Joy Rachel C. Ganchingco

Works (3)

Updated: July 5th, 2023 15:37

2018 journal article

Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis

CLINICAL AND EXPERIMENTAL ALLERGY, 48(1), 78–88.

By: T. Fukuyama  n, B. Martel n, K. Linder n, S. Ehling  n, J. Ganchingco n & W. Baeumer

author keywords: atopic dermatitis; dorsal root ganglia; hypochlorous acid; IgE; IL-13; IL-4; NC; Nga mice; sensory neurons
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Antigens, Dermatophagoides / toxicity; Antipruritics / pharmacology; Cytokines / immunology; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / immunology; Dermatitis, Atopic / pathology; Disease Models, Animal; Female; Hypochlorous Acid / pharmacology; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / immunology; Inflammation / pathology; Mice; Mice, Inbred BALB C
TL;DR: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis; however, the specific antipruritic mechanism of action remains unclear. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib

EUROPEAN JOURNAL OF PHARMACOLOGY, 794, 20–26.

By: T. Fukuyama n, J. Ganchingco n & W. Baumer  n

author keywords: JAK-inhibitor; Oclacitinib; Itch; Rebound phenomenon; Allergic dermatitis; TRPV1
MeSH headings : Animals; Behavior, Animal / drug effects; CD11c Antigen / metabolism; Calcium / metabolism; Cytokines / metabolism; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dendritic Cells / pathology; Female; Ganglia, Spinal / drug effects; Ganglia, Spinal / pathology; Immunomodulation / drug effects; Intracellular Space / drug effects; Intracellular Space / metabolism; Janus Kinase 1 / antagonists & inhibitors; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use; Pruritus / drug therapy; Pruritus / immunology; Pruritus / pathology; Pyrimidines / pharmacology; Pyrimidines / therapeutic use; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / pathology; Skin / drug effects; Skin / immunology; Skin / metabolism; Sulfonamides / pharmacology; Sulfonamides / therapeutic use; Tumor Necrosis Factor-alpha / metabolism
TL;DR: While oclacitinib significantly reduced itch during treatment the abrupt withdrawal led to a rapid rebound phenomenon which can be explained by an increase in pruritogenic cytokines and fast peripheral sensitization. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 personal communication

Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor

Fukuyama, T., Ganchingco, J. R., Mishra, S. K., Olivry, T., Rzagalinski, I., Volmer, D. A., & Baeumer, W. (2017, July).

By: T. Fukuyama n, J. Ganchingco n, S. Mishra n, T. Olivry n , I. Rzagalinski*, D. Volmer *, W. Baeumer

Contributors: T. Fukuyama n, J. Ganchingco n, S. Mishra n, T. Olivry n , I. Rzagalinski*, D. Volmer *, W. Bäumer  n

MeSH headings : Animals; Antipruritics / chemistry; Antipruritics / pharmacology; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Female; Humans; Janus Kinase Inhibitors / chemistry; Janus Kinase Inhibitors / pharmacology; Mice; Models, Molecular; Molecular Conformation; Molecular Imaging / methods; Protein Binding; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Structure-Activity Relationship; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / chemistry; TRPV Cation Channels / metabolism
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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