Latsavongsakda Sethaphong

Works (7)

Updated: July 5th, 2023 15:49

2015 journal article

Prediction of the structures of the plant-specific regions of vascular plant cellulose synthases and correlated functional analysis

Cellulose, 23(1), 145–161.

By: L. Sethaphong n, J. Davis n, E. Slabaugh n, A. Singh n, C. Haigler n  & Y. Yingling n 

Contributors: Y. Yingling n , C. Haigler n , A. Singh n, E. Slabaugh n, J. Davis n & L. Sethaphong n

author keywords: Arabidopsis thaliana; Cellulose synthesis; Computational protein structure prediction; Isoform specificity; Mutant complementation
topics (OpenAlex): Polysaccharides and Plant Cell Walls; Advanced Cellulose Research Studies; Biofuel production and bioconversion
TL;DR: Modeling of the mutant P-CR of Atcesa8R362K (fra6) suggested that changes in local structural stability and surface electrostatics may cause the mutant phenotype, and results provide structural clues about the function of plant-specific regions of CESA. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Computational and genetic evidence that different structural conformations of a non-catalytic region affect the function of plant cellulose synthase

Journal of Experimental Botany, 65(22), 6645–6653.

By: E. Slabaugh n, L. Sethaphong n, C. Xiao *, J. Amick n, C. Anderson *, C. Haigler n , Y. Yingling n 

Contributors: E. Slabaugh n, L. Sethaphong n, C. Xiao *, J. Amick n, C. Anderson *, C. Haigler n , Y. Yingling n 

author keywords: Cellulose biosynthesis; CESA; genetic complementation; protein structural modelling; rsw1 mutant; transmembrane helix
MeSH headings : Amino Acid Sequence; Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Biocatalysis; Computational Biology; Glucosyltransferases / chemistry; Glucosyltransferases / genetics; Glucosyltransferases / metabolism; Molecular Sequence Data; Mutant Proteins / metabolism; Mutation; Phenotype; Protein Structure, Secondary; Recombinant Fusion Proteins / metabolism; Sequence Alignment; Structure-Activity Relationship
topics (OpenAlex): Polysaccharides and Plant Cell Walls; Biofuel production and bioconversion; Enzyme Production and Characterization
TL;DR: Computational modelling of peptide structure, genetic complementation in Arabidopsis thaliana, and confocal microscopy provide evidence that a region between two transmembrane helices may adopt two predominant structural conformations that affect the function of plant cellulose synthase. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Tertiary model of a plant cellulose synthase

Proceedings of the National Academy of Sciences, 110(18), 7512–7517.

By: L. Sethaphong*, C. Haigler n , J. Kubicki *, J. Zimmer *, D. Bonetta *, S. DeBolt *, Y. Yingling* 

Contributors: Y. Yingling* , S. DeBolt *, D. Bonetta *, J. Zimmer *, J. Kubicki *, C. Haigler n , L. Sethaphong*

author keywords: rosette cellulose synthase complex; molecular modeling; protein structure prediction; GlycosylTransferase Family 2; beta-1,4-glucan polymerization
MeSH headings : Arabidopsis / enzymology; Bacteria / enzymology; Computational Biology; Cytosol / enzymology; Glucosyltransferases / chemistry; Glucosyltransferases / genetics; Gossypium / enzymology; Models, Molecular; Mutation / genetics; Phenotype; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary
topics (OpenAlex): Polysaccharides and Plant Cell Walls; Advanced Cellulose Research Studies; Biofuel production and bioconversion
TL;DR: The predicted tertiary structure of cotton CESA provides a platform for the biochemical engineering of plant CESAs and supports the importance of the plant-conserved region and/or class-specific region in CESA oligomerization to form the multimeric cellulose–synthesis complexes that are characteristic of plants. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 article

The relationship between enhanced enzyme activity and structural dynamics in ionic liquids: a combined computational and experimental study

Kim, H. S., Ha, S. H., Sethaphong, L., Koo, Y.-M., & Yingling, Y. G. (2013, December 2). Physical Chemistry Chemical Physics, Vol. 16, p. 2944.

