Works (7)

Updated: July 5th, 2023 15:47

2019 journal article

Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells


By: J. Bodle n, M. Hamouda n, S. Cai n, R. Williams n, S. Bernacki n & E. Loboa*

MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adipogenesis / genetics; Cell Differentiation / genetics; Cell Lineage / genetics; Cells, Cultured; Cilia / genetics; Core Binding Factor Alpha 1 Subunit / genetics; Gene Expression Regulation, Developmental / genetics; Humans; Mechanotransduction, Cellular / genetics; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Osteogenesis / genetics; Tensile Strength; Tissue Engineering
TL;DR: This study demonstrates that hASC primary cilia exhibit mechanosensitivity to cyclic tensile strain and lineage-dependent expression, which may in part regulate signaling pathways localized to the primary cilium during the differentiation process. (via Semantic Scholar)
Source: Web Of Science
Added: June 17, 2019

2016 journal article

Cell signaling in tenocytes: Response to load and ligands in health and disease

Metabolic Influences on Risk for Tendon Disorders, 920, 79–95.

By: M. Wall, N. Dyment, J. Bodle, J. Volmer, E. Loboa, A. Cederlund, A. Fox, A. Banes

Source: NC State University Libraries
Added: August 6, 2018

2016 review

Concise Review: Primary Cilia: Control Centers for Stem Cell Lineage Specification and Potential Targets for Cell-Based Therapies

[Review of ]. STEM CELLS, 34(6), 1445–1454.

By: J. Bodle n & E. Loboa n

author keywords: Primary cilia; Tissue regeneration; Adipose stem cells; Bone marrow stromal cells; Cell biology; Stem cell-microenvironment interactions; Cellular therapy; Progenitor cells
MeSH headings : Animals; Cell Lineage; Cilia / metabolism; Disease Models, Animal; Humans; Mechanotransduction, Cellular; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
TL;DR: The goal of this review is to highlight the cilium's function and integrate this knowledge into the working knowledge of stem cell biologists and tissue engineers developing regenerative medicine technologies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Facilitating Teamwork in Adolescent and Young Adult Oncology


By: R. Johnson*, C. Macpherson*, A. Smith*, R. Block* & J. Keyton*

MeSH headings : Adolescent; Adult; Communication; Cooperative Behavior; Humans; Interprofessional Relations; Male; Patient Care Team / organization & administration; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Trust; Young Adult
TL;DR: A case of a young adult patient in the days immediately after a cancer diagnosis illustrates the critical importance of three interrelated core coordinating mechanisms-closed-loop communication, shared mental models, and mutual trust-of teamwork in an adolescent and young adult multidisciplinary oncology team. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Age-Related Effects on the Potency of Human Adipose-Derived Stem Cells: Creation and Evaluation of Superlots and Implications for Musculoskeletal Tissue Engineering Applications

Tissue Engineering Part C: Methods, 20(12), 972–983.

By: J. Bodle n, S. Teeter n, B. Hluck n, J. Hardin n, S. Bernacki n & E. Loboa n

MeSH headings : Adipogenesis; Adipose Tissue / cytology; Adult; Aged; Aged, 80 and over; Aging / physiology; Cell Line; Cell Proliferation; Cell Separation; DNA / metabolism; Female; Humans; Middle Aged; Musculoskeletal System / metabolism; Osteogenesis; Postmenopause; Premenopause; Proteins / metabolism; Reproducibility of Results; Stem Cells / cytology; Tissue Engineering / methods; Young Adult
TL;DR: In general, superlots effectively represented the average differentiation behavior of each of their contributing cell populations and could provide a powerful tool for increasing experimental throughput to more efficiently utilize resources when studying hASC differentiation. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix

JOURNAL OF BIOMECHANICS, 47(9), 2211–2217.

By: P. Mathieu n, J. Bodle n & E. Loboa n

author keywords: Primary cilia; Finite element analysis; Mechanotransduction; Tensile strain; Ciliary membrane; Mechanobiology; Ciliary pocket; Adipose derived stem cells
MeSH headings : Adipose Tissue / cytology; Cells, Cultured; Cilia / physiology; Collagen; Finite Element Analysis; Humans; Mechanotransduction, Cellular; Models, Biological; Osteogenesis / physiology; Stem Cells / cytology; Stress, Mechanical
TL;DR: This is the first study to model the effects of tensile strain on the primary cilium and provides newfound insight into the potential role of thePrimary cilia as a mechanosensor, particularly in Tensile strain and potentially a multitude of other mechanical stimuli beyond fluid shear. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Adipose-Derived Stem Cells in Functional Bone Tissue Engineering: Lessons from Bone Mechanobiology


By: J. Bodle n, A. Hanson n & E. Loboa n

MeSH headings : Adipose Tissue / cytology; Adipose Tissue / physiology; Adipose Tissue / transplantation; Animals; Humans; Mechanotransduction, Cellular / physiology; Osteogenesis / physiology; Stem Cell Transplantation / trends; Stem Cells / cytology; Stem Cells / physiology; Tissue Engineering / trends
TL;DR: The current knowledge base in bone mechanobiology is outlined to investigate how the knowledge from this area has been applied to the various stem cell-based approaches to engineering bone tissue constructs. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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