Works (23)
Updated: April 4th, 2024 16:31
2022 article
Decision-Making and the Shadowy Brain — Part 1
Lubischer, J. (2022, January 15). (Vol. 1). Vol. 1.
doi.org (repository)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: September 6, 2022
2022 article
Decision-Making and the Shadowy Brain — Part 2
Lubischer, J. (2022, January 15). (Vol. 1). Vol. 1.
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: September 6, 2022
2022 article
The Secret of Learning
Lubischer, J. (2022, July 27).
Source: ORCID
Added: September 6, 2022
2016 conference paper
The formation of student learning communities in a life science first year course. Parks LD and Lubischer JL
Experimental Biology.
Source: ORCID
Added: September 6, 2022
2015 conference paper
Critical and creative thinking in the life sciences (LSC 101): Equipping and challenging students to be intentional learners. Lubischer JL, Flores JF, Kuo H-C, Parks LD
Teaching and Learning Symposium, NC State.
Source: ORCID
Added: September 6, 2022
2015 conference paper
NC State Life Sciences First Year Program (LSFY): Administrative implementation of a holistic approach to first year student success.
Gordon Research Conference on Undergraduate Biology Education Research.
Source: ORCID
Added: September 6, 2022
2015 conference paper
The science of learning and the W-curve: Two impactful lessons for freshmen in the Life Sciences First Year Program. Flores JF, Kuo H-C, Parks LD, Lubischer JL
Teaching and Learning Symposium, NC State.
Source: ORCID
Added: September 6, 2022
2014 journal article
Close Encounters of the Amphibious Kind
Science and Children, 051(06).
Source: ORCID
Added: September 6, 2022
2010 journal article
Application of Low-Frequency Alternating Current Electric Fields Via Interdigitated Electrodes: Effects on Cellular Viability, Cytoplasmic Calcium, and Osteogenic Differentiation of Human Adipose-Derived Stem Cells
TISSUE ENGINEERING PART C-METHODS, 16(6), 1377–1386.
MeSH headings : Adipose Tissue / cytology; Adult Stem Cells / cytology; Adult Stem Cells / metabolism; Adult Stem Cells / physiology; Calcium / metabolism; Cell Differentiation / physiology; Cell Proliferation; Cell Survival / physiology; Cells, Cultured; Cytoplasm / metabolism; Electric Stimulation / methods; Electricity; Electrodes; Humans; Osteoblasts / metabolism; Osteoblasts / physiology; Osteogenesis / physiology
TL;DR:
This is the first study to evaluate the effects of sinusoidal AC electric fields on hASCs and to demonstrate that acute and chronic electric field exposure can significantly increase intracellular calcium signaling and the deposition of accreted calcium under osteogenic stimulation, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function
JOURNAL OF NEUROSCIENCE, 28(1), 264–278.
author keywords: astrocyte; neuron; oligodendrocyte; GeneChip; Aldh1L1; culture; gene profiling; microarray; transcriptome; phagocytosis; astroglia; Megf10; Mertk; Draper; Mfge8
MeSH headings : Animals; Astrocytes / physiology; Brain / cytology; Brain / growth & development; Brain / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental / physiology; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Mice; Mice, Transgenic; Neurons / physiology; Oligodendroglia / physiology; Oligonucleotide Array Sequence Analysis / methods; Transcription, Genetic
TL;DR:
These findings call into question the concept of a “glial” cell class as the gene profiles of astrocyte and oligodendrocytes are as dissimilar to each other as they are to neurons, for better understanding of neural development, function, and disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat
JOURNAL OF NEUROCHEMISTRY, 94(1), 257–267.
author keywords: glutamate; muscle endplate; nitric oxide; N-methyl-D-aspartate receptor
MeSH headings : Acetylcholine / metabolism; Animals; Dipeptides / pharmacology; Extracellular Space / metabolism; Hydrolysis; In Vitro Techniques; Male; Motor Neurons / metabolism; NG-Nitroarginine Methyl Ester / pharmacology; Nerve Endings / metabolism; Neuromuscular Junction / metabolism; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / metabolism; Rats; Rats, Wistar; Synapses / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Reinnervation of the rat levator ani muscle after neonatal denervation
JOURNAL OF NEUROBIOLOGY, 63(3), 188–198.