By: H. Kim  n, S. Ha*, L. Sethaphong n, Y. Koo * & Y. Yingling n 

Contributors: H. Kim  n, S. Ha*, L. Sethaphong n, Y. Koo * & Y. Yingling n 

MeSH headings : 1-Butanol / chemistry; Esterification; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Ionic Liquids / chemistry; Lipase / chemistry; Lipase / metabolism; Molecular Dynamics Simulation; Protein Conformation; Solvents / chemistry; Vinyl Compounds / chemistry; Water / chemistry; tert-Butyl Alcohol / chemistry
topics (OpenAlex): Enzyme Catalysis and Immobilization; Ionic liquids properties and applications; Analytical Chemistry and Chromatography
TL;DR: The results demonstrate that the conformational changes of the active site cavity are directly related to enzyme activity and decrease and the electrostatic energy between solvents in this study and CALB is correlated with the structural changes leading to differences in enzyme activity. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 conference paper

X3DBio2: A visual analysis tool for biomolecular structure comparison

In P. C. Wong, D. L. Kao, M. C. Hao, C. Chen, & C. G. Healey (Eds.), Visualization and Data Analysis 2013 (Vol. 2, p. 86540W).

By: H. Yi *, S. Thakur*, L. Sethaphong n & Y. Yingling n 

Ed(s): P. Wong *, D. Kao, M. Hao, C. Chen & C. Healey

author keywords: Molecular structure comparison; Molecular visualization; Interactive exploration; Protein and nucleic acids; Sequence alignment; Structure superposition; Quaternion map; Contact map; Ramachandran plot
topics (OpenAlex): Genomics and Phylogenetic Studies; Genetics, Bioinformatics, and Biomedical Research; Bioinformatics and Genomic Networks
TL;DR: A new visual analysis tool, X3DBio2, for 3D biomolecular structure comparison and analysis, designed for elucidation of structural effects of mutations in proteins and nucleic acids and for assessment of time dependent trajectories from molecular dynamics simulations. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 article

Interactions of Cations with RNA Loop-Loop Complexes

Singh, A., Sethaphong, L., & Yingling, Y. G. (2011, August 1). Biophysical Journal, Vol. 101, p. 727–735.

By: A. Singh n, L. Sethaphong n & Y. Yingling n 

Contributors: A. Singh n, L. Sethaphong n & Y. Yingling n 

MeSH headings : Base Pairing; Base Sequence; Cations / metabolism; Metals / metabolism; Molecular Dynamics Simulation; Nucleic Acid Conformation; RNA / chemistry; RNA / genetics; RNA / metabolism; Solvents / chemistry
topics (OpenAlex): RNA and protein synthesis mechanisms; DNA and Nucleic Acid Chemistry; Bacterial Genetics and Biotechnology
TL;DR: Examining interactions of metal ions with five RNA loop-loop complexes of unique biological significance using explicit-solvent molecular-dynamics simulations revealed the presence of solvent-accessible tunnels through the major groove of loop- loop interactions that attract and retain cations. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 article

The Sequence of HIV-1 TAR RNA Helix Controls Cationic Distribution

Sethaphong, L., Singh, A., Marlowe, A. E., & Yingling, Y. G. (2010, January 14). The Journal of Physical Chemistry C, Vol. 114, p. 5506–5512.

By: L. Sethaphong n, A. Singh n, A. Marlowe n & Y. Yingling n 

Contributors: Y. Yingling n , A. Marlowe n, A. Singh n & L. Sethaphong n

topics (OpenAlex): RNA and protein synthesis mechanisms; RNA Research and Splicing; DNA and Nucleic Acid Chemistry
TL;DR: There is a sequence-dependent cationic localization toward the purine-rich run within the TAR helix and other purine -rich duplexes and the behavior is independent of ionic species or a presence of a bulge. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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