Ernest Hodgson

Works (73)

Updated: March 10th, 2025 12:14

2020 article

Role of long non-coding RNA in DEET- and fipronil-mediated alteration of transcripts associated with Phase I and Phase II xenobiotic metabolism in human primary hepatocytes

Lawrie, R. D., Mitchell, R. D., Dhammi, A., Wallace, A., Hodgson, E., & Roe, R. M. (2020, May 20). Pesticide Biochemistry and Physiology, Vol. 167.

By: R. Lawrie n, R. Mitchell n, A. Dhammi n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: Long non-coding RNA; DEET; Fipronil; Xenobiotic metabolism; Environmental chemicals; Cytochrome P450
MeSH headings : DEET; Hepatocytes; Humans; Insect Repellents; Pyrazoles; RNA, Long Noncoding
topics (OpenAlex): Cancer-related molecular mechanisms research; Pharmacogenetics and Drug Metabolism; Genomics, phytochemicals, and oxidative stress
TL;DR: The impact of two environmental chemicals used in and around homes, the insect repellent DEET and the phenylpyrazole insecticide fipronil, and the role of altered lncRNAs associated with xenobiotic induction, human diseases and chemical mixtures is discussed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2017 article

Differential Expression Profile of lncRNAs from Primary Human Hepatocytes Following DEET and Fipronil Exposure

Mitchell, R. D., III, Wallace, A. D., Hodgson, E., & Roe, R. M. (2017, October 7). International Journal of Molecular Sciences, Vol. 18.

By: R. Mitchell n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: DEET; fipronil; long non-coding RNA; lncRNA; primary liver cells; epigenetics; RNA-Seq; transcriptomics; Zika virus; human hepatocytes
MeSH headings : Cells, Cultured; DEET / pharmacology; Epigenomics / methods; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Pyrazoles / pharmacology; RNA, Long Noncoding / genetics; Zika Virus / genetics
topics (OpenAlex): Cancer-related molecular mechanisms research; Plant and Fungal Interactions Research; Insect-Plant Interactions and Control
TL;DR: This initial analysis links several of the dysregulated lncRNAs to processes and pathways critical to proper cellular function, such as the innate and adaptive immune response and the p53 signaling pathway. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Impact of Environmental Chemicals on the Transcriptome of Primary Human Hepatocytes: Potential for Health Effects

Journal of Biochemical and Molecular Toxicology, 30(8), 375–395.

By: R. Mitchell n, A. Dhammi n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: DEET; Fipronil; Gene expression; Human hepatocytes; RNA-Seq; Endocrine System; P450
MeSH headings : Chromosome Mapping; DEET / toxicity; Drug Combinations; Genome, Human; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Insect Repellents / toxicity; Insecticides / toxicity; Molecular Sequence Annotation; Primary Cell Culture; Pyrazoles / toxicity; Sequence Analysis, RNA; Transcriptome / drug effects
topics (OpenAlex): Pesticide Exposure and Toxicity; Insect and Pesticide Research; Carcinogens and Genotoxicity Assessment
TL;DR: The overall treatment responses, specific pathways, and individual transcripts affected were discussed at different levels of fold‐change and changes found in transcript levels in response to treatments will require further research to understand their importance in overall cellular, organ, and organismic function. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 article

Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations

Hodgson, E., Wallace, A. D., Shah, R. R., Choi, K., & Joo, H. (2013, November 22). Journal of Biochemical and Molecular Toxicology.

By: E. Hodgson n, A. Wallace n, R. Shah*, K. Choi n & H. Joo n

author keywords: Cytotoxicity; Human Hepatocytes; Human Variation; Microarrays; RNAseq; Toxicant Metabolism; Toxicant Interactions
MeSH headings : Enzyme Activation; Enzyme Inhibitors / pharmacology; Genetic Variation; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Liver / metabolism; Oligonucleotide Array Sequence Analysis; Risk Assessment; Subcellular Fractions / metabolism
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Metabolomics and Mass Spectrometry Studies; Liver Disease Diagnosis and Treatment
TL;DR: This review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigation of the metabolism and metabolic interactions of environmental chemicals. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 review

Human environments: Definition, scope, and the role of toxicology

[Review of ]. Toxicology and human environments, 112, 1–10.

By: E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2012 review

Metabolic interactions of environmental toxicants in humans

[Review of ]. Toxicology and human environments, 112, 349–372.

By: E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2012 book

Pesticide biotransformation and disposition

Waltham, MA: Academic Press.

Ernest Hodgson

Ed(s):

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Progress in molecular biology and translational science toxicology and human environments summary and conclusions

Toxicology and Human Environments, 112, 417–421.

By: E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2012 review

The future of human health risk assessment of environmental chemicals

[Review of ]. Toxicology and human environments, 112, 307–322.

By: E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2012 review

Toxins and venoms

[Review of ]. Toxicology and human environments, 112, 373–415.

By: E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2010 article

Human metabolism of atrazine

Joo, H., Choi, K., & Hodgson, E. (2010, May 28). Pesticide Biochemistry and Physiology.

By: H. Joo n, K. Choi n & E. Hodgson n

author keywords: Atrazine; Human liver microsomes; Cytochrome P450; Human liver S9 fractions; Human metabolism; Phase I metabolism; Phase II metabolism; Glutathione conjugation; LC/MS/MS
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Pesticide and Herbicide Environmental Studies
TL;DR: Atrazine (ATZ) metabolism by human liver microsomes, cytochrome P450 (CYP) isoforms, and human liver S9 fractions, was investigated using HPLC/PDA and LC/MS/MS. (via Semantic Scholar)
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Added: August 6, 2018

2010 article

Human variation in CYP-specific chlorpyrifos metabolism

Croom, E. L., Wallace, A. D., & Hodgson, E. (2010, August 14). Toxicology.

By: E. Croom*, A. Wallace n & E. Hodgson n

author keywords: Chlorpyrifos; CYP isoform; Desulfuration; Dearylation; Human liver microsomes; Organophosphorothioate pesticides
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Cell Line; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Humans; Insecticides / metabolism; Insecticides / toxicity; Isoenzymes / genetics; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / metabolism; Substrate Specificity / drug effects; Substrate Specificity / physiology
topics (OpenAlex): Pesticide Exposure and Toxicity; Pesticide and Herbicide Environmental Studies; Environmental Toxicology and Ecotoxicology
TL;DR: Individual variations in CPO production may need to be considered in determining the risk of chlorpyrifos poisoning, and the combination of ketoconazole and ticlopidine inhibited the majority of TCP and CPO formation. (via Semantic Scholar)
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Added: August 6, 2018

2009 article

Human hepatic CYP2B6 developmental expression: The impact of age and genotype

Croom, E. L., Stevens, J. C., Hines, R. N., Wallace, A. D., & Hodgson, E. (2009, April 7). Biochemical Pharmacology.

