Works (5)

Updated: July 5th, 2023 15:46

2016 journal article

Ancillary contributions of heterologous biotin protein ligase and carbonic anhydrase for CO2 incorporation into 3-hydroxypropionate by metabolically engineered Pyrococcus furiosus

Biotechnology and Bioengineering, 113(12), 2652–2660.

By: H. Lian, B. Zeldes, G. Lipscomb, A. Hawkins, Y. Han, A. Loder, D. Nishiyama, M. Adams, R. Kelly

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO2 fixation cycle in extremely thermoacidophilic archaea


By: A. Loder n, Y. Han n, A. Hawkins n, H. Lian n, G. Lipscomb*, G. Schut*, M. Keller*, M. Adams*, R. Kelly n

author keywords: CO2 fixation; 3-hydroxypropionate; 4-hydroxybutyrate; Metallosphaera sedula
MeSH headings : Archaea / metabolism; Carbon Dioxide / metabolism; Extremophiles / metabolism; Hydroxybutyrates / metabolism; Kinetics; Lactic Acid / analogs & derivatives; Lactic Acid / metabolism; Metabolic Clearance Rate; Metabolic Flux Analysis / methods; Metabolic Networks and Pathways / physiology; Models, Biological; Signal Transduction / physiology; Sulfolobaceae / metabolism
TL;DR: A reaction kinetics model was developed to examine the biological and biotechnological attributes of the 3HP/4HB cycle as it operates in Metallosphaera sedula and assess metabolic engineering strategies for incorporating CO2 into chemical intermediates and products of bioteschnological importance: acetyl-CoA, succinate, and 3-hydroxypropionate. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Role of 4-Hydroxybutyrate-CoA Synthetase in the CO2 Fixation Cycle in Thermoacidophilic Archaea


By: A. Hawkins n, Y. Han n, R. Bennett n, M. Adams* & R. Kelly n

MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Carbon Dioxide / metabolism; Catalysis; Catalytic Domain; Coenzyme A-Transferases / chemistry; Coenzyme A-Transferases / genetics; Coenzyme A-Transferases / metabolism; Genome, Archaeal / physiology; Hydroxybutyrates / chemistry; Hydroxybutyrates / metabolism; Sulfolobaceae / enzymology; Sulfolobaceae / genetics
TL;DR: Transcriptomic analysis of cells grown under strict H2-CO2 autotrophy was consistent with the involvement of Msed_0406 and Msed-0394, and the identification of the 4-HB CoA synthetase now completes the set of enzymes comprising the 3HP/4HB cycle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert (S)-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle


By: Y. Han n, A. Hawkins n, M. Adams* & R. Kelly n

MeSH headings : Acyl Coenzyme A / metabolism; Autotrophic Processes; Biotransformation; Carbon Dioxide / metabolism; Cobamides / metabolism; Escherichia coli / genetics; Gene Expression; Gene Expression Profiling; Heterotrophic Processes; Hydroxybutyrates / metabolism; Methylmalonyl-CoA Mutase / chemistry; Methylmalonyl-CoA Mutase / genetics; Methylmalonyl-CoA Mutase / metabolism; Protein Multimerization; Racemases and Epimerases / chemistry; Racemases and Epimerases / genetics; Racemases and Epimerases / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sulfolobaceae / enzymology; Sulfolobaceae / genetics; Sulfolobaceae / metabolism
TL;DR: Based on the highly conserved occurrence of single copies of MCE and MCM in Sulfolobaceae genomes, the M. sedula enzymes are likely to be representatives of these enzymes in the 3-HP/4-HB cycle in crenarchaeal thermoacidophiles. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Extremely Thermophilic Routes to Microbial Electrofuels

ACS CATALYSIS, 1(9), 1043–1050.

By: A. Hawkins n, Y. Han n, H. Lian n, A. Loder n, A. Menon*, I. Iwuchukwu*, M. Keller*, T. Leuko*, M. Adams*, R. Kelly n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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