Ghazala H. Ansari

Works (3)

Updated: July 5th, 2023 16:02

2000 article

Role of Modified Nucleosides of Yeast tRNA<sup>Phe</sup> in Ribosomal Binding

Ashraf, S. S., Guenther, R. H., Ansari, G., Malkiewicz, A., Sochacka, E., & Agris, P. F. (2000, January 1). Cell Biochemistry and Biophysics.

By: S. Ashraf*, R. Guenther n, G. Ansari n, A. Malkiewicz*, E. Sochacka * & P. Agris n

author keywords: tRNA(Phe); anticodon; ASL; nucleoside modification; ribosome
MeSH headings : Nucleosides / genetics; Nucleosides / metabolism; RNA, Fungal / genetics; RNA, Fungal / metabolism; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Ribosomes / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; RNA Research and Splicing
TL;DR: Effective ribosome binding of tRNAPhe is a combination of anticodon stem stability and the correct architecture and dynamics of the anticodon loop, and 2′O-methylation of guanosine at wobble position 34 (Gm34) is identified as being responsible for the characteristically enhanced chemical reactivity of C1400 in Escherichia coli 16S rRNA upon ribosomal footprinting of yeast t RNAPhe. (via Semantic Scholar)
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Added: August 6, 2018

1999 article

Structural and functional roles of the N1- and N3-protons of   at tRNA's position 39

Yarian, C. S., Basti, M. M., Cain, R. J., Ansari, G., Guenther, R. H., Sochacka, E., … Agris, P. F. (1999, September 1). Nucleic Acids Research.

By: C. Yarian n, M. Basti*, R. Cain n, G. Ansari n, R. Guenther n, E. Sochacka *, G. Czerwinska*, A. Malkiewicz*, P. Agris*

MeSH headings : Anticodon / chemistry; Genes, Fungal / genetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Protons; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Phe / chemistry; Ribosomes / chemistry; Structure-Activity Relationship; Temperature; Thermodynamics; Uridine / chemistry; Yeasts / genetics
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Mass Spectrometry Techniques and Applications
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1999 article

The uridine in “U-turn”: Contributions to tRNA-ribosomal binding

ASHRAF, S. S. A. L. M. A. N., ANSARI, G. H. A. Z. A. L. A., GUENTHER, R. I. C. H. A. R. D., SOCHACKA, E. L. Z. B. I. E. T. A., MALKIEWICZ, A. N. D. R. Z. E. J., & AGRIS, P. A. U. L. F. (1999, April 1). RNA.

By: S. Ashraf*, G. Ansari n, R. Guenther n, E. Sochacka *, A. Malkiewicz* & P. Agris n

author keywords: anticodon conformation; anticodon stem loop analogs; ASL; nucleoside modifications; ribosome; translation; tRNA(Phe) U-turn
MeSH headings : Anticodon / chemistry; Anticodon / genetics; Humans; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Nucleic Acid Denaturation; RNA, Fungal / chemistry; RNA, Fungal / genetics; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / metabolism; Ribosomes / genetics; Ribosomes / metabolism; Temperature; Uridine / chemistry; Uridine / genetics
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; RNA Research and Splicing
TL;DR: The results demonstrate that proton donations by the N3-H and 2'OH groups of U33 are not absolutely required for ribosomal binding, and suggest that the overall uridine conformation, including a dynamic (C3'-endo > C2'-endo) sugar pucker, anti-conformation, and ability of uracil to stack between C32 and A35-phosphate, are the contributing factors to a functional U-turn. (via Semantic Scholar)
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