Works (25)
Updated: July 5th, 2023 15:44
2021 journal article
TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch
BIOMOLECULES, 11(8).
author keywords: histamine; histamine H1 receptor; histamine H4 receptor; itch; signal transduction; TRPV1; TRPA1; dorsal root ganglion neurons (DRG); Ca2+-imaging
MeSH headings : Acetanilides / pharmacology; Animals; Calcium / metabolism; Capsaicin / analogs & derivatives; Capsaicin / pharmacology; Female; Ganglia, Spinal / drug effects; Ganglia, Spinal / metabolism; Gene Expression; Histamine / administration & dosage; Male; Methylhistamines / administration & dosage; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Molecular Imaging; Primary Cell Culture; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / genetics; Pruritus / metabolism; Purines / pharmacology; Ruthenium Red / pharmacology; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Signal Transduction; TRPA1 Cation Channel / antagonists & inhibitors; TRPA1 Cation Channel / genetics; TRPA1 Cation Channel / metabolism; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism
TL;DR:
Results indicate that both channels, TRPV1 and TRPA1, are involved in the transmission of histamine-induced pruritus.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 7, 2021
2020 journal article
Draft Genome Sequence of Staphylococcus pseudintermedius Strain 13-13613, Isolated from a Case of Canine Pyoderma
MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 9(7).
TL;DR:
The draft genome sequence of Staphylococcus pseudintermedius strain 13-13613, isolated from a case of canine pyoderma, contains 2,533,486 bp in 570 contigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 10, 2020
2020 journal article
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
CELL REPORTS, 31(1).
Contributors: S. Mishra n, J. Wheeler n, S. Pitake n, H. Ding *, C. Jiang *, T. Fukuyama n, J. Paps n, P. Ralph n
MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dogs; Female; Hypersensitivity / physiopathology; Integrin alpha5 / metabolism; Integrin beta3 / metabolism; Integrins / metabolism; Keratinocytes / metabolism; Male; Mice; Primates; Pruritus / metabolism; Pruritus / pathology; Sensory Receptor Cells / metabolism; Skin / metabolism
TL;DR:
A TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons is identified and the non-canonical functional role of an integrin in itch is characterized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020
2020 review
Surface distribution of pyrethroids following topical application to veterinary species: Implications for lateral transport
[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 44(1), 1–10.
author keywords: lateral transport; pyrethroids
MeSH headings : Administration, Topical; Animals; Animals, Domestic; Ectoparasitic Infestations / drug therapy; Ectoparasitic Infestations / veterinary; Insecticides / administration & dosage; Insecticides / therapeutic use; Pyrethrins / administration & dosage; Pyrethrins / therapeutic use
TL;DR:
This review attempts to demonstrate evidence for lateral transport of pyrethroids after topical administration in dogs, cattle and sheep and to present data gaps that should be addressed in follow-up studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 28, 2020
2019 journal article
Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study
VETERINARY DERMATOLOGY, 30(2), 91-+.
MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Cross-Over Studies; Dimenhydrinate / administration & dosage; Dimenhydrinate / blood; Dimenhydrinate / pharmacokinetics; Diphenhydramine / administration & dosage; Diphenhydramine / blood; Diphenhydramine / pharmacokinetics; Dogs; Female; Half-Life; Histamine / adverse effects; Histamine Antagonists / pharmacokinetics; Male; Pilot Projects; Theophylline / blood; Urticaria / chemically induced; Urticaria / drug therapy
TL;DR:
Oral absorption of diphenhydramine was approximately three times greater with a longer half-life when it was administered as the combination product dimenhydrinate, and theophylline reached plasma concentrations considered to be therapeutic for dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019
2019 journal article
Efficacy study of a topical treatment with a plant extract with antibiofilm activities using an in vivo model of canine superficial pyoderma
VETERINARY DERMATOLOGY, 31(2), 86–89.
