Works (329)

Updated: April 3rd, 2024 17:03

2022 article

Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain

Muthusamy, N., Williams, T. I., O'Toole, R., Brudvig, J. J., Adler, K. B., Weimer, J. M., … Ghashghaei, H. T. (2022, January 24). GEROSCIENCE, Vol. 1.

By: N. Muthusamy n, T. Williams n, R. O'Toole*, J. Brudvig*, K. Adler n, J. Weimer*, D. Muddiman n, H. Ghashghaei n

Contributors: N. Muthusamy n, T. Williams n, R. O’Toole*, J. Brudvig*, K. Adler n, J. Weimer*, D. Muddiman n, H. Ghashghaei n

author keywords: Aging; Behavior; Clca3; Ependymal cells; Forebrain; Marcks; Mass spectrometry; Neuroinflammation
MeSH headings : Mice; Animals; Phosphorylation; Ependyma / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Proteome / metabolism; Membrane Proteins / metabolism; Protein Kinase C / metabolism; Homeostasis; Prosencephalon / metabolism; Mammals / metabolism
TL;DR: This study provides first line of evidence for potential mechanisms that may mediate differential Marcks functions in young and old ECs, and their effect on forebrain homeostasis during aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 31, 2022

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n, K. Popowski n, M. Gracieux n, J. Cores n, K. Huang n, M. Hensley n ...

MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 23, 2020

2019 review

MARCKS and Lung Disease

[Review of ]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 60(1), 16–27.

By: M. Sheats*, Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh*, B. Dickson*, K. Adler n

author keywords: MARCKS; lung disease; inflammation; cancer
MeSH headings : Animals; Humans; Lung Diseases / metabolism; Lung Diseases / physiopathology; Myristoylated Alanine-Rich C Kinase Substrate / metabolism
TL;DR: This article summarizes the structure and cellular function of MARCKS (also including MARC KS family proteins and MARCKSL1 [MARCKS‐like protein 1]). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

2018 journal article

Does transforming growth factor-beta induce persistent airway obstruction after asthma exacerbations?

American Journal of Respiratory Cell and Molecular Biology, 58(5), 543–544.

By: K. Adler n

MeSH headings : Airway Obstruction; Asthma; Humans; Myocytes, Smooth Muscle; Smad3 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factors
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network

SCIENTIFIC REPORTS, 8.

By: J. Brudvig*, J. Cain*, R. Sears*, G. Schmidt-Grimminger*, E. Wittchen*, K. Adler n, H. Ghashghaei n, J. Weimer*

MeSH headings : Actins / metabolism; Animals; Cytoskeleton / metabolism; Female; Male; Mice; Mice, Inbred C57BL; Microtubules / metabolism; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Neurites / metabolism; Neurons / cytology; Neurons / metabolism; Phosphorylation; Primary Cell Culture; Protein Binding; Pseudopodia / metabolism; Signal Transduction; cdc42 GTP-Binding Protein / metabolism
TL;DR: It is proposed that MARCKS is uniquely positioned to regulate CDC42 localization and interactions within specialized cellular compartments, such as nascent neurites. (via Semantic Scholar)
Source: Web Of Science
Added: October 19, 2018

2017 journal article

Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies

Respiratory Research, 18(1).

By: P. Dinh n, J. Cores n, M. Hensley n, A. Vandergriff n, J. Tang n, T. Allen n, T. Caranasos*, K. Adler n, L. Lobo*, K. Cheng n

author keywords: Pulmonary progenitor cells; Lung spheroid; Stem cell
MeSH headings : Adolescent; Aged; Animals; Biopsy; Bronchi / cytology; Bronchi / physiology; Cell Culture Techniques / methods; Female; Human Umbilical Vein Endothelial Cells / physiology; Humans; Infusions, Intravenous; Lung / cytology; Lung / physiology; Male; Mice; Mice, Nude; Middle Aged; Spheroids, Cellular / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology
TL;DR: These cells could be utilized in long-term expansion of lung progenitor cells and as part of the development of cell-based therapies for the treatment of lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 55(5), 617–622.

By: Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh* & K. Adler n

author keywords: myristoylated alanine-rich C kinase substrate; acute lung injury; LPS; neutrophils
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / drug therapy; Aerosols / administration & dosage; Aerosols / pharmacology; Animals; Behavior, Animal; Bronchoalveolar Lavage Fluid; Cytokines / metabolism; Female; Inflammation Mediators / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / metabolism; Leukocytes / metabolism; Lipopolysaccharides; Lung / drug effects; Lung / metabolism; Lung / pathology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / metabolism; Mice, Inbred BALB C; Myristoylated Alanine-Rich C Kinase Substrate; NF-kappa B / metabolism; Peptides / administration & dosage; Peptides / pharmacology; Peptides / therapeutic use
TL;DR: Results implicate MARCKS protein in the pathogenesis of ALI/ARDS and suggest that MARC KS-inhibitory peptide(s), delivered by inhalation, could represent a new and potent therapeutic treatment for ALi/ARDS, even if administered well after the disease process has begun. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging

AGING CELL, 14(5), 764–773.

author keywords: aging; barrier function; Clca3; cerebral cortex; ependymal cells; lipid droplets; mucin; oxidative stress
MeSH headings : Aging / metabolism; Animals; Ependyma / cytology; Ependyma / metabolism; Homeostasis; Intracellular Signaling Peptides and Proteins / deficiency; Intracellular Signaling Peptides and Proteins / metabolism; Lipid Metabolism; Membrane Proteins / deficiency; Membrane Proteins / metabolism; Mice; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oxidative Stress; Prosencephalon / metabolism
TL;DR: It is demonstrated that metabolic and barrier functions in ECs decline significantly during aging in mice, and this work constitutes a conceptually new paradigm in the potential role of ECs in the initiation of various conditions and diseases in the aging brain. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 personal communication

A Novel Predictor of Cancer Malignancy: Up-regulation of Myristoylated Alanine-Rich C Kinase Substrate Phosphorylation in Lung Cancer

Chen, C.-H., Chiu, C.-L., Adler, K. B., & Wu, R. (2014, April 15).

By: C. Chen*, C. Chiu*, K. Adler n & R. Wu n

MeSH headings : Adenocarcinoma / genetics; Adenocarcinoma / metabolism; Adenocarcinoma / mortality; Aged; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Carcinoma / metabolism; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / mortality; Cohort Studies; Female; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Lung Neoplasms / genetics; Lung Neoplasms / metabolism; Lung Neoplasms / mortality; Male; Membrane Proteins / genetics; Membrane Proteins / metabolism; Middle Aged; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasm Invasiveness; Neoplasm Staging; Phosphorylation; Predictive Value of Tests; Prognosis; Sensitivity and Specificity; Up-Regulation
TL;DR: High phosphorylated myristoylated alanine-rich C kinase substrate (phospho-MARCKS) levels correlate with advanced stages, lymph node metastasis, and invasion of lung cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis

Oncogene, 33(28), 3696–3706.

By: C. Chen*, P. Thai*, K. Yoneda*, K. Adler n, P. Yang* & R. Wu*

MeSH headings : Animals; Cell Line, Tumor; Cell Movement / drug effects; Epithelial-Mesenchymal Transition / drug effects; Gene Expression Regulation, Neoplastic / drug effects; Humans; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / chemistry; Intracellular Signaling Peptides and Proteins / metabolism; Lung Neoplasms / pathology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / chemistry; Membrane Proteins / metabolism; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasm Invasiveness; Neoplasm Metastasis; Oncogenes / genetics; Peptide Fragments / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / antagonists & inhibitors; Phosphoproteins / chemistry; Phosphoproteins / metabolism; Phosphorylation / drug effects; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction / drug effects
TL;DR: Elevated levels of MARCKS and phospho-MARCKS are demonstrated in highly invasive lung cancer cell lines and lung cancer specimens from non-small-cell lung cancer patients and a potential use ofMARCKS-related peptides in the treatment of lung cancer metastasis is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Aerosolized MANS and BIO-11006 Peptides Inhibit Lung Cancer Metastasis in SCID Mice

International Journal of Radiation Oncology*Biology*Physics, 90(5), S51.

By: I. Parikh*, W. Long*, Q. Yin n, S. Fang n & K. Adler n

TL;DR: Almost 50% of lung adenocarcinoma of all stages harbored an identifiable driver mutation, and amongst the authors' cases, AA patients had a higher frequency of dual mutations than in other patient populations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 21, 2020

2014 journal article

In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation

Inflammation, 38(3), 1126–1141.

By: M. Sheats n, E. Sung n, K. Adler n, S. Jones n & Inflammation

author keywords: neutrophil; chemotaxis; adhesion; migration; innate immunity; PKC signaling
MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Cell Adhesion / immunology; Cell Movement; Cells, Cultured; Enzyme Inhibitors / pharmacology; Humans; Inflammation / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; N-Formylmethionine Leucyl-Phenylalanine / metabolism; Neutrophil Activation / immunology; Neutrophil Infiltration / immunology; Neutrophils / immunology; Phosphorylation; Protein Isoforms / antagonists & inhibitors; Protein Isoforms / metabolism; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / metabolism
TL;DR: It is concluded that δ-PKC-mediated MARCKS phosphorylation is essential for human neutrophil migration and adhesion in vitro, and this results implicate €1,000,000 phosphorylated actin binding protein and protein kinase C (PKC) as a key step in the inflammatory response of neutrophils. (via Semantic Scholar)
Sources: Crossref, Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Myristoylated Alanine Rich C Kinase Substrate (MARCKS) is essential to β2-integrin dependent responses of equine neutrophils

Veterinary Immunology and Immunopathology, 160(3-4), 167–176.

By: M. Sheats*, K. Pescosolido, E. Hefner*, E. Sung, K. Adler* & S. Jones*

author keywords: Neutrophil; Migration; Adhesion; Respiratory burst; Beta2-integrin; Inflammation
MeSH headings : Amino Acid Sequence; Animals; Antigen-Antibody Complex / physiology; CD18 Antigens / immunology; CD18 Antigens / physiology; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Movement / drug effects; Cell Movement / physiology; Conserved Sequence; Horses / immunology; Horses / physiology; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / physiology; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophil Infiltration / drug effects; Neutrophil Infiltration / immunology; Neutrophil Infiltration / physiology; Peptide Fragments / genetics; Peptide Fragments / pharmacology; Respiratory Burst / drug effects; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: It is demonstrated that inhibition of MARCKS function significantly attenuates β2-integrin-dependent neutrophil functions including migration, adhesion, and immune complex-mediated respiratory burst, and strongly implicate MARC KS as a potential regulator of β 2-integrins in neutrophils. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2014 journal article

Targeting Myristoylated Alanine-Rich C Kinase Substrate Phosphorylation Site Domain in Lung Cancer Mechanisms and Therapeutic Implications

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190(10), 1127–1138.

By: C. Chen*, S. Statt*, C. Chiu*, P. Thai*, M. Arif*, K. Adler n, R. Wu*

author keywords: MARCKS phosphorylation; PI3K/AKT; PIP3; lung cancer; erlotinib
MeSH headings : Animals; Cell Culture Techniques; Cell Line, Tumor; Disease Models, Animal; Erlotinib Hydrochloride; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Lung Neoplasms / drug therapy; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Membrane Proteins / metabolism; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidylinositol 3-Kinase / metabolism; Phosphatidylinositol Phosphates / metabolism; Phosphorylation / physiology; Protein Kinase Inhibitors / therapeutic use; Quinazolines / therapeutic use; Signal Transduction / physiology
TL;DR: Treatment with a 25-mer peptide targeting the MARCKS PSD motif (MPS peptide) was able to suppress tumor growth and metastasis in vivo, and reduced levels of phospho-MARCKS, phosphatidylinositol (3,4,5)-triphosphate, and AKT activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

The Red Journal at 25 Years Looking Back and Looking Ahead

Adler, K. B., Shapiro, S. D., Holtzman, M. J., & McDonald, J. A. (2014, May). AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol. 50, pp. 839–840.

By: K. Adler n, S. Shapiro*, M. Holtzman* & J. McDonald*

MeSH headings : Humans; Periodicals as Topic / trends; Publishing / trends; Respiratory System; Respiratory Tract Diseases
TL;DR: The current Editor-inChief of the Red journal has asked the original driving force/editors of the Journal when it was established in the mid1980s to contribute their own thoughts in a separate editorial and also asked the previous editors to contribute to this brief document. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils

American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.

By: J. Li, M. D’Annibale-Tolhurst, K. Adler*, S. Fang*, Q. Yin*, A. Birkenheuer*, M. Levy n, S. Jones* ...

author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein

PLOS ONE, 8(6).

By: L. Ott n, E. Sung n, A. Melvin n, M. Sheats n, J. Haugh n, K. Adler n, S. Jones n

Ed(s): P. Aspenstrom

MeSH headings : 3T3 Cells; Animals; Becaplermin; Chemotaxis / drug effects; Chemotaxis / physiology; Collagen / metabolism; Fibroblasts / cytology; Fibronectins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Proto-Oncogene Proteins c-sis / pharmacology
TL;DR: Genetic structure-function analysis revealed that MANS peptide-mediated attenuation of NIH-3T3 cell migration does not require the presence of the myristic acid moiety on the amino-terminus, and suggests that MARCKS-mediated regulation of fibroblast migration involves the MARC KS amino- terminus. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

IL-17A Induces Signal Transducers and Activators of Transcription-6-Independent Airway Mucous Cell Metaplasia

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 48(6), 711–716.

By: D. Newcomb, M. Boswell, T. Sherrill, V. Polosukhin, K. Boyd*, K. Goleniewska, S. Brody*, J. Kolls*, K. Adler n, S. Peebles

author keywords: asthma; mucous cell metaplasia; IL-17A; STAT6; IL-13
MeSH headings : Adoptive Transfer; Animals; Bronchoalveolar Lavage Fluid / immunology; Female; Interleukin-13 / metabolism; Interleukin-17 / genetics; Interleukin-17 / metabolism; Lung / immunology; Lung / pathology; Metaplasia / immunology; Metaplasia / pathology; Metaplasia / virology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mucus / metabolism; Neutrophils / metabolism; Ovalbumin / administration & dosage; Ovalbumin / immunology; Peptide Fragments / administration & dosage; Peptide Fragments / immunology; Receptors, Interleukin-17 / genetics; Receptors, Interleukin-17 / immunology; Receptors, Interleukin-17 / metabolism; Respiratory Syncytial Virus Infections / immunology; Respiratory Syncytial Virus Infections / pathology; Respiratory Syncytial Viruses / immunology; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / metabolism; STAT6 Transcription Factor / genetics; STAT6 Transcription Factor / metabolism; Th17 Cells / immunology; Transcriptional Activation
TL;DR: It is hypothesized that IL-17A induces mucous cell metaplasia independent of STAT6, and this hypothesis was tested in two murine models in which increased IL- 17A protein expression is evident. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 304(8), L511–L518.