By: E. Croom n, J. Stevens*, R. Hines *, A. Wallace n & E. Hodgson n

author keywords: CYP450; Ontogeny; CYP2B6; CYP3A; Hepatic
MeSH headings : Adolescent; Age Factors; Aryl Hydrocarbon Hydroxylases / biosynthesis; Aryl Hydrocarbon Hydroxylases / chemistry; Aryl Hydrocarbon Hydroxylases / genetics; Child; Child, Preschool; Cytochrome P-450 CYP2B6; Female; Gene Expression Regulation, Developmental / physiology; Gene Expression Regulation, Enzymologic / physiology; Genotype; Humans; Infant; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / biosynthesis; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / genetics
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Metabolism and Genetic Disorders; Diet and metabolism studies
TL;DR: Hepatic CYP2B6 protein levels were characterized in microsomal protein preparations isolated from a pediatric liver bank and showed consistency with different mechanisms controlling the ontogeny and constitutive expression of these enzymes and the lack of significant induction in the pediatric samples. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 article

Metabolic interactions of agrochemicals in humans

Hodgson, E., & Rose, R. L. (2008, March 6). Pest Management Science.

By: E. Hodgson n & R. Rose n

author keywords: cytochrome P450; environmental chemicals; hepatocytes; human metabolism; organophosphorus chemicals; risk assessment
MeSH headings : Drug Interactions; Environmental Pollutants / metabolism; Humans; Insecticides / metabolism; Microsomes, Liver / enzymology
topics (OpenAlex): Pesticide Exposure and Toxicity; Pharmacogenetics and Drug Metabolism; Poisoning and overdose treatments
TL;DR: The authors have been investigating the metabolism of a number of agrochemicals by human liver microsomes and recombinant CYP isoforms and have recently embarked on studies of the induction of XMEs in human hepatocytes. (via Semantic Scholar)
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2007 article

Human metabolic interactions of environmental chemicals

Hodgson, E., & Rose, R. L. (2007, August 1). Journal of Biochemical and Molecular Toxicology.

By: E. Hodgson n & R. Rose n

author keywords: carbaryl; chlorpyrifos; chlorpyrifos oxon; cytochrome P450 (CYP); DEET; Endosulfan; environmental chemicals; estradiol; fipronil; Hepatocytes; human metabolism; naphthalene; nonane; organophosphorus chemicals; permethrin; pyrethroids; testosterone
MeSH headings : Cholinesterase Inhibitors / metabolism; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Enzyme Induction; Estradiol / metabolism; Female; Humans; Isoenzymes / metabolism; Liver / cytology; Liver / enzymology; Male; Microsomes, Liver / enzymology; Pesticides / metabolism; Recombinant Proteins / antagonists & inhibitors; Recombinant Proteins / metabolism; Testosterone / antagonists & inhibitors; Testosterone / metabolism
topics (OpenAlex): Pesticide Exposure and Toxicity; Pharmacogenetics and Drug Metabolism; Drug-Induced Hepatotoxicity and Protection
TL;DR: Investigations utilizing recombinant human xenobiotic‐metabolizing enzymes as well as human hepatocytes have revealed a number of interactions not only between different environmental chemicals (ECs) but also between ECs and endogenous metabolites. (via Semantic Scholar)
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2007 article

Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos

Joo, H., Choi, K., Rose, R. L., & Hodgson, E. (2007, April 1). Journal of Biochemical and Molecular Toxicology.

By: H. Joo n, K. Choi n, R. Rose n & E. Hodgson n

author keywords: fipronil; nonane; human liver microsomes; cytochrome P450; CYP2B6; CYP3A4
MeSH headings : Alkanes / pharmacology; Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Enzyme Activation / drug effects; Female; Humans; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / antagonists & inhibitors; Oxidoreductases, N-Demethylating / metabolism; Pyrazoles / pharmacology
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Pesticide Exposure and Toxicity; Pesticide Residue Analysis and Safety
TL;DR: In both co‐ and preincubation experiments, CPS significantly inhibited the metabolism of fipronil or nonane by HLM although CPS inhibited the metabolization of fIPronil more effectively than that of nonane. (via Semantic Scholar)
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2006 article

Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes

Das, P. C., Cao, Y., Cherrington, N., Hodgson, E., & Rose, R. L. (2006, October 7). Chemico-Biological Interactions.

By: P. Das n, Y. Cao n, N. Cherrington *, E. Hodgson n & R. Rose n

author keywords: fipronil; human hepatic and HepG2 cells; CYP3A4; CYP2B6; CYP1A1; cytotoxicity; apoptosis
MeSH headings : Caspase 3 / metabolism; Caspase 7 / metabolism; Cell Survival / drug effects; Cells, Cultured; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction / drug effects; Gene Expression Regulation; Hepatocytes / drug effects; Hepatocytes / enzymology; Humans; Isoenzymes / genetics; Isoenzymes / metabolism; Pyrazoles / chemistry; Pyrazoles / pharmacology; RNA, Messenger / genetics; Sulfur / chemistry; Transcription, Genetic / genetics; fas Receptor / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Insect and Pesticide Research; Pesticide Exposure and Toxicity
TL;DR: The results indicate both that HepG2 cells and primary human hepatocytes are sensitive to the cytotoxic effects of fipronil and caspase-3/7 in concurrence with compromised ATP production and viability are attributed to apoptotic cell death. (via Semantic Scholar)
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Added: August 6, 2018

2006 article

Inhibition of the Human Liver Microsomal and Human Cytochrome P450 1A2 and 3A4 Metabolism of Estradiol by Deployment-Related and Other Chemicals

Usmani, K. A., Cho, T. M., Rose, R. L., & Hodgson, E. (2006, June 22). Drug Metabolism and Disposition.

By: K. Usmani*, T. Cho, R. Rose* & E. Hodgson n

MeSH headings : Carbaryl / toxicity; Chlorpyrifos / toxicity; Cholinesterase Inhibitors / toxicity; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 CYP1A2 / metabolism; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / metabolism; Female; Fonofos / toxicity; Humans; In Vitro Techniques; Kinetics; Liver / drug effects; Liver / enzymology; Male; Microsomes, Liver; Military Medicine; Recombinant Proteins / antagonists & inhibitors; Recombinant Proteins / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Estrogen and related hormone effects
TL;DR: Phenotyped HLM use showed that individuals with high levels of CYP1A2 and CYP3A4 have the greatest potential to metabolize E2, and chlorpyrifos inhibition of E2 metabolism is shown to be irreversible. (via Semantic Scholar)
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Added: August 6, 2018

2006 article

Metabolism of Endosulfan-α by Human Liver Microsomes and Its Utility as a Simultaneous in Vitro Probe for CYP2B6 and CYP3A4

Casabar, R. C. T., Wallace, A. D., Hodgson, E., & Rose, R. L. (2006, July 20). Drug Metabolism and Disposition.

By: R. Casabar n, A. Wallace, E. Hodgson* & R. Rose*

MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / metabolism; Biotransformation / drug effects; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Endosulfan / chemistry; Endosulfan / metabolism; Endosulfan / pharmacokinetics; Enzyme Inhibitors / pharmacology; Humans; Insecticides / chemistry; Insecticides / metabolism; Insecticides / pharmacokinetics; Ketoconazole / pharmacology; Kinetics; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Microsomes, Liver / metabolism; Molecular Structure; Oxidoreductases, N-Demethylating / antagonists & inhibitors; Oxidoreductases, N-Demethylating / metabolism; Oxygenases / metabolism; Steroid Hydroxylases / metabolism; Sulfates / metabolism; Ticlopidine / pharmacology
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Eicosanoids and Hypertension Pharmacology
TL;DR: It is shown that endosulfan-α is metabolized by HLMs to a single metabolite, endOSulfan sulfate, and that it has potential use, in combination with inhibitors, as an in vitro probe for CYP2B6 and 3A4 catalytic activities. (via Semantic Scholar)
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2006 article

Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes*

Choi, K., Joo, H., Rose, R. L., & Hodgso, E. (2006, November 1). Journal of Biochemical and Molecular Toxicology.

