Cynthia Vanessa Rider
Works (16)
Updated: August 20th, 2023 21:15
2010 journal article
Differences in sensitivity but not selectivity of xenoestrogen binding to alligator versus human estrogen receptor alpha
Environmental Toxicology and Chemistry, 29(9), 2064–2071.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
COMPARISON OF CHEMICAL BINDING TO RECOMBINANT FATHEAD MINNOW AND HUMAN ESTROGEN RECEPTORS ALPHA IN WHOLE CELL AND CELL-FREE BINDING ASSAYS
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 28(10), 2175–2181.
author keywords: In vitro; Saturation binding; Competitive binding; Xenoestrogens
MeSH headings : Animals; Binding Sites; Binding, Competitive; COS Cells; Cadmium Chloride / chemistry; Cadmium Chloride / pharmacology; Cell-Free System; Chlorocebus aethiops; Cyprinidae; Dibutyl Phthalate / chemistry; Dibutyl Phthalate / pharmacology; Estradiol / analogs & derivatives; Estradiol / chemistry; Estradiol / pharmacology; Estrogen Receptor alpha / chemistry; Ethinyl Estradiol / chemistry; Ethinyl Estradiol / pharmacology; Fulvestrant; Humans; Phthalic Acids / chemistry; Phthalic Acids / pharmacology; Recombinant Proteins / chemistry; Structure-Activity Relationship; Temperature; Zeranol / analogs & derivatives; Zeranol / chemistry; Zeranol / pharmacology
TL;DR:
Little evidence shows in vivo effects of phthalates on reproductive endpoints in fish, but DEHP elicited potentially antiestrogenic effects in female medaka, as evidenced by decreased vitellogenin levels, decreased gonadal‐somatic indices, and immature oocytes in DEHP‐treated females as compared to their control counter‐parts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Cumulative Effects of In Utero Administration of Mixtures of "Antiandrogens" on Male Rat Reproductive Development
TOXICOLOGIC PATHOLOGY, 37(1), 100–113.
author keywords: reproductive system; male reproduction; endocrine disrupters
MeSH headings : Androgen Antagonists / toxicity; Animals; Bridged Bicyclo Compounds / toxicity; Complex Mixtures / toxicity; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Drug Combinations; Drug Synergism; Female; Fungicides, Industrial / toxicity; Genital Diseases, Male / chemically induced; Genital Diseases, Male / embryology; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Hypospadias / chemically induced; Male; Maternal Exposure; Oxazoles / toxicity; Phthalic Acids / toxicity; Pregnancy; Rats; Receptors, Androgen / drug effects; Receptors, Androgen / metabolism; Sexual Maturation / drug effects
TL;DR:
The results indicate that compounds that act by disparate mechanisms of toxicity display cumulative, dose-additive effects when present in combination.
(via Semantic Scholar)
journals.sagepub.com (publisher PDF)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Cumulative and Antagonistic Effects of a Mixture of the Antiandrogens Vinclozolin and Iprodione in the Pubertal Male Rat
TOXICOLOGICAL SCIENCES, 111(1), 179–188.
author keywords: iprodione; vinclozolin; mixture; puberty; testosterone; androgen receptor; endocrine disruption
MeSH headings : Adrenal Glands / drug effects; Adrenal Glands / growth & development; Aminoimidazole Carboxamide / analogs & derivatives; Aminoimidazole Carboxamide / toxicity; Androgen Antagonists / toxicity; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Drug Combinations; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Hormones / blood; Hydantoins / toxicity; Liver / drug effects; Liver / growth & development; Male; Organ Size / drug effects; Oxazoles / toxicity; Rats; Rats, Sprague-Dawley; Receptors, Androgen / biosynthesis; Receptors, Androgen / drug effects; Receptors, Androgen / genetics; Receptors, Aryl Hydrocarbon / drug effects; Sexual Maturation / drug effects; Transcriptional Activation / drug effects
TL;DR:
It is demonstrated that iprodione binds to the human androgen receptor, reduces androgen-dependent gene expression, and reduces androgens-sensitive tissue weights in castrated male rats (Hershberger assay).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Development of a competitive binding assay system with recombinant estrogen receptors from multiple species
TOXICOLOGY LETTERS, 184(2), 85–89.