By: S. Fang n, A. Crews n, W. Chen*, J. Park n, Q. Yin n, X. Ren*, K. Adler n

author keywords: airway; mucin; secretion; myristoylated alanine-rich C kinase substrate; heat shock protein 70
MeSH headings : Base Sequence; Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiology; Cell Differentiation; Cells, Cultured; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / physiology; HSP40 Heat-Shock Proteins / physiology; HSP70 Heat-Shock Proteins / antagonists & inhibitors; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / physiology; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / genetics; Membrane Proteins / physiology; Microscopy, Confocal; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport; Pyrimidinones / pharmacology; RNA, Small Interfering / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: Evidence is provided of a role for HSP70 in mediating mucin secretion via interactions with MARCKS and that these interactions are critical for the cytoplasmic translocation of MARC KS upon its phosphorylation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Calpain and MARCKS protein regulation of airway mucin secretion

PULMONARY PHARMACOLOGY & THERAPEUTICS, 25(6), 427–431.

By: W. Lampe n, J. Park n, S. Fang n, A. Crews n & K. Adler n

author keywords: Airway; Mucin; MARCKS; Calpain; Secretion
MeSH headings : Bronchi / cytology; Bronchi / metabolism; Calpain / antagonists & inhibitors; Calpain / metabolism; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells / metabolism; Fluorescence; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides / administration & dosage; Oligopeptides / pharmacology; Protein Kinase C / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: Cleavage of MARCKS by Calpain may have an important role in regulation of the PKC/MARCKS pathway regulating airway mucin secretion, as opposed to the original hypothesis, inactivating Calpain caused a decrease rather than an increase in secretion. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein

Journal of Leukocyte Biology, 92(3), 633–639.

By: T. Green n, J. Park n, Q. Yin n, S. Fang n, A. Crews n, S. Jones n, K. Adler n

author keywords: cytoplasmic translocation; J774A.1 cells; monocyte chemotactic protein 1; chemotaxis
MeSH headings : Actin Cytoskeleton / immunology; Actin Cytoskeleton / metabolism; Animals; Blotting, Western; Chemotaxis, Leukocyte / physiology; Intracellular Signaling Peptides and Proteins / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Macrophages / immunology; Macrophages / metabolism; Membrane Proteins / immunology; Membrane Proteins / metabolism; Mice; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport / physiology
TL;DR: Results suggest that MARCKS is involved in directed migration of macrophages via a process involving its phosphorylation, cytoplasmic translocation, and interaction with actin. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

IL-17A-mediated STAT6 Independent Mucus Production in Mice

Journal of Allergy and Clinical Immunology, 129(2), AB199.

By: M. Boswell*, D. Newcomb*, K. Goleniewska*, S. Reiss*, K. Adler n & R. Peebles*

Source: Crossref
Added: February 21, 2020

2011 journal article

A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis

NEW ENGLAND JOURNAL OF MEDICINE, 364(16), 1503–1512.

By: M. Seibold*, A. Wise*, M. Speer*, M. Steele*, K. Brown*, J. Loyd*, T. Fingerlin*, W. Zhang* ...

MeSH headings : Aged; Case-Control Studies; Chromosomes, Human, Pair 11; Female; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Idiopathic Pulmonary Fibrosis / genetics; Linkage Disequilibrium; Lung / metabolism; Lung Diseases, Interstitial / genetics; Male; Middle Aged; Mucin-5B / genetics; Mucin-5B / metabolism; Mutation; Polymorphism, Single Nucleotide; Promoter Regions, Genetic
TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"

RESPIRATORY RESEARCH, 12.

By: K. Raiford*, J. Park n, K. Lin*, S. Fang n, A. Crews n & K. Adler n

MeSH headings : Bronchi / chemistry; Bronchi / metabolism; Cells, Cultured; Cytoplasmic Granules / chemistry; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Goblet Cells / chemistry; Goblet Cells / metabolism; Humans; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / metabolism; Membrane Glycoproteins / ultrastructure; Mucins / chemistry; Mucins / metabolism; Respiratory Mucosa / chemistry; Respiratory Mucosa / metabolism
TL;DR: This work isolated mucin granules and granule membranes from primary cultures of well differentiated human bronchial epithelial cells utilizing a novel technique of immuno-isolation, based on the presence of the calcium activated chloride channel hCLCA1 on thegranule membranes, and verified via Western blotting and co-immunoprecipitation that MARCKS, HSP70, CSP and hCL CA1 were present on the granule membrane and associated with each other. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 review

Regulation of mucin secretion and inflammation in asthma: A role for MARCKS protein?

[Review of ]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1810(11), 1110–1113.

By: T. Green n, A. Crews n, J. Park n, S. Fang n & K. Adler n

author keywords: MARCKS; Mucin; Secretion; Asthma
MeSH headings : Animals; Asthma / etiology; Humans; Inflammation / etiology; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / physiology; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate
TL;DR: The properties of MARCKS and how the protein may regulate mucin secretion at a cellular level will be discussed and the roles ofMARCKS in airway inflammation related to both influx of inflammatory cells into the lung and release of granules containing inflammatory mediators by these cells will be explored. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Two Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Paralogs are Required for Normal Development in Zebrafish

The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294(9), 1511–1524.

By: L. Ott n, Z. Mcdowell n, P. Turner n, J. Law n, K. Adler n, J. Yoder n, S. Jones n

author keywords: MARCKS; zebrafish; development
MeSH headings : Amino Acid Sequence; Animals; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Morpholinos / pharmacology; Multigene Family; Myristoylated Alanine-Rich C Kinase Substrate; Phenotype; Phylogeny; Sequence Homology, Amino Acid; Zebrafish / genetics; Zebrafish / growth & development
TL;DR: It is demonstrated that Marcksa and Marcksb are required for normal zebrafish development and suggested that zebra fish are a suitable model to further study MARCKS function. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

MARCKS and Related Chaperones Bind to Unconventional Myosin V Isoforms in Airway Epithelial Cells

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 43(2), 131–136.

By: K. Lin n, S. Fang n, J. Park n, A. Crews n & K. Adler n

author keywords: airway; mucin; MARCKS; chaperones; myosin
MeSH headings : Bronchi / pathology; Epithelial Cells / cytology; Gene Expression Regulation; HSP70 Heat-Shock Proteins / chemistry; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Biological; Molecular Chaperones; Mucins / metabolism; Myosin Heavy Chains / chemistry; Myosin Type V / chemistry; Myristoylated Alanine-Rich C Kinase Substrate; Protein Binding; Protein Isoforms; Tetradecanoylphorbol Acetate / chemistry; Transfection
TL;DR: It is reported that myristoylated alanine-rich C kinase substrate (MARCKS) also interacts with unconventional myosin isoforms within these cells, and further molecular interactions between MARCKS and these chaperones/cytoskeletal proteins are elucidated. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 article

MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac (Retracted article. See vol. 309, pg. L 750, 2015)

Foster, W. M., Adler, K. B., Crews, A. L., Potts, E. N., Fischer, B. M., & Voynow, J. A. (2010, September). AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol. 299, pp. L345–L352.

By: W. Foster*, K. Adler n, A. Crews n, E. Potts*, B. Fischer* & J. Voynow*

author keywords: myristoylated alanine-rich C kinase substrate; airway hyperresponsiveness; elastase; serotonin
MeSH headings : Aerosols; Animals; Bronchoalveolar Lavage Fluid / chemistry; Cytokines / metabolism; Goblet Cells / pathology; Inflammation / prevention & control; Inflammation Mediators / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Leukocyte Elastase / pharmacology; Lung / drug effects; Lung / physiopathology; Male; Membrane Proteins / antagonists & inhibitors; Metaplasia / chemically induced; Methacholine Chloride / administration & dosage; Mice; Mice, Inbred BALB C; Mucin 5AC / antagonists & inhibitors; Mucin 5AC / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments / pharmacology; Respiratory Hypersensitivity / chemically induced; Respiratory Hypersensitivity / physiopathology; Respiratory System / drug effects; Respiratory System / metabolism; Serotonin
TL;DR: The concept that even in airway epithelia remodeled with goblet cell metaplasia and in a state of mucin hypersecretion, exogenous attenuation of function of MARCKS protein via the MANS peptide decreases airway mucin secretion, inflammation, and hyperreactivity is supported. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Mesenchymal Stem Cells Require MARCKS Protein for Directed ChemotaxisIn Vitro

American Journal of Respiratory Cell and Molecular Biology, 43(3), 253–258.

By: J. Miller n, S. Lankford n, K. Adler n & A. Brody n

author keywords: mesenchymal; MARCKS; chemotaxis; chemokines; phosphorylation
MeSH headings : Animals; Blotting, Western; Bone Marrow Cells / cytology; Cell Differentiation; Cell Movement; Cells, Cultured; Chemokine CCL2 / pharmacology; Chemokine CXCL12 / pharmacology; Chemotaxis / drug effects; Complement C5a / pharmacology; Dose-Response Relationship, Drug; Fetal Blood; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / physiology; Lung / cytology; Lung / metabolism; Macrophages / cytology; Macrophages / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / physiology; Mesenchymal Stem Cells / cytology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments / pharmacology; Phosphorylation
TL;DR: It is illustrated, for the first time, that myristoylated alanine-rich C kinase substrate (MARCKS) protein plays an integral role in BM-MSC-directed chemotaxis in vitro. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2010 journal article

Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein Regulation of Human Neutrophil Migration

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 42(5), 586–594.

By: R. Eckert n, L. Neuder*, J. Park*, K. Adler* & S. Jones*

author keywords: inflammation; adhesion; beta 2 integrin; actin
MeSH headings : Actins / metabolism; CD18 Antigens / metabolism; Cell Adhesion / drug effects; Cell Membrane / drug effects; Cell Membrane / metabolism; Cell Polarity / drug effects; Chemotactic Factors / pharmacology; Chemotaxis, Leukocyte / drug effects; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Neutrophils / cytology; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / pharmacology; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: Treating isolated human neutrophils with MANS significantly inhibited both their migration and beta2 integrin-dependent adhesion in response to N-formyl-methionyl-leucyl-phenylalanine (fMLF), IL-8, or leukotriene (LT)B(4). (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 article

Changes in NIH Review Procedures Strengths and Weaknesses

Adler, K. B., & Abraham, E. (2009, August). AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol. 41, pp. 127–128.

By: K. Adler n & E. Abraham*

MeSH headings : National Institutes of Health (U.S.) / standards; Research; Research Support as Topic / standards; United States
Source: Web Of Science
Added: August 6, 2018

2009 article

Changes in NIH Review Procedures Strengths and Weaknesses

Adler, K. B., & Abraham, E. (2009, August 1). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 180, pp. 197–197.

By: K. Adler n & E. Abraham*

MeSH headings : Biomedical Research / standards; Humans; National Institutes of Health (U.S.); Peer Review, Research / methods; Peer Review, Research / standards; Peer Review, Research / trends; United States
TL;DR: ‘‘Change has come’’ to the scoring and review system that all NIH study sections will soon incorporate and this editorial is to describe this new system and to offer their own impressions, comments, and concerns. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Highlights of the August issue

American Journal of Respiratory Cell and Molecular Biology, 41(2), 125–126.

By: K. Adler* & S. Matalon

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Highlights of the July Issue

American Journal of Respiratory Cell and Molecular Biology, 41(1), 1–2.

By: K. Adler* & S. Matalon

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A MARCKS-related peptide attenuates both mucin hypersecretion and inflammatory cell infiltration in an elastase model of chronic bronchitis.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A332.

By: A. Crews, E. Potts, J. Voynow, B. Fischer, S. Bumgardner, K. Adler, W. Foster

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A MARCKS-related peptide inhibits MUC5AC expression in airway epithelial cells isolated from asthmatic subjects.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A814.

By: Y. Wang, K. Adler, D. Slade, T. Church, R. Webb, H. Chu, D. Jinwright, A. Crews, M. Kraft

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A potential role for airway epithelial cell mucin genes in fibrogenesis.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A727.

By: J. Park, A. Crews, S. Alper, D. Schwartz & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A proteomic analysis of proteins associated with mucin granule membranes within airway epithelial cells.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A993.

By: K. Raiford & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 article

After 20 years, what next for the Red journal?

Adler, K. B. (2008, October). AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol. 39, pp. III-IV.

By: K. Adler n

MeSH headings : Biomedical Research; Editorial Policies; Periodicals as Topic / trends; Publishing
Source: Web Of Science
Added: August 6, 2018

2008 article

Albuterol-induced oxidant stress in primary cultures of normal human bronchial epithelial cells.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A469.

By: J. Waterman, J. Jones & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Epithelial brush border proteomics and associated dysfunction.

404nOtfound, 1, 27–33.

By: X. Wang & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Inhibition of ozone-induced airway inflammation by decreasing myristoylated alanine-rich C kinase substrate function.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A495.

By: W. Jester, M. Jiang, H. Zhao, P. J., M. I., A. T., . K. B., R. Panettieri

Source: NC State University Libraries
Added: August 6, 2018

2008 article

MARCKS protein regulation of mucin secretion in airway epithelial cells: binding of MARCKS to chaperones and to MyosinV.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A993.

By: K. Lin, F. J. J., . S. & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

MARCKS regulation of mucin secretion by airway epithelial cells in vitro: interactions with chaperone proteins.

American Journal of Respiratory Cell and Molecular Biology, 102, 949–955.

By: J. Park, S. Fang, A. Crews, K. Lin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

MARCKS regulation of mucin secretion by airway epithelium in vitro - Interaction with chaperones

American Journal of Respiratory Cell and Molecular Biology, 39(1), 68–76.

By: J. Park, S. Fang, A. Crews, K. Lin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Mycoplasma pneumoniae increases airway epithelial cell MUC5AC expression in asthma.

European Respiratory Journal, 34, 43–46.

By: M. Kraft, K. Adler, J. Ingram, A. Crews, T. Atkinson, C. Cairns, D. Krause, H. Chu

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma

EUROPEAN RESPIRATORY JOURNAL, 31(1), 43–46.

