Works (73)
Updated: August 16th, 2024 13:38
2020 journal article
Role of long non-coding RNA in DEET- and fipronil-mediated alteration of transcripts associated with Phase I and Phase II xenobiotic metabolism in human primary hepatocytes
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 167.
author keywords: Long non-coding RNA; DEET; Fipronil; Xenobiotic metabolism; Environmental chemicals; Cytochrome P450
MeSH headings : DEET; Hepatocytes; Humans; Insect Repellents; Pyrazoles; RNA, Long Noncoding
TL;DR:
The impact of two environmental chemicals used in and around homes, the insect repellent DEET and the phenylpyrazole insecticide fipronil, and the role of altered lncRNAs associated with xenobiotic induction, human diseases and chemical mixtures is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020
2017 journal article
Differential Expression Profile of lncRNAs from Primary Human Hepatocytes Following DEET and Fipronil Exposure
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(10).
author keywords: DEET; fipronil; long non-coding RNA; lncRNA; primary liver cells; epigenetics; RNA-Seq; transcriptomics; Zika virus; human hepatocytes
MeSH headings : Cells, Cultured; DEET / pharmacology; Epigenomics / methods; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Pyrazoles / pharmacology; RNA, Long Noncoding / genetics; Zika Virus / genetics
TL;DR:
This initial analysis links several of the dysregulated lncRNAs to processes and pathways critical to proper cellular function, such as the innate and adaptive immune response and the p53 signaling pathway.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Impact of Environmental Chemicals on the Transcriptome of Primary Human Hepatocytes: Potential for Health Effects
Journal of Biochemical and Molecular Toxicology, 30(8), 375–395.
author keywords: DEET; Fipronil; Gene expression; Human hepatocytes; RNA-Seq; Endocrine System; P450
MeSH headings : Chromosome Mapping; DEET / toxicity; Drug Combinations; Genome, Human; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Insect Repellents / toxicity; Insecticides / toxicity; Molecular Sequence Annotation; Primary Cell Culture; Pyrazoles / toxicity; Sequence Analysis, RNA; Transcriptome / drug effects
TL;DR:
The overall treatment responses, specific pathways, and individual transcripts affected were discussed at different levels of fold‐change and changes found in transcript levels in response to treatments will require further research to understand their importance in overall cellular, organ, and organismic function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 28(1), 1–10.
author keywords: Cytotoxicity; Human Hepatocytes; Human Variation; Microarrays; RNAseq; Toxicant Metabolism; Toxicant Interactions
MeSH headings : Enzyme Activation; Enzyme Inhibitors / pharmacology; Genetic Variation; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Liver / metabolism; Oligonucleotide Array Sequence Analysis; Risk Assessment; Subcellular Fractions / metabolism
TL;DR:
This review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigation of the metabolism and metabolic interactions of environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 review
Human environments: Definition, scope, and the role of toxicology
[Review of ]. Toxicology and human environments, 112, 1–10.
Source: NC State University Libraries
Added: August 6, 2018
2012 review
Metabolic interactions of environmental toxicants in humans
[Review of ]. Toxicology and human environments, 112, 349–372.
Source: NC State University Libraries
Added: August 6, 2018
2012 book
Pesticide biotransformation and disposition
Waltham, MA: Academic Press.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Progress in molecular biology and translational science toxicology and human environments summary and conclusions
Toxicology and Human Environments, 112, 417–421.
Source: NC State University Libraries
Added: August 6, 2018
2012 review
The future of human health risk assessment of environmental chemicals
[Review of ]. Toxicology and human environments, 112, 307–322.
Source: NC State University Libraries
Added: August 6, 2018
2012 review
Toxins and venoms
[Review of ]. Toxicology and human environments, 112, 373–415.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Human metabolism of atrazine
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 98(1), 73–79.
author keywords: Atrazine; Human liver microsomes; Cytochrome P450; Human liver S9 fractions; Human metabolism; Phase I metabolism; Phase II metabolism; Glutathione conjugation; LC/MS/MS
TL;DR:
Atrazine (ATZ) metabolism by human liver microsomes, cytochrome P450 (CYP) isoforms, and human liver S9 fractions, was investigated using HPLC/PDA and LC/MS/MS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Human variation in CYP-specific chlorpyrifos metabolism
TOXICOLOGY, 276(3), 184–191.
author keywords: Chlorpyrifos; CYP isoform; Desulfuration; Dearylation; Human liver microsomes; Organophosphorothioate pesticides
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Cell Line; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Humans; Insecticides / metabolism; Insecticides / toxicity; Isoenzymes / genetics; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / metabolism; Substrate Specificity / drug effects; Substrate Specificity / physiology
TL;DR:
Individual variations in CPO production may need to be considered in determining the risk of chlorpyrifos poisoning, and the combination of ketoconazole and ticlopidine inhibited the majority of TCP and CPO formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Human hepatic CYP2B6 developmental expression: The impact of age and genotype
BIOCHEMICAL PHARMACOLOGY, 78(2), 184–190.
