Leo W. Parks

Works (9)

Updated: February 10th, 2025 16:10

2001 article

Identification of a UPC2 Homolog in Saccharomyces cerevisiae and Its Involvement in Aerobic Sterol Uptake

Shianna, K. V., Dotson, W. D., Tove, S., & Parks, L. W. (2001, February 1). Journal of Bacteriology.

By: K. Shianna n, W. Dotson n, S. Tove n & L. Parks n

MeSH headings : Amino Acid Sequence; Biological Transport; Fungal Proteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional; Point Mutation; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sterols / metabolism; Trans-Activators / genetics
topics (OpenAlex): Fungal and yeast genetics research; Microbial Metabolic Engineering and Bioproduction; Plant biochemistry and biosynthesis
TL;DR: Gas chromatographic analysis of the nonsaponifiable fractions of the various strains showed that the major sterol for all YLR228c and UPC2 combinations was ergosterol, the consensus yeast sterol. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2000 article

Biochemical modifications and transcriptional alterations attendant to sterol feeding in Phytophthora parasitica

Dotson, W. D., Tove, S. R., & Parks, L. W. (2000, March 1). Lipids.

By: W. Dotson n, S. Tove n & L. Parks n

MeSH headings : Biotransformation; Oxidoreductases / metabolism; Oxidoreductases Acting on CH-CH Group Donors; Phytophthora / genetics; Phytophthora / metabolism; Phytophthora / physiology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Spores, Fungal / physiology; Sterols / metabolism; Substrate Specificity
topics (OpenAlex): Photosynthetic Processes and Mechanisms; Genomics, phytochemicals, and oxidative stress; Microbial Metabolic Engineering and Bioproduction
TL;DR: Characterization of sterol-related metabolic effects and sterol functions in Phytophthora should lead to improved measures for control of this important group of plant pathogens. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 article

Dual physiological effects of antifungal sterol biosynthetic inhibitors on enzyme targets and on transcriptional regulation

Crowley, J. H., & Parks, L. W. (1999, April 1). Pesticide Science.

By: J. Crowley n & L. Parks n

topics (OpenAlex): Fungal Biology and Applications; Phytochemical compounds biological activities
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Source: NC State University Libraries
Added: August 6, 2018

1999 article

In Yeast, upc2-1 Confers a Decrease in Tolerance to LiCl and NaCl, Which Can Be Suppressed by the P-Type ATPase Encoded by ENA2

Leak, F. W., Tove, S., & Parks, L. W. (1999, February 1). DNA and Cell Biology.

By: F. Leak n, S. Tove* & L. Parks*

MeSH headings : Adenosine Triphosphatases / genetics; Cholesterol / pharmacokinetics; Dose-Response Relationship, Drug; Genes, Fungal / genetics; Genetic Complementation Test; Lithium Chloride / pharmacology; Mutation; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins; Sodium Chloride / pharmacology; Sterols / pharmacokinetics; Trans-Activators / genetics
topics (OpenAlex): Fungal and yeast genetics research; Microbial Metabolic Engineering and Bioproduction; Plant biochemistry and biosynthesis
TL;DR: Wild-type yeast cells are unable to take up sterols from their growth media under aerobic conditions and are relatively resistant to monovalent cations, but a yeast mutant with a defect in the aerobic exclusion of sterols was found to have increased sensitivity to LiCl and NaCl. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 article

A calcium-dependent ergosterol mutant of Saccharomyces cerevisiae

Crowley, J. H., Tove, S., & Parks, L. W. (1998, August 1). Current Genetics.

By: J. Crowley n, S. Tove n & L. Parks n

author keywords: ergosterol; antifungal; calcium; fenpropimorph; azole; ERG24 gene
MeSH headings : Antifungal Agents / pharmacology; Calcium / metabolism; Calcium / pharmacology; Culture Media; Ergosterol / analogs & derivatives; Ergosterol / biosynthesis; Ergosterol / genetics; Ergosterol / metabolism; Genes, Fungal; Morpholines / pharmacology; Mutation; Oxidoreductases / genetics; Oxidoreductases / metabolism; Phenotype; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism
topics (OpenAlex): Fungal Plant Pathogen Control; Molecular Junctions and Nanostructures; Entomopathogenic Microorganisms in Pest Control
TL;DR: A novel calcium-dependent phenotype associated with alterations in the ergosterol biosynthetic pathway in yeast is described and reduction of yeast growth with an azole inhibitor of the C-14 sterol de-methylase was also modulated by an excess of calcium ions in the culture medium. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 journal article

A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae

Journal of Bacteriology, 180(16), 4177–4183.

By: J. Crowley, F. Leak, K. Shianna, S. Tove & L. Parks

Source: NC State University Libraries
Added: August 6, 2018

1997 article

A Conditional Sterol Esterification Defect in Yeast having either asec1 orsec5 Mutation in the Secretory Pathway

TOMEO, M. E., PALERMO, L. M., TOVE, S., & PARKS, L. W. (1997, April 1). Yeast.

By: M. Tomeo n, L. Palermo n, S. Tove n & L. Parks n

topics (OpenAlex): Cellular transport and secretion; Plant Reproductive Biology; Fungal and yeast genetics research
TL;DR: Two temperature‐conditional secretory mutations, sec1 and sec5, cause the accumulation of post‐Golgi vesicles when strains containing these mutations are grown at 37°C, and double mutants containing sec6, sec14 or sec18 with either a sec1 or sec5 mutation have normal esterification levels. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1997 article

Assessment of the essentiality of ERG genes late in ergosterol biosynthesis in Saccharomyces cerevisiae

Palermo, L. M., Leak, F. W., Tove, S., & Parks, L. W. (1997, September 1). Current Genetics.

By: L. Palermo n, F. Leak n, S. Tove n & L. Parks n

author keywords: ergosterol; ERG genes; yeast; Saccharomyces
MeSH headings : 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases / genetics; Ergosterol / biosynthesis; Genes, Fungal; Methyltransferases / genetics; Mutation; Oxidoreductases / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / growth & development; Saccharomyces cerevisiae / metabolism; Selection, Genetic
topics (OpenAlex): Plant biochemistry and biosynthesis; Fungal and yeast genetics research; Biochemical and biochemical processes
TL;DR: A general trend was seen in which the earlier in the biosynthetic pathway that a mutation occurred, the less able the strain producing the defective sterols could compete with the ergosterol-producing strains. (via Semantic Scholar)
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1997 article

Requirement of heme to replace the sparking sterol function in the yeast Saccharomyces cerevisiae

Smith, S. J., & Parks, L. W. (1997, March 1). Biochimica Et Biophysica Acta (BBA) - Lipids and Lipid Metabolism.

By: S. Smith & L. Parks n

author keywords: Delta(5)-sterol; heme auxotrophy; sparking sterol; ergosterol; (Saccharomyces cerevisiae)
MeSH headings : Aminolevulinic Acid / metabolism; Ergosterol / metabolism; Heme / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / growth & development; Sterols / biosynthesis
topics (OpenAlex): Fungal and yeast genetics research; Photosynthetic Processes and Mechanisms; Metalloenzymes and iron-sulfur proteins
TL;DR: It is demonstrated here that heme, and not a heme precursor, can replace the delta 5-sparking sterol requirement of heme auxotrophic strains of yeast. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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