By: M. Kraft, K. Adler*, J. Ingram, A. Crews*, T. Atkinson, C. Cairns, D. Krause, H. Chu

author keywords: asthma; epithelial cell; MUC5AC; Mycoplasma pneumoniae; toll-like receptor 2
MeSH headings : Adult; Asthma / immunology; Asthma / metabolism; Asthma / microbiology; Bronchoscopy / methods; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / cytology; Epithelial Cells / microbiology; Female; Gene Expression Regulation; Humans; Male; Models, Biological; Mucin 5AC; Mucins / biosynthesis; Mucins / metabolism; Mycoplasma pneumoniae / metabolism; Mycoplasma pneumoniae / physiology; NF-kappa B / metabolism; Time Factors; Toll-Like Receptor 2 / metabolism
TL;DR: Mycoplasma pneumoniae exposure significantly increased MUC5AC mRNA and protein expression preferentially in airway epithelial cells isolated from asthmatic subjects, and the toll-like receptor 2 pathway may be involved in this process. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 review

Oxidant stress and airway epithelial function

[Review of ]. Free radical effects on membranes, 61, 243–255.

By: J. Waterman & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 review

Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro

[Review of ]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 40(6-7), 1379–1388.

By: K. Lin n, J. Park n, A. Crews n, Y. Li n & K. Adler n

author keywords: PAR-2; mucin; airway; secretion
MeSH headings : Bronchi / cytology; Cell Culture Techniques; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Mucins / genetics; Mucins / metabolism; Oligopeptides / chemical synthesis; Oligopeptides / chemistry; Oligopeptides / pharmacology; Papillomaviridae / physiology; RNA, Small Interfering / pharmacology; Receptor, PAR-2 / agonists; Receptor, PAR-2 / genetics; Receptor, PAR-2 / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism; Time Factors; Transfection
TL;DR: The results suggest that, since PAR-2 activation only weakly increases mucin secretion by human airway epithelial cells in vitro,PAR-2 probably is not a significant contributor to mucin hypersecretion in inflamed airways. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 review

Role of airway epithelial cells in development of asthma and allergic rhinitis

[Review of ]. RESPIRATORY MEDICINE, 102(7), 949–955.

By: Y. Wang*, C. Bai*, K. Li*, K. Adler n & X. Wang*

author keywords: airway hyper-responsiveness; allergic cascade; airway epithelium; inflammation; rhinitis
MeSH headings : Asthma / etiology; Asthma / immunology; Bronchi / immunology; Bronchi / pathology; Cytokines / metabolism; Epithelial Cells / physiology; Humans; Inflammation Mediators / metabolism; Mucus / immunology; Rhinitis / etiology; Rhinitis / immunology; Th2 Cells / immunology; Toll-Like Receptors / metabolism
TL;DR: It is hypothesized that airway epithelial cells may play as both inflammatory initiator and immuno-pathological feedback regulation between allergic rhinitis and asthma via release of systemic inflammatory mediators. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 article

A peptide against the N-terminus of MARCKS protein attenuates leukocyte migration.

404nOtfound, Vol. 175, p. A915.

By: T. Green, B. Eckert, Y. Sharief, A. Crews, K. Adler & S. Jones

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Anti-inflammatory effects of budesonide and formoterol in primary cultures of human airway epithelial cells.

404nOtfound, Vol. 175, p. A178.

By: J. Park, S. Takashi, A. Crews, A. Miller-Larsson & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma

JOURNAL OF APPLIED PHYSIOLOGY, 102(1), 399–405.

By: A. Agrawal, S. Rengarajan, K. Adler*, A. Ram, B. Ghosh, M. Fahim, B. Dickey

author keywords: myristoylated alanine-rich C kinase substrate NH2-terminus sequence; specific airway conductance; goblet cells
MeSH headings : Airway Obstruction / drug therapy; Airway Obstruction / metabolism; Airway Obstruction / physiopathology; Animals; Asthma / drug therapy; Asthma / metabolism; Asthma / physiopathology; Bronchoconstriction / drug effects; Bronchoconstriction / physiology; Bronchoconstrictor Agents / administration & dosage; Disease Models, Animal; Methacholine Chloride / administration & dosage; Mice; Mice, Inbred BALB C; Mucins / metabolism; Peptide Fragments / adverse effects; Peptide Fragments / pharmacology; Peptide Fragments / therapeutic use
TL;DR: Mulin secretion has a significant role in airway obstruction in a mouse model of allergic asthma, and strategies to inhibit mucin secretion merit further investigation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 patent

Method and compositions for altering mucus secretion

Washington, DC: U.S. Patent and Trademark Office.

By: Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Mycoplasma pneumoniae increases airway epithelial cell MUC5AC expression in asthma.

404nOtfound, Vol. 175, p. A324.

By: M. Kraft, H. Nijira Lugogo, K. Adler, A. Crews, T. Moss, M. Stalls, T. Church, D. Slade, D. Beaver, H. Chu

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Potential therapy for mucus hypersecretion in COPD.

404nOtfound, 3, 66–71.

By: J. Park n & K. Adler n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein

AMERICAN JOURNAL OF PATHOLOGY, 171(6), 1822–1830.

By: J. Park n, A. Crews n, W. Lampe n, S. Fang n, J. Park n & K. Adler n

MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Bronchi / drug effects; Bronchi / enzymology; Bronchi / metabolism; Bryostatins / pharmacology; Cell Line; Enzyme Activation; Epithelial Cells / drug effects; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / genetics; Protein Kinase C-delta / physiology; Protein Kinase Inhibitors / pharmacology; Tetradecanoylphorbol Acetate / pharmacology
Source: Web Of Science
Added: August 6, 2018

2007 article

Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein.

404nOtfound, Vol. 175, p. A752.

By: J. Park, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Proteomic analysis of mucin granule membrane-associated proteins in human airway epithelial cells: a mechanistic link between MARCKS and hClCA1?

404nOtfound, Vol. 175, p. A511.

By: K. Raiford, K. Lin, J. Park, S. Fang, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Quantification of mucin gene expression in tracheobronchial epithelium of healthy dogs and dogs with chronic bronchitis

AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(4), 435–440.

By: E. Hawkins n, A. Birkenheuer n, H. Marr n, A. Rogala n, E. Large n & K. Adler n

MeSH headings : Animals; Bronchitis, Chronic / metabolism; Bronchitis, Chronic / veterinary; DNA Primers; Dog Diseases / metabolism; Dogs; Evaluation Studies as Topic; Mucins / metabolism; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; RNA, Messenger / metabolism
TL;DR: The ability to measure mucin gene expression from tracheobronchial brushing specimens collected from client-owned dogs during routine bronchoscopy should prove to be a useful tool for the study of bronchitis in dogs and expand the usefulness of airway inflammation in dogs as a model for bronchritis in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 journal article

Role of airway epithelial dysfunction in development of acute lung injury and acute respiratory distress syndrome.

404nOtfound, 1, 149–155.

By: X. Wang*, K. Adler*, J. Erjefalt & C. Bai

TL;DR: It is hypothesized that airway epithelial cells may contribute to ALI/ARDS via Toll-like receptor-involved mediators, reactive oxygen species-involved reactions and an imbalance between protease and antiprotease activation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2007 article

The (S)?enantiomer of albuterol activates expression of iNOS via activation of NF-kB in primary cultures of normal human bronchial epithelial cells.

404nOtfound, Vol. 175, p. A178.

By: J. Waterman, J. Park, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

(R)-Albuterol elicits antiinflammatory effects in human airway epithelial cells via iNOS

American Journal of Respiratory Cell and Molecular Biology, 34(1), 119–127.

By: B. Chorley, Y. Li, S. Fang, J. Park & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

A peptide against the N-terminus of myristoylated alanine-rich C kinase substrate inhibits degranulation of human leukocytes in vitro

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 34(6), 647–652.

By: S. Takashi n, J. Park n, S. Fang n, S. Koyama n, I. Parikh n & K. Adler n

author keywords: MARCKS protein; leukocytes; degranulation
MeSH headings : Cell Degranulation; Cell Line; Dose-Response Relationship, Drug; Eosinophil Peroxidase / metabolism; Granzymes; HL-60 Cells; Humans; Killer Cells, Natural; Leukocytes / drug effects; Leukocytes / enzymology; Leukocytes / physiology; Muramidase / metabolism; Neutrophils; Peptide Fragments / pharmacology; Peroxidase / metabolism; Serine Endopeptidases / metabolism; Tetradecanoylphorbol Acetate; Time Factors; U937 Cells
TL;DR: The results indicate that MARCKS protein may play an important role in the secretion of membrane-bound granules from different leukocytes, and may be an important component of secretory pathways associated with release of granules by different cell types. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Better understanding of organ dysfunction requires proteomic involvement

JOURNAL OF PROTEOME RESEARCH, 5(5), 1060–1062.

author keywords: organ dysfunction; MODS; proteomics; biomarkers; prognosis
MeSH headings : Biomarkers / analysis; Epithelial Cells / metabolism; Epithelial Cells / pathology; Humans; Multiple Organ Failure / diagnosis; Multiple Organ Failure / metabolism; Multiple Organ Failure / physiopathology; Prognosis; Proteomics / methods; Proteomics / trends
TL;DR: It is important to have a special attention from proteomic scientists to explore the combination between advanced proteomic biotechnology, clinical proteomics, tissue imaging and profiling, and organ dysfunction score systems, to improve the clinical outcomes of patients with organ dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro

Respiratory Research, 7, 35.

By: B. Chorley, A. Crews, Y. Li, K. Adler, M. Minnicozzi & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2006 review

Epithelial proteomics in multiple organs and tissues: Similarities and variations between cells, organs, and diseases

[Review of ]. JOURNAL OF PROTEOME RESEARCH, 5(4), 743–755.

By: H. Zhao*, K. Adler*, C. Bai*, F. Tang* & X. Wang*

author keywords: epithelial cells; proteomics; differentiation; tumorigenesis; cancer; biomarkers
MeSH headings : Biomarkers, Tumor / analysis; Cell Differentiation; Cell Line, Tumor; Epithelial Cells / chemistry; Epithelial Cells / pathology; Epithelial Cells / physiology; Forecasting; Genetic Variation; Genomics; Humans; Models, Biological; Neoplasm Proteins / analysis; Neoplasms / etiology; Neoplasms / genetics; Neoplasms / pathology; Proteome / analysis; Proteomics; Sensitivity and Specificity; Severity of Illness Index
TL;DR: It is found that most of disease-associated investigation of epithelial proteomics has been focused on epithelial-origin cancer, and there is a significant gap between acute and chronic organ injury, inflammation, and multiple organ dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 article

MARCKS related peptide improves airway obstruction related to mucus secretion in a mouse model of asthma.

404nOtfound, Vol. 3, p. A713.

By: A. Agrawal, R. Subramannian, K. Adler, A. Ram, B. Ghosh, M. Farim, B. Dickey

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Mechanisms of mucus secretion in the airways.

404nOtfound, 2, 24–29.

By: K. Adler n, S. Fang n, K. Lin n & J. Park n

Source: NC State University Libraries
Added: August 6, 2018

2006 patent

Methods for regulating inflammatory mediators and peptides useful therein

Washington, DC: U.S. Patent and Trademark Office.

By: S. Takashi, I. Parikh, K. Adler, L. Martin & L. Y.

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Potential therapy for mucus hypersecretion in chronic obstructive pulmonary disease [translated into Chinese].

404nOtfound, 86, 2890–2892.

By: J. Park & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Regulation of airway mucin secretion by MARCKS protein involves the chaperones heat shock protein 70 and Cysteine string protein.

404nOtfound, Vol. 3, p. 493a.

By: J. Park n, S. Fang* & K. Adler*

MeSH headings : Blotting, Western; Bronchi / cytology; Bronchi / metabolism; HSP40 Heat-Shock Proteins / metabolism; HSP70 Heat-Shock Proteins / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins / metabolism; Protein Kinase C / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
Source: NC State University Libraries
Added: August 6, 2018

2005 article

?2-adrenergic receptor activation with (R)-albuterol attenuates GM-CSF expression via an iNOS-mediated pathway in human bronchial epithelial cells in vitro.

404nOtfound, Vol. 2, p. A757.

By: B. Chorley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2005 article

A peptide directed against the N-terminus of MARCKS protein attenuates release of myeloperoxidase (MPO) from human and canine neutrophils in vitro.

404nOtfound, Vol. 2, p. A633.

By: S. Takashi, C. Pettersen, J. Park, S. Fang, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2005 patent

Culture system for mouse tracheal epithelial cells

Washington, DC: U.S. Patent and Trademark Office.

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Cysteine String Protein is involved in mucin secretion from normal human bronchial epithelial (NHBE) cells in vitro.

404nOtfound, Vol. 2, p. A215.

By: J. Park, S. Fang & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Expert's opinion on potential role of epithelial cells in pathogenesis of organ dysfunction

Journal of Organ Dysfunction, 1(1), 24–25.

By: K. Adler n

Source: Crossref
Added: December 29, 2020

2005 article

Human Neutrophil Elastase provokes mucin secretion by NHBE cells via a Protein Kinase C delta (PKC?)?mediated mechanism.

404nOtfound, Vol. 2, p. A110.

By: J. Park, B. Chorley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C delta-mediated mechanism

AMERICAN JOURNAL OF PATHOLOGY, 167(3), 651–661.

By: J. Park n, F. He n, L. Martin n, Y. Li n, B. Chorley n & K. Adler n

MeSH headings : Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Cell Differentiation; Cells, Cultured; Enzyme Activation / drug effects; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Isoenzymes / metabolism; Leukocyte Elastase / pharmacology; Mucins / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Protein Kinase C-delta; Protein Kinase Inhibitors / pharmacology
TL;DR: The results suggest HNE stimulation of mucin release by human airway epithelial cells involves intracellular activation of PKC, specifically the delta isoform. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma

NATURE MEDICINE, 10(2), 193–196.

By: M. Singer*, L. Martin n, B. Vargaftig*, J. Park n, A. Gruber, Y. Li n, K. Adler n

MeSH headings : Animals; Asthma / metabolism; Bronchi / cytology; Bronchi / metabolism; Bronchi / pathology; Bronchial Provocation Tests; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Disease Models, Animal; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mucins / metabolism; Mucus / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Ovalbumin / administration & dosage; Ovalbumin / immunology; Peptide Fragments / administration & dosage; Peptide Fragments / chemistry; Peptide Fragments / pharmacology; Peptides / administration & dosage; Peptides / chemistry; Peptides / pharmacology; Proteins / chemistry; Proteins / genetics; Proteins / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
TL;DR: It is shown that the intratracheal instillation of this peptide blocks mucus hypersecretion in a mouse model of asthma, and a pivotal role for MARCKS protein, specifically its N-terminal region, in modulating this secretory process in mammalian airways is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 patent

Blocking peptide for inflammatory cell secretion

Washington, DC: U.S. Patent and Trademark Office.