author keywords: CYP450; Ontogeny; CYP2B6; CYP3A; Hepatic
MeSH headings : Adolescent; Age Factors; Aryl Hydrocarbon Hydroxylases / biosynthesis; Aryl Hydrocarbon Hydroxylases / chemistry; Aryl Hydrocarbon Hydroxylases / genetics; Child; Child, Preschool; Cytochrome P-450 CYP2B6; Female; Gene Expression Regulation, Developmental / physiology; Gene Expression Regulation, Enzymologic / physiology; Genotype; Humans; Infant; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / biosynthesis; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / genetics
TL;DR:
Hepatic CYP2B6 protein levels were characterized in microsomal protein preparations isolated from a pediatric liver bank and showed consistency with different mechanisms controlling the ontogeny and constitutive expression of these enzymes and the lack of significant induction in the pediatric samples.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 article
Metabolic interactions of agrochemicals in humans
Hodgson, E., & Rose, R. L. (2008, June). PEST MANAGEMENT SCIENCE, Vol. 64, pp. 617–621.
author keywords: cytochrome P450; environmental chemicals; hepatocytes; human metabolism; organophosphorus chemicals; risk assessment
MeSH headings : Drug Interactions; Environmental Pollutants / metabolism; Humans; Insecticides / metabolism; Microsomes, Liver / enzymology
TL;DR:
The authors have been investigating the metabolism of a number of agrochemicals by human liver microsomes and recombinant CYP isoforms and have recently embarked on studies of the induction of XMEs in human hepatocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 article
Human metabolic interactions of environmental chemicals
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, Vol. 21, pp. 182–186.
author keywords: carbaryl; chlorpyrifos; chlorpyrifos oxon; cytochrome P450 (CYP); DEET; Endosulfan; environmental chemicals; estradiol; fipronil; Hepatocytes; human metabolism; naphthalene; nonane; organophosphorus chemicals; permethrin; pyrethroids; testosterone
MeSH headings : Cholinesterase Inhibitors / metabolism; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Enzyme Induction; Estradiol / metabolism; Female; Humans; Isoenzymes / metabolism; Liver / cytology; Liver / enzymology; Male; Microsomes, Liver / enzymology; Pesticides / metabolism; Recombinant Proteins / antagonists & inhibitors; Recombinant Proteins / metabolism; Testosterone / antagonists & inhibitors; Testosterone / metabolism
TL;DR:
Investigations utilizing recombinant human xenobiotic‐metabolizing enzymes as well as human hepatocytes have revealed a number of interactions not only between different environmental chemicals (ECs) but also between ECs and endogenous metabolites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 21(2), 76–80.
author keywords: fipronil; nonane; human liver microsomes; cytochrome P450; CYP2B6; CYP3A4
MeSH headings : Alkanes / pharmacology; Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Enzyme Activation / drug effects; Female; Humans; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / antagonists & inhibitors; Oxidoreductases, N-Demethylating / metabolism; Pyrazoles / pharmacology
TL;DR:
In both co‐ and preincubation experiments, CPS significantly inhibited the metabolism of fipronil or nonane by HLM although CPS inhibited the metabolization of fIPronil more effectively than that of nonane.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 article
Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes
Das, P. C., Cao, Y., Cherrington, N., Hodgson, E., & Rose, R. L. (2006, December 15). CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 164, pp. 200–214.
author keywords: fipronil; human hepatic and HepG2 cells; CYP3A4; CYP2B6; CYP1A1; cytotoxicity; apoptosis
MeSH headings : Caspase 3 / metabolism; Caspase 7 / metabolism; Cell Survival / drug effects; Cells, Cultured; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction / drug effects; Gene Expression Regulation; Hepatocytes / drug effects; Hepatocytes / enzymology; Humans; Isoenzymes / genetics; Isoenzymes / metabolism; Pyrazoles / chemistry; Pyrazoles / pharmacology; RNA, Messenger / genetics; Sulfur / chemistry; Transcription, Genetic / genetics; fas Receptor / metabolism
TL;DR:
The results indicate both that HepG2 cells and primary human hepatocytes are sensitive to the cytotoxic effects of fipronil and caspase-3/7 in concurrence with compromised ATP production and viability are attributed to apoptotic cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 article
Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals
Usmani, K. A., Cho, T. M., Rose, R. L., & Hodgson, E. (2006, September). DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 1606–1614.
MeSH headings : Carbaryl / toxicity; Chlorpyrifos / toxicity; Cholinesterase Inhibitors / toxicity; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 CYP1A2 / metabolism; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / metabolism; Female; Fonofos / toxicity; Humans; In Vitro Techniques; Kinetics; Liver / drug effects; Liver / enzymology; Male; Microsomes, Liver; Military Medicine; Recombinant Proteins / antagonists & inhibitors; Recombinant Proteins / metabolism
TL;DR:
Phenotyped HLM use showed that individuals with high levels of CYP1A2 and CYP3A4 have the greatest potential to metabolize E2, and chlorpyrifos inhibition of E2 metabolism is shown to be irreversible.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes
Journal of Biochemical and Molecular Toxicology, 20(6), 279–291.
