Works (7)
Updated: August 22nd, 2023 21:19
2010 journal article
Pharmacokinetics of radiolabeled tungsten (W-188) in male Sprague-Dawley rats following acute sodium tungstate inhalation
INHALATION TOXICOLOGY, 22(1), 69–76.
author keywords: Inhalation; kinetics; tungsten
MeSH headings : Administration, Inhalation; Aerosols; Animals; Inhalation Exposure; Male; Metabolic Clearance Rate; Models, Biological; Radioisotopes; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / pharmacokinetics
TL;DR:
Evaluated the pharmacokinetics of inhaled tungstate (WO4) in rats found the kidney, adrenal, spleen, femur, lymph nodes, and brain continued to accumulate small amounts of tungsten as reflected by tissue:blood activity ratios that increased throughout the 21-day period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Acute sodium tungstate inhalation is associated with minimal olfactory transport of tungsten (W-188) to the rat brain
NEUROTOXICOLOGY, 30(3), 445–450.
author keywords: Inhalation; Olfactory transport; Brain; Tungsten; Single-dose; Rat
MeSH headings : Administration, Inhalation; Aerosols; Animals; Corpus Striatum / metabolism; Male; Olfactory Pathways / metabolism; Pituitary Gland / metabolism; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / administration & dosage; Tungsten Compounds / blood; Tungsten Compounds / pharmacokinetics
TL;DR:
The data suggest that olfactory transport plays a minimal role in delivering tungsten to the rat brain, i.e., approximately 1-3% of the amount ofTungsten seen in the olf factory epithelium suggesting that o aroma transport plays an important role in transporting metals to the CNS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation
INHALATION TOXICOLOGY, 20(3), 245–256.
MeSH headings : Acetaldehyde / toxicity; Air Pollutants / toxicity; Animals; Benchmarking; Cell Proliferation / drug effects; Cross-Linking Reagents / toxicity; DNA / chemistry; DNA / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; No-Observed-Adverse-Effect Level; Olfactory Mucosa / drug effects; Olfactory Mucosa / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Protein Binding / drug effects; Proteins / chemistry; Proteins / drug effects; Rats; Rats, Inbred F344; Rhinitis / chemically induced; Rhinitis / pathology
TL;DR:
The severity of the ONL demonstrated dose-and temporal-dependent behaviors, with minimal effects noted at 150–500 ppm acetaldehyde and moderately severe lesions seen in the highest exposure group, with increased lesion severity and extent as the exposure duration increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice
Chemico-Biological Interactions, 173(3), 166–178.
MeSH headings : Animals; Atmosphere Exposure Chambers; Benzene / toxicity; Benzene Derivatives / urine; Body Weight / drug effects; Bone Marrow Cells / drug effects; DNA / chemistry; DNA / drug effects; Drug Administration Schedule; Glutathione / blood; Glutathione / metabolism; Inhalation Exposure; Liver / drug effects; Liver / metabolism; Male; Mice; Micronuclei, Chromosome-Defective / chemically induced; Molecular Structure; Mutagenicity Tests; Time Factors; Toluene / toxicity
TL;DR:
The higher frequency of micronucleated PCE following benzene and toLUene co-exposure when compared with mice exposed to benzene or toluene alone suggests that, at the doses used in this study, toluenes can enhance benzene-induced clastogenic or aneugenic bone marrow injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Metabolomic analyses of body fluids after subchronic manganese inhalation in rhesus monkeys
TOXICOLOGICAL SCIENCES, 106(1), 46–54.
author keywords: metabolomics; metal; neurotoxicity
MeSH headings : Air Pollutants / blood; Air Pollutants / toxicity; Air Pollutants / urine; Animals; Biomarkers / blood; Biomarkers / urine; Chromatography, Liquid; Cluster Analysis; Environmental Monitoring; Globus Pallidus / drug effects; Globus Pallidus / metabolism; Inhalation Exposure; Macaca mulatta; Male; Manganese Compounds / blood; Manganese Compounds / urine; Metabolomics / methods; Principal Component Analysis; Sulfates / blood; Sulfates / toxicity; Sulfates / urine; Tandem Mass Spectrometry
TL;DR:
Biochemical changes identified in manganese-exposed monkeys included endpoints relate to oxidative stress and neurotransmission (aminobutyrate, glutamine, phenylalanine), and 27 metabolites with statistically significant expression differences were structurally confirmed by MS-MS methods.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Nasal uptake of inhaled acrolein in rats
INHALATION TOXICOLOGY, 20(3), 217–225.
MeSH headings : Acrolein / pharmacokinetics; Air Pollutants / pharmacokinetics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione / metabolism; Inhalation Exposure; Lung / metabolism; Male; Nasal Cavity / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / metabolism
TL;DR:
Acrolein UE in naive animals was dependent on the concentration of inspired acrolein, airflow rate, and duration of exposure, with increased UE occurring with lower ac rolein exposure concentrations, and a statistically significant decline in UE occurred during the exposures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Respiratory tract responses in male rats following subchronic acrolein inhalation
INHALATION TOXICOLOGY, 20(3), 205–216.
MeSH headings : Acrolein / toxicity; Air Pollutants / toxicity; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Mucosa / drug effects; Nasal Mucosa / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Rats; Rats, Inbred F344; Respiratory System / drug effects; Respiratory System / pathology; Rhinitis / chemically induced; Rhinitis / pathology; Turbinates / drug effects; Turbinates / pathology
TL;DR:
Acrolein exposure was associated with inflammation, hyperplasia, and squamous metaplasia of the respiratory epithelium, and the lateral wall was amongst the most sensitive locations for these responses and increased respiratory epithelial cell proliferation occurred following 4 to 30 days of exposure to ≥ 0.6 ppm acrolein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018