Chad R. Blystone
Works (9)
Updated: July 5th, 2023 15:55
2009 journal article
Cumulative and Antagonistic Effects of a Mixture of the Antiandrogens Vinclozolin and Iprodione in the Pubertal Male Rat
TOXICOLOGICAL SCIENCES, 111(1), 179–188.
author keywords: iprodione; vinclozolin; mixture; puberty; testosterone; androgen receptor; endocrine disruption
MeSH headings : Adrenal Glands / drug effects; Adrenal Glands / growth & development; Aminoimidazole Carboxamide / analogs & derivatives; Aminoimidazole Carboxamide / toxicity; Androgen Antagonists / toxicity; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Drug Combinations; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Hormones / blood; Hydantoins / toxicity; Liver / drug effects; Liver / growth & development; Male; Organ Size / drug effects; Oxazoles / toxicity; Rats; Rats, Sprague-Dawley; Receptors, Androgen / biosynthesis; Receptors, Androgen / drug effects; Receptors, Androgen / genetics; Receptors, Aryl Hydrocarbon / drug effects; Sexual Maturation / drug effects; Transcriptional Activation / drug effects
academic.oup.com (publisher PDF)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
TOXICOLOGICAL SCIENCES, 105(1), 153–165.
author keywords: androgens; prenatal; reproductive tract; phthalates; cumulative risk; structure activity relationship
MeSH headings : Animals; Body Weight / drug effects; Dibutyl Phthalate / analogs & derivatives; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Dose-Response Relationship, Drug; Female; Fetus / drug effects; Logistic Models; Male; Phthalic Acids / toxicity; Pregnancy; Rats; Rats, Sprague-Dawley; Testis / drug effects; Testis / metabolism; Testosterone / biosynthesis
Source: Web Of Science
Added: August 6, 2018
2008 article
Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development
Wilson, V. S., Blystone, C. R., Hotchkiss, A. K., Rider, C. V., & Gray, L. E., Jr. (2008, April). INTERNATIONAL JOURNAL OF ANDROLOGY, Vol. 31, pp. 178–185.
author keywords: androgen receptor; anti-androgen; linuron; phthalate; prochloraz; reproductive development; vinclozolin
MeSH headings : Androgen Antagonists / pharmacology; Animals; Genitalia, Male / drug effects; Genitalia, Male / embryology; Male; Rats
Source: Web Of Science
Added: August 6, 2018
2008 journal article
High throughput adjustable 96-well plate assay for androgen receptor binding: A practical approach for EDC screening using the chimpanzee AR
TOXICOLOGY LETTERS, 181(2), 126–131.
author keywords: Baculovirus; Screening; Androgen; Receptor; Chimpanzee
MeSH headings : Animals; Binding, Competitive; Cell Line; Endocrine Disruptors / metabolism; Guanidine / chemistry; Pan troglodytes; Rats; Receptors, Androgen / genetics; Receptors, Androgen / metabolism; Recombinant Proteins / metabolism; Spodoptera
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat
Toxicological Sciences, 95(1), 227–239.
MeSH headings : Anal Canal / drug effects; Anal Canal / growth & development; Animals; Antifungal Agents / toxicity; Body Weight / drug effects; Cell Shape / drug effects; Dose-Response Relationship, Drug; Eating / drug effects; Female; Fertility / drug effects; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Genitalia, Male / pathology; Homeostasis / drug effects; Liver / drug effects; Liver / pathology; Male; Nitriles / toxicity; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reproduction / drug effects; Sexual Maturation / drug effects; Sperm Motility / drug effects; Spermatozoa / drug effects; Spermatozoa / pathology; Testosterone / blood; Time Factors; Triazoles / toxicity
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production
TOXICOLOGY LETTERS, 174(1-3), 74–81.
author keywords: iprodione; steroidogenesis; puberty; testosterone; endocrine disruption
MeSH headings : Aminoimidazole Carboxamide / analogs & derivatives; Aminoimidazole Carboxamide / toxicity; Animals; Cell Line; Endocrine Disruptors / toxicity; Epididymis / drug effects; Epididymis / growth & development; Fungicides, Industrial / toxicity; Humans; Hydantoins / toxicity; Male; Rats; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Seminal Vesicles / drug effects; Seminal Vesicles / growth & development; Sexual Maturation / drug effects; Testis / drug effects; Testis / metabolism; Testosterone / blood; Testosterone / metabolism
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat
TOXICOLOGICAL SCIENCES, 97(1), 65–74.
author keywords: prochloraz; testosterone; antiandrogen; puberty; Hershberger; steroidgenesis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; Androgen Antagonists / toxicity; Androgen Receptor Antagonists; Androgens / metabolism; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors / toxicity; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / enzymology; Genitalia, Male / growth & development; Genitalia, Male / metabolism; Imidazoles / toxicity; Male; No-Observed-Adverse-Effect Level; Orchiectomy; Organ Size / drug effects; Progesterone / blood; Rats; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Sexual Development / drug effects; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / metabolism; Testosterone / blood; Testosterone / metabolism; Testosterone Propionate / pharmacology; Time Factors; Toxicity Tests / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition
TOXICOLOGICAL SCIENCES, 97(2), 512–519.
author keywords: prochloraz; testosterone; CYP17; steroidogenesis; fetal testis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; 17-alpha-Hydroxyprogesterone / metabolism; Amniotic Fluid / metabolism; Androgen Receptor Antagonists; Androstenedione / blood; Androstenedione / metabolism; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Estradiol / biosynthesis; Estradiol / blood; Female; Fetus / drug effects; Fetus / metabolism; Fungicides, Industrial / pharmacokinetics; Fungicides, Industrial / toxicity; Gene Expression / drug effects; Imidazoles / pharmacokinetics; Imidazoles / toxicity; Male; Phosphoproteins / biosynthesis; Pregnancy; Progesterone / biosynthesis; Progesterone / blood; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / biosynthesis; Steroid 17-alpha-Hydroxylase / genetics; Steroids / biosynthesis; Testis / drug effects; Testis / embryology; Testis / metabolism; Testosterone / biosynthesis; Testosterone / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
Effect of conazole fungicides on reproductive development in the female rat
Reproductive Toxicology (Elmsford, N.Y.), 22(4), 647–658.
Source: NC State University Libraries
Added: August 6, 2018