By: K. Choi n, H. Joo n, R. Rose n & E. Hodgso n

MeSH headings : Adult; Biotransformation; Chlorpyrifos / analogs & derivatives; Chlorpyrifos / analysis; Chlorpyrifos / chemistry; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Chromatography, High Pressure Liquid; Female; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Male; Mass Spectrometry; Middle Aged; Subcellular Fractions
topics (OpenAlex): Pesticide Exposure and Toxicity; Pharmacogenetics and Drug Metabolism; Pesticide and Herbicide Environmental Studies
TL;DR: The results suggest that human liver plays an important role in detoxification, rather than activation, of CPS, and phase II‐related conjugates, including O‐ and S‐glucuronides, were identified in CPS‐treated human hepatocytes, although the O‐sulfate of TCP conjugate was found only when human liver S9 fractions were used as the enzyme source. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2006 review

NTP-CERHR Expert Panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate

[Review of ]. Reproductive Toxicology (Elmsford, N.Y.), 22(3), 291–399.

By: R. Kavlock, D. Barr, K. Boekelheide, W. Breslin, P. Breysse, R. Chapin, K. Gaido, E. Hodgson ...

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Organophosphorus Chemicals: Potent Inhibitors of the Human Metabolism of Steroid Hormones and Xenobiotics

Hodgson, E., & Rose, R. L. (2006, January 1). Drug Metabolism Reviews.

By: E. Hodgson n & R. Rose n

author keywords: carbaryl; chlorpyrifos; chlorpyrifos oxon; cytochrome P450 (CYP); DEET; estradiol; human CYP isoforms; human liver microsomes; organophosphorus insecticides; permethrin; testosterone
MeSH headings : Animals; Carbaryl / metabolism; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; DEET / metabolism; Depression, Chemical; Estrogens / metabolism; Female; Humans; Insect Repellents / metabolism; Insecticides / metabolism; Insecticides / pharmacology; Male; Organophosphorus Compounds / pharmacology; Steroids / metabolism; Testosterone / metabolism; Xenobiotics / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Pesticide Exposure and Toxicity; Estrogen and related hormone effects
TL;DR: Recent studies have demonstrated that organophosphate insecticides containing this moiety are potent inhibitors of the metabolism of both xenobiotics and endogenous substrates by human liver microsomes and by specific human cytochrome P450 isoforms. (via Semantic Scholar)
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2006 article

The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals

Hodgson, E., & Rose, R. L. (2006, October 25). Pharmacology & Therapeutics.

By: E. Hodgson n & R. Rose n

author keywords: agrochemicals; cytochrome p450; cytochrome p450 2B6; environmental chemicals; induction; industrial chemicals; inhibition; metabolism; polymorphisms; xenobiotics
MeSH headings : Agrochemicals / metabolism; Aryl Hydrocarbon Hydroxylases / metabolism; Cytochrome P-450 CYP2B6; Environmental Pollutants / metabolism; Humans; Oxidoreductases, N-Demethylating / metabolism; Xenobiotics / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug-Induced Hepatotoxicity and Protection; Computational Drug Discovery Methods
TL;DR: Cytochrome P450 (CYP) 2B6 is a human CYP isoform found in variable amounts in the liver and other organs and its role in the metabolism of environmental xenobiotics is concentrated on. (via Semantic Scholar)
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2006 article

Thiodiglycol, the hydrolysis product of sulfur mustard: Analysis of in vitro biotransformation by mammalian alcohol dehydrogenases using nuclear magnetic resonance

Brimfield, A. A., Novak, M. J., & Hodgson, E. (2006, January 19). Toxicology and Applied Pharmacology.

By: A. Brimfield*, M. Novak* & E. Hodgson n

author keywords: sulfur mustard; thiodiglycol; in vitro metabolism; alcohol dehydrogenase; NMR
MeSH headings : Alcohol Dehydrogenase / metabolism; Animals; Biotransformation; Horses; Humans; Hydrolysis; Isoenzymes / metabolism; Liver / enzymology; Magnetic Resonance Spectroscopy; Mustard Gas / metabolism; Sulfhydryl Compounds / metabolism
topics (OpenAlex): Pesticide Exposure and Toxicity; Drug-Induced Hepatotoxicity and Protection; Pharmacogenetics and Drug Metabolism
TL;DR: The use of proton NMR to monitor the oxidative reaction with structural confirmation by independent synthesis allowed us to establish the ultimate product, 2-hydroxyethylthioacetic acid, and to identify an intermediate equilibrium mixture consisting of 2-Hydroxy methylthioacetaldehyde, 2,2'-bis- Hydroxyethylsulfide hydrate and the cyclic 1,4-oxathian-2-ol. (via Semantic Scholar)
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2005 article

Discussion and conclusions

Alavanja, M. C. R., Bonner, M. R., Furlong, C. E., Allen, R., & Hodgson, E. (2005, June 23). Journal of Biochemical and Molecular Toxicology.

By: M. Alavanja*, M. Bonner *, C. Furlong *, R. Allen * & E. Hodgson n

MeSH headings : Agriculture; Cohort Studies; Genetic Predisposition to Disease; Health Surveys; Humans; National Institutes of Health (U.S.); Neoplasms / epidemiology; Neoplasms / etiology; Neoplasms / genetics; Risk Factors; United States / epidemiology; United States Environmental Protection Agency
topics (OpenAlex): Chemistry and Chemical Engineering; History and advancements in chemistry; Pesticide and Herbicide Environmental Studies
Source: Web Of Science
Added: August 6, 2018

2005 article

Human Metabolism and Metabolic Interactions of Deployment-Related Chemicals

Hodgson, E., & Rose, R. L. (2005, January 1). Drug Metabolism Reviews.

By: E. Hodgson n & R. Rose n

author keywords: alcohol dehydrogenase; aldehyde dehydrogenase; carbamates; chemical warfare agents; cytochrome P450; deployment-related chemicals; jet fuel components; metabolic interactions; metabolism; organophosphorus compounds; pyrethroids; repellents; xenobiotic-metabolizing enzymes
MeSH headings : Drug Interactions; Humans; Inactivation, Metabolic; Military Medicine; Xenobiotics / metabolism
topics (OpenAlex): Pesticide Exposure and Toxicity; Carcinogens and Genotoxicity Assessment
TL;DR: Initial studies have examined the human metabolism by cytochrome P450, other phase I enzymes, and their isoforms and, in some cases, their polymorphic variants of compounds such as chlorpyrifos, carbaryl, DEET, permethrin, and pyridostigmine bromide, and, to a lesser extent, other chemicals from the same chemical and use classes. (via Semantic Scholar)
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2005 article

IN VITRO METABOLISM OF NAPHTHALENE BY HUMAN LIVER MICROSOMAL CYTOCHROME P450 ENZYMES

Cho, T. M., Rose, R. L., & Hodgson, E. (2005, October 26). Drug Metabolism and Disposition.

