Margaret Maria Reiff

Works (1)

Updated: July 5th, 2023 15:41

2014 journal article

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(42), 14722–14725.

By: W. Sun*, T. Jiang*, Y. Lu*, M. Reiff*, R. Mo* & Z. Gu*

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; DNA / chemistry; DNA / metabolism; Deoxyribonucleases / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Liberation; Humans; MCF-7 Cells; Models, Molecular; Molecular Conformation; Nanoparticles / chemistry
TL;DR: In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy. (via Semantic Scholar)
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