Works (5)

Updated: July 5th, 2023 15:39

2022 journal article

Discharge summaries provided to owners of pets newly diagnosed with cancer exceed recommended readability levels


By: J. Medland n, S. Marks n & J. Intile n

MeSH headings : Animals; Comprehension; Internet; Neoplasms / diagnosis; Neoplasms / veterinary; North Carolina; Patient Discharge; United States
TL;DR: Owner-directed written information regarding a diagnosis of cancer at a single teaching hospital exceeded readability levels recommended by the American Medical Association and NIH and was above the average reading level of most US adults. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022

2020 journal article

Long-term postoperative pain evaluation in dogs with thoracolumbar intervertebral disk herniation after hemilaminectomy


By: N. Zidan n, J. Medland n & N. Olby n

author keywords: algometry; mechanical thresholds; neuropathic pain; postoperative pain; spinal cord injury
MeSH headings : Animals; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Displacement / surgery; Laminectomy / adverse effects; Laminectomy / veterinary; Male; Neuralgia / veterinary; Pain Measurement / veterinary; Pain, Postoperative / veterinary; Prospective Studies; Sensory Thresholds; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary
TL;DR: Improving long‐term pain assessment of SCI dogs is important for offering treatment options and advising owners, and Mechanical sensory thresholds normalize by 6 months after surgery in most dogs with SCI. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 29, 2020

2017 journal article

Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity


By: C. Pohl*, J. Medland n, E. Mackey n, L. Edwards n, K. Bagley n, M. DeWilde*, K. Williams*, A. Moeser*

author keywords: developmental origins of health and disease; early life adversity; intestinal permeability; large animal model; mast cell; mast cell plexitis; translational research
MeSH headings : Animals; Cell Count; Colon / pathology; Diarrhea / etiology; Disease Models, Animal; Enteric Nervous System / pathology; Female; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Intestines / pathology; Intestines / physiopathology; Male; Mast Cells / metabolism; Mast Cells / physiology; Stress, Psychological / complications; Sus scrofa; Tryptases / metabolism; Weaning
TL;DR: Early life adversity is a risk factor for development of gastrointestinal disorders later in life and the underlying mechanisms through which ELA and sex interact to influence disease susceptibility remains poorly understood. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Early life adversity in piglets induces long-term upregulation of the enteric cholinergic nervous system and heightened, sex-specific secretomotor neuron responses


By: J. Medland n, C. Pohl*, L. Edwards n, S. Frandsen n, K. Bagley n, Y. Li*, A. Moeser*

author keywords: cholinergic neurons; early life adversity; enteric nervous system development; irritable bowel syndrome; porcine model
MeSH headings : Animals; Cholinergic Neurons / metabolism; Disease Models, Animal; Enteric Nervous System / metabolism; Female; Irritable Bowel Syndrome / metabolism; Male; Motor Neurons / metabolism; Sex Factors; Stress, Psychological / metabolism; Swine; Up-Regulation; Weaning
TL;DR: A porcine model of ELA, early weaning stress (EWS), is utilized to investigate the influence of Ela on the development and function of the enteric nervous system (ENS). (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 review

Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications


By: C. Pohl*, J. Medland n & A. Moeser*

author keywords: irritable bowel syndrome; models; murine; porcine; stress
MeSH headings : Adrenal Glands / metabolism; Adrenal Glands / physiopathology; Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Enteric Nervous System / metabolism; Enteric Nervous System / physiopathology; Gastrointestinal Diseases / etiology; Gastrointestinal Diseases / metabolism; Gastrointestinal Diseases / physiopathology; Gastrointestinal Diseases / psychology; Humans; Hypothalamo-Hypophyseal System / metabolism; Hypothalamo-Hypophyseal System / physiopathology; Intestinal Mucosa / metabolism; Intestines / innervation; Intestines / physiopathology; Risk Factors; Species Specificity; Stress, Psychological / complications; Stress, Psychological / metabolism; Stress, Psychological / physiopathology; Stress, Psychological / psychology; Translational Research, Biomedical / methods
TL;DR: This review focuses on animal models of early-life stress-induced GI disease, with a specific emphasis on translational aspects of each model to specific human GI disease states. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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