By: L. Martin, K. Adler & Y. Li

Source: NC State University Libraries
Added: August 6, 2018

2004 article

Inducible nitric oxide synthase/protein kinase G signaling pathway suppresses granulocyte macrophage colony stimulating factor transcription in normal human bronchial epithelial cells in vitro

American Journal of Respiratory and Critical Care Medicine, Vol. 169, p. A421.

By: B. Chorley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2004 article

MARCKS protein interaction with the ?secretory module? regulates airway mucin secretion.

American Journal of Respiratory and Critical Care Medicine, Vol. 169, p. A535.

By: J. Park, S. Fang, A. Gruber & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and Gob-5

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 170(3), 306–312.

By: K. Hashimoto n, B. Graham n, S. Ho n, K. Adler n, R. Collins n, S. Olson n, W. Zhou n, T. Suzutani n ...

author keywords: mucin; MUC5ac; gob-5; respiratory syncytial virus
MeSH headings : Animals; Chloride Channels / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Interleukin-17 / metabolism; Lung / pathology; Mice; Mice, Inbred BALB C; Mucin 5AC; Mucins / metabolism; Mucoproteins / metabolism; Ovalbumin; Respiratory Hypersensitivity / complications; Respiratory Hypersensitivity / metabolism; Respiratory Hypersensitivity / pathology; Respiratory Hypersensitivity / virology; Respiratory Syncytial Virus Infections / complications; Respiratory Syncytial Virus Infections / metabolism; Respiratory Syncytial Virus Infections / pathology; Respiratory Syncytial Viruses
TL;DR: There was significantly increased staining for gob-5 and Muc5ac in the airways of OVA/RSV mice compared with either OVA mice or allergically sensitized mice that were challenged with inactivated RSV, and virtually no detectable staining in the RSV group. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2004 article

Small interfering RNA?s directed against MARCKS protein and Heat Shock Protein 70 (Hsp70) attenuate mucin secretion in human airway epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 169, p. A712.

By: S. Fang, J. Park & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 article

A myristoylated peptide directed against the N-terminal region of MARCKS protein inhibits mucin secretion in ovalbumin sensitized/challenged mice in vivo.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A17.

By: B. Vargaftig, M. Singer, L. Martin, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Activation of protease-activated receptors?2 (PAR-2) is not associated with enhanced mucin secretion by well-differentiated normal human bronchial epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A204.

By: K. Lin, J. Park, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Differential effects of albuterol isomers on normal human bronchial epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A205.

By: B. Chorley, L. Martin, A. Crews, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Effects of TNF alpha on expression of ICAM-1 in human airway epithelial cells in vitro: Oxidant-mediated pathways and transcription factors

FREE RADICAL BIOLOGY AND MEDICINE, 35(9), 1158–1167.

By: T. Krunkosky n, L. Martin n, B. Fischer n, J. Voynow* & K. Adler n

author keywords: intercellular adhesion molecule 1; normal human bronchial epithelial cells; nuclear factor kappa beta; CAAT/enhancer binding protein; free radicals
MeSH headings : Antioxidants / pharmacology; Antioxidants / toxicity; Bronchi / cytology; CCAAT-Enhancer-Binding Proteins / metabolism; Cell Line; Consensus Sequence / genetics; Cysteine Endopeptidases / metabolism; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Gene Expression Regulation / drug effects; Humans; Intercellular Adhesion Molecule-1 / genetics; Leupeptins / pharmacology; Multienzyme Complexes / antagonists & inhibitors; Multienzyme Complexes / metabolism; NF-kappa B / metabolism; Oxidants / metabolism; Promoter Regions, Genetic / genetics; Proteasome Endopeptidase Complex; Pyrrolidines / pharmacology; Pyrrolidines / toxicity; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reactive Oxygen Species / metabolism; Response Elements / genetics; Signal Transduction / drug effects; Thiocarbamates / pharmacology; Thiocarbamates / toxicity; Thiourea / analogs & derivatives; Thiourea / pharmacology; Thiourea / toxicity; Transcription Factors / metabolism; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: Results suggest that although TNFα enhances binding of C/EBP and NFκB complexes in NHBE cells, C-EBP binding seems to involve an oxidant-dependent mechanism, whereas activation of NFκBs complexes utilizes the ubiquitin-proteasome pathway, a mechanism that seems to be unaltered by the presence of antioxidants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 article

Human neutrophil elastase provokes release of MUC5B mucin from normal bronchial epithelial cells in vitro via a PKC-dependent mechanism.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A203.

By: J. Park, F. He, Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Phenotypic comparison of allergic airway responses to house dust mite in three rat strains

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 284(4), L588–L598.

By: P. Singh n, M. Daniels*, D. Winsett*, J. Richards*, D. Doerfler*, G. Hatch*, K. Adler n, M. Gilmour*

author keywords: genetic variability; atopy; asthma
MeSH headings : Animals; Asthma / genetics; Asthma / immunology; Asthma / pathology; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / immunology; Cell Division / immunology; Female; Genetic Variation / immunology; Hypersensitivity / genetics; Hypersensitivity / immunology; Hypersensitivity / pathology; Immunoglobulin E / blood; Immunoglobulin G / blood; Interferon-gamma / analysis; Interleukin-13 / analysis; Lung / immunology; Lung / pathology; Lymph Nodes / cytology; Lymph Nodes / immunology; Lymphocytes / cytology; Lymphocytes / immunology; Phenotype; Pyroglyphidae / immunology; Rats; Rats, Inbred BN; Rats, Inbred Lew; Rats, Sprague-Dawley; Species Specificity
TL;DR: Because BN rats developed stronger clinical hallmarks of allergic asthma under various immunization regimes compared with SD and L rats, it is concluded that the BN is the most appropriate strain for studying allergic asthma-like responses in rats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 article

Proliferation of the airway epithelium in asthma - Are inflammatory cells required?

Booth, B. W., Newcomb, D. C., McKane, S. A., Crews, A. L., Adler, K. B., Bonner, J. C., & Martin, L. D. (2003, March). CHEST, Vol. 123, pp. 384S–385S.

By: B. Booth n, D. Newcomb n, S. McKane n, A. Crews n, K. Adler n, J. Bonner*, L. Martin n

MeSH headings : Asthma / pathology; Asthma / physiopathology; Cell Physiological Phenomena; Humans; In Vitro Techniques; Inflammation / pathology; Inflammation / physiopathology; Respiratory Mucosa / pathology; Respiratory Mucosa / physiopathology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 article

Respiratory syncytial virus infection upregulates Muc5ac and gob-5 lung protein expression only in the setting of allergic inflammation.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A425.

By: K. Hashimoto, B. Graham, S. Ho, K. Adler, R. Collins, P. Jones, K. Jarzecka, J. Furlong, R. Peebles

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Role of oxidative stress and p38MAP kinase in murine pulmonary responses to LPS and diesel exhaust particles.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A622.

By: P. Singh, C. Dick, E. Boykin, D. Andrews, K. Adler & I. Gilmour

Source: NC State University Libraries
Added: August 6, 2018

2002 article

Airways inflammation and COPD - Epithelial-neutrophil interactions

Pettersen, C. A., & Adler, K. B. (2002, May). CHEST, Vol. 121, pp. 142S–150S.

By: C. Pettersen n & K. Adler n

author keywords: airways inflammation; apoptosis; chemoattractants; chemokines; COPD; cytokines; epithelium; neutrophil
MeSH headings : Cell Adhesion Molecules / metabolism; Humans; Inflammation / physiopathology; Inflammation Mediators / metabolism; Neutrophil Activation / immunology; Pulmonary Disease, Chronic Obstructive / immunology; Respiratory Mucosa / immunology; Signal Transduction / immunology
TL;DR: Neutrophils are recognized as major cellular mediators of inflammation and contain specific and highly regulated mechanisms for controlling the expression of adhesion molecules that allow for their tethering and migration into inflammatory sites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 article

Diesel exhaust particles increase lung injury and inflammation during early sensitization in brown Norway rats.

Toxicological Sciences, Vol. 66, p. 147.

By: P. Singh, M. Daniels, D. Winsett, J. Richards, L. Bishop, C. Dick, M. Madden, K. Adler, M. Gilmour

Source: NC State University Libraries
Added: August 6, 2018

2002 article

Effects of allergic airways disease on influenza virus infection in brown Norway rats.

American Journal of Respiratory and Critical Care Medicine, Vol. 165, p. A183.

By: P. Singh, D. Winsett, M. Daniels, C. Dick, K. Adler & M. Gilmour

Source: NC State University Libraries
Added: August 6, 2018

2002 article

IL-13 induces intracellular translocation and release of TGF? in human bronchial epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 165, p. A814.

By: B. Booth, K. Adler & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Secretion-competent mouse tracheal epithelial cell culture from the genetically altered mouse - Pathway analysis via gene array

Chest, 121(3), 79S.

By: L. Martin n, K. Adler n, N. Akley n, A. Crews n & L. Sharova*

TL;DR: This work presents a new Epithelial Repair Model of In Vitro Gene Expression in an http://chestjournal.chestpubs.org/content/121/3_suppl/79S.xhtml ( distributed without the prior written permission of the copyright holder). (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Airway epithelium and mucus - Intracellular signaling pathways for gene expression and secretion

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 25(4), 397–400.

By: K. Adler n & Y. Li n

MeSH headings : Animals; Cells, Cultured; Gene Expression Regulation; Humans; Mucin-5B; Mucins / physiology; Mucus / physiology; Respiratory Mucosa / cytology; Respiratory Mucosa / physiology; Signal Transduction; Uridine Triphosphate / metabolism
TL;DR: The development of defined, serum-free medium, as well as improvements in the types of substrata beneath the cultured cells, gave researchers the ability to culture airway epithelial cells that looked and acted somewhat like their in vivo counterparts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 article

Autocrine production of TGFa mediates interleukin 13-induced proliferation of human airway epithelial cells during development of a mucous phenotype in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 163, p. A738.

By: B. Booth, J. Bonner, K. Adler & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2001 article

Differentiation of murine tracheal epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 163, p. A225.

By: M. Macchione, N. Akley, K. Adler & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Enhanced expression of mucin genes in a guinea pig model of allergic asthma

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 25(5), 644–651.

By: Y. Li n, L. Martin n, M. Minnicozzi n, S. Greenfeder n, J. Fine n, C. Pettersen n, B. Chorley n, K. Adler n

MeSH headings : Amino Acid Sequence; Animals; Antineoplastic Agents / pharmacology; Asthma / physiopathology; Base Sequence; Bronchial Hyperreactivity / physiopathology; Cells, Cultured; Chemokine CCL11; Chemokines, CC / genetics; Cloning, Molecular; Conserved Sequence; Disease Models, Animal; Eosinophils / immunology; Gene Expression / physiology; Guinea Pigs; Histamine / pharmacology; Hypersensitivity / physiopathology; Inflammation Mediators / pharmacology; Molecular Sequence Data; Mucin 5AC; Mucin-2; Mucins / genetics; Ovalbumin / immunology; Ovalbumin / pharmacology; RNA, Messenger / analysis; Respiratory Mucosa / cytology; Respiratory Mucosa / physiology; Trachea / cytology; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: Results of these studies suggest that the OVA-sensitized guinea pig responds to allergic challenge with enhanced expression of genes that likely play a role in increased airway inflammation and mucin overproduction, and enhanced mucin gene expression appears to occur before eosinophil infiltration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 chapter

Interleukin-13 induced mucous cell hyperplasia in airway epithelium.

In Cilia and mucus: from development to respiratory disease. (pp. 253–263).

By: L. Martin, M. Macchione, J. Bonner, B. Booth, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-alpha

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 25(6), 739–743.

By: B. Booth n, K. Adler n, J. Bonner n, F. Tournier n & L. Martin n

MeSH headings : Bronchi / cytology; Bronchi / drug effects; Cell Division / drug effects; Cells, Cultured / cytology; Cells, Cultured / drug effects; Enzyme Inhibitors / pharmacology; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / physiology; Humans; Interleukin-13 / pharmacology; Models, Biological; Quinazolines; Signal Transduction / drug effects; Signal Transduction / physiology; Transforming Growth Factor alpha / antagonists & inhibitors; Transforming Growth Factor alpha / immunology; Transforming Growth Factor alpha / metabolism; Tyrphostins / pharmacology
TL;DR: This study provides the first experimental evidence that IL-13 can initiate a proliferative response of human airway epithelium in the absence of inflammatory cells or other cell types. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 article

Interleukin-13, a mediator of subepithelial fibrosis, enhances growth factor production and proliferation in human airway epithelial cells

Booth, B., Bonner, J., Akley, N., Macchione, M., Adler, K., & Martin, L. D. (2001, July). CHEST, Vol. 120, pp. 15S–15S.

By: B. Booth n, J. Bonner*, N. Akley n, M. Macchione n, K. Adler n & L. Martin n

TL;DR: Injured airways with regions of regenerating/differentiating cells and regions of normal fully differentiated cells have been mimicked by examining the effects of IL-13 on normal human bronchial epithelial cells during mucociliary differentiation in air/liquid interface culture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 article

MARCKS protein interaction with the cellular contractile machinery may regulate mucin secretion by human airway epithelium.

American Journal of Respiratory and Critical Care Medicine, Vol. 163, p. A225.

By: Y. Li, C. Pettersen, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro

JOURNAL OF BIOLOGICAL CHEMISTRY, 276(44), 40982–40990.

By: Y. Li*, L. Martin*, G. Spizz & K. Adler*

MeSH headings : Actins / metabolism; Amino Acid Sequence; Cyclic GMP-Dependent Protein Kinases / metabolism; Cytoplasm / metabolism; Down-Regulation; Enzyme Activation; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Exocytosis; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Molecular Sequence Data; Mucins / metabolism; Myosins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C / metabolism; Proteins / physiology; Trachea / cytology; Trachea / enzymology; Trachea / metabolism
TL;DR: Several novel intracellular targets for pharmacological intervention in disorders involving aberrant secretion of respiratory mucin are suggested and may relate to other lesions involving exocytosis of membrane-bound granules in various cells and tissues. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 chapter

MARCKS protein: a potential modulator of airway mucin secretion.

In Cilia and mucus: from development to respiratory disease. (pp. 179–193).

