Paul S. Sheeran

Works (18)

Updated: July 22nd, 2023 21:14

2015 journal article

Dual-Frequency Acoustic Droplet Vaporization Detection for Medical Imaging

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 62(9), 1623–1633.

By: C. Arena  n, A. Novell n, P. Sheeran n, C. Puett  n, L. Moyer n & P. Dayton n

MeSH headings : Fluorocarbons / chemistry; Microbubbles; Microscopy, Acoustic / methods; Phantoms, Imaging; Transducers; Ultrasonography / methods
TL;DR: Results indicate that it is possible to generate high-sensitivity, high-contrast images of vaporization events and has the potential to be applied in combination with dropletmediated therapy to track treatment outcomes or as a standalone diagnostic system to monitor the physical properties of the surrounding environment. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 article

Dynamics of volatile phase-change contrast agents: Theoretical model and experimental measurements

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 2273–2276.

By: A. Doinikov *, A. Bouakaz *, P. Sheeran n & P. Dayton n

author keywords: contrast agent; acoustic droplet vaporization; perfluorocarbon; ultrasound imaging; modeling
TL;DR: A new theoretical model is reported on that describes the conversion of a PFC droplet into a vapor bubble and subsequent bubble evolution and is validated by comparison with in vitro experimental data acquired by ultra-high-speed video microscopy for decafluorobutane (DFB) and octafLUoropropane (OFP) microdroplets of different sizes. (via Semantic Scholar)
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2014 article

In Vivo Quantification of Image Enhancement and Circulation Kinetics for Phase Change Perfluorocarbon Agents Using Custom Pulse Sequences

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 417–420.

By: P. Sheeran n, J. Rojas n, C. Puett  n, J. Hjelmquist n, C. Arena  n & P. Dayton n

TL;DR: This study develops a custom pulse sequence to vaporize and image droplets using the Verasonics research platform, and demonstrates a novel concept in contrast-enhanced ultrasound: capture of droplet-generated contrast wash-out in the target organ. (via Semantic Scholar)
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Added: August 6, 2018

2014 article

Ultrasound Imaging from Vaporization Signals Emitted by Phase Change Contrast Agents

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 1778–1781.

By: C. Arena n, A. Novell n, P. Sheeran n, C. Puett n, L. Phillips n & P. Dayton n

author keywords: acoustic droplet vaporization; contrast enhanced ultrasound; nanodroplet; nanoemulsion; perfluorocarbon
TL;DR: It is demonstrated that this event can be used to generate an ultrasound image, and that the signal can be separated from that of a conventional microbubble. (via Semantic Scholar)
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2014 journal article

Vaporization dynamics of volatile perfluorocarbon droplets: A theoretical model and in vitro validation

MEDICAL PHYSICS, 41(10).

By: A. Doinikov *, P. Sheeran*, A. Bouakaz * & P. Dayton*

author keywords: ultrasound imaging; ultrasound contrast agent; acoustic droplet vaporization; perfluorocarbon; theoretical model
MeSH headings : Acoustic Stimulation; Acoustics; Algorithms; Computer Simulation; Contrast Media / chemistry; Fluorocarbons / chemistry; Gases / chemistry; Hydrodynamics; Microfluidics; Microscopy, Video; Models, Theoretical; Thermodynamics; Volatilization
TL;DR: An improved theoretical model is developed that allows one to simulate the growth of a vapor bubble inside a PFC droplet until the liquid PFC is completely converted into vapor, and the subsequent overexpansion and damped oscillations of the vapor bubble, including the influence of an externally applied acoustic pulse. (via Semantic Scholar)
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Added: August 6, 2018

2013 journal article

Flow-focusing regimes for accelerated production of monodisperse drug-loadable microbubbles toward clinical-scale applications

LAB ON A CHIP, 13(24), 4816–4826.

By: R. Shih*, D. Bardin*, T. Martz*, P. Sheeran*, P. Dayton* & A. Lee *

MeSH headings : Contrast Media / chemistry; Drug Carriers / chemistry; Gases; Microbubbles; Microfluidic Analytical Techniques / methods; Pressure; Time Factors
TL;DR: Analysis and characterization of high-speed dual-layer bubble generation will enable more-predictive production control, at rates practical for in vivo or clinical use, before clinical use can be practical. (via Semantic Scholar)
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2013 journal article

Phase change events of volatile liquid perfluorocarbon contrast agents produce unique acoustic signatures

PHYSICS IN MEDICINE AND BIOLOGY, 59(2), 379–401.