MeSH headings : Administration, Topical; Animals; Anti-Bacterial Agents / administration & dosage; Biofilms / drug effects; Cross-Over Studies; Disease Models, Animal; Dog Diseases / drug therapy; Dogs; Female; Male; Microbial Sensitivity Tests; Plant Extracts / administration & dosage; Proof of Concept Study; Pyoderma / drug therapy; Pyoderma / veterinary; Skin / microbiology; Skin / pathology; Staphylococcus / drug effects
TL;DR:
Topical application of W16P576 markedly reduced lesion development in this proof of principle study and clinical trials are warranted to estimate benefits for dogs with naturally occurring pyoderma under field conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 2, 2019
2018 journal article
Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model
BMC PHARMACOLOGY & TOXICOLOGY, 19.
author keywords: Atopic dermatitis; Dorsal root ganglia; Hypochlorous acid; Tofacitinib; IgE; IL-4; IL-13; NC/Nga mice; Sensory neurons
MeSH headings : Administration, Topical; Animals; Cells, Cultured; Cytokines / immunology; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / immunology; Disease Models, Animal; Female; Ganglia, Spinal / cytology; Hypochlorous Acid / therapeutic use; Immunoglobulin E / blood; Mice; Neurons / drug effects; Neurons / immunology; Piperidines / therapeutic use; Protein Kinase Inhibitors / therapeutic use; Pyrimidines / therapeutic use; Pyrroles / therapeutic use; Skin / drug effects; Skin / immunology
TL;DR:
Dorsal root ganglia neurons re-stimulated with a range of mediators of itch showed a reduced response compared to the vehicle control mice, when isolated from tofacitinib or HOCl treated mice, indicating a similar beneficial potential of topical high dose PR022 HOCl in gel and tofacinib, in a translational murine model of atopic dermatitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Impact of synthetic canine cerumen on in vitro penetration of auricular skin of dogs by florfenicol, terbinafine, and betamethasone acetate
AMERICAN JOURNAL OF VETERINARY RESEARCH, 79(3), 333–341.
MeSH headings : Administration, Cutaneous; Animals; Betamethasone / pharmacokinetics; Cerumen / chemistry; Chromatography, High Pressure Liquid / veterinary; Dogs / metabolism; Female; Gels; Male; Naphthalenes / pharmacokinetics; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Terbinafine; Thiamphenicol / analogs & derivatives; Thiamphenicol / pharmacokinetics
TL;DR:
3H-betamethasone acetate, 14C-terbinafine hydrochloride, and florfenicol were all absorbed in vitro through healthy auricular skin specimens within the first 24 hours after topical application, and synthetic canine cerumen had no impact on dermal absorption in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Janus kinase inhibitors differ in their affinity to the TRPV1 receptor - implications for their use in itch and pain
Journal of Veterinary Pharmacology and Therapeutics, 41, 160–160.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Neuromedin B: Characterization of a novel peripheral pruritogen
Journal of Veterinary Pharmacology and Therapeutics, 41, 48–48.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis
CLINICAL AND EXPERIMENTAL ALLERGY, 48(1), 78–88.
author keywords: atopic dermatitis; dorsal root ganglia; hypochlorous acid; IgE; IL-13; IL-4; NC; Nga mice; sensory neurons
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Antigens, Dermatophagoides / toxicity; Antipruritics / pharmacology; Cytokines / immunology; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / immunology; Dermatitis, Atopic / pathology; Disease Models, Animal; Female; Hypochlorous Acid / pharmacology; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / immunology; Inflammation / pathology; Mice; Mice, Inbred BALB C
TL;DR:
It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis; however, the specific antipruritic mechanism of action remains unclear.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 personal communication
Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor
Fukuyama, T., Ganchingco, J. R., Mishra, S. K., Olivry, T., Rzagalinski, I., Volmer, D. A., & Baeumer, W. (2017, July).
Contributors: T. Fukuyama n, J. Ganchingco n, S. Mishra n, T. Olivry n , I. Rzagalinski*, D. Volmer *, W. Bäumer n
MeSH headings : Animals; Antipruritics / chemistry; Antipruritics / pharmacology; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Female; Humans; Janus Kinase Inhibitors / chemistry; Janus Kinase Inhibitors / pharmacology; Mice; Models, Molecular; Molecular Conformation; Molecular Imaging / methods; Protein Binding; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Structure-Activity Relationship; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / chemistry; TRPV Cation Channels / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Nocifensive Behaviors in Mice with Radiation-Induced Oral Mucositis
RADIATION RESEARCH, 187(3), 397–403.
