Works (1)
Updated: July 5th, 2023 15:41
2014 journal article
Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(42), 14722–14725.
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; DNA / chemistry; DNA / metabolism; Deoxyribonucleases / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Liberation; Humans; MCF-7 Cells; Models, Molecular; Molecular Conformation; Nanoparticles / chemistry
TL;DR:
In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy.
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doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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