author keywords: In vitro; Alligator; Quail; Salamander; Fathead minnow
MeSH headings : Alligators and Crocodiles; Animals; Baculoviridae / genetics; Binding, Competitive; Biological Assay / methods; Cloning, Molecular; Cyprinidae; Estrogen Receptor alpha / biosynthesis; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Humans; Insecta; Ligands; Quail; Species Specificity; Urodela
TL;DR:
A new system using full-length recombinant baculovirus-expressed estrogen receptors which allows for direct comparison of binding across species without the need to sacrifice animals is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
TOXICOLOGICAL SCIENCES, 105(1), 153–165.
author keywords: androgens; prenatal; reproductive tract; phthalates; cumulative risk; structure activity relationship
MeSH headings : Animals; Body Weight / drug effects; Dibutyl Phthalate / analogs & derivatives; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Dose-Response Relationship, Drug; Female; Fetus / drug effects; Logistic Models; Male; Phthalic Acids / toxicity; Pregnancy; Rats; Rats, Sprague-Dawley; Testis / drug effects; Testis / metabolism; Testosterone / biosynthesis
TL;DR:
It is demonstrated that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 article
A mixture of seven antiandrogens induces reproductive malformations in rats
Rider, C. V., Furr, J., Wilson, V. S., & Gray, L. E., Jr. (2008, April). INTERNATIONAL JOURNAL OF ANDROLOGY, Vol. 31, pp. 249–262.
author keywords: antiandrogens; dose addition; endocrine disruption; mixtures; reproductive malformations; toxic equivalency
MeSH headings : Androgen Antagonists / toxicity; Animals; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens / toxicity
TL;DR:
Results indicate that chemicals that disrupt foetal tissues during sexual differentiation act in a cumulative, dose-additive manner irrespective of the specific cellular mechanism of toxicity.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 article
Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development
Wilson, V. S., Blystone, C. R., Hotchkiss, A. K., Rider, C. V., & Gray, L. E., Jr. (2008, April). INTERNATIONAL JOURNAL OF ANDROLOGY, Vol. 31, pp. 178–185.
author keywords: androgen receptor; anti-androgen; linuron; phthalate; prochloraz; reproductive development; vinclozolin
MeSH headings : Androgen Antagonists / pharmacology; Animals; Genitalia, Male / drug effects; Genitalia, Male / embryology; Male; Rats
TL;DR:
As more and more molecular studies with anti-androgenic compounds are conducted, the number of mechanisms by which compounds can affect the androgen signalling pathway is likely to increase.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 conference paper
Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats
Environmental Research (New York, N.Y.), 108(2), 168–176.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: Altered fetal steroid hormones and genes
TOXICOLOGICAL SCIENCES, 99(1), 190–202.
author keywords: endocrine disruptors; developmental toxicity; postnatal; epididymis; RT-PCR; reproductive tract; male; phthalates
MeSH headings : Animals; Animals, Newborn; Cholesterol Side-Chain Cleavage Enzyme / genetics; Cholesterol Side-Chain Cleavage Enzyme / metabolism; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Drug Synergism; Drug Therapy, Combination; Female; Fetal Development / drug effects; Gene Expression Regulation, Developmental / drug effects; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / embryology; Humans; Insulin / genetics; Insulin / metabolism; Male; Maternal Exposure; Organ Size / drug effects; Organogenesis / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / pathology; Proteins / genetics; Proteins / metabolism; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Reproduction / drug effects; Testis / drug effects; Testis / embryology; Testis / metabolism; Testosterone / metabolism
TL;DR:
The data indicate that individual phthalates with a similar mechanism of action, but with different active metabolites, can elicit dose-additive effects when administered as a mixture.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
A candidate juvenoid hormone receptor cis-element in the Daphnia magna hb2 hemoglobin gene promoter
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 247(1-2), 91–102.
author keywords: methyl farnesoate; juvenoid; crustacean; response element; sex determination
MeSH headings : Animals; Base Sequence; Cycloheximide / pharmacology; Daphnia / genetics; Daphnia / physiology; Fatty Acids, Unsaturated / metabolism; Hemoglobins / biosynthesis; Hemoglobins / genetics; Hemoglobins / physiology; Juvenile Hormones / metabolism; Molecular Sequence Data; Promoter Regions, Genetic; Pyridines / metabolism; RNA, Messenger / biosynthesis; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Response Elements; Signal Transduction
TL;DR:
Induction of hb2 by juvenoids was not dependent upon the synthesis of secondary transcription factors that bound the JRE but was likely due to activation of the gene directly by the juvenoid-receptor complex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Atrazine stimulates hemoglobin accumulation in Daphnia magna: Is it hormonal or hypoxic?