By: T. Cho n, R. Rose* & E. Hodgson*

MeSH headings : Cytochrome P-450 Enzyme System / metabolism; Humans; Isoenzymes / metabolism; Kinetics; Microsomes, Liver / chemistry; Microsomes, Liver / metabolism; Molecular Structure; Naphthalenes / chemistry; Naphthalenes / metabolism; Naphthalenes / pharmacokinetics; Naphthoquinones / chemistry; Naphthoquinones / metabolism
topics (OpenAlex): Eicosanoids and Hypertension Pharmacology; Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms
TL;DR: Primary And Secondary Metabolites of Naphthalene Produced By Phlms And P450 Isoforms are identified, which helps identify the primary and secondary metabolites of the gas. (via Semantic Scholar)
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2005 article

Pesticide metabolism and potential for metabolic interactions

Rose, R. L., & Hodgson, E. (2005, September 1). Journal of Biochemical and Molecular Toxicology.

By: R. Rose n & E. Hodgson n

MeSH headings : Agriculture; Cytochrome P-450 Enzyme System / drug effects; Cytochrome P-450 Enzyme System / metabolism; Humans; Microsomes, Liver / enzymology; Occupational Exposure; Pesticides / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Pesticide and Herbicide Environmental Studies; Drug Transport and Resistance Mechanisms
TL;DR: This research presents a new probabilistic approach to understanding the role of phosphorous in the build-up of CLRs and its role in the immune response to CLRs. (via Semantic Scholar)
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2005 journal article

Pesticide metabolism in humans, including polymorphisms

Scandinavian Journal of Work, Environment & Health, 31, 156–163.

By: R. Rose, J. Tang, J. Choi, Y. Cao, A. Usmani, N. Cherrington, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2005 article

The metabolism of nonane, a JP-8 jet fuel component, by human liver microsomes, P450 isoforms and alcohol dehydrogenase and inhibition of human P450 isoforms by JP-8

Edwards, J. E., Rose, R. L., & Hodgson, E. (2005, January 25). Chemico-Biological Interactions.

By: J. Edwards  n, R. Rose n & E. Hodgson n

author keywords: nonane; JP-8; metabolism; cytochrome P450; alcohol dehydrogenase
MeSH headings : Alcohol Dehydrogenase / metabolism; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; DEET / pharmacokinetics; Estradiol / metabolism; Fossil Fuels; Humans; Hydrocarbons / pharmacokinetics; Hydrocarbons / toxicity; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Testosterone / metabolism
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Pharmacogenetics and Drug Metabolism; Toxic Organic Pollutants Impact
TL;DR: JP-8 showed modest inhibition of testosterone, estradiol and carbaryl metabolism, but had a more significant effect on the metabolism of DEET, suggesting that at least some of the components of JP-8 might be metabolized by CYPs 1A2and/or 2B6. (via Semantic Scholar)
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2005 article

Toxicology of AHS important chemicals

Hodgson, E., & Rose, R. L. (2005, June 23). Journal of Biochemical and Molecular Toxicology.

By: E. Hodgson n & R. Rose n

MeSH headings : Agriculture; Animals; Health Surveys; Humans; Insecticides / toxicity; Pesticides / toxicity
topics (OpenAlex): Insect Resistance and Genetics; Pesticide and Herbicide Environmental Studies; Environmental Toxicology and Ecotoxicology
TL;DR: This research presents a new probabilistic approach to understanding the role of phosphorous in the build-up of cancer in women and its role in the immune response to chemotherapy. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2004 article

IN VITRO SULFOXIDATION OF THIOETHER COMPOUNDS BY HUMAN CYTOCHROME P450 AND FLAVIN-CONTAINING MONOOXYGENASE ISOFORMS WITH PARTICULAR REFERENCE TO THE CYP2C SUBFAMILY

Usmani, K. A., Karoly, E. D., Hodgson, E., & Rose, R. L. (2004, February 21). Drug Metabolism and Disposition.

By: K. Usmani n, E. Karoly*, E. Hodgson* & R. Rose*

MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System / metabolism; Enzyme Inhibitors / pharmacology; Humans; In Vitro Techniques; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Mixed Function Oxygenases / antagonists & inhibitors; Monoamine Oxidase / metabolism; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfaphenazole / pharmacology; Sulfides / metabolism; Sulfoxides / metabolism; Ticlopidine / pharmacology
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Glutathione Transferases and Polymorphisms
TL;DR: The results indicate that current models of the substrate binding site of the CYP2C subfamily would not effectively predict thioether pesticide metabolism, and the substrate specificity of CYP 2Cs is more extensive than is currently believed, and some reevaluation of structure-activity relationships may be required. (via Semantic Scholar)
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Added: August 6, 2018

2004 article

In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol

Usmani, K. A., Hodgson, E., & Rose, R. L. (2004, November 8). Chemico-Biological Interactions.

By: K. Usmani*, E. Hodgson n & R. Rose n

author keywords: carbofuran; metabolism; human liver microsomes; cytochrome P450; CYP3MA4; testosterone; interactions
MeSH headings : Animals; Carbofuran / metabolism; Carbofuran / pharmacology; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / metabolism; Drug Interactions / physiology; Estradiol / metabolism; Estradiol / pharmacology; Humans; In Vitro Techniques; Isoenzymes / metabolism; Ketoconazole / pharmacology; Liver / cytology; Liver / enzymology; Mice; Microsomes, Liver / enzymology; Pesticides / metabolism; Rats; Testosterone / metabolism; Testosterone / pharmacology
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Cholinesterase and Neurodegenerative Diseases; Drug Transport and Resistance Mechanisms
TL;DR: Investigating the comparative in vitro metabolism of carbofuran from human, rat, and mouse liver microsomes and characterize the specific enzymes involved in such metabolism found that individuals with high levels of CYP3A4 have the greatest potential to metabolize carb ofuran to its major metabolite. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam

Tang, J., Usmani, K. A., Hodgson, E., & Rose, R. L. (2004, April 1). Chemico-Biological Interactions.

By: J. Tang n, K. Usmani n, E. Hodgson n & R. Rose n

author keywords: fipronil; metabolism; human liver microsomes; cytochrome p450; CYP3A4; interaction
MeSH headings : Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / metabolism; Diazepam / metabolism; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors / pharmacology; Humans; Insecticides / metabolism; Isoenzymes / metabolism; Ketoconazole / pharmacology; Microsomes, Liver / enzymology; Pyrazoles / metabolism; Rats; Species Specificity; Testosterone / metabolism
topics (OpenAlex): Insect and Pesticide Research; Pesticide Residue Analysis and Safety; Pesticide Exposure and Toxicity
TL;DR: The results suggest that fipronil has the potential to interact with a wide range of xenobiotics or endogenous chemicals that are CYP3A4 substrates and that fIPronil may be a useful substrate for the characterization of CYP 3A4 in HLM. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 article

Non-target toxicology of a new mosquito larvicide, trypsin modulating oostatic factor

Thompson, D. M., Young, H. P., Edens, F. W., Olmstead, A. W., LeBlanc, G. A., Hodgson, E., & Roe, R. M. (2004, September 25). Pesticide Biochemistry and Physiology, Vol. 80, pp. 131–142.