MeSH headings : Animals; Behavior, Animal / radiation effects; Mice; Neurons / pathology; Neurons / radiation effects; Nociception / radiation effects; Radiation Injuries, Experimental / pathology; Radiation Injuries, Experimental / physiopathology; Stomatitis / pathology; Stomatitis / physiopathology; Trigeminal Ganglion / pathology
TL;DR:
Data validate an appropriate model for cancer treatment related discomfort in humans and quantify resultant discomfort, and characterize peripheral sensitization following radiation-induced glossitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo
JOURNAL OF DERMATOLOGICAL SCIENCE, 83(2), 106–115.
author keywords: Natural killer cells; Histamine H4 receptor; CCL17/TARC; Dermal dendritic cells; Allergic contact dermatitis
MeSH headings : Animals; Chemokine CCL17 / metabolism; Chemotaxis / drug effects; Coculture Techniques; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Atopic / immunology; Dermatitis, Atopic / metabolism; Disease Models, Animal; Female; Histamine / metabolism; Humans; Indoles / pharmacology; Killer Cells, Natural / drug effects; Killer Cells, Natural / metabolism; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Piperazines / pharmacology; Pyrimidines / pharmacology; Receptors, G-Protein-Coupled / agonists; Receptors, G-Protein-Coupled / antagonists & inhibitors; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Receptors, Histamine / genetics; Receptors, Histamine / metabolism; Receptors, Histamine H4; Skin / cytology; Skin / drug effects; Skin / metabolism; Toluene 2,4-Diisocyanate / toxicity
TL;DR:
The H4R is identified as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation and is suggested to be beneficial in diseases like AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis
ARCHIVES OF DERMATOLOGICAL RESEARCH, 308(10), 711–721.
author keywords: Superoxide dismutase mimics; BMX-010; BMX-001; Allergic dermatitis; Mice
MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Cell Line; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Allergic Contact / drug therapy; Disease Models, Animal; Ear; Female; Humans; Infant, Newborn; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-1beta / metabolism; Interleukin-4 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metalloporphyrins / administration & dosage; Metalloporphyrins / therapeutic use; Mice; Mice, Inbred BALB C; Pruritus / drug therapy; Skin / drug effects; Skin / metabolism; Skin Cream; Superoxide Dismutase / metabolism; Toluene 2,4-Diisocyanate / toxicity; p-Methoxy-N-methylphenethylamine / toxicity
TL;DR:
Topical treatment with BMX cream resulted in a significant decrease in scratching behaviour in the compound 48/80 model, but not in the TDI model, and interestingly, the concentration of the cytokines IL-1β and IL-4 in inflamed skin was reduced by 80–90 % by all treatment options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Aggression behaviour induced by oral administration of the Janus-kinase inhibitor tofacitinib, but not oclacitinib, under stressful conditions
European Journal of Pharmacology, 764, 278–282.
MeSH headings : Administration, Oral; Aggression / drug effects; Animals; Anti-Allergic Agents / adverse effects; Anti-Allergic Agents / pharmacokinetics; Anti-Allergic Agents / therapeutic use; Anti-Inflammatory Agents / adverse effects; Anti-Inflammatory Agents / pharmacokinetics; Anti-Inflammatory Agents / therapeutic use; Behavior, Animal / drug effects; Brain / metabolism; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / metabolism; Disease Models, Animal; Female; Janus Kinases / antagonists & inhibitors; Janus Kinases / metabolism; Male; Mice, Inbred BALB C; Piperidines / adverse effects; Piperidines / pharmacokinetics; Piperidines / therapeutic use; Protein Kinase Inhibitors / adverse effects; Protein Kinase Inhibitors / pharmacokinetics; Protein Kinase Inhibitors / therapeutic use; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / adverse effects; Pyrimidines / pharmacokinetics; Pyrimidines / therapeutic use; Pyrroles / adverse effects; Pyrroles / pharmacokinetics; Pyrroles / therapeutic use; Stress, Psychological; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use; Toluene 2,4-Diisocyanate
TL;DR:
Results suggest that aggression was induced by tofacitinib under some kind of stressful environment, and indicates a possible role of the JAK-STAT pathway in modulation of aggression behaviour.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2015 article
Development of an Allergen-induced Atopic Itch Model in Dogs: A Preliminary Report
ACTA DERMATO-VENEREOLOGICA, Vol. 96, pp. 400–401.
MeSH headings : Animals; Anti-Allergic Agents / pharmacology; Antigens, Dermatophagoides; Behavior, Animal; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / immunology; Dermatitis, Atopic / psychology; Disease Models, Animal; Dogs; Glucocorticoids / pharmacology; Motor Activity; Prednisolone / pharmacology; Pruritus / drug therapy; Pruritus / immunology; Pruritus / psychology; Reproducibility of Results; Time Factors
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes
AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(7), 649–655.