MeSH headings : Adult; Biotransformation; Chlorpyrifos / analogs & derivatives; Chlorpyrifos / analysis; Chlorpyrifos / chemistry; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Chromatography, High Pressure Liquid; Female; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Male; Mass Spectrometry; Middle Aged; Subcellular Fractions
TL;DR:
The results suggest that human liver plays an important role in detoxification, rather than activation, of CPS, and phase II‐related conjugates, including O‐ and S‐glucuronides, were identified in CPS‐treated human hepatocytes, although the O‐sulfate of TCP conjugate was found only when human liver S9 fractions were used as the enzyme source.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2006 article
Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4
Casabar, R. C. T., Wallace, A. D., Hodgson, E., & Rose, R. L. (2006, October). DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 1779–1785.
MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / metabolism; Biotransformation / drug effects; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Endosulfan / chemistry; Endosulfan / metabolism; Endosulfan / pharmacokinetics; Enzyme Inhibitors / pharmacology; Humans; Insecticides / chemistry; Insecticides / metabolism; Insecticides / pharmacokinetics; Ketoconazole / pharmacology; Kinetics; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Microsomes, Liver / metabolism; Molecular Structure; Oxidoreductases, N-Demethylating / antagonists & inhibitors; Oxidoreductases, N-Demethylating / metabolism; Oxygenases / metabolism; Steroid Hydroxylases / metabolism; Sulfates / metabolism; Ticlopidine / pharmacology
TL;DR:
It is shown that endosulfan-α is metabolized by HLMs to a single metabolite, endOSulfan sulfate, and that it has potential use, in combination with inhibitors, as an in vitro probe for CYP2B6 and 3A4 catalytic activities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 review
NTP-CERHR Expert Panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate
[Review of ]. Reproductive Toxicology (Elmsford, N.Y.), 22(3), 291–399.
Source: NC State University Libraries
Added: August 6, 2018
2006 review
Organophosphorus chemicals: Potent inhibitors of the human metabolism of steroid hormones and xenobiotics
[Review of ]. DRUG METABOLISM REVIEWS, 38(1-2), 149–162.
author keywords: carbaryl; chlorpyrifos; chlorpyrifos oxon; cytochrome P450 (CYP); DEET; estradiol; human CYP isoforms; human liver microsomes; organophosphorus insecticides; permethrin; testosterone
MeSH headings : Animals; Carbaryl / metabolism; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; DEET / metabolism; Depression, Chemical; Estrogens / metabolism; Female; Humans; Insect Repellents / metabolism; Insecticides / metabolism; Insecticides / pharmacology; Male; Organophosphorus Compounds / pharmacology; Steroids / metabolism; Testosterone / metabolism; Xenobiotics / metabolism
TL;DR:
Recent studies have demonstrated that organophosphate insecticides containing this moiety are potent inhibitors of the metabolism of both xenobiotics and endogenous substrates by human liver microsomes and by specific human cytochrome P450 isoforms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 review
The importance of cytochrome P4502B6 in the human metabolism of environmental chemicals
[Review of ]. PHARMACOLOGY & THERAPEUTICS, 113(2), 420–428.
author keywords: agrochemicals; cytochrome p450; cytochrome p450 2B6; environmental chemicals; induction; industrial chemicals; inhibition; metabolism; polymorphisms; xenobiotics
MeSH headings : Agrochemicals / metabolism; Aryl Hydrocarbon Hydroxylases / metabolism; Cytochrome P-450 CYP2B6; Environmental Pollutants / metabolism; Humans; Oxidoreductases, N-Demethylating / metabolism; Xenobiotics / metabolism
TL;DR:
Cytochrome P450 (CYP) 2B6 is a human CYP isoform found in variable amounts in the liver and other organs and its role in the metabolism of environmental xenobiotics is concentrated on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Thiodiglycol, the hydrolysis product of sulfur mustard: Analysis of in vitro biotransformation by mammalian alcohol dehydrogenases using nuclear magnetic resonance
TOXICOLOGY AND APPLIED PHARMACOLOGY, 213(3), 207–215.
author keywords: sulfur mustard; thiodiglycol; in vitro metabolism; alcohol dehydrogenase; NMR
MeSH headings : Alcohol Dehydrogenase / metabolism; Animals; Biotransformation; Horses; Humans; Hydrolysis; Isoenzymes / metabolism; Liver / enzymology; Magnetic Resonance Spectroscopy; Mustard Gas / metabolism; Sulfhydryl Compounds / metabolism
TL;DR:
The use of proton NMR to monitor the oxidative reaction with structural confirmation by independent synthesis allowed us to establish the ultimate product, 2-hydroxyethylthioacetic acid, and to identify an intermediate equilibrium mixture consisting of 2-Hydroxy methylthioacetaldehyde, 2,2'-bis- Hydroxyethylsulfide hydrate and the cyclic 1,4-oxathian-2-ol.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 review
Human metabolism and metabolic interactions of deployment-related chemicals
[Review of ]. DRUG METABOLISM REVIEWS, 37(1), 1–39.
author keywords: alcohol dehydrogenase; aldehyde dehydrogenase; carbamates; chemical warfare agents; cytochrome P450; deployment-related chemicals; jet fuel components; metabolic interactions; metabolism; organophosphorus compounds; pyrethroids; repellents; xenobiotic-metabolizing enzymes
MeSH headings : Drug Interactions; Humans; Inactivation, Metabolic; Military Medicine; Xenobiotics / metabolism
TL;DR:
Initial studies have examined the human metabolism by cytochrome P450, other phase I enzymes, and their isoforms and, in some cases, their polymorphic variants of compounds such as chlorpyrifos, carbaryl, DEET, permethrin, and pyridostigmine bromide, and, to a lesser extent, other chemicals from the same chemical and use classes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 article
In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes
Cho, T. M., Rose, R. L., & Hodgson, E. (2006, January). DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 176–183.
