Kembra L. Howdeshell

Works (4)

Updated: July 5th, 2023 15:54

2008 journal article

A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner

TOXICOLOGICAL SCIENCES, 105(1), 153–165.

By: K. Howdeshell*, V. Wilson *, J. Furr*, C. Lambright*, C. Rider n, C. Blystone n, A. Hotchkiss n, L. Gray *

author keywords: androgens; prenatal; reproductive tract; phthalates; cumulative risk; structure activity relationship
MeSH headings : Animals; Body Weight / drug effects; Dibutyl Phthalate / analogs & derivatives; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Dose-Response Relationship, Drug; Female; Fetus / drug effects; Logistic Models; Male; Phthalic Acids / toxicity; Pregnancy; Rats; Rats, Sprague-Dawley; Testis / drug effects; Testis / metabolism; Testosterone / biosynthesis
TL;DR: It is demonstrated that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 conference paper

Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats

Environmental Research (New York, N.Y.), 108(2), 168–176.

By: K. Howdeshell, C. Rider, V. Wilson & L. Gray

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: Altered fetal steroid hormones and genes

TOXICOLOGICAL SCIENCES, 99(1), 190–202.

By: K. Howdeshell n, J. Furr*, C. Lambright*, C. Rider n, V. Wilson * & L. Gray *

author keywords: endocrine disruptors; developmental toxicity; postnatal; epididymis; RT-PCR; reproductive tract; male; phthalates
MeSH headings : Animals; Animals, Newborn; Cholesterol Side-Chain Cleavage Enzyme / genetics; Cholesterol Side-Chain Cleavage Enzyme / metabolism; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Drug Synergism; Drug Therapy, Combination; Female; Fetal Development / drug effects; Gene Expression Regulation, Developmental / drug effects; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / embryology; Humans; Insulin / genetics; Insulin / metabolism; Male; Maternal Exposure; Organ Size / drug effects; Organogenesis / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / pathology; Proteins / genetics; Proteins / metabolism; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Reproduction / drug effects; Testis / drug effects; Testis / embryology; Testis / metabolism; Testosterone / metabolism
TL;DR: The data indicate that individual phthalates with a similar mechanism of action, but with different active metabolites, can elicit dose-additive effects when administered as a mixture. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Gestational and lactational exposure to ethinyl estradiol, but not bisphenol a, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male long evans hooded rat

TOXICOLOGICAL SCIENCES, 102(2), 371–382.

By: K. Howdeshell*, J. Furr*, C. Lambright*, V. Wilson *, B. Ryan n & L. Gray *

author keywords: ethinyl estradiol; bisphenol A; male reproduction; Long Evans rat; testes; epididymal sperm
MeSH headings : Anal Canal / abnormalities; Anal Canal / drug effects; Anal Canal / pathology; Animals; Animals, Newborn; Benzhydryl Compounds; Body Weight / drug effects; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Epididymis / drug effects; Epididymis / pathology; Estrogens / toxicity; Ethinyl Estradiol / toxicity; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / pathology; Lactation / drug effects; Male; Maternal Exposure; Organ Size / drug effects; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / pathology; Rats; Rats, Long-Evans; Seminal Vesicles / drug effects; Seminal Vesicles / pathology; Sperm Count; Spermatozoa / drug effects; Spermatozoa / pathology; Testis / drug effects; Testis / pathology
TL;DR: It is demonstrated that developmental exposure to oral micromolar doses of EE can permanently disrupt the reproductive tract of the male rat. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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