / genetics; Sequence Homology, Amino Acid; Species Specificity
TL;DR:
Results demonstrate that RXR expression is associated with reproductive tract recrudescence in both sexes; although, the timing of recrUDescence may dictate sex-specific development.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
The contribution of steroidal androgens and estrogens to reproductive maturation of the eastern mud snail Ilyanassa obsoleta
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 156(1), 15–26.
author keywords: androgens; estrogens; retinoids; neogastropod; gastropod; imposex; tributyltin; bisphenol A
MeSH headings : Amino Acid Sequence; Androgens / physiology; Animals; Estradiol / metabolism; Estrogens / physiology; Female; Male; Molecular Sequence Data; Phylogeny; RNA, Messenger / metabolism; Receptors, Androgen / metabolism; Receptors, Estrogen / analysis; Receptors, Estrogen / metabolism; Reproduction / physiology; Sexual Maturation / physiology; Snails / physiology; Testosterone / metabolism
TL;DR:
In conclusion, testosterone may have a role in male reproductive tract recrudescence; however, this putative activity is independent of a NR3C4-type androgen receptor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition
TOXICOLOGICAL SCIENCES, 97(2), 512–519.
author keywords: prochloraz; testosterone; CYP17; steroidogenesis; fetal testis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; 17-alpha-Hydroxyprogesterone / metabolism; Amniotic Fluid / metabolism; Androgen Receptor Antagonists; Androstenedione / blood; Androstenedione / metabolism; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Estradiol / biosynthesis; Estradiol / blood; Female; Fetus / drug effects; Fetus / metabolism; Fungicides, Industrial / pharmacokinetics; Fungicides, Industrial / toxicity; Gene Expression / drug effects; Imidazoles / pharmacokinetics; Imidazoles / toxicity; Male; Phosphoproteins / biosynthesis; Pregnancy; Progesterone / biosynthesis; Progesterone / blood; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / biosynthesis; Steroid 17-alpha-Hydroxylase / genetics; Steroids / biosynthesis; Testis / drug effects; Testis / embryology; Testis / metabolism; Testosterone / biosynthesis; Testosterone / physiology
TL;DR:
It is demonstrated that PCZ lowers testicular testosterone synthesis by inhibiting CYP17 activity which likely contributes to the induced malformations in androgen-dependent tissues of male offspring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Kinetic characterization of the inhibition of acyl coenzyme A: Steroid acyltransferases by tributyltin in the eastern mud snail (Ilyanassa obsoleta)
AQUATIC TOXICOLOGY, 78(3), 233–242.
author keywords: tributyltin; imposex; acyl coenzyme A; steroid acyltransferase; testosterone; 17 beta-estradiol; endocrine; snail
MeSH headings : Acyltransferases / antagonists & inhibitors; Acyltransferases / drug effects; Acyltransferases / pharmacokinetics; Animals; Esterification / drug effects; Estradiol / metabolism; Female; Kinetics; Microsomes / enzymology; Palmitoyl Coenzyme A / metabolism; Snails / drug effects; Snails / enzymology; Testosterone / metabolism; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
TL;DR:
The results of this study supply the much-needed mechanistic support for the hypothesis that TBT elevates free testosterone in neogastropods by inhibiting their major regulatory process for maintaining free testosterone homeostasis-the fatty acid esterification of testosterone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 article
Testosterone-fatty acid esterification: A unique target for the endocrine toxicity of tributyltin to gastropods
LeBlanc, G. A., Gooding, M. P., & Sternberg, R. M. (2005, February). INTEGRATIVE AND COMPARATIVE BIOLOGY, Vol. 45, pp. 81–87.
TL;DR:
Observations of imposex and free testosterone levels were elevated in field collected snails containing high tin levels, while testosterone-fatty acid ester pools were reduced in these organisms, indicating that tributyltin elevates free testosterone by reducing the retention of testosterone as fatty acid-esters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
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