MeSH headings : Cytochrome P-450 Enzyme System / metabolism; Humans; Isoenzymes / metabolism; Kinetics; Microsomes, Liver / chemistry; Microsomes, Liver / metabolism; Molecular Structure; Naphthalenes / chemistry; Naphthalenes / metabolism; Naphthalenes / pharmacokinetics; Naphthoquinones / chemistry; Naphthoquinones / metabolism
TL;DR:
Primary And Secondary Metabolites of Naphthalene Produced By Phlms And P450 Isoforms are identified, which helps identify the primary and secondary metabolites of the gas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Molecular Biomarker Workshop - Agricultural Health Study - Discussion and conclusions
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 19(3), 192–193.
MeSH headings : Agriculture; Cohort Studies; Genetic Predisposition to Disease; Health Surveys; Humans; National Institutes of Health (U.S.); Neoplasms / epidemiology; Neoplasms / etiology; Neoplasms / genetics; Risk Factors; United States / epidemiology; United States Environmental Protection Agency
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Pesticide metabolism and potential for metabolic interactions
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 19(4), 276–277.
MeSH headings : Agriculture; Cytochrome P-450 Enzyme System / drug effects; Cytochrome P-450 Enzyme System / metabolism; Humans; Microsomes, Liver / enzymology; Occupational Exposure; Pesticides / metabolism
TL;DR:
This research presents a new probabilistic approach to understanding the role of phosphorous in the build-up of CLRs and its role in the immune response to CLRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Pesticide metabolism in humans, including polymorphisms
Scandinavian Journal of Work, Environment & Health, 31, 156–163.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
The metabolism of nonane, a JP-8 jet fuel component, by human liver microsomes, P450 isoforms and alcohol dehydrogenase and inhibition of human P450 isoforms by JP-8
CHEMICO-BIOLOGICAL INTERACTIONS, 151(3), 203–211.
author keywords: nonane; JP-8; metabolism; cytochrome P450; alcohol dehydrogenase
MeSH headings : Alcohol Dehydrogenase / metabolism; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; DEET / pharmacokinetics; Estradiol / metabolism; Fossil Fuels; Humans; Hydrocarbons / pharmacokinetics; Hydrocarbons / toxicity; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Testosterone / metabolism
TL;DR:
JP-8 showed modest inhibition of testosterone, estradiol and carbaryl metabolism, but had a more significant effect on the metabolism of DEET, suggesting that at least some of the components of JP-8 might be metabolized by CYPs 1A2and/or 2B6.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Toxicology of AHS important chemicals
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 19(3), 180–181.
MeSH headings : Agriculture; Animals; Health Surveys; Humans; Insecticides / toxicity; Pesticides / toxicity
TL;DR:
This research presents a new probabilistic approach to understanding the role of phosphorous in the build-up of cancer in women and its role in the immune response to chemotherapy.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol
CHEMICO-BIOLOGICAL INTERACTIONS, 150(3), 221–232.
author keywords: carbofuran; metabolism; human liver microsomes; cytochrome P450; CYP3MA4; testosterone; interactions
MeSH headings : Animals; Carbofuran / metabolism; Carbofuran / pharmacology; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / metabolism; Drug Interactions / physiology; Estradiol / metabolism; Estradiol / pharmacology; Humans; In Vitro Techniques; Isoenzymes / metabolism; Ketoconazole / pharmacology; Liver / cytology; Liver / enzymology; Mice; Microsomes, Liver / enzymology; Pesticides / metabolism; Rats; Testosterone / metabolism; Testosterone / pharmacology
TL;DR:
Investigating the comparative in vitro metabolism of carbofuran from human, rat, and mouse liver microsomes and characterize the specific enzymes involved in such metabolism found that individuals with high levels of CYP3A4 have the greatest potential to metabolize carb ofuran to its major metabolite.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam
CHEMICO-BIOLOGICAL INTERACTIONS, 147(3), 319–329.
author keywords: fipronil; metabolism; human liver microsomes; cytochrome p450; CYP3A4; interaction
MeSH headings : Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / metabolism; Diazepam / metabolism; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors / pharmacology; Humans; Insecticides / metabolism; Isoenzymes / metabolism; Ketoconazole / pharmacology; Microsomes, Liver / enzymology; Pyrazoles / metabolism; Rats; Species Specificity; Testosterone / metabolism
TL;DR:
The results suggest that fipronil has the potential to interact with a wide range of xenobiotics or endogenous chemicals that are CYP3A4 substrates and that fIPronil may be a useful substrate for the characterization of CYP 3A4 in HLM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily
DRUG METABOLISM AND DISPOSITION, 32(3), 333–339.
MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System / metabolism; Enzyme Inhibitors / pharmacology; Humans; In Vitro Techniques; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Mixed Function Oxygenases / antagonists & inhibitors; Monoamine Oxidase / metabolism; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfaphenazole / pharmacology; Sulfides / metabolism; Sulfoxides / metabolism; Ticlopidine / pharmacology
TL;DR:
The results indicate that current models of the substrate binding site of the CYP2C subfamily would not effectively predict thioether pesticide metabolism, and the substrate specificity of CYP 2Cs is more extensive than is currently believed, and some reevaluation of structure-activity relationships may be required.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Non-target toxicology of a new mosquito larvicide, trypsin modulating oostatic factor
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 80(3), 131–142.
author keywords: trypsin modulating oostatic factor; TMOF; insecticide; mosquito; mouse; rabbit; duck; water flea
TL;DR:
It appears from these studies that T MOF can be degraded by vertebrate digestive proteases and technical TMOF is not toxic to the non-target organisms examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
In vitro human phase I metabolism of xenobiotics I: Pesticides and related compounds used in agriculture and public health, May 2003
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 17(4), 201–206.
author keywords: alcohol dehydrogenase; aldehyde dehydrogenase; carbamates; cytochrome P450; CYP; flavin-containing monooxygenase; FMO; human metabolism; nicotinoids; pesticides; pyrethroids; repellents
MeSH headings : Agriculture; Animals; Cytochrome P-450 Enzyme System / metabolism; Databases, Protein; Herbicides / metabolism; Humans; Insecticides / metabolism; Isoenzymes / metabolism; Pesticides / metabolism; Public Health; Xenobiotics / metabolism
TL;DR:
This is the first revision of a database covering human phase I enzymes and their isoforms that metabolize pesticides and related compounds that includes carbamate, nicotinoid, and pyrethroid insecticides and insect repellents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals
DRUG METABOLISM AND DISPOSITION, 31(4), 384–391.
MeSH headings : Chlorpyrifos / pharmacology; Cholinesterase Inhibitors / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Gonadal Steroid Hormones / metabolism; Humans; In Vitro Techniques; Isoenzymes / metabolism; Kinetics; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Steroid Hydroxylases / metabolism; Testosterone / metabolism
TL;DR:
Kinetic analysis indicated that chlorpyrifos was one of the most potent inhibitors of major TST metabolites followed by fonofos and phorate, and inhibited major T ST metabolites noncompetitively and irreversibly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
In vitro human metabolism and interactions of repellent N,N-diethyl-M-toluamide
DRUG METABOLISM AND DISPOSITION, 30(3), 289–294.
MeSH headings : Animals; Biotransformation; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DEET / analogs & derivatives; DEET / metabolism; DEET / pharmacokinetics; Drug Interactions; Enzyme Induction / drug effects; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Female; Humans; In Vitro Techniques; Insect Repellents / metabolism; Insect Repellents / pharmacokinetics; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Male; Mice; Microsomes, Liver / enzymology; Oxidation-Reduction; Permethrin / metabolism; Permethrin / pharmacology; Pyridostigmine Bromide / metabolism; Pyridostigmine Bromide / pharmacology; Rats; Rats, Long-Evans; Spectrometry, Fluorescence
TL;DR:
Use of phenotyped HLMs demonstrated that individuals with high levels of CYP2B6, 3A4, 2C19, and 2A6 have the greatest potential to metabolize DEET.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
In vitro human metabolism of permethrin: the role of human alcohol and aldehyde dehydrogenases
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 74(3), 117–128.
author keywords: permethrin; permethrin metabolism; human alcohol dehydrogenase; human aldehyde dehydrogenase
TL;DR:
It appears that PBOH is oxidized to P BCHO by ADH and subsequently to PBCOOH by ALDH, although PBCHO does not accumulate during microsomal incubation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos
CHEMICO-BIOLOGICAL INTERACTIONS, 141(3), 229–241.
author keywords: carbaryl; human lifer microsomes; metabolism
MeSH headings : Adult; Carbaryl / metabolism; Cells, Cultured; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation / drug effects; Insecticides / metabolism; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Kinetics; Male; Microsomes, Liver; Molecular Structure
TL;DR:
In vitro metabolic activities of human liver microsomes (HLM) and human cytochrome P450 (CYP) isoforms toward carbaryl were investigated and the production of carbaryl methylol was primarily the result of metabolism by CYP2B6.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Cloning, sequencing, heterologous expression, and ch;characterization of murine cytochrome p450 3a25*(Cyp3a25), a testosterone 6 beta-hydroxylase
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 15(2), 90–99.
author keywords: Cyp3a-25; cloning; sequencing; heterologous expression; metabolism and distribution; testosterone 6 beta-hydroxylase
MeSH headings : Aging; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Northern; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Escherichia coli / genetics; Female; Immunoblotting; Isoenzymes / genetics; Male; Mice; Molecular Sequence Data; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / genetics; Pregnancy; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Tissue Distribution; Transfection
TL;DR:
It was demonstrated by RT‐PCR that the CYP3A25 mRNA is present in both fetal and adult tissues, including liver, lung, intestines, kidney, and brain and Northern blotting demonstrated that expression is greatest in the liver and small intestine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Genetically modified plants and human health risks: Can additional research reduce uncertainties and increase public confidence?