MeSH headings : Animals; Azathioprine / administration & dosage; Azathioprine / pharmacology; Cell Line; Cell Survival / drug effects; Dogs; Dose-Response Relationship, Drug; Hepatocytes / drug effects; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / pharmacology; Mercaptopurine / administration & dosage; Mercaptopurine / pharmacology; Thioguanine / administration & dosage; Thioguanine / pharmacology
TL;DR:
Results indicated that thiopurines adversely affected the viability of canine hepatocytes in a time- and concentration-dependent manner but had a nonsignificant effect on the LDH and ALT activities and free glutathione depletion of those hepatocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis
ALLERGY, 71(2), 189–197.
author keywords: Allergic inflammation; atopic dermatitis; histamine H4 receptor; OVA
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; Cytokines / biosynthesis; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Disease Models, Animal; Epidermis / immunology; Epidermis / metabolism; Epidermis / pathology; Female; Immunoglobulin E / immunology; Lymph Nodes / immunology; Lymph Nodes / metabolism; Mice; Mice, Knockout; Ovalbumin / adverse effects; Piperidines / pharmacology; Pyridines / pharmacology; Receptors, G-Protein-Coupled / antagonists & inhibitors; Receptors, G-Protein-Coupled / deficiency; Receptors, G-Protein-Coupled / genetics; Receptors, Histamine / deficiency; Receptors, Histamine / genetics; Receptors, Histamine H4; Skin / immunology; Skin / metabolism; Skin / pathology
TL;DR:
The histamine H4 receptor (H4R) was brought into focus as a new therapeutic target for the treatment of allergic disorders such as atopic dermatitis (AD).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 354(3), 394–405.
MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents / administration & dosage; Antipruritics / administration & dosage; Cytokines / metabolism; Dermatitis, Allergic Contact / drug therapy; Dermatitis, Allergic Contact / metabolism; Disease Models, Animal; Female; Inflammation / drug therapy; Inflammation / metabolism; Janus Kinases / antagonists & inhibitors; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Piperidines / administration & dosage; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / administration & dosage; Pyrroles / administration & dosage; Skin / drug effects; Skin / metabolism; Sulfonamides / administration & dosage
TL;DR:
Oral treatment with JAK inhibitors reduced itch behavior dramatically but had only little effect on the inflammatory response, whereas topical treatment improved both itch and inflammatory response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Vaccination of calves with yeast- and bacterial-expressed paramyosin from the bovine lungworm Dictyocaulus viviparus
PARASITE IMMUNOLOGY, 37(12), 614–623.
author keywords: bovine lungworm; Dictyocaulus viviparus; immunization; nematode; paramyosin; vaccine
MeSH headings : Animals; Antibodies, Helminth / immunology; Antigens, Helminth / genetics; Antigens, Helminth / immunology; Cattle; Cattle Diseases / prevention & control; Dictyocaulus / immunology; Dictyocaulus Infections / prevention & control; Escherichia coli / genetics; Escherichia coli / metabolism; Female; Helminth Proteins / genetics; Helminth Proteins / immunology; Immunoglobulin G / immunology; Larva; Leukocytes, Mononuclear / immunology; Male; Recombinant Proteins; Tropomyosin / genetics; Tropomyosin / immunology; Vaccination / veterinary; Vaccines / immunology; Yeasts / genetics; Yeasts / metabolism
TL;DR:
All vaccinated cattle showed a significant rise in specific antibodies, particularly IgG and its subclass IgG1, and detected the native lungworm PMY in immunoblots starting 2 weeks after the first vaccination, suggesting a different rPMY‐adjuvant combination or combined vaccination with additional recombinant antigens might be a promising future approach towards a new vaccine against lungworms in cattle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells
MOLECULAR IMMUNOLOGY, 59(1), 10–18.
