Jun Tang

Works (5)

Updated: July 5th, 2023 15:59

2005 journal article

Pesticide metabolism in humans, including polymorphisms

Scandinavian Journal of Work, Environment & Health, 31, 156–163.

By: R. Rose, J. Tang, J. Choi, Y. Cao, A. Usmani, N. Cherrington, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam

CHEMICO-BIOLOGICAL INTERACTIONS, 147(3), 319–329.

By: J. Tang n, K. Usmani n, E. Hodgson n & R. Rose n

author keywords: fipronil; metabolism; human liver microsomes; cytochrome p450; CYP3A4; interaction
MeSH headings : Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / metabolism; Diazepam / metabolism; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors / pharmacology; Humans; Insecticides / metabolism; Isoenzymes / metabolism; Ketoconazole / pharmacology; Microsomes, Liver / enzymology; Pyrazoles / metabolism; Rats; Species Specificity; Testosterone / metabolism
TL;DR: The results suggest that fipronil has the potential to interact with a wide range of xenobiotics or endogenous chemicals that are CYP3A4 substrates and that fIPronil may be a useful substrate for the characterization of CYP 3A4 in HLM. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 journal article

In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos

CHEMICO-BIOLOGICAL INTERACTIONS, 141(3), 229–241.

By: J. Tang n, Y. Cao n, R. Rose n & E. Hodgson n

author keywords: carbaryl; human lifer microsomes; metabolism
MeSH headings : Adult; Carbaryl / metabolism; Cells, Cultured; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation / drug effects; Insecticides / metabolism; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Kinetics; Male; Microsomes, Liver; Molecular Structure
TL;DR: In vitro metabolic activities of human liver microsomes (HLM) and human cytochrome P450 (CYP) isoforms toward carbaryl were investigated and the production of carbaryl methylol was primarily the result of metabolism by CYP2B6. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 journal article

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos

Journal of Pharmacology and Experimental Therapeutics, 299(3), 825–831.

By: D. Dai, J. Tang, R. Rose, E. Hodgson, R. Bienstock, H. Mohrenweiser, J. Goldstein

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes

Drug Metabolism and Disposition, 29(9), 1201–1204.

By: J. Tang, Y. Cao, R. Rose, A. Brimfield, D. Dai, J. Goldstein, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

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