By: Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2001 article

Role of receptor tyrosine kinases and mitogen-activated protein kinases in metal-induced pulmonary fibrosis

Bonner, J. C., Wang, Y. Z., Zhang, P., Rice, A., Zhang, L. M., Adler, K., … Kagan, E. (2001, July). CHEST, Vol. 120, pp. 55S–56S.

By: J. Bonner*, Y. Wang*, P. Zhang*, A. Rice*, L. Zhang n, K. Adler n, N. Choe*, E. Kagan*

Source: Web Of Science
Added: August 6, 2018

2001 journal article

Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor - A mitogen for lung fibroblasts

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 24(2), 123–131.

By: L. Zhang n, A. Rice n, K. Adler n, P. Sannes n, L. Martin n, W. Gladwell n, J. Koo n, T. Gray n, J. Bonner n

MeSH headings : Blotting, Northern; Blotting, Western; Bronchi / drug effects; Bronchi / metabolism; Cells, Cultured; DNA Primers / chemistry; Enzyme Inhibitors / pharmacology; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor / biosynthesis; Epidermal Growth Factor / genetics; Epithelial Cells / drug effects; Epithelial Cells / metabolism; ErbB Receptors / antagonists & inhibitors; Fibroblast Growth Factor 2 / metabolism; Fibroblasts / drug effects; Heparin-binding EGF-like Growth Factor; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Lung / physiology; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Protein Tyrosine Phosphatases / antagonists & inhibitors; RNA, Messenger / metabolism; Receptors, Platelet-Derived Growth Factor / antagonists & inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Vanadium / pharmacology; p38 Mitogen-Activated Protein Kinases
TL;DR: It is reported that conditioned medium from normal human bronchial epithelial cells (NHBECs) contains mitogenic activity for human lung fibroblasts that is blocked by the epidermal growth factor receptor (EGF-R) tyrosine kinase inhibitor AG1478 and by neutralizing antibodies raised against heparin-binding epidermis growth factor-like growth factor (HB-EGF). (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 chapter

Air-liquid interface culture systems for exposure of differentiated cells to oxidant stress.

In Models and methods in cell signaling and gene expression applications to oxidative stress research. (pp. 15–30).

By: F. He, K. Adler, N. Akley, B. Fischer, N. Jiang, T. Krunkosky, L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Differential generation of intracellular oxidants by TNF? and exogenous superoxide affords distinct expression of IL-6 in human airway epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A152.

By: L. Martin, T. Krunkosky & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro - Signaling pathways controlling surface and gene expression

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 22(6), 685–692.

By: T. Krunkosky n, B. Fischer n, L. Martin n, N. Jones n, N. Akley n & K. Adler n

MeSH headings : Antibodies, Monoclonal; Bronchi / cytology; Cell Line; Epithelial Cells / enzymology; Epithelial Cells / immunology; Flow Cytometry; Gene Expression / immunology; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1 / genetics; Intercellular Adhesion Molecule-1 / immunology; L-Lactate Dehydrogenase / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; Promoter Regions, Genetic / physiology; RNA Processing, Post-Transcriptional / physiology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Respiratory Mucosa / cytology; Signal Transduction / immunology; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) becaus... (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Induction of heparin-binding epidermal growth factor (HB-EGF) mRNA in normal human bronchial epithelial cells by metal-induced oxidative stress.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A149.

By: J. Bonner, L. Zhang, P. Sannes, L. Martin, W. Gladwell, J. Koo, T. Gray, K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Interaction of TGF? and EGF receptor mediates IL-13 induced mucous cell hyperplasia in human airway epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A779.

By: L. Martin, J. Bonner, M. Macchione, B. Booth, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 article

MARCKS protein: a key intracellular molecule controlling mucin secretion by human airway goblet cells.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A259.

By: Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Mechanisms of human neutrophil elastase-induced mucin hypersecretion by human airway epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A155.

By: F. He, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Myristoylated alanine-rich C-kinase substrate protein: A major intracellular regulatory molecule controlling secretion of mucin by human airway goblet cells.

Chest, Vol. 117, pp. 266S–267S.

By: K. Adler, Y. Li & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Residual oil fly ash induces cytotoxicity and mucin secretion by guinea pig tracheal epithelial cells via an oxidant-mediated mechanism

TOXICOLOGY AND APPLIED PHARMACOLOGY, 163(3), 221–230.

By: N. Jiang n, K. Dreher*, J. Dye*, Y. Li n, J. Richards*, L. Martin n, K. Adler n

author keywords: mucin; cytotoxicity; residual oil fly ash; oxidant
MeSH headings : Animals; Antioxidants / pharmacology; Carbon / toxicity; Cell Survival / drug effects; Cells, Cultured; Coal Ash; Dust / adverse effects; Epithelial Cells / drug effects; Gene Expression / drug effects; Guinea Pigs; Industrial Waste; Metals / toxicity; Mucins / biosynthesis; Mucins / genetics; Mucins / metabolism; Oxidants / pharmacology; Particulate Matter; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Trachea / cytology; Trachea / drug effects; Trachea / metabolism
TL;DR: ROFA enhances mucin secretion and generates toxicity in vitro to airway epithelium via a mechanism(s) involving generation of oxidant stress, perhaps related to depletion of cellular antioxidant capacity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Response of human airway epithelium in vitro to inflammatory mediators - Dependence on the state of cellular differentiation

Martin, L. D., Norford, D., Voynow, J., & Adler, K. B. (2000, May). CHEST, Vol. 117, pp. 267S–267S.

By: L. Martin n, D. Norford*, J. Voynow* & K. Adler n

TL;DR: The data suggest that the response of the airway epithelium to inflammatory mediators may be markedly different in undifferentiated vs fully differentiated cells, and these responses may play a role in further exacerbation of airway inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 article

Cloning and expression of guinea pig MUC2 and MUC5AC genes.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A852.

By: Y. Li, S. Greenfeder, L. Martin, M. Minnicozzi, J. Voynow & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Development of monoclonal antibodies against bovine mucin core 2 beta 6 N-acetylglucosaminyltransferase

GLYCOCONJUGATE JOURNAL, 16(9), 555–562.

By: C. Li n, N. Joshee*, K. Adler n & P. Cheng*

author keywords: core 2 N-acetylglucosaminyltransferase; glycosyltransferase; monoclonal antibodies; mucin
MeSH headings : Animals; Antibodies, Monoclonal / biosynthesis; Blotting, Western; Cattle; Cloning, Molecular; Escherichia coli / genetics; Escherichia coli / metabolism; Fluorescent Antibody Technique; Histidine; Humans; Hybridomas / metabolism; Mice; N-Acetylglucosaminyltransferases / genetics; N-Acetylglucosaminyltransferases / immunology; Peptides / genetics; Recombinant Fusion Proteins / biosynthesis; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / immunology
TL;DR: Seven hybridomas were obtained which secreted MAbs against bovine C2TF in mouse ascites with titers ranging from 1:1280 to 1:40960 as assessed by immunofluorescence assay (IF), and isotyping revealed that all seven MAbs were IgG (4 IgG1, 2 IgG2b and 1 IgG 2a). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 article

Myristoylated alanine-rich C kinase substrate (MARCKS) is produced by human airway epithelial cells and is phosphorylated by PKC and PKG.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A723.

By: Y. Li, F. He, L. Martin, T. Krunkosky, T. Lincoln, T. Cornwell, K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Normal human bronchial epithelial cells produce heparin-binding epidermal growth factor (HB-EGF), a mitogen for human lung fibroblasts in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A508.

By: L. Zhang, K. Adler, P. Sannes & J. Bonner

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 277(3), L498–L510.

By: J. Dye*, K. Adler n, J. Richards* & K. Dreher*

author keywords: particulate matter; airway epithelial cells; gene induction; oxidative stress
MeSH headings : Animals; Carbon / pharmacology; Cell Survival / drug effects; Cells, Cultured; Chemokine CXCL2; Coal Ash; Cytokines / genetics; Epithelial Cells / drug effects; Epithelial Cells / physiology; Gene Expression / drug effects; Interleukin-6 / genetics; Male; Metals / pharmacology; Monokines / genetics; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase Type II; Particulate Matter; Rats; Rats, Sprague-Dawley; Solubility; Trachea / drug effects; Trachea / pathology; Trachea / physiopathology
TL;DR: Generation of an oxidative stress was critical to induction of the ROFA- or vanadium-induced effects on airway epithelial gene expression, cytokine production, and cytotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 article

TNF? effects on human airway epithelial cells in vitro: molecular mechanisms of enhanced mucin production/secretion and ICAM-I expression.

404nOtfound, Vol. 8, p. S55.

By: K. Adler, L. Martin, J. Voynow & T. Krunkosky

Source: NC State University Libraries
Added: August 6, 2018

1999 article

TNF?-induced ICAM-1 expression in airway epithelium: involvement of IkB?.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A184.

By: T. Krunkosky, L. Martin, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Transcription factor activation during oxidant-regulated interleukin-6 expression in normal human bronchial epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A447.

By: L. Martin, T. Krunkosky & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro

Fischer, B. M., Rochelle, L. G., Voynow, J. A., Akley, N. J., & Adler, K. B. (1999, March). AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol. 20, pp. 413–422.

By: B. Fischer n, L. Rochelle n, J. Voynow n, N. Akley n & K. Adler n

MeSH headings : Animals; Cyclic GMP / biosynthesis; Cyclic GMP-Dependent Protein Kinases; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / immunology; Female; Guanylate Cyclase / metabolism; Guinea Pigs; Male; Models, Biological; Mucins / metabolism; Nitric Oxide / biosynthesis; Nitric Oxide Synthase / metabolism; Protein Kinase C / antagonists & inhibitors; Protein Kinases / metabolism; Signal Transduction; Trachea / cytology; Trachea / drug effects; Trachea / immunology; Tumor Necrosis Factor-alpha / pharmacology; Type C Phospholipases / antagonists & inhibitors
TL;DR: The results suggest that TNF-alpha stimulates secretion of mucin by GPTE cells via a mechanism(s) dependent on PC-PLC and PKC, and involving activation of NOS, generation of NO, production of cGMP, and activation of PKG. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 article

Upregulation of mucin gene expression in airway epithelial cells by inflammatory mediators.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A36.

By: Y. Kim, J. Koo, D. Norford, T. Gray, K. Adler & P. Nettesheim

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Cloning of guinea pig Muc2 cDNA and MUC2 gene expression in guinea pig airway epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 157, p. A728.

By: Y. Li, L. Martin, M. Minnicozzi & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro

FREE RADICAL BIOLOGY AND MEDICINE, 24(5), 863–868.

By: L. Rochelle*, B. Fischer n & K. Adler n

author keywords: oxygen radicals; nitric oxide; airway epithelium; free radical
MeSH headings : Animals; Cell Line; Enzyme Activation; Epithelial Cells / metabolism; Free Radicals; Guinea Pigs; Macrophages / metabolism; Mice; Nitric Oxide Synthase / metabolism; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen / metabolism; Oxidative Stress / physiology; Reactive Oxygen Species / metabolism; Trachea / cytology; Trachea / metabolism
TL;DR: Both ROS and RNS can be measured in the same lysates from airway epithelial cells, and that both ROS andRNS are produced in these cells in response to different stimuli. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Effects of inflammatory mediators and drugs on mucus secretion and mucociliary function.

404nOtfound, 149, 245–248.

By: K. Adler, B. Fischer, L. Martin & J. Voynow

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Exposure of differentiated rodent airway epithelial cells in vitro to particles of residual fly ash (ROFA) induces cytotoxicity and generation of reactive oxygen species.

Proceedings of the 10th International Colloquium on Lung Fibrosis, Vol. 10, p. 26.

By: K. Adler, N. Jiang, J. Dye & K. Dreher

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Expression of nitric oxide synthase isoforms in normal human tracheobronchial epithelial cells in vitro: Dependence on retinoic acid and the state of differentiation

EXPERIMENTAL LUNG RESEARCH, 24(3), 355–366.

By: D. Norford*, J. Koo*, T. Gray*, K. Alder n & P. Nettesheim*

author keywords: nitric oxide synthase; tracheobronchial epithelium; retinoic acid; airway differentiation
MeSH headings : Blotting, Northern; Blotting, Western; Bronchi / cytology; Bronchi / drug effects; Cell Differentiation / drug effects; Cells, Cultured; DNA Primers / chemistry; Epithelial Cells / enzymology; Gene Expression Regulation, Enzymologic / drug effects; Humans; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase / metabolism; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; RNA, Messenger / metabolism; Tretinoin / pharmacology
TL;DR: The studies show that constitutive expression of the NOS isoforms is differentially regulated and that iNOS and eNOS mRNA levels are dependent on the stage of mucous and squamous differentiation, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Intracellular reactive oxygen and nitrogen species as signaling molecules in airway epithelium.

Environmental Health Perspectives, 106, 1197–1203.

By: L. Martin, T. Krunkosky, J. Voynow & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1998 chapter

Intracellular regulation of airway mucin secretion.

In Cilia, mucus and mucociliary interactions (pp. 143–151).

By: B. Fischer, C. Li, H. Li, N. Choe, D. Wright, L. Rochelle, K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Mechanisms of TNF? signaling in airway epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 157, p. A198.

By: T. Krunkosky, B. Fischer, J. Dodam & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Mucin biosynthesis: Molecular cloning and expression of bovine lung mucin core 2 N-acetylglucosaminyltransferase cDNA

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 18(3), 343–352.

By: C. Li n, K. Adler n & P. Cheng n

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Carbohydrate Sequence; Cattle; Cloning, Molecular; DNA, Complementary / genetics; Genomic Library; Immunohistochemistry; Lung / enzymology; Molecular Sequence Data; Mucins / biosynthesis; N-Acetylglucosaminyltransferases / genetics; Recombinant Proteins / biosynthesis; Research Design; Sequence Analysis, DNA; Sequence Homology, Amino Acid
TL;DR: A cDNA clone containing a 2,150-bp insert was isolated from a bovine lung lambdagt10 cDNA library by cross-species hybridization using a DNA probe generated by polymerase chain reaction (PCR) employing a human cDNA that encodes mucin core 2 beta6-N-acetylglucosaminyltransferase (hC2TF) as the template. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 chapter

Oxidant-regulated gene expression in inflammatory lung disease.

In Acute respiratory distress syndrome: cellular and molecular mechanisms and clinical management. (pp. 187–195).

