Yanqi Ye

Works (24)

Updated: March 4th, 2026 20:04

2020 article

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., … Gu, Z. (2020, February 3). Nature Biomedical Engineering.

By: J. Yu n, J. Wang n, Y. Zhang n, G. Chen n, W. Mao *, Y. Ye n, A. Kahkoska *, J. Buse *, R. Langer *, Z. Gu n

MeSH headings : Animals; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Disease Models, Animal; Drug Delivery Systems; Humans; Insulin / pharmacology; Insulin Secretion / drug effects; Male; Mice, Inbred C57BL; Needles; Swine; Swine, Miniature; Transdermal Patch
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Advanced Drug Delivery Systems; Lipid Membrane Structure and Behavior
TL;DR: It is shown that a single removable transdermal patch, bearing microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix, and fabricated via in situ photopolymerization, regulated blood glucose in insulin-deficient diabetic mice and minipigs. (via Semantic Scholar)
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Source: Web Of Science
Added: February 17, 2020

2019 journal article

Extraction of Plant DNA by Microneedle Patch for Rapid Detection of Plant Diseases

ACS Nano, 13(6), 6540–6549.

By: R. Paul n, A. Saville n , J. Hansel n, Y. Ye n, C. Ball n, A. Williams  n, X. Chang*, G. Chen n ...

author keywords: plant disease; DNA extraction; microneedle patch; Phytophthora infestans; nucleic acid amplification; point-of-care diagnostics
MeSH headings : DNA Barcoding, Taxonomic / instrumentation; DNA Barcoding, Taxonomic / methods; DNA, Fungal / chemistry; DNA, Fungal / genetics; Solanum lycopersicum / microbiology; Metagenomics / instrumentation; Metagenomics / methods; Needles; Phytophthora / genetics; Phytophthora / pathogenicity; Plant Diseases / microbiology; Plant Leaves / chemistry; Plant Leaves / microbiology
topics (OpenAlex): Transgenic Plants and Applications; Plant tissue culture and regeneration; Plant Virus Research Studies
TL;DR: A simple, cell-lysis-free, and purification-free DNA extraction method that could be a transformative approach to facilitate rapid sample preparation for molecular diagnosis of various plant diseases directly in the field is developed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 15, 2019

2018 article

Cardiac cell–integrated microneedle patch for treating myocardial infarction

Tang, J., Wang, J., Huang, K., Ye, Y., Su, T., Qiao, L., … Cheng, K. (2018, November 2). Science Advances, Vol. 4.

By: J. Tang n, J. Wang*, K. Huang n , Y. Ye*, T. Su n, L. Qiao  n, M. Hensley n, T. Caranasos * ...

MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
topics (OpenAlex): Neuroscience and Neural Engineering; Advancements in Transdermal Drug Delivery; Nerve injury and regeneration
TL;DR: The microneedle patch integrated with cardiac stromal cells (MN-CSCs) represents an innovative approach delivering therapeutic cells for heart regeneration and polymeric MNs are used to create “channels” between host myocardium and therapeutic CSCs to promote heart repair. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018

2018 article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

Hu, Q., Sun, W., Wang, J., Ruan, H., Zhang, X., Ye, Y., … Gu, Z. (2018, October 17). Nature Biomedical Engineering.

By: Q. Hu n, W. Sun*, J. Wang n, H. Ruan  n, X. Zhang*, Y. Ye n, S. Shen *, C. Wang  n ...

MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
topics (OpenAlex): Hematopoietic Stem Cell Transplantation; Immune Cell Function and Interaction; CAR-T cell therapy research
TL;DR: It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 26, 2018

2018 article

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

Wang, C., Wang, J., Zhang, X., Yu, S., Wen, D., Hu, Q., … Gu, Z. (2018, February 21). Science Translational Medicine.

By: C. Wang  n, J. Wang n, X. Zhang n, S. Yu  n, D. Wen n, Q. Hu n, Y. Ye n, H. Bomba  n ...

MeSH headings : Animals; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine / analogs & derivatives; Deoxycytidine / therapeutic use; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Immunotherapy / methods; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / metabolism; Gemcitabine
topics (OpenAlex): Nanoplatforms for cancer theranostics; Immune cells in cancer; Nanoparticle-Based Drug Delivery
TL;DR: A ROS-responsive hydrogel scaffold controls release of gemcitabine and immune checkpoint inhibitor for enhanced antitumor activity and promotes an immune-mediated tumor regression in the tumor-bearing mice, with prevention of tumor recurrence after primary resection. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2018 article

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

Yan, J., Zhang, X., Liu, Y., Ye, Y., Yu, J., Chen, Q., … Gu, Z. (2018, December 13). Nano Research.