TOXICOLOGICAL SCIENCES, 63(2), 153–156.
MeSH headings : Food Hypersensitivity / etiology; Food Hypersensitivity / immunology; Humans; Mutagenicity Tests; Plants, Edible / adverse effects; Plants, Edible / genetics; Plants, Genetically Modified / adverse effects; Plants, Genetically Modified / growth & development; Public Opinion; Research Design / standards; Risk Assessment; Social Control, Formal; Technology Assessment, Biomedical
TL;DR:
Development of direct tests that involve interaction between the actual transgenic protein in question and the immune system is essential if confidence in the regulatory system is to be restored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos
Journal of Pharmacology and Experimental Therapeutics, 299(3), 825–831.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
In vitro human phase I metabolism of xenobiotics I: Pesticides and related chemicals used in agriculture and public health, September 2001
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 15(6), 296–299.
author keywords: human metabolism; cytochrome P-450; CYP; flavin-containing monooxygenase; FMO; pesticides
MeSH headings : Cytochromes / metabolism; Herbicides / metabolism; Humans; Isoenzymes / metabolism; Pesticides / metabolism; Xenobiotics / metabolism
TL;DR:
This initial version includes enzymes and isoforms that metabolize organophosphorus insecticides, chloroacetamide herbicides and triazine herbicides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes
Drug Metabolism and Disposition, 29(9), 1201–1204.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Modulation of mouse P450 isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the environmental chemicals mirex, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene, vinclozolin, and flutamide
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 70(3), 127–141.
TL;DR:
It is demonstrated that structurally diverse environmental chemicals including mirex, 2,2-Bis( p -chlorophenyl)-1,1-dichloroethylene (DDE), vinclozolin, and flutamide are capable of inducing several mouse liver CYP isozymes that may significantly impact testosterone metabolism and this may be a contributing factor in their antiandrogenic effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes.
ENVIRONMENTAL HEALTH PERSPECTIVES, 108(12), 1151–1157.
author keywords: chloroacetamide herbicides; human cytochrome P450; in vitro metabolism
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Detection of resistant insects and IPM
Emerging Technologies for Integrated Pest Management : Concepts, Research, and Implementation, 67.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 14(2), 118–120.
author keywords: flavin-containing monooxygenase; FMO; FMO isoforms; tamoxifen; human; mouse
TL;DR:
The Km value for tamoxifen is 1.2 mM for mouse FMO1 (human F MO1 is not expressed in adults) and 1.4 mM for human FMO3, with no detectable activity being expressed toward tamoxIFen by FMO5 from either mouse or human, derived from experiments using 3H‐tamox ifen as substrate in which the product, tamoxIfen N‐oxide, was measured directly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
The federal government's Agricultural Health Study: A critical review with suggested improvements
HUMAN AND ECOLOGICAL RISK ASSESSMENT, 6(1), 47–71.
author keywords: epidemiology; pesticides; farmworkers; health effects
TL;DR:
The design of the Agricultural Health Study is examined, important program strengths and flaws are identified, various improvements in the program are suggested, and ancillary studies that could be undertaken to strengthen the AHS are recommended.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Constitutive expression and induction of CYP1B1 mRNA in the mouse
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 13(5), 249–251.
TL;DR:
The induction of CYP1B1 mRNA by PBO or ACN was higher in DBA/2 (Ahrd) than in C57BL/6 (Ahrb−1) mice, while 3‐methylcholanthrene induced CYP2B1 more in C 57BL/ 6 than in Dba/2 mice, suggesting that CYP 1B1 may also be induced by more than one mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 article
In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms
Coleman, S., Liu, S. M., Linderman, R., Hodgson, E., & Rose, R. L. (1999, August 30). CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 122, pp. 27–39.
author keywords: alachlor; CDEPA; human CYP; herbicides
MeSH headings : Acetamides / metabolism; Animals; Cytochrome P-450 Enzyme System / metabolism; Female; Herbicides / metabolism; Humans; In Vitro Techniques; Isoenzymes / metabolism; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Rats; Rats, Long-Evans
TL;DR:
It is demonstrated that male human liver microsomes are able to metabolize alachlor to CDEPA, a widely used pre-emergent chloroacetanilide herbicide which has been classified by the USEPA as a probable human carcinogen and 2,6-diethylbenzoquinone imine (DEBQI), a putative carcinogenic metabolite.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Induction and inhibition of pesticide-metabolizing enzymes: roles in synergism of pesticides and pesticide action
TOXICOLOGY AND INDUSTRIAL HEALTH, 15(1-2), 6–11.