By: D. Thompson n, H. Young n, F. Edens n, A. Olmstead n, G. LeBlanc n , E. Hodgson n, R. Roe n 

author keywords: trypsin modulating oostatic factor; TMOF; insecticide; mosquito; mouse; rabbit; duck; water flea
topics (OpenAlex): Insect Resistance and Genetics; Insect and Pesticide Research; Insect Pest Control Strategies
TL;DR: It appears from these studies that T MOF can be degraded by vertebrate digestive proteases and technical TMOF is not toxic to the non-target organisms examined. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 article

In vitro human phase I metabolism of xenobiotics I: Pesticides and related compounds used in agriculture and public health, may 2003

Hodgson, E. (2003, July 1). Journal of Biochemical and Molecular Toxicology.

By: E. Hodgson n

author keywords: alcohol dehydrogenase; aldehyde dehydrogenase; carbamates; cytochrome P450; CYP; flavin-containing monooxygenase; FMO; human metabolism; nicotinoids; pesticides; pyrethroids; repellents
MeSH headings : Agriculture; Animals; Cytochrome P-450 Enzyme System / metabolism; Databases, Protein; Herbicides / metabolism; Humans; Insecticides / metabolism; Isoenzymes / metabolism; Pesticides / metabolism; Public Health; Xenobiotics / metabolism
topics (OpenAlex): Pesticide Exposure and Toxicity; Pesticide and Herbicide Environmental Studies; Carcinogens and Genotoxicity Assessment
TL;DR: This is the first revision of a database covering human phase I enzymes and their isoforms that metabolize pesticides and related compounds that includes carbamate, nicotinoid, and pyrethroid insecticides and insect repellents. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 article

Inhibition and Activation of the Human Liver Microsomal and Human Cytochrome P450 3A4 Metabolism of Testosterone by Deployment-Related Chemicals

Usmani, K. A., Rose, R. L., & Hodgson, E. (2003, March 18). Drug Metabolism and Disposition.

By: K. Usmani n, R. Rose* & E. Hodgson*

MeSH headings : Chlorpyrifos / pharmacology; Cholinesterase Inhibitors / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Gonadal Steroid Hormones / metabolism; Humans; In Vitro Techniques; Isoenzymes / metabolism; Kinetics; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Steroid Hydroxylases / metabolism; Testosterone / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Hormonal and reproductive studies; Estrogen and related hormone effects
TL;DR: Kinetic analysis indicated that chlorpyrifos was one of the most potent inhibitors of major TST metabolites followed by fonofos and phorate, and inhibited major T ST metabolites noncompetitively and irreversibly. (via Semantic Scholar)
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Added: August 6, 2018

2002 article

In Vitro Human Metabolism and Interactions of Repellent N,N-Diethyl-m-Toluamide

Usmani, K. A., Rose, R. L., Goldstein, J. A., Taylor, W. G., Brimfield, A. A., & Hodgson, E. (2002, March 1). Drug Metabolism and Disposition.

By: K. Usmani n, R. Rose*, J. Goldstein*, W. Taylor, A. Brimfield & E. Hodgson*

MeSH headings : Animals; Biotransformation; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DEET / analogs & derivatives; DEET / metabolism; DEET / pharmacokinetics; Drug Interactions; Enzyme Induction / drug effects; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Female; Humans; In Vitro Techniques; Insect Repellents / metabolism; Insect Repellents / pharmacokinetics; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Male; Mice; Microsomes, Liver / enzymology; Oxidation-Reduction; Permethrin / metabolism; Permethrin / pharmacology; Pyridostigmine Bromide / metabolism; Pyridostigmine Bromide / pharmacology; Rats; Rats, Long-Evans; Spectrometry, Fluorescence
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug-Induced Hepatotoxicity and Protection; Plant Toxicity and Pharmacological Properties
TL;DR: Use of phenotyped HLMs demonstrated that individuals with high levels of CYP2B6, 3A4, 2C19, and 2A6 have the greatest potential to metabolize DEET. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2002 article

In vitro human metabolism of permethrin: the role of human alcohol and aldehyde dehydrogenases

Choi, J., Rose, R. L., & Hodgson, E. (2002, November 1). Pesticide Biochemistry and Physiology.

By: J. Choi n, R. Rose n & E. Hodgson n

author keywords: permethrin; permethrin metabolism; human alcohol dehydrogenase; human aldehyde dehydrogenase
topics (OpenAlex): Pesticide Exposure and Toxicity; Carcinogens and Genotoxicity Assessment; Drug-Induced Hepatotoxicity and Protection
TL;DR: It appears that PBOH is oxidized to P BCHO by ADH and subsequently to PBCOOH by ALDH, although PBCHO does not accumulate during microsomal incubation. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 article

In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos

Tang, J., Cao, Y., Rose, R. L., & Hodgson, E. (2002, October 1). Chemico-Biological Interactions.

By: J. Tang n, Y. Cao n, R. Rose n & E. Hodgson n

author keywords: carbaryl; human lifer microsomes; metabolism
MeSH headings : Adult; Carbaryl / metabolism; Cells, Cultured; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation / drug effects; Insecticides / metabolism; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Kinetics; Male; Microsomes, Liver; Molecular Structure
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Pesticide Exposure and Toxicity
TL;DR: In vitro metabolic activities of human liver microsomes (HLM) and human cytochrome P450 (CYP) isoforms toward carbaryl were investigated and the production of carbaryl methylol was primarily the result of metabolism by CYP2B6. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 article

Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6β‐hydroxylase

Dai, D., Bai, R., Hodgson, E., & Rose, R. L. (2001, January 1). Journal of Biochemical and Molecular Toxicology.

By: D. Dai, R. Bai n, E. Hodgson n & R. Rose n

author keywords: Cyp3a-25; cloning; sequencing; heterologous expression; metabolism and distribution; testosterone 6 beta-hydroxylase
MeSH headings : Aging; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Northern; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Escherichia coli / genetics; Female; Immunoblotting; Isoenzymes / genetics; Male; Mice; Molecular Sequence Data; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / genetics; Pregnancy; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Tissue Distribution; Transfection
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Hormonal Regulation and Hypertension
TL;DR: It was demonstrated by RT‐PCR that the CYP3A25 mRNA is present in both fetal and adult tissues, including liver, lung, intestines, kidney, and brain and Northern blotting demonstrated that expression is greatest in the liver and small intestine. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 article

Genetically Modified Plants and Human Health Risks: Can Additional Research Reduce Uncertainties and Increase Public Confidence?

Hodgson, E. (2001, October 1). Toxicological Sciences.

By: E. Hodgson n

MeSH headings : Food Hypersensitivity / etiology; Food Hypersensitivity / immunology; Humans; Mutagenicity Tests; Plants, Edible / adverse effects; Plants, Edible / genetics; Plants, Genetically Modified / adverse effects; Plants, Genetically Modified / growth & development; Public Opinion; Research Design / standards; Risk Assessment; Social Control, Formal; Technology Assessment, Biomedical
topics (OpenAlex): Genetically Modified Organisms Research; Transgenic Plants and Applications; Biotechnology and Related Fields
TL;DR: Development of direct tests that involve interaction between the actual transgenic protein in question and the immune system is essential if confidence in the regulatory system is to be restored. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos

Journal of Pharmacology and Experimental Therapeutics, 299(3), 825–831.