By: J. Yan  n, X. Zhang n, Y. Liu n, Y. Ye n, J. Yu n, Q. Chen n, J. Wang n, Y. Zhang n ...

author keywords: liquid metal; melanin nanoparticles; nanomedicine; shape-controlled synthesis; photothermal therapy
topics (OpenAlex): Gold and Silver Nanoparticles Synthesis and Applications; Extracellular vesicles in disease; Quantum Dots Synthesis And Properties
TL;DR: Interestingly, shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of MNPs, and among these shapes, EGaIn nanorice has the best photothermal conversion efficiency, which could be leveraged for photothermal therapy. (via Semantic Scholar)
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Source: Web Of Science
Added: June 17, 2019

2018 article

Topical and Transdermal Nanomedicines for Cancer Therapy

Ye, Y., Wang, J., Sun, W., Bomba, H. N., & Gu, Z. (2018, November 12). Bioanalysis.

By: Y. Ye n, J. Wang n, W. Sun n, H. Bomba n & Z. Gu n

topics (OpenAlex): Advancements in Transdermal Drug Delivery; Nanoparticle-Based Drug Delivery; Advanced Drug Delivery Systems
TL;DR: This chapter summarizes the principles and the recent innovations in the field of transdermal nanomedicine together with opportunities and challenges in clinical translation. (via Semantic Scholar)
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Source: Web Of Science
Added: October 26, 2020

2017 article

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs

Wang, C., Sun, W., Ye, Y., Bomba, H. N., & Gu, Z. (2017, January 1). Theranostics.

By: C. Wang n, W. Sun n, Y. Ye n, H. Bomba  n & Z. Gu n

author keywords: artificial immune cells; lymphoid organs
MeSH headings : Animals; Antigen-Presenting Cells / immunology; Artificial Cells / chemistry; Artificial Cells / immunology; Biomimetic Materials / chemistry; Humans; Lymphoid Tissue / cytology; Lymphoid Tissue / immunology
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Monoclonal and Polyclonal Antibodies Research
TL;DR: This review surveys the latest studies on engineering biomimetic materials for immunotherapy, focusing on the perspectives of bioengineering artificial antigen presenting cells and lymphoid organs. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2017 article

Red Blood Cells for Glucose‐Responsive Insulin Delivery

Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., … Gu, Z. (2017, March 7). Advanced Materials.

By: C. Wang n, Y. Ye n, W. Sun n, J. Yu n, J. Wang n, D. Lawrence *, J. Buse *, Z. Gu n

MeSH headings : Erythrocytes; Glucose; Insulin
topics (OpenAlex): Erythrocyte Function and Pathophysiology; Pancreatic function and diabetes; Lipid Membrane Structure and Behavior
TL;DR: This work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast responsiveness and the binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of BG level in vivo. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 article

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Wang, C., Ye, Y., Hu, Q., Bellotti, A., & Gu, Z. (2017, May 26). Advanced Materials.

By: C. Wang n, Y. Ye n, Q. Hu n, A. Bellotti  n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; cell therapy; drug delivery
MeSH headings : Animals; Antigen-Presenting Cells / cytology; Antigen-Presenting Cells / metabolism; Antigens / genetics; Antigens / immunology; Antigens / metabolism; Biocompatible Materials / chemistry; Cell- and Tissue-Based Therapy; Humans; Immunologic Factors / metabolism; Immunologic Factors / therapeutic use; Immunotherapy; Nanostructures / chemistry; Neoplasms / therapy
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Nanoplatforms for cancer theranostics
TL;DR: An overview of the latest studies on engineering biomaterials for the enhancement of anticancer immunity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune‐modulating scaffolds. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

Nano Research, 10(4), 1393–1402.

By: J. Di n, J. Yu n, Q. Wang *, S. Yao  n, D. Suo  n, Y. Ye n, M. Pless n, Y. Zhu n , Y. Jing n, Z. Gu*

Contributors: J. Di n, J. Yu n, Q. Wang *, S. Yao  n, D. Suo  n, Y. Ye n, M. Pless n, Y. Zhu n , Y. Jing n, Z. Gu*

author keywords: controlled drug delivery; focused ultrasound; diabetes; nanocapsule; microgel
topics (OpenAlex): Diabetes Management and Research; Spectroscopy Techniques in Biomedical and Chemical Research; Advancements in Transdermal Drug Delivery
TL;DR: It is demonstrated that this ultrasound-triggered insulin delivery system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 article

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

Wang, C., Ye, Y., Hochu, G. M., Sadeghifar, H., & Gu, Z. (2016, March 21). Nano Letters.

