Works (17)
Updated: July 7th, 2023 21:13
2013 journal article
Bone marrow-derived cells participate in the formation of normal and neoplastic lung stroma
Anticancer Research, 33(3), 831–836.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Polyomavirus-Associated Nephritis in 2 Horses
Veterinary Pathology, 50(5), 769–774.
author keywords: kidney; horse; myocarditis; nephritis; polyomavirus
MeSH headings : Animals; Blood Chemical Analysis / veterinary; Capsid Proteins / genetics; DNA Primers / genetics; Fatal Outcome; Female; Horse Diseases / immunology; Horse Diseases / pathology; Horse Diseases / virology; Horses; Immunocompromised Host / immunology; Immunoglobulin G / blood; Immunohistochemistry / veterinary; Kidney Cortex Necrosis / pathology; Kidney Cortex Necrosis / veterinary; Kidney Cortex Necrosis / virology; Male; Nephritis, Interstitial / pathology; Nephritis, Interstitial / veterinary; Nephritis, Interstitial / virology; Phylogeny; Polyomavirus / genetics; Polyomavirus Infections / pathology; Polyomavirus Infections / veterinary
TL;DR:
2 Standardbred horses with tubular necrosis and tubulointerstitial nephritis associated with productive equine polyomvirus infection that resembles BK polyomavirus nephropathy in immunocompromised humans are described.
(via Semantic Scholar)
open access via journals.sagepub.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development
CELL CYCLE, 11(2), 335–342.
author keywords: cell cycle; D-type cyclins; skin; carcinogenesis; epidermis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin D2 / metabolism; Cyclin D3 / genetics; Cyclin D3 / metabolism; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras) / genetics; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tumor Burden
TL;DR:
Modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Morphologic and Molecular Analysis of 39 Spontaneous Feline Pulmonary Carcinomas
VETERINARY PATHOLOGY, 49(6), 971–978.
author keywords: cat; lung cancer; immunohistochemistry; thyroid transcription factor-1; surfactant protein a; epidermal growth factor receptor; p53
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Adenocarcinoma, Bronchiolo-Alveolar / metabolism; Adenocarcinoma, Bronchiolo-Alveolar / pathology; Adenocarcinoma, Bronchiolo-Alveolar / veterinary; Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Carcinoma, Adenosquamous / metabolism; Carcinoma, Adenosquamous / pathology; Carcinoma, Adenosquamous / veterinary; Cat Diseases / genetics; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Immunohistochemistry / veterinary; Incidence; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Lung Neoplasms / veterinary; Male; Neoplasm Metastasis; North Carolina; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Pulmonary Surfactant-Associated Protein A / genetics; Pulmonary Surfactant-Associated Protein A / metabolism; Sequence Analysis, DNA / veterinary; Thyroid Nuclear Factor 1; Transcription Factors / genetics; Transcription Factors / metabolism; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR:
Results indicate that primary lung carcinomas are rare but aggressive tumors in cats, thereby warranting further studies on molecular carcinogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Nasopharyngeal oncocytoma in a cat
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 23(2), 391–394.
author keywords: Cats; nasopharynx; neoplasm; oncocytoma
MeSH headings : Adenoma, Oxyphilic / pathology; Adenoma, Oxyphilic / veterinary; Animals; Cat Diseases / pathology; Cats; Fatal Outcome; Immunohistochemistry / veterinary; Male; Nasopharynx / pathology
TL;DR:
A 5-year-old male neutered Siamese cat was referred because of nasal swelling, nasal discharge, and oral respiration and computed tomography and necropsy revealed a firm tan mass in the nasopharynx, occluding the nasal passage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Skp2 Is Necessary for Myc-Induced Keratinocyte Proliferation but Dispensable for Myc Oncogenic Activity in the Oral Epithelium
AMERICAN JOURNAL OF PATHOLOGY, 178(6), 2470–2477.
MeSH headings : Animals; Cell Cycle Proteins / metabolism; Cell Proliferation; Epidermis / metabolism; Epidermis / pathology; Epithelium / metabolism; Epithelium / pathology; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Transgenic; Mouth / pathology; Mouth Neoplasms / metabolism; Mouth Neoplasms / pathology; Phenotype; Precancerous Conditions / pathology; Proto-Oncogene Proteins c-myc / metabolism; S-Phase Kinase-Associated Proteins / metabolism
TL;DR:
It is suggested that Skp2 and p27(Kip1) are critical for Myc-driven keratinocyte proliferation; however, MyC-mediated tumorigenesis in the oral epithelium is independent of the Skp 2-p27( Kip 1) axis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Characterization of side population cells in human malignant mesothelioma cell lines
LUNG CANCER, 70(2), 146–151.