author keywords: cytochrome P450; flavin-containing monooxyhenases; induction; inhibition; methylenedioxyphenyl compounds; pesticide-metabolizing enzymes; phorate; piperonyl butoxide; synergism
MeSH headings : Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction; Humans; Insecticides / pharmacokinetics; Multienzyme Complexes / metabolism; Pesticides / pharmacokinetics; Phorate / pharmacokinetics; Xenobiotics / pharmacokinetics
TL;DR:
Synergism of the toxic action of pesticides is discussed with particular emphasis on the methylenedioxyphenyl (benzodioxole) (MDP) synergists and on how studies of these compounds may relate to the general significance of pesticide synergism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Basic principles and rationale for the use of insect genes in bioremediation: esterases, phosphotriesterase, cytochrome P450 and epoxide hydrolase
Reviews in Toxicology, 2(1998), 169–178.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 357(1), 45–57.
author keywords: cytochrome P450; CYP2Cs; mouse; cDNA cloning; cDNA expression; arachidonic acid metabolism; liver; extrahepatic; mRNA expression
MeSH headings : Amino Acid Sequence; Animals; Arachidonic Acid / metabolism; Aryl Hydrocarbon Hydroxylases; Base Sequence; Catalysis; Cloning, Molecular; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Enzyme Activation; Female; Humans; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Male; Mice; Microsomes, Liver / enzymology; Molecular Sequence Data; Organ Specificity / genetics; Polymerase Chain Reaction; RNA, Messenger / biosynthesis; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases / biosynthesis; Steroid Hydroxylases / genetics; Steroid Hydroxylases / metabolism
TL;DR:
Five murine cytochrome P450 (CYP) 2C cDNAs were cloned and characterized, including four new members of this subfamily, and the presence of CYP2C29 mRNA in liver as well as in extrahepatic tissues including brain, kidney, lung, heart, and intestine was demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Common mechanism of toxicity: A case study of organophosphorus pesticides
Fundamental and Applied Toxicology, 41(1), 8–20.
Source: NC State University Libraries
Added: August 6, 2018
1998 book
Dictionary of toxicology (2nd ed.)
London: MacMillan Reference; New York: Grove Dictionaries.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Flavin-containing monooxygenase and cytochrome P450 mediated metabolism of pesticides: from mouse to human
Reviews in Toxicology, 2(1998), 231–243.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5)
Journal of Biochemical and Molecular Toxicology, 12(1998), 205–212.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5
XENOBIOTICA, 28(7), 673–682.
MeSH headings : Adult; Animals; Female; Humans; Liver / embryology; Liver / metabolism; Male; Mice; Microsomes, Liver / metabolism; Middle Aged; Oxygenases / biosynthesis; Rats; Sex Characteristics; Species Specificity
TL;DR:
The mouse and rat exhibit substantial differences in the gender expression of flavin-containing monooxygenase (FMO) forms, and Methimazole, imipramine and thiobenzamide are much better substrates for FMO1 than for F MO3 or FMO5.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Cytochrome P450 (CYP)9A1 in Heliothis virescens: The first member of a new CYP family
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 27(6), 605–615.
author keywords: CYP9A1; cytochrome P450; insecticide resistance; Heliothis virescens
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / isolation & purification; DNA, Complementary; Female; Insecticide Resistance; Male; Molecular Sequence Data; Moths / enzymology; Moths / genetics; Sequence Homology, Amino Acid
TL;DR:
Comparative Western and Northern blot studies indicate that expression of CYP9A1 in thiodicarb selected populations of tobacco budworm is associated with insecticide resistance and the pattern of restriction fragment length polymorphism (RELP) variation in offspring of single-pair matings demonstrated autosomal inheritance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1997 journal article
Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): Comparison with the human isoform
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 347(1), 9–18.
author keywords: flavin-containing monooxygenase 3; FMO3; FMO3 sequence; FMO3 expression
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Catalysis; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors / pharmacology; Enzyme Stability; Escherichia coli / genetics; Female; Gene Expression; Humans; Hydrogen-Ion Concentration; Liver / enzymology; Male; Methimazole / metabolism; Mice; Molecular Sequence Data; Oxygenases / chemistry; Oxygenases / genetics; Oxygenases / metabolism; RNA, Messenger / analysis; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Sequence Analysis, DNA; Sequence Homology, Amino Acid
TL;DR:
The sequence of mouse flavin-containing monooxygenase 3 (FMO3) was obtained from several clones isolated from a mouse liver cDNA library and results of immunoblotting confirmed the tissue- and gender-dependent expression of mouse FMO3.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse
CHEMICO-BIOLOGICAL INTERACTIONS, 105(1), 53–63.