TOXICOLOGICAL SCIENCES, 93(2), 443–449.
author keywords: cumulative toxicity; terpenoids; mixture modeling; invertebrates; endocrine disruption
MeSH headings : Animals; Atrazine / toxicity; Daphnia / drug effects; Daphnia / metabolism; Dose-Response Relationship, Drug; Hemoglobins / genetics; Hemoglobins / metabolism; Herbicides / toxicity; Hypoxia-Inducible Factor 1 / physiology; Pyridines / toxicity; RNA, Messenger / analysis
TL;DR:
Results from this study demonstrate that mixtures modeling can be used to assess a chemical's mechanism of action and that atrazine likely stimulates hemoglobin accumulation through the oxygen-sensing pathway.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
An integrated addition and interaction model for assessing toxicity of chemical mixtures
TOXICOLOGICAL SCIENCES, 87(2), 520–528.
author keywords: synergy; cumulative toxicity; predictive model; toxicodynamic; hazard assessment; risk assessment
MeSH headings : Acetylcholinesterase / metabolism; Algorithms; Animals; Cholinesterase Inhibitors / toxicity; Daphnia / physiology; Dose-Response Relationship, Drug; Drug Interactions; Environmental Pollutants / toxicity; Malathion / toxicity; Models, Biological; Models, Statistical; Parathion / toxicity; Pesticide Synergists / toxicity; Piperonyl Butoxide / toxicity; Toxicity Tests / methods
TL;DR:
A mathematical model that combines concepts of concentration addition, response addition, and toxicokinetic chemical interaction to assess toxicity of chemical mixtures is developed and holds promise as a means for assessing hazard of complex chemical mixture.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Covert signal disruption: Anti-ecdysteroidal activity of bisphenol a involves cross talk between signaling pathways
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 24(1), 146–152.
author keywords: crustacean; pollutant; reproduction; steroid; terpenoid
MeSH headings : Animals; Benzhydryl Compounds; Daphnia / drug effects; Daphnia / embryology; Daphnia / growth & development; Dose-Response Relationship, Drug; Ecdysteroids / antagonists & inhibitors; Ecdysterone / pharmacology; Juvenile Hormones / physiology; Molting / drug effects; Phenols / antagonists & inhibitors; Phenols / toxicity; Sex Differentiation / drug effects; Signal Transduction / drug effects; Time; Water Pollutants, Chemical / toxicity
TL;DR:
It is demonstrated that bisphenol A is chronically toxic to daphnids, probably through its ability to interfere with ecdysteroid/juvenoid regulated processes, however, effects are elicited at levels that are not likely to pose environmental concern.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Stress signaling: coregulation of hemoglobin and male sex determination through a terpenoid signaling pathway in a crustacean
JOURNAL OF EXPERIMENTAL BIOLOGY, 208(1), 15–23.
author keywords: Cladocera; juvenoid; endocrine disruption; evolution; nuclear receptor; Daphnia magna
MeSH headings : Analysis of Variance; Animals; Base Sequence; DNA Primers; Daphnia / physiology; Electrophoresis; Fatty Acids, Unsaturated / pharmacology; Hemoglobins / genetics; Hemoglobins / metabolism; Male; Molecular Sequence Data; Reproduction / physiology; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sex Differentiation / drug effects; Signal Transduction / physiology; Spectrophotometry; Stress, Physiological / metabolism; Terpenes / metabolism
TL;DR:
It is demonstrated that two responses to environmental stress signaling in the crustacean Daphnia magna - hemoglobin accumulation and male offspring production - are co-elevated by the crustACEan terpenoid hormone methyl farnesoate and several synthetic analogs, suggesting that both processes are regulated by the same ter penoid signaling pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
13. Climate Action
(Web of Science)
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Abstracts from the Eleventh International Symposium on Pollutant Responses in Marine Organisms (PRIMO 11) - Endocrine disrupters
Marine Environmental Research, 54(3-5), 741–754.
Source: NC State University Libraries
Added: August 6, 2018
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