Dong-Young Ryu

author keywords: Mouse; Liver tumors; Iron metabolism; Ceruloplasmin; DMT1 IRE(+)

MeSH headings : Adenoma, Liver Cell / chemically induced; Adenoma, Liver Cell / genetics; Adenoma, Liver Cell / metabolism; Animals; Antimicrobial Cationic Peptides / genetics; Antimicrobial Cationic Peptides / metabolism; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Ceruloplasmin / genetics; Ceruloplasmin / metabolism; Copper / metabolism; Diethylnitrosamine; Ferritins / genetics; Ferritins / metabolism; Gene Expression Regulation, Neoplastic; Hepcidins; Immunoblotting; Injections, Subcutaneous; Iron / blood; Iron / metabolism; Iron-Dextran Complex / administration & dosage; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / metabolism; Male; Mice; Mice, Inbred C3H; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transferrin / metabolism

TL;DR: It is suggested that diethylnitrosamine-induced liver adenoma-bearing mice have abnormal iron metabolism and that dysregulation of iron metabolism-related genes contributes to iron deficiency in the adenomas. (via Semantic Scholar)

TL;DR: The induction of CYP1B1 mRNA by PBO or ACN was higher in DBA/2 (Ahrd) than in C57BL/6 (Ahrb−1) mice, while 3‐methylcholanthrene induced CYP2B1 more in C 57BL/ 6 than in Dba/2 mice, suggesting that CYP 1B1 may also be induced by more than one mechanism. (via Semantic Scholar)

author keywords: piperonyl butoxide; acenaphthylene; CYP1A1; CYP1A2; Ah receptor; C57BL/6; DBA/2; Ah receptor knockout (AHR(-/-)) mouse

MeSH headings : Acenaphthenes / pharmacology; Animals; Blotting, Northern; Blotting, Western; Cycloheximide / pharmacology; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 Enzyme System / genetics; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Isoenzymes / genetics; Liver / enzymology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperonyl Butoxide / pharmacology; Polychlorinated Dibenzodioxins / pharmacology; Polymerase Chain Reaction / methods; RNA, Heterogeneous Nuclear / analysis; RNA-Directed DNA Polymerase; Teratogens / pharmacology

TL;DR: The results suggest that PBO, but not ACN, induces CYP1A1 through a weak activation of AHR, and it is assumed that the transcriptional induction of CYP 1A2 by PBO and ACN is AHR-independent. (via Semantic Scholar)

author keywords: flavin-containing monooxygenases; FM01; FM03; FM05; FMO expression; hormonal regulation; testosterone; 17 beta-estradiol; progesterone

MeSH headings : Animals; Blotting, Western; Castration; Estradiol / blood; Estradiol / pharmacology; Female; Gene Expression Regulation, Enzymologic; Isoenzymes / metabolism; Liver / drug effects; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Organ Size / drug effects; Ovariectomy; Oxygenases / metabolism; Progesterone / blood; Progesterone / pharmacology; RNA, Messenger / metabolism; Seminal Vesicles / drug effects; Testosterone / blood; Testosterone / pharmacology; Uterus / drug effects

TL;DR: In males and females, F MO5 levels were unaffected by gonadectomy or hormone administration, thus indicating a sex hormone-independent mechanism of regulation for this isoform, and Interestingly, FMO1 protein levels were increased in sexually intact males following treatment with 17 beta-estradiol; however, only a slight increase in FMO3 protein level was observed. (via Semantic Scholar)