author keywords: Sphingosine-1-phosphate; Dendritic cells; IL-12; IL-23; IL-27; MAPK
MeSH headings : Androstadienes / pharmacology; Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Cells, Cultured; Dendritic Cells / cytology; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Enzyme Inhibitors / pharmacology; Gene Expression / drug effects; Immunoblotting; Interleukin-12 / biosynthesis; Interleukin-23 / biosynthesis; Interleukin-27 / biosynthesis; Lipopolysaccharides / pharmacology; Lysophospholipids / pharmacology; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Oxadiazoles / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation / drug effects; Pyrazoles / pharmacology; Pyridines / pharmacology; Receptors, Lysosphingolipid / agonists; Receptors, Lysosphingolipid / antagonists & inhibitors; Receptors, Lysosphingolipid / genetics; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction / drug effects; Sphingosine / analogs & derivatives; Sphingosine / pharmacology; Thiophenes / pharmacology; Wortmannin; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
S1P has an anti-inflammatory impact on the production of IL-12 family cytokines, indicating therapeutic potential for S1P treatment of several inflammatory diseases like psoriasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
PCR detects bands consistent with the expression of receptors associated with pruritus in canine dorsal root ganglia
VETERINARY DERMATOLOGY, 25(1), 9-+.
MeSH headings : Animals; Dog Diseases / etiology; Dogs; Ganglia, Spinal / metabolism; Gene Expression Regulation / physiology; Pruritus / genetics; Pruritus / metabolism; Pruritus / veterinary; RNA / genetics; RNA / metabolism; Receptor, Endothelin A / genetics; Receptor, Endothelin A / metabolism; Receptors, Histamine / genetics; Receptors, Histamine / metabolism; Receptors, Interleukin / genetics; Receptors, Interleukin / metabolism; Receptors, Neurokinin-1 / genetics; Receptors, Neurokinin-1 / metabolism; Receptors, Opioid / genetics; Receptors, Opioid / metabolism; Reverse Transcriptase Polymerase Chain Reaction / veterinary; TRPV Cation Channels / genetics; TRPV Cation Channels / metabolism; Toll-Like Receptor 7 / genetics; Toll-Like Receptor 7 / metabolism
TL;DR:
The aim of the study was to analyse the expression of receptors for various mediators of pruritus in canine DRG, and PCR analysis detected bands consistent with theexpression of receptors associated with pruritis in canineDRG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Pharmacokinetics and thrombolytic effects of the recombinant tissue-type plasminogen activator in horses
BMC VETERINARY RESEARCH, 9.
author keywords: Alteplase; Recombinant tissue plasminogen activator; Thrombus; Clot formation; Hypercoagulopathy
MeSH headings : Animals; Area Under Curve; Female; Fibrinogen / analysis; Fibrinolytic Agents / administration & dosage; Fibrinolytic Agents / pharmacokinetics; Fibrinolytic Agents / therapeutic use; Half-Life; Horses / metabolism; Infusions, Intravenous / veterinary; Male; Partial Thromboplastin Time / veterinary; Prothrombin Time / veterinary; Thrombin Time / veterinary; Thrombosis / drug therapy; Thrombosis / veterinary; Tissue Plasminogen Activator / administration & dosage; Tissue Plasminogen Activator / pharmacokinetics; Tissue Plasminogen Activator / therapeutic use
TL;DR:
Findings indicate that a single dose of 1 mg/kg alteplase results in rt-PA plasma concentrations comparable to those in humans and might be sufficient for a thrombolytic therapy in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis
JOURNAL OF DERMATOLOGICAL SCIENCE, 71(1), 29–36.
author keywords: Imiquimod; Psoriasis; SCID mice; Sphingosine-1-phosphate
MeSH headings : Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / pharmacology; Betamethasone / analogs & derivatives; Betamethasone / pharmacology; Calcitriol / analogs & derivatives; Calcitriol / pharmacology; Cell Differentiation / drug effects; Cell Proliferation / drug effects; Dermatologic Agents / administration & dosage; Dermatologic Agents / pharmacology; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Imiquimod; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Local Lymph Node Assay; Lysophospholipids / administration & dosage; Lysophospholipids / pharmacology; Mice; Mice, Inbred BALB C; Mice, SCID; Propylene Glycols / administration & dosage; Propylene Glycols / pharmacology; Psoriasis / chemically induced; Psoriasis / drug therapy; Psoriasis / metabolism; Psoriasis / pathology; Receptors, Lysosphingolipid / drug effects; Receptors, Lysosphingolipid / metabolism; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Transplantation; Sphingosine / administration & dosage; Sphingosine / analogs & derivatives; Sphingosine / pharmacology; Sphingosine-1-Phosphate Receptors; Time Factors
TL;DR:
Results imply that topical administration of S1P might be a new option for the treatment of mild to moderate psoriasis lesions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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