Chad R. Blystone

Works (9)

Updated: July 5th, 2023 15:55

2009 article

Cumulative and Antagonistic Effects of a Mixture of the Antiandrogens Vinclozolin and Iprodione in the Pubertal Male Rat

Blystone, C. R., Lambright, C. S., Cardon, M. C., Furr, J., Rider, C. V., Hartig, P. C., … Gray, L. E. (2009, June 29). Toxicological Sciences.

By: C. Blystone n, C. Lambright*, M. Cardon*, J. Furr*, C. Rider n, P. Hartig*, V. Wilson *, L. Gray *

author keywords: iprodione; vinclozolin; mixture; puberty; testosterone; androgen receptor; endocrine disruption
MeSH headings : Adrenal Glands / drug effects; Adrenal Glands / growth & development; Aminoimidazole Carboxamide / analogs & derivatives; Aminoimidazole Carboxamide / toxicity; Androgen Antagonists / toxicity; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Drug Combinations; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Hormones / blood; Hydantoins / toxicity; Liver / drug effects; Liver / growth & development; Male; Organ Size / drug effects; Oxazoles / toxicity; Rats; Rats, Sprague-Dawley; Receptors, Androgen / biosynthesis; Receptors, Androgen / drug effects; Receptors, Androgen / genetics; Receptors, Aryl Hydrocarbon / drug effects; Sexual Maturation / drug effects; Transcriptional Activation / drug effects
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Hormonal and reproductive studies; Estrogen and related hormone effects
TL;DR: It is demonstrated that iprodione binds to the human androgen receptor, reduces androgen-dependent gene expression, and reduces androgens-sensitive tissue weights in castrated male rats (Hershberger assay). (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner

Howdeshell, K. L., Wilson, V. S., Furr, J., Lambright, C. R., Rider, C. V., Blystone, C. R., … Gray, L. E. (2008, April 14). Toxicological Sciences.

By: K. Howdeshell*, V. Wilson  n, J. Furr n, C. Lambright n, C. Rider n, C. Blystone n, A. Hotchkiss n, L. Gray n

author keywords: androgens; prenatal; reproductive tract; phthalates; cumulative risk; structure activity relationship
MeSH headings : Animals; Body Weight / drug effects; Dibutyl Phthalate / analogs & derivatives; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Dose-Response Relationship, Drug; Female; Fetus / drug effects; Logistic Models; Male; Phthalic Acids / toxicity; Pregnancy; Rats; Rats, Sprague-Dawley; Testis / drug effects; Testis / metabolism; Testosterone / biosynthesis
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Carcinogens and Genotoxicity Assessment
TL;DR: It is demonstrated that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Diverse mechanisms of anti‐androgen action: impact on male rat reproductive tract development

Wilson, V. S., Blystone, C. R., Hotchkiss, A. K., Rider, C. V., & Gray, L. E. (2008, March 3). International Journal of Andrology.

By: V. Wilson *, C. Blystone n, A. Hotchkiss n, C. Rider n & L. Gray*

author keywords: androgen receptor; anti-androgen; linuron; phthalate; prochloraz; reproductive development; vinclozolin
MeSH headings : Androgen Antagonists / pharmacology; Animals; Genitalia, Male / drug effects; Genitalia, Male / embryology; Male; Rats
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Carcinogens and Genotoxicity Assessment
TL;DR: As more and more molecular studies with anti-androgenic compounds are conducted, the number of mechanisms by which compounds can affect the androgen signalling pathway is likely to increase. (via Semantic Scholar)
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Added: August 6, 2018

2008 article

High throughput adjustable 96-well plate assay for androgen receptor binding: A practical approach for EDC screening using the chimpanzee AR☆

HARTIG, P., CARDON, M., BLYSTONE, C., GRAYJR, L., & WILSON, V. (2008, July 19). Toxicology Letters.

By: P. Hartig*, M. Cardon*, C. Blystone n, L. Grayjr * & V. Wilson*

author keywords: Baculovirus; Screening; Androgen; Receptor; Chimpanzee
MeSH headings : Animals; Binding, Competitive; Cell Line; Endocrine Disruptors / metabolism; Guanidine / chemistry; Pan troglodytes; Rats; Receptors, Androgen / genetics; Receptors, Androgen / metabolism; Recombinant Proteins / metabolism; Spodoptera
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Pharmacological Effects and Assays; Hormonal and reproductive studies
TL;DR: A highly modified 96-well plate assay which employs a baculovirus expressed recombinant primate androgen receptor which is publically available and exploits the unique ability of some mammalian androgen receptors to remain biologically active after guanidine hydrochloride (GdnHCl) solubilization. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production☆

BLYSTONE, C., LAMBRIGHT, C., FURR, J., WILSON, V., & GRAYJR, L. (2007, September 4). Toxicology Letters.