By: D. Dai, J. Tang, R. Rose, E. Hodgson, R. Bienstock, H. Mohrenweiser, J. Goldstein

Source: NC State University Libraries
Added: August 6, 2018

2001 article

In vitro human phase I metabolism of xenobiotics I: Pesticides and related chemicals used in agriculture and public health, September 2001

Hodgson, E. (2001, November 26). Journal of Biochemical and Molecular Toxicology.

By: E. Hodgson n

author keywords: human metabolism; cytochrome P-450; CYP; flavin-containing monooxygenase; FMO; pesticides
MeSH headings : Cytochromes / metabolism; Herbicides / metabolism; Humans; Isoenzymes / metabolism; Pesticides / metabolism; Xenobiotics / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Carcinogens and Genotoxicity Assessment; Pesticide Exposure and Toxicity
TL;DR: This initial version includes enzymes and isoforms that metabolize organophosphorus insecticides, chloroacetamide herbicides and triazine herbicides. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes

Drug Metabolism and Disposition, 29(9), 1201–1204.

By: J. Tang, Y. Cao, R. Rose, A. Brimfield, D. Dai, J. Goldstein, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2001 article

Modulation of Mouse P450 Isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the Environmental Chemicals Mirex, 2,2-Bis(p-chlorophenyl)-1,1-dichloroethylene, Vinclozolin, and Flutamide

Dai, D., Cao, Y., Falls, G., Levi, P. E., Hodgson, E., & Rose, R. L. (2001, July 1). Pesticide Biochemistry and Physiology.

By: D. Dai*, Y. Cao n, G. Falls*, P. Levi n, E. Hodgson n & R. Rose n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Effects and risks of endocrine disrupting chemicals; Hormonal and reproductive studies
TL;DR: It is demonstrated that structurally diverse environmental chemicals including mirex, 2,2-Bis( p -chlorophenyl)-1,1-dichloroethylene (DDE), vinclozolin, and flutamide are capable of inducing several mouse liver CYP isozymes that may significantly impact testosterone metabolism and this may be a contributing factor in their antiandrogenic effects. (via Semantic Scholar)
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2000 article

Comparative Metabolism of Chloroacetamide Herbicides and Selected Metabolites in Human and Rat Liver Microsomes

Coleman, S., Linderman, R., Hodgson, E., & Rose, R. L. (2000, December 1). Environmental Health Perspectives.

By: S. Coleman*, R. Linderman n, E. Hodgson* & R. Rose*

author keywords: chloroacetamide herbicides; human cytochrome P450; in vitro metabolism
topics (OpenAlex): Pesticide Residue Analysis and Safety; Pesticide Exposure and Toxicity
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Detection of resistant insects and IPM

Emerging Technologies for Integrated Pest Management : Concepts, Research, and Implementation, 67.

By: R. Roe , W. Bailey, F. Gould , C. Sorenson, G. Kennedy , J. Bacheler, R. Rose, E. Hodgson, C. Sutula

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation

Hodgson, E., Rose, R. L., Cao, Y., Dehal, S. S., & Kupfer, D. (2000, January 1). Journal of Biochemical and Molecular Toxicology.

By: E. Hodgson*, R. Rose n, Y. Cao n, S. Dehal* & D. Kupfer*

author keywords: flavin-containing monooxygenase; FMO; FMO isoforms; tamoxifen; human; mouse
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Receptor Mechanisms and Signaling; Estrogen and related hormone effects
TL;DR: The Km value for tamoxifen is 1.2 mM for mouse FMO1 (human F MO1 is not expressed in adults) and 1.4 mM for human FMO3, with no detectable activity being expressed toward tamoxIFen by FMO5 from either mouse or human, derived from experiments using 3H‐tamox ifen as substrate in which the product, tamoxIfen N‐oxide, was measured directly. (via Semantic Scholar)
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2000 article

The Federal Government's Agricultural Health Study: A Critical Review with Suggested Improvements

Gray, G. M., Goldstein, B. D., Bailar, J., Davis, D. L., Delzell, E., Dost, F., … Graham, J. D. (2000, January 1). Human and Ecological Risk Assessment An International Journal.

By: G. Gray *, B. Goldstein *, J. Bailar*, D. Davis *, E. Delzell*, F. Dost*, R. Greenberg*, M. Hatch * ...

author keywords: epidemiology; pesticides; farmworkers; health effects
topics (OpenAlex): Pesticide Exposure and Toxicity
TL;DR: The design of the Agricultural Health Study is examined, important program strengths and flaws are identified, various improvements in the program are suggested, and ancillary studies that could be undertaken to strengthen the AHS are recommended. (via Semantic Scholar)
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Added: August 6, 2018

1999 article

Constitutive expression and induction of CYP1B1 mRNA in the mouse

Ryu, D.-Y., & Hodgson, E. (1999, January 1). Journal of Biochemical and Molecular Toxicology.

By: D. Ryu n & E. Hodgson n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Drug-Induced Hepatotoxicity and Protection
TL;DR: The induction of CYP1B1 mRNA by PBO or ACN was higher in DBA/2 (Ahrd) than in C57BL/6 (Ahrb−1) mice, while 3‐methylcholanthrene induced CYP2B1 more in C 57BL/ 6 than in Dba/2 mice, suggesting that CYP 1B1 may also be induced by more than one mechanism. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 article

In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms

Coleman, S., Liu, S., Linderman, R., Hodgson, E., & Rose, R. L. (1999, August 1). Chemico-Biological Interactions.

By: S. Coleman*, S. Liu  n, R. Linderman n, E. Hodgson n & R. Rose n

author keywords: alachlor; CDEPA; human CYP; herbicides
MeSH headings : Acetamides / metabolism; Animals; Cytochrome P-450 Enzyme System / metabolism; Female; Herbicides / metabolism; Humans; In Vitro Techniques; Isoenzymes / metabolism; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Rats; Rats, Long-Evans
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Carcinogens and Genotoxicity Assessment; Pesticide Exposure and Toxicity
TL;DR: It is demonstrated that male human liver microsomes are able to metabolize alachlor to CDEPA, a widely used pre-emergent chloroacetanilide herbicide which has been classified by the USEPA as a probable human carcinogen and 2,6-diethylbenzoquinone imine (DEBQI), a putative carcinogenic metabolite. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1999 article

Induction and inhibition of pesticide-metabolizing enzymes: roles in synergism of pesticides and pesticide action

Hodgson, E. (1999, February 1). Toxicology and Industrial Health.

