2022 article

Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail-docking

Nixon, E., Chittenden, J. T., Baynes, R. E., & Messenger, K. M. (2022, July 14). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 7.

By: E. Nixon n, J. Chittenden*, R. Baynes n & K. Messenger n

author keywords: NSAID; pain; pharmacodynamics; pharmacokinetics; piglet
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin / analogs & derivatives; Dinoprostone; Hydrocortisone; Ketoprofen / pharmacology; Ketoprofen / therapeutic use; Male; Orchiectomy / veterinary; Pain / veterinary; Swine; Tail
Sources: Web Of Science, ORCID
Added: July 16, 2022

2019 journal article

Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration

Archives of Toxicology, 93(7), 1865–1880.

By: M. Li*, Y. Cheng*, J. Chittenden n, R. Baynes n, L. Tell*, J. Davis*, T. Vickroy*, J. Riviere n, Z. Lin*

author keywords: Flunixin; Interactive physiologically based pharmacokinetic (iPBPK) model; Food safety; Drug residues; Withdrawal intervals (WDIs); Food Animal Residue Avoidance Databank (FARAD)
MeSH headings : Animals; Animals, Domestic / metabolism; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Databases, Factual; Drug Residues / pharmacokinetics; Food Contamination / analysis; Food Contamination / prevention & control; Food Safety / methods; Models, Biological; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
Sources: Web Of Science, Crossref
Added: August 12, 2019

2016 journal article

Assessment of penetrant and vehicle mixture properties on transdermal permeability using a mixed effect pharmacokinetic model of ex vivo porcine skin

Biopharmaceutics & Drug Disposition, 37(7), 387–396.

By: J. Chittenden n & J. Riviere*

author keywords: quantitative structure property relationship; transdermal permeability; vehicle mixture; ex vivo; mixed-effect model
MeSH headings : Administration, Cutaneous; Animals; Models, Biological; Permeability; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Swine
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Quantification of vehicle mixture effects on in vitro transdermal chemical flux using a random process diffusion model

Journal of Controlled Release, 217, 74–81.

By: J. Chittenden n & J. Riviere*

author keywords: Transdermal absorption; Chemical mixture; QSPR; Skin permeability; Mathematical modeling; In vitro model
MeSH headings : 1-Octanol / chemistry; Animals; Diffusion; Models, Biological; Molecular Weight; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Swine; Water / chemistry
Sources: Web Of Science, Crossref
Added: August 6, 2018

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