By: C. Blystone n, C. Lambright*, J. Furr*, V. Wilson * & L. Grayjr *

author keywords: iprodione; steroidogenesis; puberty; testosterone; endocrine disruption
MeSH headings : Aminoimidazole Carboxamide / analogs & derivatives; Aminoimidazole Carboxamide / toxicity; Animals; Cell Line; Endocrine Disruptors / toxicity; Epididymis / drug effects; Epididymis / growth & development; Fungicides, Industrial / toxicity; Humans; Hydantoins / toxicity; Male; Rats; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Seminal Vesicles / drug effects; Seminal Vesicles / growth & development; Sexual Maturation / drug effects; Testis / drug effects; Testis / metabolism; Testosterone / blood; Testosterone / metabolism
topics (OpenAlex): Testicular diseases and treatments; Hormonal and reproductive studies; Sperm and Testicular Function
TL;DR: Evidence is provided that IPRO differs from the dicarboximides procymidone and vinclozolin in that the effects on male rat pubertal development result from an inhibition of steroidogenesis and not AR antagonism. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Prochloraz Inhibits Testosterone Production at Dosages below Those that Affect Androgen-Dependent Organ Weights or the Onset of Puberty in the Male Sprague Dawley Rat

Blystone, C. R., Furr, J., Lambright, C. S., Howdeshell, K. L., Ryan, B. C., Wilson, V. S., … Gray, L. E. (2007, January 18). Toxicological Sciences, Vol. 97, pp. 65–74.

By: C. Blystone n, J. Furr*, C. Lambright*, K. Howdeshell *, B. Ryan*, V. Wilson *, G. LeBlanc n , L. Gray*

author keywords: prochloraz; testosterone; antiandrogen; puberty; Hershberger; steroidgenesis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; Androgen Antagonists / toxicity; Androgen Receptor Antagonists; Androgens / metabolism; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors / toxicity; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / enzymology; Genitalia, Male / growth & development; Genitalia, Male / metabolism; Imidazoles / toxicity; Male; No-Observed-Adverse-Effect Level; Orchiectomy; Organ Size / drug effects; Progesterone / blood; Rats; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Sexual Development / drug effects; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / metabolism; Testosterone / blood; Testosterone / metabolism; Testosterone Propionate / pharmacology; Time Factors; Toxicity Tests / methods
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Pesticide Exposure and Toxicity; Hormonal and reproductive studies
TL;DR: The fact that hormone levels were affected at dosage eightfold below that which delayed the onset of puberty suggests that rather large reductions in serum testosterone may be required to delay puberty and consistently reduce androgen-dependent tissue weights. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

Sensitivity of Fetal Rat Testicular Steroidogenesis to Maternal Prochloraz Exposure and the Underlying Mechanism of Inhibition

Blystone, C. R., Lambright, C. S., Howdeshell, K. L., Furr, J., Sternberg, R. M., Butterworth, B. C., … Gray, L. E. (2007, January 18). Toxicological Sciences, Vol. 97, pp. 512–519.

By: C. Blystone n, C. Lambright*, K. Howdeshell *, J. Furr*, R. Sternberg n, B. Butterworth*, E. Durhan*, E. Makynen* ...

author keywords: prochloraz; testosterone; CYP17; steroidogenesis; fetal testis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; 17-alpha-Hydroxyprogesterone / metabolism; Amniotic Fluid / metabolism; Androgen Receptor Antagonists; Androstenedione / blood; Androstenedione / metabolism; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Estradiol / biosynthesis; Estradiol / blood; Female; Fetus / drug effects; Fetus / metabolism; Fungicides, Industrial / pharmacokinetics; Fungicides, Industrial / toxicity; Gene Expression / drug effects; Imidazoles / pharmacokinetics; Imidazoles / toxicity; Male; Phosphoproteins / biosynthesis; Pregnancy; Progesterone / biosynthesis; Progesterone / blood; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / biosynthesis; Steroid 17-alpha-Hydroxylase / genetics; Steroids / biosynthesis; Testis / drug effects; Testis / embryology; Testis / metabolism; Testosterone / biosynthesis; Testosterone / physiology
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Carcinogens and Genotoxicity Assessment; Toxic Organic Pollutants Impact
TL;DR: It is demonstrated that PCZ lowers testicular testosterone synthesis by inhibiting CYP17 activity which likely contributes to the induced malformations in androgen-dependent tissues of male offspring. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Disruption of Testosterone Homeostasis as a Mode of Action for the Reproductive Toxicity of Triazole Fungicides in the Male Rat

Goetz, A. K., Ren, H., Schmid, J. E., Blystone, C. R., Thillainadarajah, I., Best, D. S., … Dix, D. J. (2006, October 3). Toxicological Sciences.

By: A. Goetz n, H. Ren*, J. Schmid*, C. Blystone n, I. Thillainadarajah*, D. Best*, H. Nichols*, L. Strader* ...

MeSH headings : Anal Canal / drug effects; Anal Canal / growth & development; Animals; Antifungal Agents / toxicity; Body Weight / drug effects; Cell Shape / drug effects; Dose-Response Relationship, Drug; Eating / drug effects; Female; Fertility / drug effects; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Genitalia, Male / pathology; Homeostasis / drug effects; Liver / drug effects; Liver / pathology; Male; Nitriles / toxicity; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reproduction / drug effects; Sexual Maturation / drug effects; Sperm Motility / drug effects; Spermatozoa / drug effects; Spermatozoa / pathology; Testosterone / blood; Time Factors; Triazoles / toxicity
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Pesticide Exposure and Toxicity; Carcinogens and Genotoxicity Assessment
TL;DR: Insemination and fertility were impaired by myclobutanil and triadimefon treatment, consistent with the disruption of testosterone homeostasis as a key event in the mode of action for triazole-induced reproductive toxicity. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Effect of conazole fungicides on reproductive development in the female rat

Reproductive Toxicology (Elmsford, N.Y.), 22(4), 647–658.

By: J. Rockett, M. Narotsky, K. Thompson, I. Thillainadarajah, C. Blystone, A. Goetz, H. Ren, D. Best ...

Source: NC State University Libraries
Added: August 6, 2018

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