author keywords: Mesothelioma; Side population; Cancer stem cell; Hoechst 33342; Tumorigenicity; Flow cytometry
MeSH headings : Animals; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cisplatin / pharmacology; Feasibility Studies; Flow Cytometry; Gene Expression Regulation, Developmental; Humans; Mesothelioma / diagnosis; Mesothelioma / drug therapy; Mesothelioma / pathology; Mice; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells / drug effects; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Side-Population Cells / drug effects; Side-Population Cells / metabolism; Side-Population Cells / pathology
TL;DR:
The data indicated that SP assay may not be appropriate for enriching putative CSCs in HMM cell lines, and thus warrants the development of a novel tool for mesothelial CSC study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Recurrent Sebaceous Carcinoma in an African Hedgehog (Atelerix albiventris)
JOURNAL OF VETERINARY MEDICAL SCIENCE, 72(7), 947–949.
author keywords: hedgehog; immunohistochemistry; neoplasm; sebaceous carcinoma
MeSH headings : Adenocarcinoma, Sebaceous / pathology; Adenocarcinoma, Sebaceous / veterinary; Animals; Autopsy / methods; Autopsy / veterinary; Cytoplasm / pathology; Hedgehogs; Male; Neoplasm Invasiveness; Neoplasm Recurrence, Local / pathology; Neoplasm Recurrence, Local / veterinary; Skin / pathology; Vacuoles / pathology
TL;DR:
On necropsy, the mass has penetrated the underlying intercostal musculature, without metastasis to distant organs, and is the first report of a sebaceous carcinoma in an African hedgehog.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Expression of thioredoxin during progression of hamster and human cholangiocarcinoma
CANCER SCIENCE, 101(1), 281–288.
MeSH headings : Animals; Bile Duct Neoplasms / chemistry; Bile Duct Neoplasms / pathology; Bile Ducts, Intrahepatic; Blotting, Western; Cholangiocarcinoma / chemistry; Cholangiocarcinoma / pathology; Cricetinae; Disease Progression; Humans; Immunohistochemistry; Mesocricetus; Precancerous Conditions / chemistry; Precancerous Conditions / pathology; Thioredoxins / analysis; Thioredoxins / physiology
TL;DR:
The results strongly suggested that the redox regulatory function of Trx plays an important role in bile duct cell transformation and tumor progression during cholangiocarcinogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Inhibition of the insulin-like growth factor 1 receptor pathway enhances the antitumor effect of cisplatin in human malignant mesothelioma cell lines
CANCER LETTERS, 278(1), 49–55.
author keywords: Malignant mesothelioma; Insulin-like growth factor 1 receptor; AG1024; Cisplatin; Chemoresistance
MeSH headings : Antineoplastic Agents / therapeutic use; Apoptosis / drug effects; Cell Division / drug effects; Cell Line, Tumor / drug effects; Cisplatin / therapeutic use; Humans; Mesothelioma / drug therapy; Pleural Neoplasms / drug therapy; Receptor, IGF Type 1 / antagonists & inhibitors; Signal Transduction / drug effects; Tyrphostins / therapeutic use
TL;DR:
This study supports the conjecture that inhibition of the IGF-1R pathway may be a useful target for reducing toxicity and alleviating chemoresistance to traditional anticancer drugs in HMM patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Pleomorphic leiomyosarcoma in the hind leg of a Taiwanese macaque (Macaca cyclopis)
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 21(4), 564–567.
author keywords: Immunohistochemistry; monkeys; muscle; pleomorphic leiomyosarcoma
MeSH headings : Animals; Leiomyosarcoma / classification; Leiomyosarcoma / pathology; Leiomyosarcoma / veterinary; Macaca; Male; Monkey Diseases / classification; Monkey Diseases / pathology
TL;DR:
The gross, microscopic, and immunohistochemical findings supported the diagnosis of pleomorphic leiomyosarcoma, and the mass infiltrated the surrounding skeletal muscle with no evidence of distant metastasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Porcine abortion outbreak associated with Toxoplasma gondii in Jeju Island, Korea
JOURNAL OF VETERINARY SCIENCE, 10(2), 147–151.
author keywords: abortion; pig; sow mortality; tachyzoite; Toxoplasma gondii
MeSH headings : Aborted Fetus; Abortion, Veterinary / blood; Abortion, Veterinary / epidemiology; Abortion, Veterinary / parasitology; Abortion, Veterinary / pathology; Animals; Antibodies, Protozoan / blood; Disease Outbreaks / veterinary; Female; Hepatomegaly / parasitology; Hepatomegaly / veterinary; Immunohistochemistry / veterinary; Korea / epidemiology; Latex Fixation Tests / veterinary; Pregnancy; Splenomegaly / parasitology; Splenomegaly / veterinary; Swine; Swine Diseases / blood; Swine Diseases / epidemiology; Swine Diseases / parasitology; Swine Diseases / pathology; Toxoplasma / isolation & purification; Toxoplasmosis, Animal / blood; Toxoplasmosis, Animal / epidemiology; Toxoplasmosis, Animal / parasitology; Toxoplasmosis, Animal / pathology
TL;DR:
This report deals with the acute onset of an abortion outbreak and high sow mortality in one pig herd consisted of 1,200 pigs and 120 sows on Jeju Island, Korea, which is the first report of porcine toxoplasmosis with a high abortion rate and sow deaths in Korea.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Prevalence of Hepatic Parasites in Korean Wild Rats (Rattus norvegicus) and Their Association With Pulmonary Arteriolar Medial Hypertrophy
VETERINARY PATHOLOGY, 47(2), 292–297.