By: C. Wang n, Y. Ye n, G. Hochu n, H. Sadeghifar  n & Z. Gu n

author keywords: Anti-PD-1; cancer immunotherapy; microneedle patch; melanoma; drug delivery
MeSH headings : Animals; Antibodies, Neoplasm / immunology; Antibodies, Neoplasm / pharmacology; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Immunotherapy / instrumentation; Immunotherapy / methods; Mice; Needles; Programmed Cell Death 1 Receptor / immunology; Skin Neoplasms / immunology; Skin Neoplasms / pathology; Skin Neoplasms / therapy
topics (OpenAlex): Immunotherapy and Immune Responses; Advancements in Transdermal Drug Delivery; Monoclonal and Polyclonal Antibodies Research
TL;DR: It is found that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Internalized compartments encapsulated nanogels for targeted drug delivery

Yu, J., Zhang, Y., Sun, W., Wang, C., Ranson, D., Ye, Y., … Gu, Z. (2016, January 1). Nanoscale.

By: J. Yu n, Y. Zhang n, W. Sun n, C. Wang n, D. Ranson n, Y. Ye n, Y. Weng *, Z. Gu n

MeSH headings : Doxorubicin / administration & dosage; Drug Delivery Systems; Ferrous Compounds; Hyaluronic Acid; Nanoparticles; Silicon Dioxide
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics; Polymer Surface Interaction Studies
TL;DR: This study illustrates the potential of utilizing an internalized compartments encapsulated formulation for targeted cancer therapy, and offers guidelines for developing a natural particulate-inspired drug delivery system. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Investigation and intervention of autophagy to guide cancer treatment with nanogels

Zhang, X., Liang, X., Gu, J., Chang, D., Zhang, J., Chen, Z., … Gu, Z. (2016, November 14). Nanoscale.

By: X. Zhang n, X. Liang *, J. Gu *, D. Chang*, J. Zhang*, Z. Chen n, Y. Ye n, C. Wang n ...

MeSH headings : Animals; Autophagy; Chloroquine / administration & dosage; Doxorubicin / administration & dosage; Drug Delivery Systems; Endocytosis; Endosomes; Exocytosis; Female; Gels; Humans; MCF-7 Cells; Mice; Mice, SCID; Nanoparticles; Neoplasms, Experimental / drug therapy; Rhodamines; Xenograft Model Antitumor Assays; rab GTP-Binding Proteins / metabolism
topics (OpenAlex): Autophagy in Disease and Therapy; Calcium signaling and nucleotide metabolism; Cellular transport and secretion
TL;DR: Investigation and intervention of the autophagy pathway could provide a new method to improve the therapeutic effect of anticancer nanogels and be sequestered in autophagosomes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Local delivery of checkpoints antibodies

Wang, C., Ye, Y., & Gu, Z. (2016, September 26). Human Vaccines & Immunotherapeutics.

By: C. Wang n, Y. Ye n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; drug delivery; immune checkpoint inhibitors; microneedle
MeSH headings : Antibodies / administration & dosage; Biomedical Research / trends; Humans; Immunologic Factors / administration & dosage; Immunotherapy / methods; Molecular Targeted Therapy / methods; Neoplasms / immunology; Neoplasms / therapy
topics (OpenAlex): Immunotherapy and Immune Responses; Cancer Immunotherapy and Biomarkers; CAR-T cell therapy research
TL;DR: Recent efforts utilizing immunoengineering for local delivery of these immune checkpoint antibodies are introduced in the field of cancer immunotherapy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery

Advanced Materials, 28(16), 3115–3121.

By: Y. Ye n, J. Yu n, C. Wang n, N. Nguyen n, G. Walker n, J. Buse *, Z. Gu n

MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Experimental / pathology; Insulin / metabolism; Insulin Secretion; Islets of Langerhans / metabolism; Mice; Needles; Time Factors
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Lipid Membrane Structure and Behavior; Protein Interaction Studies and Fluorescence Analysis
TL;DR: An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation that can quickly reduce the blood-sugar levels of chemically induced type-1 diabetic mice. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 article

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

Shi, D., Xu, X., Ye, Y., Song, K., Cheng, Y., Di, J., … Gu, Z. (2016, January 12). ACS Nano.

By: D. Shi *, X. Xu *, Y. Ye n, K. Song *, Y. Cheng, J. Di n, Q. Hu n, J. Li ...

author keywords: drug delivery; tissue engineering; hydrogel; regenerative medicine; nanoparticles
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Proteoglycans and glycosaminoglycans research; Silk-based biomaterials and applications
TL;DR: The effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology makes the chondrogenesis efficient and persistent. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

Ye, Y., Wang, J., Hu, Q., Hochu, G. M., Xin, H., Wang, C., & Gu, Z. (2016, September 6). ACS Nano.