By: L. Martin n, T. Krunkosky n, J. Voynow* & K. Adler n

TL;DR: Acute respiratory distress syndrome is characterized by severe hypoxemia, diffuse pulmonary infiltrates and poor lung compliance in the absence of left heart failure. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1998 article

Particles of Residual Oil Fly Ash (ROFA) induce toxicity and mucin hypersecretion in rodent airway epithelial cells in vitro via an oxidant-mediated mechanism.

Toxicology Letters, Vol. 95, p. 224.

By: K. Adler*, N. Jiang, J. Dye* & K. Dreher*

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Regulation of nitric oxide synthase (NOS) isoforms in human tracheobronchial cells by retinoic acid.

American Journal of Respiratory and Critical Care Medicine, Vol. 157, p. A769.

By: D. Norford, J. Koo, T. Gray & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Residual oil fly ash (ROFA) induces cytotoxicity and enhances mucin secretion by guinea pig airway epithelial cells in vitro via an oxidant mediated mechanism.

American Journal of Respiratory and Critical Care Medicine, Vol. 157, p. A150.

By: N. Jiang, K. Dreher & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1998 article

The role of reactive oxygen and nitrogen species in airway epithelial gene expression

Martin, L. D., Krunkosky, T. M., Voynow, J. A., & Adler, K. B. (1998, October). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 106, pp. 1197–1203.

By: L. Martin n, T. Krunkosky n, J. Voynow n & K. Adler n

author keywords: reactive oxygen/nitrogen species; signal transduction; intracellular oxidants; ICAM-1; IL-6; TNF-alpha
Source: Web Of Science
Added: August 6, 2018

1998 article

Vanadium content and related oxidative stress appear to determine airway epithelial cell responses to emission source particulate matter.

FASEB Journal, Vol. 12, p. A337.

By: J. Dye, K. Adler, L. Rochelle & K. Dreher

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Airway epithelial cell responses to fly ash (ROFA) particles: contribution of soluble transition metals.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A197.

By: J. Dye, K. Adler, J. Richards & K. Dreher

Source: NC State University Libraries
Added: August 6, 2018

1997 chapter

Airway epithelial cells in asthma.

In Allergy and allergic diseases. (pp. 263–283).

By: L. Cohn, B. Fischer & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 review

Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators

[Review of ]. EUROPEAN RESPIRATORY JOURNAL, 10(9), 2139–2146.

By: L. Martin n, L. Rochelle n, B. Fischer n, T. Krunkosky n & K. Adler n

author keywords: airway; cytokines; eicosanoids; epithelium; inflammation; reactive oxygen/nitrogen species
MeSH headings : Animals; Cytokines / metabolism; Epithelium / metabolism; Humans; Inflammation / metabolism; Inflammation / physiopathology; Inflammation Mediators / metabolism; Lipid Metabolism; Reactive Oxygen Species / metabolism; Respiratory System / metabolism; Respiratory System / pathology
TL;DR: The production of cytokines by the airway epithelium is shown to play a role in causing inflammation associated with respiratory diseases, and molecular mechanisms governing the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleUKin-8 ( IL-8) are discussed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 article

Effects of tumour necrosis factor-alpha on airway epithelial cells in vitro.

404nOtfound, Vol. 3, p. 74.

By: K. Adler, T. Krunkosky & B. Fischer

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Epithelial injury induced by exposure to residual oil fly-ash particles: Role of reactive oxygen species?

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 17(5), 625–633.

By: J. Dye n, K. Adler n, J. Richards n & K. Dreher n

MeSH headings : Air Pollution; Animals; Cell Line; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Industrial Oils / toxicity; Oxidative Stress; Rats; Reactive Oxygen Species / metabolism; Trachea / drug effects; Trachea / pathology
TL;DR: In vitro findings suggest that ROFA-induced RTE cell injury may be mediated by hydroxyl-radical-like reactive oxygen species (i.e., species scavenged by DMTU) that are generated via non-nitric oxide pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 article

Inflammatory mediators increase intracellular reactive oxygen and nitrogen species (ROS/RNS) in airway epithelial cells.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A437.

By: L. Rochelle, B. Fischer, K. Boehm, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 chapter

Interactions between oxidant gases and airway epithelial cells; in vitro in vivo correlations.

In Correlations between in vitro and in vivo investigations in inhalation toxicology. (pp. 216–229).

By: D. Wright, C. Li, B. Fischer, K. Yagaloff & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Intracellular regulation of mucin secretion.

Proceedings of the International Congress on Cilia, Mucus and Mucociliary Interations., p. 15.

By: K. Adler, C. Li, H. Li, N. Choe & B. Fischer

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Mechanisms of TNF?-induced ICAM-1 expression in airway epithelium.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A207.

By: T. Krunkosky, L. Martin, B. Fischer & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Molecular cloning and expression of a mucin core 2 N-acetylglucosaminyltransferase cDNA.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A434.

By: P. Cheng, C. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Ozone induced DNA single strand breaks in human and guinea pig lung cells in vivo

Inhalation Toxicology, 9(9), 811–828.

By: J. Lee, M. Madden, G. Hatch, G. Bottei, D. Peden, K. Adler, R. Devlin

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Secretory inhibition by airway epithelium increases with age.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A427.

By: T. Murphy, N. Akley, P. Chitapo & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 article

TNF? and oxidant-induced expression of Interleukin-6 in normal human bronchial epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A206.

By: L. Martin, T. Krunkosky, L. Rochelle & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 article

The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates

Martin, L. D., Krunkosky, T. M., Dye, J. A., Fischer, B. M., Jiang, N. F., Rochelle, L. G., … Adler, K. B. (1997, September). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 105, pp. 1301–1307.

By: L. Martin*, T. Krunkosky, J. Dye, B. Fischer*, N. Jiang, L. Rochelle*, N. Akley*, K. Dreher, K. Adler*

author keywords: reactive oxygen/nitrogen species; signal transduction; airway inflammation; mucin hypersecretion; ICAM-1; TNF-alpha
Source: Web Of Science
Added: August 6, 2018

1996 article

Airway epithelium: A primary source for growth factors related to development of fibrosis?

Proceedings of the 9th International Colloquium on Lung Fibrosis, Vol. 9, p. 29.

By: K. Adler, M. Menard & P. Sannes

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Effect of pertussis toxin and B-Oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages.

American Journal of Veterinary Research, 57, 574–579.

By: J. Dodam, K. Adler & N. Olson

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Environmental toxins induce intracellular responses of airway epithelium through reactive species of oxygen and nitrogen

Rochelle, L. G., Fischer, B. M., Krunkosky, T. M., Wright, D. T., & Adler, K. B. (1996, March). CHEST, Vol. 109, pp. S35–S39.

By: L. Rochelle n, B. Fischer n, T. Krunkosky n, D. Wright n & K. Adler n

MeSH headings : Air Pollutants / adverse effects; Animals; Free Radicals / adverse effects; Humans; Nitrogen / adverse effects; Reactive Oxygen Species / adverse effects; Respiratory System / cytology; Respiratory System / drug effects
Source: Web Of Science
Added: August 6, 2018

1996 article

Histamine stimulates secretion of mucin and activates phospholipase C in airway epithelium: evidence for independent pathways.

American Journal of Respiratory and Critical Care Medicine, Vol. 153, p. A539.

By: H. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Injury of rat tracheal epithelial cultures by exposure to residual oil fly ash (ROFA) involves generation of the hydroxyl radical.

American Journal of Respiratory and Critical Care Medicine, Vol. 153, p. A542.

By: J. Dye, K. Adler, J. Richards & K. Dreher

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis

EXPERIMENTAL EYE RESEARCH, 62(1), 21–28.

By: J. Allen n, M. McGahan n, J. Ferrell n, K. Adler n & L. Fleisher n

author keywords: nitric oxide; uveitis; nitric oxide synthase; nitric oxide synthase inhibitors; inflammation
MeSH headings : Animals; Aqueous Humor / metabolism; Arginine / analogs & derivatives; Arginine / therapeutic use; Cell Count / drug effects; Dose-Response Relationship, Drug; Eye Proteins / drug effects; Guanidines / therapeutic use; Kinetics; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / physiology; Nitric Oxide Synthase / antagonists & inhibitors; Rabbits; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism; Uveitis, Anterior / prevention & control
TL;DR: Investigation of the effects of NOS inhibitors with different NOS isoform specificities in the rabbit model of endotoxin-induced ocular inflammation suggests that cNOS may play a greater role in the earlier stages of this developing inflammatory response, and extends others' observations that NO is a key mediator in uveitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1996 article

Nitric oxide: A key signaling molecule regulating airway mucin secretion.

Proceedings of the 9th World Congress on Bronchology & World Congress on Bronchoesophagology., Vol. 9, p. S060.

By: K. Adler, D. Wright, C. Li, H. Li, N. Choe, L. Rochell, B. Fischer

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Oxidant stress stimulates mucin secretion and PLG in airway epithelium via a nitric oxide-dependent mechanism

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 271(5), L854–L861.

By: D. Wright n, B. Fischer n, C. Li n, L. Rochelle n, N. Akley n & K. Adler n

author keywords: airway epithelial cells; second messengers; nitric oxide; phospholipase C
MeSH headings : Animals; Cell Transformation, Viral; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium / drug effects; Epithelium / physiology; Guinea Pigs; Humans; Hydrogen Peroxide / pharmacology; Molsidomine / analogs & derivatives; Molsidomine / pharmacology; Mucins / biosynthesis; Mucins / metabolism; Nitric Oxide / pharmacology; Penicillamine / analogs & derivatives; Penicillamine / pharmacology; Peroxides / pharmacology; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxides / pharmacology; Trachea / physiology; Type C Phospholipases / metabolism; Xanthine Oxidase; omega-N-Methylarginine / pharmacology; tert-Butylhydroperoxide
TL;DR: The results suggest that intracellularly generated radical species of nitrogen and oxygen may be important modulators of the response of airway epithelial cells to external oxidant stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1996 article

Reactive oxygen species provoke secretion of mucin and activate phospholipase C in airway epithelial cells in vitro via a mechanism dependent on nitric oxide and hydroxyl free radical.

Molecules to Man, Proceedings of Keystone Symposium, p. 20.

By: K. Adler, D. Wright & B. Fischer

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Role of airway epithelium in airway inflammation.

Proceedings of the Symposium on Airway Mucus (Seoul, 1996)., p. 32.

By: K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Role or reactive oxygen and nitrogen species in the response of airway epithelium to particulates.

Proceedings of the 6th International Meeting of the Toxicology of Natural and Man-Made Fibrous and Non-Fibrous Particles., Vol. 6, p. 139.

By: K. Adler, T. Krunkosky, B. Fischer, L. Rochelle, L. Martin, K. Dreher, N. Jiang, J. Dye

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: Possible signal transduction mechanisms

CYTOKINES AND ADHESION MOLECULES IN LUNG INFLAMMATION, Vol. 796, pp. 30–37.

By: T. Krunkosky n, B. Fischer n, N. Akley n & K. Adler n

MeSH headings : Adult; Antigens, CD / metabolism; Antioxidants / pharmacology; Bronchi / cytology; Bronchi / metabolism; Cell Line; Epithelium / metabolism; Flow Cytometry; Humans; Intercellular Adhesion Molecule-1 / metabolism; Protein Kinase C / metabolism; Receptors, Tumor Necrosis Factor / metabolism; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: Results indicate that TNF alpha-induced ICAM-1 surface expression is a specific receptor-mediated response (TNF-R1), which is mediated by mechanisms dependent on PKC and intracellular reactive oxygen species. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1996 article

Tumor necrosis factor alpha (TNF?) provokes expression of intercellular adhesion molecule-1 (ICAM-1) on human bronchial epithelial cells in primary culture.

American Journal of Respiratory and Critical Care Medicine, Vol. 153, p. A27.

By: T. Krunkosky, B. Fischer, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Tumor necrosis factor-alpha (TNF?) induced mucin secretion: dependence on nitric oxide (NO) and cyclic GMP.

American Journal of Respiratory and Critical Care Medicine, Vol. 153, p. A538.

By: B. Fischer, L. Rochelle, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Use of the single cell gel electrophoresis assay (SCGE) for detection of oxidant-induced DNA single strand breaks (SSB) in human lung cells in vitro.

Toxicology and Applied Pharmacology, 141, 195–204.

By: J. Lee*, M. Madden*, W. Reed*, K. Adler n & R. Devlin*

MeSH headings : Bronchi / drug effects; Cells, Cultured; Cryopreservation; DNA Damage; DNA, Single-Stranded / drug effects; Electrophoresis / methods; Epithelium / drug effects; Humans; Hydrogen Peroxide / toxicity; Oxidants / toxicity; Ozone / toxicity
Source: NC State University Libraries
Added: August 6, 2018

1995 article

Effects of tumor necrosis factor alpha (TNF?) on expression of ICAM-1 and inflammation-associated genes in airway epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 151, p. A366.

By: T. Krunkosky, B. Fischer, D. Wright, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1995 article

Endogenously-generated nitric oxide (NO) may be a key signaling molecule in hypersecretion of mucin by guinea pig tracheal epithelial (GPTE) cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 151, p. A337.

By: B. Fischer, D. Wright, H. Li, C. Li, L. Cohn, N. Akley, K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1995 journal article

HISTAMINE PROVOKES TURNOVER OF INOSITOL PHOSPHOLIPIDS IN GUINEA-PIG AND HUMAN AIRWAY EPITHELIAL-CELLS VIA AN H-1-RECEPTOR G-PROTEIN-DEPENDENT MECHANISM

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 12(4), 416–424.

By: H. Li*, N. Choe, D. Wright & K. Adler*

MeSH headings : Adult; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins / physiology; Gene Expression; Guinea Pigs; Humans; Inositol Phosphates / metabolism; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols / metabolism; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases / metabolism; RNA, Messenger / genetics; Receptors, Histamine H1 / physiology; Signal Transduction; Sodium Fluoride / pharmacology; Virulence Factors, Bordetella / pharmacology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1995 journal article

HYPERSECRETION OF MUCIN IN RESPONSE TO INFLAMMATORY MEDIATORS BY GUINEA-PIG TRACHEAL EPITHELIAL-CELLS IN-VITRO IS BLOCKED BY INHIBITION OF NITRIC-OXIDE SYNTHASE

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 13(5), 526–530.

