Robin M. Sternberg

Works (7)

Updated: July 14th, 2023 21:16

2009 article

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

Sternberg, R. M., Gooding, M. P., Hotchkiss, A. K., & LeBlanc, G. A. (2009, August 3). Ecotoxicology, Vol. 19, pp. 4–23.

By: R. Sternberg n, M. Gooding n, A. Hotchkiss n & G. LeBlanc n 

author keywords: Mollusk; Endocrinology; Tributyltin; Imposex; Retinoid X-receptor
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Female; Male; Models, Biological; Photoperiod; Retinoid X Receptors / metabolism; Sex Characteristics; Sex Differentiation / drug effects; Signal Transduction / drug effects; Snails / drug effects; Snails / physiology; Temperature; Tretinoin / metabolism; Trialkyltin Compounds / metabolism; Trialkyltin Compounds / toxicity
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Marine Ecology and Invasive Species
TL;DR: A cohesive model is provided for the environmental-endocrine regulation of reproduction in gastropods and it is proposed that TBT causes imposex through the inappropriate activation of this signaling pathway. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Environmental cues trigger seasonal regression of primary and accessory sex organs of the mud snail, Ilyanassa obsoleta

Hotchkiss, A. K., Sternberg, R. M., & LeBlanc, G. A. (2008, April 17). Journal of Molluscan Studies, Vol. 74, pp. 301–303.

By: A. Hotchkiss*, R. Sternberg* & G. LeBlanc* 

topics (OpenAlex): Mollusks and Parasites Studies; Parasite Biology and Host Interactions
TL;DR: Whether the seasonal onset of regression in mud snails is controlled by two environmental cues, photoperiod or temperature is investigated, which is an accurate predictor of changing seasons. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Synchronized Expression of Retinoid X Receptor mRNA with Reproductive Tract Recrudescence in an Imposex-Susceptible Mollusc

Sternberg, R. M., Hotchkiss, A. K., & LeBlanc, G. A. (2008, January 16). Environmental Science & Technology, Vol. 42, pp. 1345–1351.

By: R. Sternberg n, A. Hotchkiss n & G. LeBlanc n 

MeSH headings : Amino Acid Sequence; Animals; Female; Male; Molecular Sequence Data; Mollusca / anatomy & histology; Phylogeny; RNA, Messenger / genetics; Reproduction; Retinoid X Receptors / chemistry; Retinoid X Receptors / genetics; Sequence Homology, Amino Acid; Species Specificity
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Marine Ecology and Invasive Species
TL;DR: Results demonstrate that RXR expression is associated with reproductive tract recrudescence in both sexes; although, the timing of recrUDescence may dictate sex-specific development. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

The contribution of steroidal androgens and estrogens to reproductive maturation of the eastern mud snail Ilyanassa obsoleta

Sternberg, R. M., Hotchkiss, A. K., & LeBlanc, G. A. (2008, January 30). General and Comparative Endocrinology, Vol. 156, pp. 15–26.

By: R. Sternberg n, A. Hotchkiss n & G. LeBlanc n 

author keywords: androgens; estrogens; retinoids; neogastropod; gastropod; imposex; tributyltin; bisphenol A
MeSH headings : Amino Acid Sequence; Androgens / physiology; Animals; Estradiol / metabolism; Estrogens / physiology; Female; Male; Molecular Sequence Data; Phylogeny; RNA, Messenger / metabolism; Receptors, Androgen / metabolism; Receptors, Estrogen / analysis; Receptors, Estrogen / metabolism; Reproduction / physiology; Sexual Maturation / physiology; Snails / physiology; Testosterone / metabolism
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Reproductive biology and impacts on aquatic species
TL;DR: In conclusion, testosterone may have a role in male reproductive tract recrudescence; however, this putative activity is independent of a NR3C4-type androgen receptor. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

Sensitivity of Fetal Rat Testicular Steroidogenesis to Maternal Prochloraz Exposure and the Underlying Mechanism of Inhibition

Blystone, C. R., Lambright, C. S., Howdeshell, K. L., Furr, J., Sternberg, R. M., Butterworth, B. C., … Gray, L. E. (2007, January 18). Toxicological Sciences, Vol. 97, pp. 512–519.

By: C. Blystone n, C. Lambright*, K. Howdeshell *, J. Furr*, R. Sternberg n, B. Butterworth*, E. Durhan*, E. Makynen* ...

author keywords: prochloraz; testosterone; CYP17; steroidogenesis; fetal testis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; 17-alpha-Hydroxyprogesterone / metabolism; Amniotic Fluid / metabolism; Androgen Receptor Antagonists; Androstenedione / blood; Androstenedione / metabolism; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Estradiol / biosynthesis; Estradiol / blood; Female; Fetus / drug effects; Fetus / metabolism; Fungicides, Industrial / pharmacokinetics; Fungicides, Industrial / toxicity; Gene Expression / drug effects; Imidazoles / pharmacokinetics; Imidazoles / toxicity; Male; Phosphoproteins / biosynthesis; Pregnancy; Progesterone / biosynthesis; Progesterone / blood; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / biosynthesis; Steroid 17-alpha-Hydroxylase / genetics; Steroids / biosynthesis; Testis / drug effects; Testis / embryology; Testis / metabolism; Testosterone / biosynthesis; Testosterone / physiology
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Carcinogens and Genotoxicity Assessment; Toxic Organic Pollutants Impact
TL;DR: It is demonstrated that PCZ lowers testicular testosterone synthesis by inhibiting CYP17 activity which likely contributes to the induced malformations in androgen-dependent tissues of male offspring. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Kinetic characterization of the inhibition of acyl coenzyme A:Steroid acyltransferases by tributyltin in the eastern mud snail (Ilyanassa obsoleta)

Sternberg, R. M., & LeBlanc, G. A. (2006, March 25). Aquatic Toxicology, Vol. 78, pp. 233–242.

By: R. Sternberg n & G. LeBlanc n 

author keywords: tributyltin; imposex; acyl coenzyme A; steroid acyltransferase; testosterone; 17 beta-estradiol; endocrine; snail
MeSH headings : Acyltransferases / antagonists & inhibitors; Acyltransferases / drug effects; Acyltransferases / pharmacokinetics; Animals; Esterification / drug effects; Estradiol / metabolism; Female; Kinetics; Microsomes / enzymology; Palmitoyl Coenzyme A / metabolism; Snails / drug effects; Snails / enzymology; Testosterone / metabolism; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Marine Ecology and Invasive Species
TL;DR: The results of this study supply the much-needed mechanistic support for the hypothesis that TBT elevates free testosterone in neogastropods by inhibiting their major regulatory process for maintaining free testosterone homeostasis-the fatty acid esterification of testosterone. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Testosterone-Fatty Acid Esterification: A Unique Target for the Endocrine Toxicity of Tributyltin to Gastropods

LeBlanc, G., Gooding, M. P., & Sternberg, R. M. (2005, January 1). Integrative and Comparative Biology, Vol. 45, pp. 81–87.

By: G. LeBlanc n , M. Gooding & R. Sternberg

topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Marine Ecology and Invasive Species
TL;DR: Observations of imposex and free testosterone levels were elevated in field collected snails containing high tin levels, while testosterone-fatty acid ester pools were reduced in these organisms, indicating that tributyltin elevates free testosterone by reducing the retention of testosterone as fatty acid-esters. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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