By: Y. Ye n, J. Wang n, Q. Hu  n, G. Hochu n, H. Xin n, C. Wang n, Z. Gu n

author keywords: drug delivery; immunotherapy; anti-PD1; IDO; microneedle
MeSH headings : Animals; Cell Cycle Checkpoints / drug effects; Drug Delivery Systems; Immunosuppression Therapy; Immunotherapy / methods; Indoleamine-Pyrrole 2,3,-Dioxygenase / therapeutic use; Melanoma / therapy; Programmed Cell Death 1 Receptor / therapeutic use; Skin Neoplasms / therapy; Tumor Microenvironment
topics (OpenAlex): Immunotherapy and Immune Responses; Advancements in Transdermal Drug Delivery; Cancer Immunotherapy and Biomarkers
TL;DR: This synergistic immunotherapy strategy locally targets the immunoinhibitory receptor programmed cell death protein 1 (PD1) and immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) for the treatment of melanoma through a microneedle-based transcutaneous delivery approach and achieves potent antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

Hu, Q., Sun, W., Lu, Y., Bomba, H. N., Ye, Y., Jiang, T., … Gu, Z. (2016, January 19). Nano Letters.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang *, A. Isaacson *, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
topics (OpenAlex): Nanoplatforms for cancer theranostics; Nanoparticle-Based Drug Delivery; RNA Interference and Gene Delivery
TL;DR: Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Versatile protein nanogels prepared by in situ polymerization

Macromolecular Chemistry and Physics, 213(3), 333–343.

By: Y. Ye, J. Yu & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2015 article

Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles

Di, J., Yu, J., Ye, Y., Ranson, D., Jindal, A., & Gu, Z. (2015, May 26). Cellular and Molecular Bioengineering.

By: J. Di n, J. Yu n, Y. Ye n, D. Ranson n, A. Jindal n & Z. Gu n

author keywords: Insulin delivery; Diabetes; Glucose responsive; Bio-inspired; Hyaluronic acid; Dextran
topics (OpenAlex): Pancreatic function and diabetes; Diabetes Management and Research; Advanced Drug Delivery Systems
TL;DR: In vitro studies demonstrated that the insulin release rate associated with HA microgels was effectively regulated by changes in the glucose concentration, and validated that a single injection of the developed formulation stabilized the blood glucose levels in the normoglycemic state for over 1 week. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 article

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

Yu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., … Gu, Z. (2015, June 22). Proceedings of the National Academy of Sciences.

By: J. Yu n, Y. Zhang n, Y. Ye n, R. DiSanto n, W. Sun n, D. Ranson n, F. Ligler n, J. Buse *, Z. Gu n

author keywords: diabetes; drug delivery; glucose-responsive; hypoxia-sensitive; microneedle
MeSH headings : Animals; Blood Glucose / analysis; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Glucose / metabolism; Glucose Oxidase / metabolism; Humans; Hyaluronic Acid / chemistry; Hyaluronic Acid / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Hypoxia / metabolism; Insulin / administration & dosage; Insulin / chemistry; Insulin / metabolism; Male; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Molecular Structure; Oxidation-Reduction; Reproducibility of Results
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Advanced Drug Delivery Systems; Lipid Membrane Structure and Behavior
TL;DR: The “smart insulin patch” with a new enzyme-based glucose-responsive mechanism can regulate the blood glucose of type 1 diabetic mice to achieve normal levels, with faster responsiveness compared with the commonly used pH-sensitive formulations, and can avoid the risk of hypoglycemia. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 article

Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots

Di, J., Yao, S., Ye, Y., Cui, Z., Yu, J., Ghosh, T. K., … Gu, Z. (2015, August 10). ACS Nano, Vol. 9, pp. 9407–9415.

By: J. Di n, S. Yao n, Y. Ye n, Z. Cui n, J. Yu n, T. Ghosh n , Y. Zhu n , Z. Gu n

Contributors: J. Di n, S. Yao n, Y. Ye n, Z. Cui n, J. Yu n, T. Ghosh n , Y. Zhu n , Z. Gu n

author keywords: drug delivery; wearable devices; stimuli-responsive; nanoparticles; microdepots
MeSH headings : Animals; Drug Delivery Systems; Drug Liberation; Elastomers / chemistry; Elastomers / pharmacology; Mice; Nanoparticles / chemistry; Polymers / chemistry; Polymers / pharmacology
topics (OpenAlex): Advanced Sensor and Energy Harvesting Materials; Advancements in Transdermal Drug Delivery; Hydrogels: synthesis, properties, applications
TL;DR: This work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Versatile Protein Nanogels Prepared by In Situ Polymerization

Ye, Y., Yu, J., & Gu, Z. (2015, October 27). Macromolecular Chemistry and Physics.

By: Y. Ye n, J. Yu n & Z. Gu n

author keywords: drug delivery; in situ polymerization; nanogels; protein; stimuli-responsive
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Glycosylation and Glycoproteins Research; Graphene and Nanomaterials Applications
TL;DR: Allowing a range of stimuli-responsive formulations for on-demand release, in a spatial, temporal, and dosagecontrolled manner, is highlighted and future opportunities as well as challenges of protein nanogels are discussed. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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