By: K. Adler*, B. Fischer, H. Li*, N. Choe & D. Wright

MeSH headings : Animals; Arginine / analogs & derivatives; Arginine / pharmacology; Cells, Cultured; Enzyme Inhibitors / pharmacology; Guinea Pigs; Histamine / pharmacology; Inflammation Mediators / pharmacology; Mucins / metabolism; Nitric Oxide Synthase / antagonists & inhibitors; Platelet Activating Factor / drug effects; Secretory Rate / drug effects; Superoxides / metabolism; Trachea / metabolism; Tumor Necrosis Factor-alpha / pharmacology; omega-N-Methylarginine
TL;DR: The results suggest that each of these inflammation-associated mediators provokes airway epithelial mucin secretion via a mechanism involving intracellular production of nitric oxide (NO) as a critical signaling molecule. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1995 article

Ozone exposure in vivo induces increases in DNA single strand breaks in human and guinea pig lung cells.

American Journal of Respiratory and Critical Care Medicine, Vol. 151, p. A498.

By: J. Lee, M. Madden, G. Hatch, G. Bottei, W. Reed, K. Adler, R. Devlin

Source: NC State University Libraries
Added: August 6, 2018

1995 article

Reactive nitrogen species (RNS) stimulate secretion of mucin by primary cultures of guinea pig tracheal epithelial (GPTE) cells.

American Journal of Respiratory and Critical Care Medicine, Vol. 151, p. A337.

By: D. Wright, C. Li, B. Fischer, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1995 journal article

Tumor necrosis factor alpha (TNF?) stimulates mucin secretion and gene expression in airway epithelium invitro.

Chest, 107, 133S–135.

By: B. Fischer n, T. Krunkosky n, D. Wright n, M. Dolan-O'Keefe n & K. Adler*

MeSH headings : Amino Acid Oxidoreductases / genetics; Animals; Bronchi / metabolism; Cells, Cultured; Epithelium / metabolism; Gene Expression; Guinea Pigs; Mucins / metabolism; Nitric Oxide Synthase; Phospholipases A / genetics; RNA, Messenger / analysis; Superoxide Dismutase / genetics; Tumor Necrosis Factor-alpha / pharmacology; Tumor Necrosis Factor-alpha / physiology
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1994 chapter

Alternatives to in vivo toxicological testing of rodent airway epithelia.

In Animal test alternatives: refinement-reduction-replacement. (pp. 233–239).

By: L. Cohn & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

Antioxidant scavenging by guinea pig and human airway epithelial cells in vitro: mechanisms of H2O2 clearance.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 265(10), 397–404.

By: L. Cohn & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

Effects of cigarette smoke on epithelial cells of the respiratory tract.

404nOtfound, 49, 825–834.

By: J. Dye n & K. Adler n

MeSH headings : Epithelium / metabolism; Epithelium / pathology; Humans; Mucociliary Clearance / physiology; Respiratory System / metabolism; Respiratory System / pathology; Smoking / adverse effects
TL;DR: Early events in the response to cigarette smoke or its components may be critical, and certainly an understanding of these events may help to elucidate the pathogenetic mechanisms of many chronic respiratory diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1994 article

Effects of oxidant stress on airway epithelial cells in vitro.

FASEB Journal, Vol. 8, p. A896.

By: K. Adler, D. Wright, B. Fischer, L. Cohn, C. Li, H. Li, N. Choe, N. Akley

Source: NC State University Libraries
Added: August 6, 2018

1994 article

Effects of tumor necrosis factor alpha (TNF?) on airway epithelial cells in vitro.

Proceedings of the 8th International Colloquium on Lung Fibrosis, Vol. 8, p. 3.

By: K. Adler, B. Fischer, D. Wright & M. Dolan-O'Keefe

Source: NC State University Libraries
Added: August 6, 2018

1994 article

INTERACTIONS BETWEEN RESPIRATORY EPITHELIAL-CELLS AND CYTOKINES - RELATIONSHIPS TO LUNG INFLAMMATION

CELLS AND CYTOKINES IN LUNG INFLAMMATION, Vol. 725, pp. 128–145.

By: K. Adler n, B. Fischer n, D. Wright n, L. Cohn n & S. Becker*

MeSH headings : Animals; Asthma / physiopathology; Cytokines / physiology; Epithelial Cells; Epithelium / physiology; Humans; Inflammation / immunology; Inflammation / physiopathology; Lung / cytology; Lung / physiology; Lung / physiopathology; Respiratory Physiological Phenomena; Respiratory System / cytology; Respiratory System / physiopathology
TL;DR: Activity of respiratory epithelial cells in vitro as sources of cytokines and inflammatory mediators is investigated, finding that production and release of these cytokines increases substantially after exposure to specific inflammatory stimuli, such as TNF or IL-1, and after viral infection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1994 journal article

Interactions of oxygen radicals with airway epithelium.

Environmental Health Perspectives. Supplements, 102(11), 85–90.

By: D. Wright n, L. Cohn n, H. Li n, B. Fischer n, C. Li n & K. Adler n

MeSH headings : Animals; Antioxidants / metabolism; Epithelium / drug effects; Epithelium / physiopathology; Humans; Oxidoreductases / metabolism; Reactive Oxygen Species / pharmacology; Respiratory System / drug effects; Respiratory System / physiopathology
TL;DR: Reactive oxygen species (ROS) have been implicated in the pathogenesis of numerous disease processes and Respiratory epithelium may be intimately involved in defense against, and pathophysiologic changes invoked by, ROS. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1994 article

Lipid ozonation products activate phospholipases in guinea pig and human airway epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 149, p. A320.

By: D. Wright, M. Friedman, W. Pryor, G. Squadrito, M. Salgo & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

OZONE STIMULATES RELEASE OF PLATELET-ACTIVATING-FACTOR AND ACTIVATES PHOSPHOLIPASES IN GUINEA-PIG TRACHEAL EPITHELIAL-CELLS IN PRIMARY CULTURE

TOXICOLOGY AND APPLIED PHARMACOLOGY, 127(1), 27–36.

By: D. Wright n, K. Adler n, N. Akley n, L. Dailey n & M. Friedman n

MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Enzyme Activation / drug effects; Female; Glycerophospholipids; Guinea Pigs; Inositol Phosphates / metabolism; Male; Mucins / metabolism; Ozone / toxicity; Phosphatidic Acids / metabolism; Phospholipases / metabolism; Phosphorylation / drug effects; Platelet Activating Factor / metabolism; Trachea / cytology; Trachea / drug effects; Trachea / enzymology; Trachea / metabolism
TL;DR: The results suggest that GPTE cells respond to O3 exposure in vitro by increasing production and/or release of PAF via a mechanism that may involve activation of PLA2, PLC, and PLD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1994 journal article

PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST GUINEA-PIG TRACHEAL MUCINS

HYBRIDOMA, 13(4), 281–287.

By: C. Li*, P. Cheng & K. Adler*

MeSH headings : Animals; Antibodies, Monoclonal / immunology; Blotting, Western; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Microscopy, Immunoelectron; Mucins / analysis; Mucins / immunology; Periodic Acid / immunology; Species Specificity; Trachea / chemistry; Trachea / immunology
TL;DR: Thirty-five hybridomas that secrete mouse monoclonal antibodies against guinea pig tracheal mucins were established and should be useful for immunomeasurement of mucin secretion in vivo and in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1994 article

Platelet activating factor and histamine activate phospholipase C in airway epithelial cells in vitro via a pertussis toxin sensitive G protein.

American Journal of Respiratory and Critical Care Medicine, Vol. 149, p. A985.

By: N. Choe, H. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1994 article

Reactive oxygen species (ROS) activate phospholipase C in guinea pig and human airway epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 149, p. A315.

By: D. Wright, N. Akley, H. Li, B. Fischer & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1994 article

Tumor necrosis factor alpha (TNF?) stimulates mucin secretion and gene expression in airway epithelium in vitro.

Proceedings of the 37th Aspen Lung Conference., Vol. 37, p. 17.

By: K. Adler, B. Fischer, N. Akley & M. Dolan-O'Keefe

Source: NC State University Libraries
Added: August 6, 2018

1994 article

Use of the single cell gel electrophoresis assay (SCGE) for detection of oxidant-induced DNA single strand breaks (SSB) in human lung cells.

American Journal of Respiratory and Critical Care Medicine, Vol. 149, p. A158.

By: J. Lee, M. Madden, W. Reed, K. Adler & R. Devlin

Source: NC State University Libraries
Added: August 6, 2018

1993 article

Antioxidant scavenging by guinea pig and human airway epithelial cells in vitro: mechanisms of H2O2 clearance.

American Review of Respiratory Disease, Vol. 147, p. A440.

By: L. Cohn & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

RAT TRACHEAL EPITHELIAL-CELL DIFFERENTIATION IN-VITRO

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 29A(6), 481–492.

By: L. Kaartinen, P. Nettesheim*, K. Adler n & S. Randell*

author keywords: COLLAGEN; DIFFERENTIATION; KERATIN; MUCIN; RETINOIDS; TRANSGLUTAMINASE
TL;DR: The ability to modulate RTE cell phenotypes in culture will facilitate future studies investigating molecular regulation of tracheal cell proliferation, differentiation, and function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1993 chapter

Study of xenobiotics and airway epithelium in vitro.

In Fiber toxicology. (pp. 171–194).

By: L. Cohn, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1993 article

Use of air/liquid interface cultures to assess polarized responses of airway epithelium to toxicants.

In Vitro Cellular & Developmental Biology. Animal, Vol. 29A, p. 46A.

By: K. Adler & L. Cohn

Source: NC State University Libraries
Added: August 6, 2018

1993 conference paper

Use of air/liquid interface guinea pig tracheal epithelial cell culture system for assessment of interactions between inhaled substances and airways.

Proceedings of the Toxicol Forum 1993 Annual Winter Meeting, 1993(Winter), 14–19.

By: K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1993 article

Use of air/liquid interface guinea pig tracheal epithelial cell culture systems for assessment of interactions between inhaled substances and airways.

Proceedings of the Toxicology Forum 1993., Vol. 1993.

By: K. Adler & L. Cohn

Source: NC State University Libraries
Added: August 6, 2018

1992 article

Airway epithelial cells release factor(s) that stimulate proliferation of airway smooth muscle cells in vitro.

Molecular Biology of the Cell, Vol. 3, p. 175a.

By: P. Rippetoe, M. Absher, W. Makrides, K. Adler & J. Evans

Source: NC State University Libraries
Added: August 6, 2018

1992 article

Guinea pig tracheal epithelial cells in primary air/liquid interface culture scavenge H2O2 via a mechanism only partially dependent on catalase and the glutathione system.

FASEB Journal, Vol. 6, p. A939.

By: K. Adler & L. Cohn

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

INFLAMMATORY MEDIATORS AND THE GENERATION AND RELEASE OF REACTIVE OXYGEN SPECIES BY AIRWAY EPITHELIUM INVITRO

CHEST, 101(3), S53–S54.

By: K. Adler n, V. Kinnula, N. Akley n, J. Lee n, L. Cohn n & J. Crapo n

MeSH headings : Animals; Cells, Cultured; Endothelins / pharmacology; Epithelium / metabolism; Guinea Pigs; Hydrogen Peroxide / metabolism; Platelet Activating Factor / pharmacology; Trachea / metabolism
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1992 review

INTERACTIONS BETWEEN AIRWAY EPITHELIUM AND MEDIATORS OF INFLAMMATION

[Review of ]. EXPERIMENTAL LUNG RESEARCH, 18(3), 299–322.

By: L. Cohn n & K. Adler n

MeSH headings : Bronchi / metabolism; Epithelial Cells; Epithelium / metabolism; Humans; Inflammation / metabolism; Trachea / metabolism
TL;DR: Recent studies have indicated that airway epithelial cells also can act as "effector" cells, responding to a variety of exogenous and/or endogenous stimuli by generating and releasing additional mediators of inflammation, such as eicosanoids, reactive oxygen species, and cytokines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1992 article

Ozone increases platelet activating factor and activates phospholipases (PLA2 and PLC) in primary guinea pig tracheal epithelial cells (GPTE).

American Review of Respiratory Disease, Vol. 145, p. A99.

By: M. Friedman, D. Wright, L. Dailey, N. Akley, R. Devlin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

PLATELET-ACTIVATING-FACTOR PROVOKES RELEASE OF MUCIN-LIKE GLYCOPROTEINS FROM GUINEA-PIG RESPIRATORY EPITHELIAL-CELLS VIA A LIPOXYGENASE-DEPENDENT MECHANISM

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 6(5), 550–556.

By: K. Adler n, N. Akley n & W. Glasgow n

MeSH headings : Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors / pharmacology; Epithelium / metabolism; Glyceryl Ethers / pharmacology; Guinea Pigs; Hydroxyeicosatetraenoic Acids / metabolism; In Vitro Techniques; Indomethacin / pharmacology; Lipoxygenase / physiology; Lipoxygenase Inhibitors / pharmacology; Masoprocol / pharmacology; Mucins / metabolism; Phospholipid Ethers / pharmacology; Platelet Activating Factor / pharmacology; Platelet Membrane Glycoproteins; Receptors, Cell Surface / antagonists & inhibitors; Receptors, G-Protein-Coupled; Thiazoles / pharmacology; Trachea / metabolism
TL;DR: The results suggest that PAF stimulates release of MLG by guinea pig tracheal epithelial cells in vitro by a mechanism involving binding of PAF to receptors on epithelial cell surfaces, stimulation of lipoxygenase metabolism of arachidonic acid to HETEs within the epithelium, and stimulation of secretion by these epithelial-derived HetEs via an autocrine or paracrine mechanism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1992 journal article

RELEASE OF REACTIVE OXYGEN SPECIES BY GUINEA-PIG TRACHEAL EPITHELIAL-CELLS INVITRO

AMERICAN JOURNAL OF PHYSIOLOGY, 262(6), L708–L712.

By: V. Kinnula*, K. Adler*, N. Ackley* & J. Crapo*

author keywords: HYDROGEN PEROXIDE; PLATELET-ACTIVATING FACTOR; AIRWAY EPITHELIUM
MeSH headings : Analysis of Variance; Animals; Cell Membrane / metabolism; Cells, Cultured; Epithelium / drug effects; Epithelium / metabolism; Guinea Pigs; Hydrogen Peroxide / metabolism; Indomethacin / pharmacology; Male; Platelet Activating Factor / pharmacology; Tetradecanoylphorbol Acetate / pharmacology; Trachea / metabolism
TL;DR: The results suggest that tracheal epithelial cells can be stimulated to generate reactive oxygen species into the airway lumen and that this occurs in response to inflammatory mediators that act through protein kinase C. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1991 article

Airway epithelium generates and releases reactive oxygen species in response to activation of protein kinase C.

Proceedings Fo the 4th International Conference on Environmental Lung Disease (Montreal, 1991), Vol. 4, p. 2.