author keywords: axotomy; motoneuronal death; denervation; motor unit; fatigability; maximum tetanic tension; development
MeSH headings : Age Factors; Animals; Animals, Newborn / physiology; Axotomy / methods; Male; Motor Neurons / physiology; Muscle Contraction / physiology; Muscle Denervation / methods; Muscle, Skeletal / innervation; Muscle, Skeletal / physiology; Rats; Rats, Sprague-Dawley
TL;DR:
The data suggest that motoneurons that survived injury on postnatal day 14 innervated more muscle fibers than normal and exhibited a similar ability to functionally reinnervate the target muscle as those motoneURons that survive injury on P21.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Fluorescent proteins expressed in mouse transgenic lines mark subsets of glia, neurons, macrophages, and dendritic cells for vital examination.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience.
author keywords: neuromuscular junction; Schwann cell; microglia; Langerhans cell; astrocyte; S100 beta; S100B; motor neuron; variegation; Bergmann glia
MeSH headings : Adipocytes / cytology; Animals; Cell Line; Dendritic Cells / cytology; Green Fluorescent Proteins / biosynthesis; Humans; Langerhans Cells / cytology; Lens, Crystalline / cytology; Luminescent Proteins / biosynthesis; Macrophages / cytology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Nerve Growth Factors; Neuroglia / cytology; Neuromuscular Junction / cytology; Neurons / cytology; Receptors, Cholinergic / analysis; Recombinant Fusion Proteins / biosynthesis; S100 Calcium Binding Protein beta Subunit; S100 Proteins / biosynthesis; S100 Proteins / genetics; Schwann Cells / chemistry; Schwann Cells / cytology; Schwann Cells / ultrastructure; Transgenes
TL;DR:
It is shown that lines with labeled macrophages can be used to follow the accumulation of these cells at sites of injury and suggests that Schwann cells at individual synapses are clonally related, a finding with implications for how these cells might be sorted during postnatal development.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2022
1999 journal article
Neonatal partial denervation results in nodal but not terminal sprouting and a decrease in efficacy of remaining neuromuscular junctions in rat soleus muscle.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience.
author keywords: Schwann cells; synapse elimination; NMJ; synaptic strength; development; motoneuron; curare
MeSH headings : Aging / physiology; Animals; Animals, Newborn / physiology; Denervation / methods; Electric Stimulation; Motor Neurons / physiology; Muscle Contraction / physiology; Muscle, Skeletal / innervation; Nerve Regeneration / physiology; Neuromuscular Junction / physiology; Rats; Rats, Inbred Strains; Schwann Cells / physiology; Synapses / physiology
TL;DR:
It was found that terminal (but not nodal) sprouting was absent in partially denervated neonatal muscles, which suggests that terminal Schwann cells, previously reported to guide terminal sprouts to denervate endplates in adult muscles, are necessary for the formation and growth of terminal sprouting.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2022
1999 journal article
Regulation of terminal Schwann cell number at the adult neuromuscular junction.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience.
author keywords: NMJ; SNB; motoneuron; steroid hormone; synaptic plasticity; perisynaptic Schwann cells
MeSH headings : Animals; Castration; Male; Motor Endplate / anatomy & histology; Motor Neurons / cytology; Motor Neurons / drug effects; Muscles / anatomy & histology; Muscles / drug effects; Neuroglia / cytology; Neuromuscular Junction / anatomy & histology; Rats; Rats, Sprague-Dawley; Schwann Cells / cytology; Testosterone / pharmacology
TL;DR:
The data suggest that TSC number is a dynamic property of the neuromuscular synapse that is actively regulated throughout life.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2022
1999 journal article
Respecified larval proleg and body wall muscles circulate hemolymph in developing wings of Manduca sexta pupae.
The Journal of Experimental Biology.
Source: ORCID
Added: September 6, 2022
1996 journal article
Target muscles and sensory afferents do not influence steroid-regulated, segment-specific death of identified motoneurons in Manduca sexta.
Journal of Neurobiology.
Source: ORCID
Added: September 6, 2022
1995 journal article
Axotomy of developing rat spinal motoneurons: cell survival, soma size, muscle recovery, and the influence of testosterone.
Journal of Neurobiology.
author keywords: SPINAL NUCLEUS OF THE BULBOCAVERNOSUS,; MOTONEURONAL DEVELOPMENT; ANDROGEN; SYNAPSE ELIMINATION; CELL DEATH
MeSH headings : Animals; Axons / drug effects; Axons / physiology; Cell Survival; Male; Motor Neurons / drug effects; Motor Neurons / physiology; Muscles / innervation; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Testosterone / pharmacology; Time Factors
TL;DR:
The inability of SNB motoneurons to recover from axonal injury from their developmental elimination of synaptic terminals was dissociated in time, which may reflect an increase in motor unit size, a decrease in polyneuronal innervation bySNB mot oneurons that survive axotomy on P14, or a combination of the two.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 6, 2022
1995 journal article
Axotomy transiently down-regulates androgen receptors in motoneurons of the spinal nucleus of the bulbocavernosus.