By: E. Hodgson n

author keywords: cytochrome P450; flavin-containing monooxyhenases; induction; inhibition; methylenedioxyphenyl compounds; pesticide-metabolizing enzymes; phorate; piperonyl butoxide; synergism
MeSH headings : Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction; Humans; Insecticides / pharmacokinetics; Multienzyme Complexes / metabolism; Pesticides / pharmacokinetics; Phorate / pharmacokinetics; Xenobiotics / pharmacokinetics
topics (OpenAlex): Pesticide and Herbicide Environmental Studies; Pharmacogenetics and Drug Metabolism; Environmental Toxicology and Ecotoxicology
TL;DR: Synergism of the toxic action of pesticides is discussed with particular emphasis on the methylenedioxyphenyl (benzodioxole) (MDP) synergists and on how studies of these compounds may relate to the general significance of pesticide synergism. (via Semantic Scholar)
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1998 journal article

Basic principles and rationale for the use of insect genes in bioremediation: esterases, phosphotriesterase, cytochrome P450 and epoxide hydrolase

Reviews in Toxicology, 2(1998), 169–178.

By: R. Roe , E. Hodgson, R. Rose, D. Thompson, C. Devorshak, D. Anspaugh, R. Linderman, S. Harris, M. Tomalski

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Cloning and Expression of Murine CYP2Cs and Their Ability to Metabolize Arachidonic Acid

Luo, G., Zeldin, D. C., Blaisdell, J. A., Hodgson, E., & Goldstein, J. A. (1998, September 1). Archives of Biochemistry and Biophysics.

By: G. Luo, D. Zeldin *, J. Blaisdell*, E. Hodgson n & J. Goldstein*

author keywords: cytochrome P450; CYP2Cs; mouse; cDNA cloning; cDNA expression; arachidonic acid metabolism; liver; extrahepatic; mRNA expression
MeSH headings : Amino Acid Sequence; Animals; Arachidonic Acid / metabolism; Aryl Hydrocarbon Hydroxylases; Base Sequence; Catalysis; Cloning, Molecular; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Enzyme Activation; Female; Humans; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Male; Mice; Microsomes, Liver / enzymology; Molecular Sequence Data; Organ Specificity / genetics; Polymerase Chain Reaction; RNA, Messenger / biosynthesis; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases / biosynthesis; Steroid Hydroxylases / genetics; Steroid Hydroxylases / metabolism
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Eicosanoids and Hypertension Pharmacology; Biochemical Acid Research Studies
TL;DR: Five murine cytochrome P450 (CYP) 2C cDNAs were cloned and characterized, including four new members of this subfamily, and the presence of CYP2C29 mRNA in liver as well as in extrahepatic tissues including brain, kidney, lung, heart, and intestine was demonstrated. (via Semantic Scholar)
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1998 journal article

Common mechanism of toxicity: A case study of organophosphorus pesticides

Fundamental and Applied Toxicology, 41(1), 8–20.

By: B. Mileson, W. Chen, W. Dettbarn, M. Ehrich, A. Eldefrawi, D. Gaylor, K. Hamernik, E. Hodgson ...

Source: NC State University Libraries
Added: August 6, 2018

1998 book

Dictionary of toxicology (2nd ed.)

London: MacMillan Reference; New York: Grove Dictionaries.

By: E. Hodgson, R. Mailman, J. Chambers & R. Dow

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Flavin-containing monooxygenase and cytochrome P450 mediated metabolism of pesticides: from mouse to human

Reviews in Toxicology, 2(1998), 231–243.

By: E. Hodgson, N. Cherrington, S. Coleman, S. Liu, J. Falls, Y. Cao, J. Goldstein, R. Rose

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Molecular Cloning, Sequence, and Expression of Mouse Flavin‐Containing Monooxygenases 1 and 5 (FMO1 and FMO5)

Cherrington, N. J., Falls, J. G., Rose, R. L., Clements, K. M., Philpot, R. M., Levi, P. E., & Hodgson, E. (1998, January 1). Journal of Biochemical and Molecular Toxicology.

By: N. Cherrington n, J. Falls n, R. Rose n, K. Clements n, R. Philpot*, P. Levi n, E. Hodgson n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Pesticide and Herbicide Environmental Studies
Source: NC State University Libraries
Added: August 6, 2018

1998 article

Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5

CHERRINGTON, N. J., CAO, Y. A. N., CHERRINGTON, J. W., ROSE, R. L., & HODGSON*, E. (1998, January 1). Xenobiotica.

By: N. Cherrington n, Y. Cao n, J. Cherrington n, R. Rose n & E. Hodgson* n

MeSH headings : Adult; Animals; Female; Humans; Liver / embryology; Liver / metabolism; Male; Mice; Microsomes, Liver / metabolism; Middle Aged; Oxygenases / biosynthesis; Rats; Sex Characteristics; Species Specificity
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Effects and risks of endocrine disrupting chemicals
TL;DR: The mouse and rat exhibit substantial differences in the gender expression of flavin-containing monooxygenase (FMO) forms, and Methimazole, imipramine and thiobenzamide are much better substrates for FMO1 than for F MO3 or FMO5. (via Semantic Scholar)
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1997 article

Cytochrome P450 (CYP)9A1 in Heliothis virescens: the first member of a new CYP family

Rose, R. L., Goh, D., Thompson, D. M., Verma, K. D., Heckel, D. G., Gahan, L. J., … Hodgson, E. (1997, June 1). Insect Biochemistry and Molecular Biology, Vol. 27, pp. 605–615.

By: R. Rose n, D. Goh*, D. Thompson*, K. Verma*, D. Heckel *, L. Gahan*, R. Roe* , E. Hodgson*

author keywords: CYP9A1; cytochrome P450; insecticide resistance; Heliothis virescens
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / isolation & purification; DNA, Complementary; Female; Insecticide Resistance; Male; Molecular Sequence Data; Moths / enzymology; Moths / genetics; Sequence Homology, Amino Acid
topics (OpenAlex): Insect Resistance and Genetics; Viral Infectious Diseases and Gene Expression in Insects; Insect and Pesticide Research
TL;DR: Comparative Western and Northern blot studies indicate that expression of CYP9A1 in thiodicarb selected populations of tobacco budworm is associated with insecticide resistance and the pattern of restriction fragment length polymorphism (RELP) variation in offspring of single-pair matings demonstrated autosomal inheritance. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1997 article

Molecular Cloning, Sequencing, and Expression inEscherichia coliof Mouse Flavin-Containing Monooxygenase 3 (FMO3): Comparison with the Human Isoform

Falls, J. G., Cherrington, N. J., Clements, K. M., Philpot, R. M., Levi, P. E., Rose, R. L., & Hodgson, E. (1997, November 1). Archives of Biochemistry and Biophysics.

By: J. Falls n, N. Cherrington n, K. Clements n, R. Philpot*, P. Levi n, R. Rose n, E. Hodgson n

author keywords: flavin-containing monooxygenase 3; FMO3; FMO3 sequence; FMO3 expression
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Catalysis; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors / pharmacology; Enzyme Stability; Escherichia coli / genetics; Female; Gene Expression; Humans; Hydrogen-Ion Concentration; Liver / enzymology; Male; Methimazole / metabolism; Mice; Molecular Sequence Data; Oxygenases / chemistry; Oxygenases / genetics; Oxygenases / metabolism; RNA, Messenger / analysis; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Sequence Analysis, DNA; Sequence Homology, Amino Acid
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Effects and risks of endocrine disrupting chemicals
TL;DR: The sequence of mouse flavin-containing monooxygenase 3 (FMO3) was obtained from several clones isolated from a mouse liver cDNA library and results of immunoblotting confirmed the tissue- and gender-dependent expression of mouse FMO3. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 article

Regulation of Mouse Liver Flavin-Containing Monooxygenases 1 and 3 by Sex Steroids

Falls, J. G., Ryu, D.-Y., Cao, Y., Levi, P. E., & Hodgson, E. (1997, June 1). Archives of Biochemistry and Biophysics.