author keywords: C hepatica; C fasciolaris; Korea; pulmonary arteriolar hypertrophy; Rattus norvegicus; rats
MeSH headings : Animals; Animals, Wild; Histocytochemistry; Korea / epidemiology; Liver Diseases, Parasitic / epidemiology; Liver Diseases, Parasitic / parasitology; Liver Diseases, Parasitic / veterinary; Lung Diseases, Parasitic / epidemiology; Lung Diseases, Parasitic / parasitology; Lung Diseases, Parasitic / veterinary; Prevalence; Rats; Rodent Diseases / epidemiology; Rodent Diseases / parasitology; Taenia / isolation & purification; Taeniasis / epidemiology; Taeniasis / parasitology; Taeniasis / veterinary
TL;DR:
This report is the first to suggest a significant association between parasite-induced hepatitis and pulmonary arteriolar hypertrophy in rodents, and further studies are warranted for the use of C hepatica–infected rats as an animal model to explore the underlying mechanisms of portopulmonary hypertension in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Genetic Alterations in K-ras and p53 Cancer Genes in Lung Neoplasms from B6C3F1 Mice Exposed to Cumene
TOXICOLOGIC PATHOLOGY, 36(5), 720–726.
author keywords: K-ras; p53; cumene; lung; mouse
MeSH headings : Adenocarcinoma, Bronchiolo-Alveolar / chemically induced; Adenocarcinoma, Bronchiolo-Alveolar / genetics; Adenocarcinoma, Bronchiolo-Alveolar / pathology; Animals; Benzene Derivatives / toxicity; Carcinoma / chemically induced; Carcinoma / genetics; Carcinoma / pathology; Codon; Exons; Genes, p53 / genetics; Genes, ras; Immunohistochemistry; Loss of Heterozygosity; Lung Neoplasms / chemically induced; Lung Neoplasms / genetics; Lung Neoplasms / pathology; Mice; Mice, Inbred Strains; Point Mutation; Tumor Suppressor Protein p53 / genetics
TL;DR:
The pattern of mutations identified in the lung tumors suggests that DNA damage and genomic instability may be contributing factors to the mutation profile and development of lung cancer in mice exposed to cumene.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Regulation of iron metabolism-related genes in diethylnitrosamine-induced mouse liver tumors
TOXICOLOGY LETTERS, 184(3), 151–158.
author keywords: Mouse; Liver tumors; Iron metabolism; Ceruloplasmin; DMT1 IRE(+)
MeSH headings : Adenoma, Liver Cell / chemically induced; Adenoma, Liver Cell / genetics; Adenoma, Liver Cell / metabolism; Animals; Antimicrobial Cationic Peptides / genetics; Antimicrobial Cationic Peptides / metabolism; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Ceruloplasmin / genetics; Ceruloplasmin / metabolism; Copper / metabolism; Diethylnitrosamine; Ferritins / genetics; Ferritins / metabolism; Gene Expression Regulation, Neoplastic; Hepcidins; Immunoblotting; Injections, Subcutaneous; Iron / blood; Iron / metabolism; Iron-Dextran Complex / administration & dosage; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / metabolism; Male; Mice; Mice, Inbred C3H; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transferrin / metabolism
TL;DR:
It is suggested that diethylnitrosamine-induced liver adenoma-bearing mice have abnormal iron metabolism and that dysregulation of iron metabolism-related genes contributes to iron deficiency in the adenomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis
CANCER RESEARCH, 67(20), 9713–9720.
MeSH headings : Animals; Carcinogens; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Cyclin-Dependent Kinase 2 / deficiency; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Disease Progression; Enzyme Activation; Female; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate; ras Proteins / metabolism
TL;DR:
Overall, it is established that ras-induced tumors are more susceptible to CDK2 ablation than myc-induced tumorigenesis, suggesting that the efficacy of targetingCDK2 in tumor development and malignant progression is dependent on the oncogenic pathway involved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Genitourinary rhabdomyosarcoma with systemic metastasis in a young dog
VETERINARY PATHOLOGY, 44(4), 518–520.
author keywords: dogs; rhabdomyosarcoma; sarcoma botryoldes; urinary bladder; uterus
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Female; Neoplasm Metastasis; Rhabdomyosarcoma / diagnosis; Rhabdomyosarcoma / pathology; Rhabdomyosarcoma / secondary; Rhabdomyosarcoma / veterinary; Urogenital Neoplasms / diagnosis; Urogenital Neoplasms / pathology; Urogenital Neoplasms / veterinary
TL;DR:
Genitourinary rhabdomyosarcoma with multisystemic metastases was made on a 2-year-old intact female Golden Retriever due to rapidly progressing depression, ascites, dysuria, abdominal pain, and severe vaginal bleeding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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