author keywords: piperonyl butoxide; acenaphthylene; CYP1A1; CYP1A2; Ah receptor; C57BL/6; DBA/2; Ah receptor knockout (AHR(-/-)) mouse
MeSH headings : Acenaphthenes / pharmacology; Animals; Blotting, Northern; Blotting, Western; Cycloheximide / pharmacology; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 Enzyme System / genetics; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Isoenzymes / genetics; Liver / enzymology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperonyl Butoxide / pharmacology; Polychlorinated Dibenzodioxins / pharmacology; Polymerase Chain Reaction / methods; RNA, Heterogeneous Nuclear / analysis; RNA-Directed DNA Polymerase; Teratogens / pharmacology
TL;DR:
The results suggest that PBO, but not ACN, induces CYP1A1 through a weak activation of AHR, and it is assumed that the transcriptional induction of CYP 1A2 by PBO and ACN is AHR-independent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 article
Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids
Falls, J. G., Ryu, D. Y., Cao, Y., Levi, P. E., & Hodgson, E. (1997, June 15). ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 342, pp. 212–223.
author keywords: flavin-containing monooxygenases; FM01; FM03; FM05; FMO expression; hormonal regulation; testosterone; 17 beta-estradiol; progesterone
MeSH headings : Animals; Blotting, Western; Castration; Estradiol / blood; Estradiol / pharmacology; Female; Gene Expression Regulation, Enzymologic; Isoenzymes / metabolism; Liver / drug effects; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Organ Size / drug effects; Ovariectomy; Oxygenases / metabolism; Progesterone / blood; Progesterone / pharmacology; RNA, Messenger / metabolism; Seminal Vesicles / drug effects; Testosterone / blood; Testosterone / pharmacology; Uterus / drug effects
TL;DR:
In males and females, F MO5 levels were unaffected by gonadectomy or hormone administration, thus indicating a sex hormone-independent mechanism of regulation for this isoform, and Interestingly, FMO1 protein levels were increased in sexually intact males following treatment with 17 beta-estradiol; however, only a slight increase in FMO3 protein level was observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 book
Textbook of modern toxicology
Stamford, Conn.: Appleton & Lange.
Source: NC State University Libraries
Added: August 6, 2018
1996 patent
Insecticide resistance associated cytochrome 450
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1995 article
Pesticide-metabolizing enzymes
Hodgson, E., Rose, R. L., Ryu, D. Y., Falls, G., Blake, B. L., & Levi, P. E. (1995, December). TOXICOLOGY LETTERS, Vol. 82-3, pp. 73–81.
author keywords: pesticide-metabolizing enzymes; cytochrome P450; flavin-containing monooxygenase (FMO); methylenedioxyphenyl compounds; phorate
MeSH headings : Animals; Cytochrome P-450 Enzyme System / metabolism; Humans; Mice; Oxygenases / metabolism; Pesticides / metabolism; Substrate Specificity
TL;DR:
The isozyme specificity of methylenedioxyphenyl synergists for induction of P450 in mouse liver involves P450s 1A1, 1A2 and 2B10, including a non-Ah receptor-dependent mechanism for 1A3 induction and the substrate specificity of mouse and human P450 and FMO isozymes is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1992 journal article
ENZYMATIC AND IMMUNOHISTOCHEMICAL STUDIES ON THE ROLE OF CYTOCHROME-P450 AND THE FLAVIN-CONTAINING MONOOXYGENASE OF MOUSE SKIN IN THE METABOLISM OF PESTICIDES AND OTHER XENOBIOTICS
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 43(1), 53–66.
Contributors: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiroriviere n, R. Misra n & n
TL;DR:
Although the overall phorate sulfoxidation rate in mouse skin microsomes was only 3 to 4% of the rate seen in liver, FMO appears to assume a greater relative role to P450 in the metabolic processes in skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1984 chapter
Biochemical mechanisms of resistance to insecticides
In Origins and development of adaptation (p. 167). London: Pitman.
Source: NC State University Libraries
Added: August 6, 2018
1983 chapter
Characterization of cytochrome P-450 in studies of insecticide resistance
In G. P. Georghiou & T. Saito (Eds.), Pest resistance to pesticides (p. 207). New York: Plenum Press.
Ed(s): G. Georghiou & T. Saito
Source: NC State University Libraries
Added: August 6, 2018
1983 review
THE SIGNIFICANCE OF CYTOCHROME-P-450 IN INSECTS
[Review of ]. INSECT BIOCHEMISTRY, 13(3), 237–246.
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1977 journal article
SUBSTITUTION OF CHOLINE BY RELATED COMPOUNDS IN DIET OF ARGYROTAENIA-VELUTINANA AND HELIOTHIS-VIRESCENS
JOURNAL OF INSECT PHYSIOLOGY, 23(7), 801–804.
MeSH headings : Animals; Choline / metabolism; Lepidoptera / metabolism
TL;DR:
Argyrotaenia velutinana, the red-banded leaf roller, and Heliothis virescens, the tobacco budworm, both require choline for growth and development when reared on semisynthetic diets and no choline analog tested can adequately replace choline in the diet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1974 article
MICROSOMAL CYTOCHROME-P-450 - CHARACTERIZATION AND POSSIBLE ROLE IN INSECTICIDE RESISTANCE IN MUSCA-DOMESTICA
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Vol. 22, pp. 360–366.
MeSH headings : Animals; Chromosomes; Cytochrome P-450 Enzyme System / isolation & purification; Genetics, Population; Houseflies; Insecticide Resistance; Insecticides; Microsomes / metabolism
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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