Yousuf Sharief

Works (4)

Updated: July 5th, 2023 15:57

2008 journal article

Tonic protein kinase A activity maintains inactive beta 2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase

JOURNAL OF LEUKOCYTE BIOLOGY, 83(4), 964–971.

By: C. Chilcoat n, Y. Sharief n & S. Jones n 

author keywords: PMN; PKA; ROCK; avidity; adhesion; cytoskeleton
MeSH headings : Adult; CD18 Antigens / blood; CD18 Antigens / drug effects; Carbazoles / pharmacology; Cell Adhesion; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / blood; Homeostasis; Humans; Indoles / pharmacology; Myosin-Light-Chain Kinase / blood; Neutrophils / enzymology; Neutrophils / physiology; Oligopeptides / pharmacology; Phosphorylation; Pyrroles / pharmacology; rho-Associated Kinases / blood
TL;DR: It is demonstrated that tonic PKA activity prevents activation of β2 integrins and adhesion by inhibiting MLC phosphorylation via a MLCK‐dependent but ROCK‐independent pathway. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 129(3-4), 181–191.

By: R. Eckert n, Y. Sharief n & S. Jones n 

author keywords: Other animals; Inflammation; Laminitis
MeSH headings : Animals; CD18 Antigens / metabolism; Cell Adhesion; Cells, Cultured; Chemotaxis, Leukocyte / physiology; Dose-Response Relationship, Drug; Enzyme Inhibitors / pharmacology; Gene Expression Regulation / physiology; Horses / physiology; Imidazoles / pharmacology; Inflammation / metabolism; Leukotriene B4 / metabolism; Neutrophils / metabolism; Pyridines / pharmacology; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: Findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 article

A peptide against the N-terminus of MARCKS protein attenuates leukocyte migration.

404nOtfound, Vol. 175, p. A915.

By: T. Green, B. Eckert, Y. Sharief, A. Crews, K. Adler & S. Jones 

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis

JOURNAL OF LEUKOCYTE BIOLOGY, 78(1), 248–258.

By: S. Jones n  & Y. Sharief n

author keywords: integrin; adhesion; migration; actin cytoskeleton; phosphatidylinositol-3 kinase
MeSH headings : Actin Cytoskeleton / drug effects; Actin Cytoskeleton / metabolism; CD18 Antigens / metabolism; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Polarity / drug effects; Cell Polarity / physiology; Cells, Cultured; Chemotaxis, Leukocyte / drug effects; Chemotaxis, Leukocyte / physiology; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / metabolism; Cytoskeleton / drug effects; Cytoskeleton / enzymology; Dose-Response Relationship, Drug; Enzyme Activation / drug effects; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Humans; Neutrophils / drug effects; Neutrophils / enzymology; Peptides / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors
TL;DR: The data suggest that asymmetrical PKA activity is necessary and sufficient for actin cytoskeletal polarization and migration during neutrophil chemotaxis, and suggest PI‐3K is an effector of PKA during Chemotaxis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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