By: K. Adler, V. Kinnula, N. Akley & J. Crapo

Source: NC State University Libraries
Added: August 6, 2018

1991 article

DEVELOPMENT AND CHARACTERIZATION OF A RAPID-ONSET RODENT INHALATION MODEL OF ASBESTOSIS FOR DISEASE PREVENTION

TOXICOLOGIC PATHOLOGY, Vol. 19, pp. 412–418.

By: B. Mossman*, Y. Janssen*, J. Marsh*, A. Sesko*, M. Shatos*, J. Doherty*, K. Adler*, D. Hemenway* ...

author keywords: ASBESTOS; BRONCHOALVEOLAR LAVAGE; ANTIOXIDANTS; FIBROSIS; LUNG
MeSH headings : Administration, Inhalation; Alkaline Phosphatase / analysis; Animals; Asbestosis / enzymology; Asbestosis / etiology; Asbestosis / prevention & control; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Disease Models, Animal; Male; Neutrophils / drug effects; Peptidyl-Dipeptidase A / analysis; Rats; Rats, Inbred F344; Superoxide Dismutase / analysis
Source: Web Of Science
Added: August 6, 2018

1991 chapter

Effects of inflammatory mediators on epithelial function and integrity.

In Lung biology in health and disease. (pp. 377–402).

By: K. Adler & D. Henke

Source: NC State University Libraries
Added: August 6, 2018

1991 article

Effects of inflammatory mediators on generation and release of reactive oxygen species by airway epithelium in vitro.

Proceedings of the 34th Aspen Lung Conference., Vol. 34, p. 33.

By: K. Adler, V. Kinnula, N. Akley, J. Lee & J. Crapo

Source: NC State University Libraries
Added: August 6, 2018

1991 article

INVITRO STUDIES OF MECHANISMS OF LUNG INJURY IN THE RODENT

TOXICOLOGIC PATHOLOGY, Vol. 19, pp. 419–427.

By: L. Cohn n & K. Adler n

author keywords: RESPIRATORY EPITHELIUM; INVITRO RESPONSE; AIRWAY RESPONSE
MeSH headings : Animals; Cells, Cultured; Epithelium / drug effects; Guinea Pigs; Lung / cytology; Lung / drug effects; Mice; Organ Culture Techniques; Rats; Trachea / drug effects
TL;DR: Several procedures which enhance the differentiated state have been evaluated, which include maintenance on more physiologically-relevant substrata, such as collagen gels, use of defined serum-free medium and use of air/liquid interface systems. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1991 article

In vitro studies on mechanisms of lung injury in the rodent.

Proceedings of the 10th International Symposium of Society of Toxicological Pathologists, Vol. 10.

By: K. Adler & L. Cohn

Source: NC State University Libraries
Added: August 6, 2018

1991 chapter

Methods to study interactions between inhaled substances and epithelium of the respiratory tract in vitro.

In Microbeam analysis- 1990. (pp. 457–458).

By: J. Lee, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1991 article

Modulation of rat tracheal epithelial cell differentiation in culture.

American Review of Respiratory Disease, Vol. 143, p. A146.

By: L. Kaartinen, P. Nettesheim, K. Adler & S. Randell

Source: NC State University Libraries
Added: August 6, 2018

1991 article

Platelet activating factor provokes release of mucin like glycoproteins from guinea pig tracheal epithelial cells via a lipoxygenase-dependent mechanism.

American Review of Respiratory Disease, Vol. 143, p. A147.

By: W. Glasgow, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1991 journal article

Specific interactions with extracellular matrix may influence epithelial repair mechanisms in the pulmonary alveolus.

Chest, 99, 70S–71.

By: P. Sannes, B. Peters & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

Alveolar Type II cell response in rats exposed to aerosols of alpha cristobalite.

American Journal of Pathology, 136, 923–931.

By: R. Low, K. Leslie, D. Hemenway, P. Absher, K. Alder, M. Giancola, P. Vacek

Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

CHARACTERIZATION OF GUINEA-PIG TRACHEAL EPITHELIAL-CELLS MAINTAINED IN BIPHASIC ORGANOTYPIC CULTURE - CELLULAR COMPOSITION AND BIOCHEMICAL-ANALYSIS OF RELEASED GLYCOCONJUGATES

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2(2), 145–154.

By: K. Adler n, P. Cheng n & K. Kim n

MeSH headings : Amino Acids / analysis; Animals; Cells, Cultured; Chromatography, Gel; Culture Techniques; Epithelial Cells; Epithelium / analysis; Glycoconjugates / analysis; Guinea Pigs; Male; Microscopy, Electron; Molecular Weight; Proteoglycans / analysis; Trachea / analysis; Trachea / cytology; Trachea / ultrastructure
TL;DR: The results indicate that this organotypic cell culture system mimics quite closely morphology of mucosal epithelium in intact airways and that the cells release high molecular weight glycoconjugates with biochemical properties of mucin-type glycoproteins, well-suited for studies of muc in secretion and other functions of respiratory epithelial cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1990 chapter

Contractile cells in normal and fibrotic lungs.

In Pathology reviews. (pp. 25–37).

By: K. Adler n, R. Low n, K. Leslie n, J. Mitchell n & J. Evans n

TL;DR: In interstitial fibrosis, as well as several other forms of lung injury, there is an apparent increase in smooth muscle cells organized into bundles within areas of the lung where these cells normally are present but difficult to detect, such as the alveolar duct. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

INHIBITION OF LUNG INJURY, INFLAMMATION, AND INTERSTITIAL PULMONARY FIBROSIS BY POLYETHYLENE GLYCOL-CONJUGATED CATALASE IN A RAPID INHALATION MODEL OF ASBESTOSIS

AMERICAN REVIEW OF RESPIRATORY DISEASE, 141(5), 1266–1271.

By: B. Mossman*, J. Marsh, A. Sesko, S. Hill, M. Shatos, J. Doherty, J. Petruska, K. Adler* ...

MeSH headings : Animals; Asbestos; Asbestos, Crocidolite; Asbestosis / prevention & control; Bronchoalveolar Lavage Fluid / analysis; Catalase / administration & dosage; Catalase / pharmacology; Disease Models, Animal; Hydroxyproline / analysis; Lung / analysis; Lung / drug effects; Male; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / pharmacology; Pulmonary Fibrosis / prevention & control; Rats; Rats, Inbred F344; Superoxide Dismutase / administration & dosage; Superoxide Dismutase / pharmacology
TL;DR: A novel method of chronic administration of antioxidant enzymes was developed to determine if lung injury, inflammation, and asbestosis could be inhibited in vivo in a rapid-onset, inhalation model of disease, and inactivated PEG-catalase failed to boost serum levels of catalase and did not inhibit asbestos-induced elevation of hydroxyproline in lung. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1990 article

Interactions between extracellular matrix, airway and alveolar epithelium: alterations in fibrosis and possible pathogenetic significance.

Proceedings of the Sixth International Colloquium Pulmonary Fibrosis., Vol. 6, p. 39.

By: K. Adler, B. Peters, T. Krunkosky & P. Sannes

Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

OXYGEN METABOLITES STIMULATE RELEASE OF HIGH-MOLECULAR-WEIGHT GLYCOCONJUGATES BY CELL AND ORGAN-CULTURES OF RODENT RESPIRATORY EPITHELIUM VIA AN ARACHIDONIC ACID-DEPENDENT MECHANISM

JOURNAL OF CLINICAL INVESTIGATION, 85(1), 75–85.

By: K. Adler*, W. Holdenstauffer & J. Repine

MeSH headings : Animals; Arachidonic Acids / isolation & purification; Arachidonic Acids / metabolism; Catalase / pharmacology; Cell Survival / drug effects; Cells, Cultured; Chromatography, High Pressure Liquid; Epithelium / drug effects; Epithelium / metabolism; Epithelium / ultrastructure; Glycoconjugates / metabolism; Guinea Pigs; Hydrogen Peroxide / pharmacology; Kinetics; L-Lactate Dehydrogenase / metabolism; Male; Mannitol / pharmacology; Microscopy, Electron; Microscopy, Electron, Scanning; Organ Culture Techniques; Polyethylene Glycols / pharmacology; Rabbits; Superoxide Dismutase / pharmacology; Superoxides / pharmacology; Thiourea / analogs & derivatives; Thiourea / pharmacology; Trachea / cytology; Trachea / metabolism; Xanthine Oxidase / metabolism
TL;DR: O2 metabolites increase release of respiratory HMG through a mechanism involving cyclooxygenase metabolism of arachidonic acid with production mainly of PGF2a, which may be fundamental to the pathogenesis of a variety of lung diseases associated with hypersecretion of mucus and/or other epithelial fluids. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1990 article

Oxygen metabolites stimulate inositol lipid turnover in guinea pig airway epithelial cells in organotypic culture.

American Review of Respiratory Disease, Vol. 141, p. A107.

By: K. Adler, N. Akley & J. Lee

Source: NC State University Libraries
Added: August 6, 2018

1990 article

Specific interactions with extracellular matrix may influence epithelial repair mechanisms in the pulmonary alveolus.

Proceedings of the 30th Aspen Lung Conference., Vol. 30, p. 24.

By: P. Sannes, B. Peters & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1989 chapter

A novel culture system for maintaining differentiated epithelial cells between air and liquid phases: A possible model for studying interactions between mineral fibers, gases and airway epithelium.

In Biological interaction of inhaled mineral fibers and cigarette smoke (pp. 381–390).

By: K. Adler, N. Akley, G. Ayers, W. Holden-Stauffer, J. Khosla & K. Kim

Source: NC State University Libraries
Added: August 6, 2018

1989 journal article

Alpha smooth muscle actin in parenchymal cells of bleomycin injured rat lung.

Laboratory Investigation, 60, 643–650.

By: J. Mitchell, J. Woodcock-Mitchell, S. Reynolds, R. Low, K. Leslie, K. Adler, G. Gabbiani, O. Skalli

Source: NC State University Libraries
Added: August 6, 2018

1989 journal article

Biology of disease: Contractile cells in normal and fibrotic lungs.

Laboratory Investigation, 60, 473–485.

By: K. Adler, R. Low, K. Leslie, J. Mitchell & J. Evans

Source: NC State University Libraries
Added: August 6, 2018

1989 article

Oxidant injury to rodent airway epithelium in primary culture stimulates intracellular production of oxygen free radicals, arachidonic acid metabolism, and mucin secretion.

American Review of Respiratory Disease, Vol. 139, p. A403.

By: K. Adler, N. Akley & W. Holden-Stauffer

Source: NC State University Libraries
Added: August 6, 2018

1988 journal article

A biphasic chamber system for maintaining polarity of differentiation of cultured respiratory tract epithelial cells.

In Vitro Cellular & Developmental Biology. Animal, 24, 420–428.

By: J. Whitcutt*, K. Adler* & R. Wu*

MeSH headings : Animals; Cell Differentiation; Cricetinae; Culture Techniques / methods; Epithelial Cells; Female; Male; Mesocricetus; Microscopy, Electron, Scanning; Rabbits; Rats; Rats, Inbred F344; Respiratory System / cytology
TL;DR: The results suggest that, at least for guinea pigs, the combination of feeding methods provided by the Whitcutt chamber can be used to achieve differentiated cultures of tracheal epithelial cells with a polarity of differentiation that is similar to that observed in intact airways in vivo. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1988 article

A new culture system for maintaining differentiated rodent respiratory epithelial cells between air and liquid phases: an excellent model for studying interactions between mineral fibers and airway epithelium in vitro.

Proceedings of the Fourth International Workshop on Effects on Cells (Quebec, 1988), Vol. 4, p. 10.

By: K. Adler & K. Kim

Source: NC State University Libraries
Added: August 6, 2018

1988 journal article

Alterations in pulmonary vascular responsiveness following hyperoxic injury to the lung.

Chest, 93, 147S–149.

By: J. Coflesky, K. Adler & J. Evans

Source: NC State University Libraries
Added: August 6, 2018

1988 article

An autoradiographic and biochemical analysis of cellular proliferation in pulmonary arteries following in vivo hyperoxia.

American Review of Respiratory Disease, Vol. 137, p. 388.

By: J. Coflesky, K. Adler, J. Woodcock-Mitchell, J. Mitchell & J. Evans

Source: NC State University Libraries
Added: August 6, 2018

1988 journal article

BRONCHOALVEOLAR LAVAGE LIPIDS DURING DEVELOPMENT OF BLEOMYCIN-INDUCED FIBROSIS IN RATS - RELATIONSHIP TO ALTERED EPITHELIAL-CELL MORPHOLOGY

AMERICAN REVIEW OF RESPIRATORY DISEASE, 138(3), 709–713.

By: R. Low, K. Adler*, J. Woodcockmitchell, M. Giancola & P. Vacek

MeSH headings : Animals; Bleomycin / toxicity; Bronchoalveolar Lavage Fluid / analysis; Epithelium / metabolism; Epithelium / pathology; Lipids / analysis; Male; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / pathology; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Pulmonary Surfactants / analysis; Rats; Rats, Inbred F344; Specific Pathogen-Free Organisms; Time Factors
TL;DR: Changes in lipid metabolism by alveolar epithelial cells following bleomycin-induced lung injury may be responsible for altered lavage lipid recovery and may directly be related to processes that take place duringAlveolar type II cell hyperplasia followed by transition to type I cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1988 article

Exposure of rodent airway epithelium in vitro to oxidants stimulates cyclooxygenase metabolism of arachidonic acid.

Proceedings of the 5th International Colloquium on Pulmonary Fibrosis (Lyon, France, 1988), Vol. 5, p. 5.

By: K. Adler & W. Holden-Stauffer

Source: NC State University Libraries
Added: August 6, 2018

1988 article

Morphometric and biochemical characterization of a chamber system for maintaining differentiated guinea pig respiratory mucosal cells between air and liquid phases.

American Review of Respiratory Disease, Vol. 137, p. 14.

By: K. Adler, J. Khosla & K. Kim

Source: NC State University Libraries
Added: August 6, 2018

1988 article

Oxidant injury to airway epithelium in vitro stimulates cyclooxygenase metabolism of arachidonic acid and secretion of mucin.

Journal of Cell Biology, Vol. 107, p. 350a.

By: K. Adler, N. Akley & W. Holden-Stauffer

Source: NC State University Libraries
Added: August 6, 2018

1988 chapter

Oxygen radicals stimulate secretion of mucin by rodent airway epithelial cells in organotypic culture.

In Oxy radicals in molecular biology and pathology (pp. 101–108).

By: K. Adler & N. Akley

Source: NC State University Libraries
Added: August 6, 2018

1988 article