Garrett Hayes Wheaton

Works (6)

Updated: April 24th, 2025 02:32

2018 article

Extremely Thermoacidophilic Metallosphaera Species Mediate Mobilization and Oxidation of Vanadium and Molybdenum Oxides

Wheaton, G. H., Vitko, N. P., Counts, J. A., Dulkis, J. A., Podolsky, I., Mukherjee, A., & Kelly, R. M. (2018, December 18). Applied and Environmental Microbiology, Vol. 85.

By: G. Wheaton n, N. Vitko n, J. Counts n, J. Dulkis n, I. Podolsky n, A. Mukherjee n, R. Kelly n 

author keywords: Metallosphaera; biomining; extreme thermoacidophily; metal biooxidation; molybdenum; vanadium
MeSH headings : Archaeal Proteins / genetics; Copper / metabolism; Ferric Compounds / metabolism; Gene Expression Profiling; Genome, Archaeal; Hot Temperature; Hydrogen-Ion Concentration; Molybdenum / metabolism; Oxidation-Reduction; Oxides / metabolism; Oxygen; Sulfolobaceae / genetics; Sulfolobaceae / metabolism; Sulfur Compounds / metabolism; Transcriptome; Uranium / metabolism; Vanadium / metabolism
topics (OpenAlex): Metal Extraction and Bioleaching; Extraction and Separation Processes; Radioactive element chemistry and processing
TL;DR: Results suggest that direct oxidation of V and Mo occurs, in addition to Fe-mediated oxidation, such that both direct and indirect mechanisms are involved in the mobilization of redox-active metals by Metallosphaera species. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 11, 2019

2017 article

VapC toxins drive cellular dormancy under uranium stress for the extreme thermoacidophile Metallosphaera prunae

Mukherjee, A., Wheaton, G. H., Counts, J. A., Ijeomah, B., Desai, J., & Kelly, R. M. (2017, June 6). Environmental Microbiology, Vol. 19, pp. 2831–2842.

By: A. Mukherjee n, G. Wheaton n, J. Counts n, B. Ijeomah n, J. Desai n & R. Kelly n 

MeSH headings : Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / metabolism; Gene Expression Regulation, Bacterial / physiology; RNA Stability / physiology; Sulfolobaceae / genetics; Sulfolobaceae / growth & development; Sulfolobaceae / metabolism; Transcriptome; Uranium / metabolism
topics (OpenAlex): Radioactive element chemistry and processing; Metal Extraction and Bioleaching; Trace Elements in Health
TL;DR: M. prunae utilizes VapC toxins for post-transcriptional regulation under uranium stress to enter a cellular dormant state, thereby providing an adaptive response to what would otherwise be a deleterious environmental perturbation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

Transcriptomes of the Extremely Thermoacidophilic Archaeon Metallosphaera sedula Exposed to Metal “Shock” Reveal Generic and Specific Metal Responses

Wheaton, G. H., Mukherjee, A., & Kelly, R. M. (2016, May 23). Applied and Environmental Microbiology, Vol. 82, pp. 4613–4627.

By: G. Wheaton n, A. Mukherjee n & R. Kelly n 

MeSH headings : Acids / metabolism; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Genome, Archaeal; Hot Temperature; Metals / metabolism; Open Reading Frames; Sulfolobaceae / genetics; Sulfolobaceae / isolation & purification; Sulfolobaceae / metabolism; Transcriptome
topics (OpenAlex): Metal Extraction and Bioleaching; Extraction and Separation Processes; Corrosion Behavior and Inhibition
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

The Confluence of Heavy Metal Biooxidation and Heavy Metal Resistance: Implications for Bioleaching by Extreme Thermoacidophiles

Wheaton, G., Counts, J., Mukherjee, A., Kruh, J., & Kelly, R. (2015, July 7). Minerals, Vol. 5, pp. 397–451.

By: G. Wheaton n, J. Counts n, A. Mukherjee n, J. Kruh n & R. Kelly n 

author keywords: extreme thermoacidophiles; bioleaching; heavy metal resistance; heavy metal biooxidation; archaea
topics (OpenAlex): Metal Extraction and Bioleaching; Extraction and Separation Processes; Radioactive element chemistry and processing
TL;DR: Here, extreme thermoacidophiles are examined from the perspectives of biodiversity, heavy metal biooxidation, metal resistance mechanisms, microbe-solid interactions, and application of these archaea in biomining operations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Role of an Archaeal PitA Transporter in the Copper and Arsenic Resistance of Metallosphaera sedula, an Extreme Thermoacidophile

McCarthy, S., Ai, C., Wheaton, G., Tevatia, R., Eckrich, V., Kelly, R., & Blum, P. (2014, August 4). Journal of Bacteriology, Vol. 196, pp. 3562–3570.

By: S. McCarthy, C. Ai, G. Wheaton n, R. Tevatia, V. Eckrich, R. Kelly n , P. Blum

MeSH headings : Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Arsenic / metabolism; Arsenic / toxicity; Biological Transport; Copper / metabolism; Copper / toxicity; Gene Expression Regulation, Archaeal / physiology; Genome, Archaeal; Molecular Sequence Data; Sulfolobaceae / drug effects; Sulfolobaceae / metabolism
topics (OpenAlex): Metal Extraction and Bioleaching; Trace Elements in Health; Arsenic contamination and mitigation
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Uranium extremophily is an adaptive, rather than intrinsic, feature for extremely thermoacidophilic Metallosphaera species

Mukherjee, A., Wheaton, G. H., Blum, P. H., & Kelly, R. M. (2012, September 25). Proceedings of the National Academy of Sciences, Vol. 109, pp. 16702–16707.

By: A. Mukherjee n, G. Wheaton n, P. Blum * & R. Kelly n 

author keywords: uranium oxidation; uranium resistance; chemolithotrophy; terminal oxidases
MeSH headings : Adaptation, Physiological / drug effects; Adaptation, Physiological / genetics; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Electrophoresis, Gel, Two-Dimensional; Environmental Pollutants / chemistry; Environmental Pollutants / toxicity; Gene Expression Regulation, Archaeal / drug effects; Mutation; RNA Stability / drug effects; RNA, Archaeal / genetics; RNA, Archaeal / metabolism; Species Specificity; Sulfolobaceae / classification; Sulfolobaceae / genetics; Sulfolobaceae / metabolism; Time Factors; Transcriptome / genetics; Uranium / chemistry; Uranium / toxicity
topics (OpenAlex): Radioactive element chemistry and processing; Metal Extraction and Bioleaching; Geochemistry and Elemental Analysis
TL;DR: The results point to uranium extremophily as an adaptive, rather than intrinsic, feature for Metallosphaera species, driven by environmental factors. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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