Works (3)

Updated: July 21st, 2023 21:17

2022 journal article

brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury

SCIENTIFIC REPORTS, 12(1).

By: V. Kouprianov, A. Selmek*, J. Ferguson n, X. Mo* & H. Shive*

MeSH headings : Animals; Zebrafish
TL;DR: The altered cell behaviors identified in brca2-mutant embryonic and adult tissues, particularly in adult tissues at high risk for cancer, indicate that the effects of BRCA2 mutation on cellular phenotypes are both context- and tissue-dependent. (via Semantic Scholar)
Source: Web Of Science
Added: February 7, 2022

2019 journal article

Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a brca2-Mutant Zebrafish Model

JOURNAL OF ONCOLOGY, 2019.

By: L. Mensah n, J. Ferguson n & H. Shive n

TL;DR: It is determined that combined brca2/tp53 mutations uniquely disrupt meiotic progression and that sex significantly influences ploidy outcome in zebrafish cancers, and evidence is provided to support a link between BRCA2 mutation, tumor diploidy, and poor survival outcome. (via Semantic Scholar)
Source: Web Of Science
Added: March 25, 2019

2019 journal article

Sequential Immunofluorescence and Immunohistochemistry on Cryosectioned Zebrafish Embryos

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (147).

By: J. Ferguson n & H. Shive n

author keywords: Biology; Issue 147; Zebrafish; embryos; immunohistochemistry; immunofluorescence; colocalization; intercellular interaction
MeSH headings : Animals; Cryoultramicrotomy; Embryo, Nonmammalian / anatomy & histology; Immunohistochemistry; Zebrafish / anatomy & histology; Zebrafish / embryology
TL;DR: The purpose of the method described herein is to perform sequential immunofluorescence and/or immunohistochemistry on individual cryosections derived from early-stage zebrafish embryos to achieve precise identification of protein expression at the single-cell level. (via Semantic Scholar)
Source: Web Of Science
Added: June 24, 2019

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