Yosuke Sakamachi

Works (5)

Updated: July 21st, 2025 14:37

2025 article

TAK1 inhibition activates pore-forming proteins to block intracellular bacterial growth through modulating mitochondria

López-Pérez, W., González-Calderón, R. E., Sai, K., Rai, P., MacStudy, J. M., Sakamachi, Y., … Ninomiya-Tsuji, J. (2025, June 18). Cell Death and Disease, Vol. 16.

By: W. López-Pérez  n, R. González-Calderón n, K. Sai n, P. Rai *, J. MacStudy n, Y. Sakamachi n, C. Parsons n, S. Kathariou n, M. Fessler *, J. Ninomiya-Tsuji* 

MeSH headings : MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / genetics; Mitochondria / metabolism; Mitochondria / drug effects; Reactive Oxygen Species / metabolism; Humans; Animals; Mice; Apoptosis; Necroptosis; Pyroptosis; Signal Transduction
topics (OpenAlex): Inflammasome and immune disorders; Cell death mechanisms and regulation
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 18, 2025

2021 article

TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization

López-Pérez, W., Sai, K., Sakamachi, Y., Parsons, C., Kathariou, S., & Ninomiya-Tsuji, J. (2021, June 14). Proceedings of the National Academy of Sciences, Vol. 118.

By: W. López-Pérez n, K. Sai n, Y. Sakamachi n, C. Parsons n, S. Kathariou n & J. Ninomiya-Tsuji n 

Contributors: W. López-Pérez n, K. Sai n, Y. Sakamachi n, C. Parsons n, S. Kathariou n & J. Ninomiya-Tsuji n 

author keywords: TAK1; ROS; mitochondria; intracellular bacteria
MeSH headings : Animals; Bacteria / growth & development; Caspase 3 / metabolism; Colony Count, Microbial; Hydrogen Sulfide / pharmacology; Intracellular Space / microbiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Mice; Mitochondria / metabolism; Reactive Oxygen Species / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Salmonella / drug effects; Salmonella / growth & development; Yersinia / drug effects
topics (OpenAlex): Yersinia bacterium, plague, ectoparasites research; Immune Response and Inflammation; Vibrio bacteria research studies
TL;DR: A previously unrecognized host defense mechanism is revealed, which is initiated by host recognition of pathogen-induced impairment in a host protein, TAK1, but not directly of pathogens. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021

2020 article

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury

Hussain, S., Johnson, C. G., Sciurba, J., Meng, X., Stober, V. P., Liu, C., … Garantziotis, S. (2020, January 28). ELife.

By: S. Hussain *, C. Johnson *, J. Sciurba n, X. Meng *, V. Stober*, C. Liu *, J. Cyphert-Daly*, K. Bulek * ...

MeSH headings : Animals; Cells, Cultured; Humans; Inflammation / immunology; Inflammation / metabolism; Lung / immunology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / genetics; Myeloid Differentiation Factor 88 / metabolism; Polymorphism, Single Nucleotide / genetics; Signal Transduction / genetics; Signal Transduction / immunology; Toll-Like Receptor 4 / genetics; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 5 / genetics; Toll-Like Receptor 5 / metabolism
topics (OpenAlex): Immune Response and Inflammation; Respiratory Support and Mechanisms; Neonatal Respiratory Health Research
TL;DR: It is demonstrated that immune cells of human carriers of a dominant negative TLR5 allele have decreased inflammatory response to O3 exposure ex vivo and LPS exposure in vitro, and suggests an updated paradigm for TLR4/TLR5 signaling. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 16, 2020

2017 article

Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1

Mihaly, S. R., Sakamachi, Y., Ninomiya-Tsuji, J., & Morioka, S. (2017, June 1). Scientific Reports, Vol. 7.

By: S. Mihaly n, Y. Sakamachi n, J. Ninomiya-Tsuji n  & S. Morioka n

Contributors: S. Mihaly n, Y. Sakamachi n, J. Ninomiya-Tsuji n  & S. Morioka n

topics (OpenAlex): Cell death mechanisms and regulation; Phagocytosis and Immune Regulation
TL;DR: This work identified a previously uncharacterized cell death pathway regulated by TAK1, which is unexpectedly provoked by inhibition of caspase activity and necroptosis cascades and surprisingly found that caspases and RIPK3 inhibitions do not completely suppress cell death in Tak1-deficient cells. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

TAK1 regulates resident macrophages by protecting lysosomal integrity

Sakamachi, Y., Morioka, S., Mihaly, S. R., Takaesu, G., Foley, J. F., Fessler, M. B., & Ninomiya-Tsuji, J. (2017, February 9). Cell Death and Disease, Vol. 8.

By: Y. Sakamachi n, S. Morioka n, S. Mihaly n, G. Takaesu  n, J. Foley *, M. Fessler *, J. Ninomiya-Tsuji n 

Contributors: Y. Sakamachi n, S. Morioka n, S. Mihaly n, G. Takaesu  n, J. Foley *, M. Fessler *, J. Ninomiya-Tsuji n 

MeSH headings : Animals; Cell Death / physiology; Cell Survival / physiology; Embryonic Development / physiology; Lung / metabolism; Lysosomes / metabolism; MAP Kinase Kinase Kinases / metabolism; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Protective Agents / metabolism; Receptors, Tumor Necrosis Factor, Type I / metabolism; Signal Transduction / physiology; Thymocytes / physiology; Thymus Gland / metabolism; Toll-Like Receptors / metabolism
topics (OpenAlex): Zebrafish Biomedical Research Applications; Immune Cell Function and Interaction; Immune cells in cancer
TL;DR: The results suggest that autocrine and potentially paracrine TNF kills Tak1-deficient macrophages during development, and reveal that TAK1 signaling maintains proper macrophage populations through protecting lysosomal integrity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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