By: J. Falls*, D. Ryu  n, Y. Cao n, P. Levi n & E. Hodgson n

author keywords: flavin-containing monooxygenases; FM01; FM03; FM05; FMO expression; hormonal regulation; testosterone; 17 beta-estradiol; progesterone
MeSH headings : Animals; Blotting, Western; Castration; Estradiol / blood; Estradiol / pharmacology; Female; Gene Expression Regulation, Enzymologic; Isoenzymes / metabolism; Liver / drug effects; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Organ Size / drug effects; Ovariectomy; Oxygenases / metabolism; Progesterone / blood; Progesterone / pharmacology; RNA, Messenger / metabolism; Seminal Vesicles / drug effects; Testosterone / blood; Testosterone / pharmacology; Uterus / drug effects
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Estrogen and related hormone effects; Neuroscience and Neuropharmacology Research
TL;DR: In males and females, F MO5 levels were unaffected by gonadectomy or hormone administration, thus indicating a sex hormone-independent mechanism of regulation for this isoform, and Interestingly, FMO1 protein levels were increased in sexually intact males following treatment with 17 beta-estradiol; however, only a slight increase in FMO3 protein level was observed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 article

Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse

Ryu, D.-Y., Levi, P. E., & Hodgson, E. (1997, June 1). Chemico-Biological Interactions.

By: D. Ryu, P. Levi n & E. Hodgson n

author keywords: piperonyl butoxide; acenaphthylene; CYP1A1; CYP1A2; Ah receptor; C57BL/6; DBA/2; Ah receptor knockout (AHR(-/-)) mouse
MeSH headings : Acenaphthenes / pharmacology; Animals; Blotting, Northern; Blotting, Western; Cycloheximide / pharmacology; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 Enzyme System / genetics; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Isoenzymes / genetics; Liver / enzymology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperonyl Butoxide / pharmacology; Polychlorinated Dibenzodioxins / pharmacology; Polymerase Chain Reaction / methods; RNA, Heterogeneous Nuclear / analysis; RNA-Directed DNA Polymerase; Teratogens / pharmacology
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Toxic Organic Pollutants Impact
TL;DR: The results suggest that PBO, but not ACN, induces CYP1A1 through a weak activation of AHR, and it is assumed that the transcriptional induction of CYP 1A2 by PBO and ACN is AHR-independent. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 book

Textbook of modern toxicology

Stamford, Conn.: Appleton & Lange.

By: E. Hodgson & P. Levi

Source: NC State University Libraries
Added: August 6, 2018

1996 patent

Insecticide resistance associated cytochrome 450

Washington, DC: U.S. Patent and Trademark Office.

By: R. Roe , E. Hodgson & R. Rose

Source: NC State University Libraries
Added: August 6, 2018

1995 article

Pesticide-metabolizing enzymes

Hodgson, E., Rose, R. L., Ryu, D.-Y., Falls, G., Blake, B. L., & Levi, P. E. (1995, December 1). Toxicology Letters.

By: E. Hodgson*, R. Rose n, D. Ryu  n, G. Falls n, B. Blake n & P. Levi n

author keywords: pesticide-metabolizing enzymes; cytochrome P450; flavin-containing monooxygenase (FMO); methylenedioxyphenyl compounds; phorate
MeSH headings : Animals; Cytochrome P-450 Enzyme System / metabolism; Humans; Mice; Oxygenases / metabolism; Pesticides / metabolism; Substrate Specificity
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Pesticide and Herbicide Environmental Studies; Pesticide Exposure and Toxicity
TL;DR: The isozyme specificity of methylenedioxyphenyl synergists for induction of P450 in mouse liver involves P450s 1A1, 1A2 and 2B10, including a non-Ah receptor-dependent mechanism for 1A3 induction and the substrate specificity of mouse and human P450 and FMO isozymes is discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1992 article

Enzymatic and immunohistochemical studies on the role of cytochrome P450 and the flavin-containing monooxygenase of mouse skin in the metabolism of pesticides and other xenobiotics

Venkatesh, K., Levi, P. E., Inman, A. O., Monteiro-Riviere, N. A., Misra, R., & Hodgson, E. (1992, May 1). Pesticide Biochemistry and Physiology, Vol. 43, pp. 53–66.

By: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiro-Riviere n , R. Misra  n & E. Hodgson n

Contributors: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiroriviere n , R. Misra  n & E. Hodgson n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Pesticide and Herbicide Environmental Studies
TL;DR: Although the overall phorate sulfoxidation rate in mouse skin microsomes was only 3 to 4% of the rate seen in liver, FMO appears to assume a greater relative role to P450 in the metabolic processes in skin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1984 chapter

Biochemical mechanisms of resistance to insecticides

In Origins and development of adaptation (p. 167). London: Pitman.

By: E. Hodgson, N. Motoyama, D. Evered & G. Collins

Source: NC State University Libraries
Added: August 6, 2018

1983 chapter

Characterization of cytochrome P-450 in studies of insecticide resistance

In G. P. Georghiou & T. Saito (Eds.), Pest resistance to pesticides (p. 207). New York: Plenum Press.

By: E. Hodgson, A. Kulkarni, G. Georghiou & T. Saito

Ed(s): G. Georghiou & T. Saito

Source: NC State University Libraries
Added: August 6, 2018

1983 article

The significance of cytochrome P-450 in insects

Hodgson, E. (1983, January 1). Insect Biochemistry.

By: E. Hodgson n

topics (OpenAlex): Insect and Pesticide Research; Insect Pest Control Strategies; Insect Resistance and Genetics
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1977 article

Substitution of choline by related compounds in the diet of Argyrotaenia velutinana and Heliothis virescens

Hodgson, E., Ligon, B. G., & Rock, G. C. (1977, January 1). Journal of Insect Physiology.

By: E. Hodgson n, B. Ligon n & G. Rock n

MeSH headings : Animals; Choline / metabolism; Lepidoptera / metabolism
topics (OpenAlex): Insect behavior and control techniques; Insect-Plant Interactions and Control; Insect and Pesticide Research
TL;DR: Argyrotaenia velutinana, the red-banded leaf roller, and Heliothis virescens, the tobacco budworm, both require choline for growth and development when reared on semisynthetic diets and no choline analog tested can adequately replace choline in the diet. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1974 article

Microsomal cytochrome P-450. Characterization and possible role in insecticide resistance in Musca domestica

Hodgson, E., Tate, L. G., Kulkarni, A. P., & Plapp, F. W. (1974, May 1). Journal of Agricultural and Food Chemistry.

By: E. Hodgson*, L. Tate, A. Kulkarni & F. Plapp

MeSH headings : Animals; Chromosomes; Cytochrome P-450 Enzyme System / isolation & purification; Genetics, Population; Houseflies; Insecticide Resistance; Insecticides; Microsomes / metabolism
topics (OpenAlex): Insect Resistance and Genetics; Fungal Biology and Applications; Entomopathogenic Microorganisms in Pest Control
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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