Brain Research.
author keywords: PG-21; IMMUNOHISTOCHEMISTRY; SNB; STEROID; TESTOSTERONE; SPINAL CORD
MeSH headings : Aging / metabolism; Animals; Animals, Newborn / growth & development; Animals, Newborn / metabolism; Autoradiography; Axons / physiology; Denervation; Down-Regulation; Immunohistochemistry; Male; Motor Neurons / metabolism; Nervous System Physiological Phenomena; Penis / innervation; Rats; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Spinal Cord / physiology; Time Factors
TL;DR:
Axotomy-induced down-regulation of androgen receptors does not underlie the inability of SNB motoneurons to respond to androgen treatment several months after pudendal nerve cut in development, and is interesting in light of reports that testosterone treatment can facilitate mot oneuronal regeneration after nerve cut.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 6, 2022
1995 journal article
Evidence for target regulation of the development of androgen sensitivity in rat spinal motoneurons.
Developmental Neuroscience.
author keywords: AXOTOMY; BC MUSCLE; LA MUSCLE; RETROGRADE INFLUENCE OF TARGET MUSCLE; SNB; SOMA SIZE; TESTOSTERONE
MeSH headings : Androgens / physiology; Animals; Axons / physiology; Male; Motor Neurons / physiology; Motor Neurons / ultrastructure; Muscle, Skeletal / innervation; Muscle, Skeletal / physiology; Organ Size / physiology; Rats; Rats, Sprague-Dawley; Spinal Cord / cytology; Spinal Cord / growth & development; Spinal Cord / physiology; Spinal Nerves / physiology; Testosterone / metabolism; Testosterone / physiology
TL;DR:
Separation from the target muscles during an early critical period in development blocked the differentiation of androgen sensitivity by SNB motoneurons, consistent with a role for the target in the normal development of steroid sensitivity by CNS neurons.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2022
1992 journal article
Transient and permanent effects of androgen during synapse elimination in the levator ani muscle of the rat.
Journal of Neurobiology.
author keywords: NEUROMUSCULAR JUNCTION; SYNAPSE ELIMINATION; TESTOSTERONE; LEVATOR ANI MUSCLE
MeSH headings : Aging / physiology; Androgens / pharmacology; Animals; Male; Muscles / drug effects; Muscles / innervation; Muscles / physiology; Neuromuscular Junction / drug effects; Orchiectomy; Rats; Rats, Inbred Strains; Staining and Labeling; Synapses / drug effects; Testosterone / pharmacology
TL;DR:
The present results indicate that the androgenic effect on synapse elimination is permanent, in that high levels of multiple innervation persisted for 12 months after the end of androgen treatment, and the effect on muscle fiber diameter was not maintained for this period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 6, 2022
1990 journal article
Autoradiographic localization of progestin-concentrating cells in the brain of the zebra finch.
The Journal of Comparative Neurology.
MeSH headings : Animals; Autoradiography; Birds / physiology; Brain / cytology; Brain Chemistry; Male; Neurons / analysis; Progestins / analysis; Vocalization, Animal / physiology
TL;DR:
The autoradiographic method was used to investigate the distribution of progestin‐concentrating cells in the brain of the adult male zebra finch (Poephila guttata) after injection of the radiolabeled synthetic progESTin [17α‐methyl‐3H]‐promegestone, and found areas of progestsin action in the avian central nervous system outside of the known song system.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2022
1987 journal article
The effects of D1 and D2 receptor antagonists on pain sensitivity and morphine analgesia in the rat.
Proceedings of the Western Pharmacology Society.
Source: ORCID
Added: September 6, 2022
Employment
Updated: February 28th, 2020 11:24
2001 - present
NC State University Raleigh, NC, US
Associate Department Head
Biological Sciences
2016 - 2020
NC State University Raleigh, NC, US
Founding Director, BA in Biology
Biological Sciences
2014 - 2019
NC State University Raleigh, NC, US
Founding Director, Life Sciences First Year Program
interdepartmental
1996 - 2001
University of Texas Austin, TX, US
Postdoctoral Research Associate
Neurobiology
1993 - 1996
University of Oregon Eugene, OR, US
Postdoctoral Research Associate
Neuroscience
Education
Updated: February 28th, 2020 11:10
University of California Los Angeles Los Angeles, CA, US
Ph.D.
Neuroscience
University of California Los Angeles Los Angeles, CA, US
M.A.
Psychology
Stanford University Stanford, CA, US
A.B.
Human Biology Program
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