Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles
Di, J., Yu, J., Ye, Y., Ranson, D., Jindal, A., & Gu, Z. (2015, May 26). Cellular and Molecular Bioengineering.
author keywords: Insulin delivery; Diabetes; Glucose responsive; Bio-inspired; Hyaluronic acid; Dextran
topics (OpenAlex): Pancreatic function and diabetes; Diabetes Management and Research; Advanced Drug Delivery Systems
TL;DR:
In vitro studies demonstrated that the insulin release rate associated with HA microgels was effectively regulated by changes in the glucose concentration, and validated that a single injection of the developed formulation stabilized the blood glucose levels in the normoglycemic state for over 1 week.
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