Works (5)
Updated: July 5th, 2023 15:46
2016 journal article
Ancillary contributions of heterologous biotin protein ligase and carbonic anhydrase for CO2 incorporation into 3-hydroxypropionate by metabolically engineered Pyrococcus furiosus
Biotechnology and Bioengineering, 113(12), 2652–2660.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO2 fixation cycle in extremely thermoacidophilic archaea
METABOLIC ENGINEERING, 38, 446–463.
author keywords: CO2 fixation; 3-hydroxypropionate; 4-hydroxybutyrate; Metallosphaera sedula
MeSH headings : Archaea / metabolism; Carbon Dioxide / metabolism; Extremophiles / metabolism; Hydroxybutyrates / metabolism; Kinetics; Lactic Acid / analogs & derivatives; Lactic Acid / metabolism; Metabolic Clearance Rate; Metabolic Flux Analysis / methods; Metabolic Networks and Pathways / physiology; Models, Biological; Signal Transduction / physiology; Sulfolobaceae / metabolism
TL;DR:
A reaction kinetics model was developed to examine the biological and biotechnological attributes of the 3HP/4HB cycle as it operates in Metallosphaera sedula and assess metabolic engineering strategies for incorporating CO2 into chemical intermediates and products of bioteschnological importance: acetyl-CoA, succinate, and 3-hydroxypropionate.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert (S)-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(17), 6194–6202.
MeSH headings : Acyl Coenzyme A / metabolism; Autotrophic Processes; Biotransformation; Carbon Dioxide / metabolism; Cobamides / metabolism; Escherichia coli / genetics; Gene Expression; Gene Expression Profiling; Heterotrophic Processes; Hydroxybutyrates / metabolism; Methylmalonyl-CoA Mutase / chemistry; Methylmalonyl-CoA Mutase / genetics; Methylmalonyl-CoA Mutase / metabolism; Protein Multimerization; Racemases and Epimerases / chemistry; Racemases and Epimerases / genetics; Racemases and Epimerases / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sulfolobaceae / enzymology; Sulfolobaceae / genetics; Sulfolobaceae / metabolism
TL;DR:
Based on the highly conserved occurrence of single copies of MCE and MCM in Sulfolobaceae genomes, the M. sedula enzymes are likely to be representatives of these enzymes in the 3-HP/4-HB cycle in crenarchaeal thermoacidophiles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Role of 4-Hydroxybutyrate-CoA Synthetase in the CO2 Fixation Cycle in Thermoacidophilic Archaea
JOURNAL OF BIOLOGICAL CHEMISTRY, 288(6), 4012–4022.
MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Carbon Dioxide / metabolism; Catalysis; Catalytic Domain; Coenzyme A-Transferases / chemistry; Coenzyme A-Transferases / genetics; Coenzyme A-Transferases / metabolism; Genome, Archaeal / physiology; Hydroxybutyrates / chemistry; Hydroxybutyrates / metabolism; Sulfolobaceae / enzymology; Sulfolobaceae / genetics
TL;DR:
Transcriptomic analysis of cells grown under strict H2-CO2 autotrophy was consistent with the involvement of Msed_0406 and Msed-0394, and the identification of the 4-HB CoA synthetase now completes the set of enzymes comprising the 3HP/4HB cycle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Extremely Thermophilic Routes to Microbial Electrofuels
ACS CATALYSIS, 1(9), 1043–1050.
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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