By: P. Sheeran n, T. Matsunaga* & P. Dayton n

MeSH headings : Acoustics; Contrast Media / chemistry; Fluorocarbons / chemistry; Volatilization
TL;DR: This study demonstrates through high-speed video microscopy and US interrogation that PCCAs composed of highly volatile perfluorocarbons (PFCs) exhibit unique acoustic behavior that can be detected and differentiated from standard microbubble contrast agents. (via Semantic Scholar)
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2013 journal article

Phase-transition thresholds and vaporization phenomena for ultrasound phase-change nanoemulsions assessed via high-speed optical microscopy

PHYSICS IN MEDICINE AND BIOLOGY, 58(13), 4513–4534.

By: P. Sheeran n, T. Matsunaga* & P. Dayton n

MeSH headings : Emulsions / analysis; Emulsions / chemistry; Emulsions / radiation effects; Gases / analysis; Gases / chemistry; Gases / radiation effects; High-Energy Shock Waves; Materials Testing / methods; Microscopy, Video / methods; Nanoparticles / chemistry; Nanoparticles / radiation effects; Nanoparticles / ultrastructure; Phase Transition / radiation effects; Radiation Dosage; Sonication / methods
TL;DR: Results show that decafluorobutane nanoemulsions with peak diameters on the order of 200 nm can be optimally vaporized with short pulses using pressures amenable to clinical diagnostic ultrasound machines. (via Semantic Scholar)
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2013 journal article

TOWARD ULTRASOUND MOLECULAR IMAGING WITH PHASE-CHANGE CONTRAST AGENTS: AN IN VITRO PROOF OF PRINCIPLE

ULTRASOUND IN MEDICINE AND BIOLOGY, 39(5), 893–902.

By: P. Sheeran*, J. Streeter n, L. Mullin n, T. Matsunaga* & P. Dayton n

author keywords: Perfluorocarbon droplet; Acoustic droplet vaporization; Molecular imaging; Contrast agent; Phase-change
MeSH headings : Cells, Cultured; Contrast Media / analysis; Contrast Media / chemical synthesis; Endothelial Cells / diagnostic imaging; Female; Fluorocarbons / chemical synthesis; Humans; Molecular Imaging / methods; Pilot Projects; Ultrasonography / methods
TL;DR: A PCCA-based platform for molecular imaging using α(v)β(3)-targeted nanoscale PCCAs composed of low-boiling-point perfluorocarbons is demonstrated. (via Semantic Scholar)
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2013 journal article

Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets

JOURNAL OF CONTROLLED RELEASE, 172(3), 795–804.

By: C. Chen *, P. Sheeran n, S. Wu*, O. Olumolade *, P. Dayton n & E. Konofagou *

author keywords: Acoustically-activated nanodroplets; Phase-shift droplets; Microbubbles; Focused ultrasound; Blood
MeSH headings : Acoustics; Animals; Blood-Brain Barrier / metabolism; Contrast Media / chemistry; Contrast Media / metabolism; Dextrans / administration & dosage; Drug Delivery Systems / methods; Hippocampus / metabolism; Male; Mice; Mice, Inbred C57BL; Nanostructures / chemistry; Sonication / methods
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Source: Web Of Science
Added: August 6, 2018

2012 journal article

Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons

BIOMATERIALS, 33(11), 3262–3269.

By: P. Sheeran n, S. Luois*, L. Mullin n, T. Matsunaga* & P. Dayton n

author keywords: Ultrasound; Nanoparticle; Fluorocarbon; Phospholipid; Thermally responsive material; Acoustically responsive material
MeSH headings : Contrast Media / chemical synthesis; Contrast Media / radiation effects; Fluorocarbons / chemistry; Fluorocarbons / radiation effects; Gases / chemical synthesis; Gases / radiation effects; Materials Testing; Nanoparticles / chemistry; Nanoparticles / radiation effects; Phase Transition / radiation effects; Sonication / methods; Transition Temperature; Ultrasonography / methods
TL;DR: The relationship between size, thermal stability and sensitivity to ultrasound as a function of PFC boiling point and ambient temperature is illustrated and the potential for low boiling point PFCs is demonstrated as a useful new class of compounds for activatable agents, which can be tailored to the desired application. (via Semantic Scholar)
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Source: Web Of Science
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2012 journal article

Microfluidic Generation of Acoustically Active Nanodroplets

SMALL, 8(12), 1876–1879.

By: T. Martz*, D. Bardin*, P. Sheeran n, A. Lee * & P. Dayton n

author keywords: microfluidics; nanodroplets; contrast agents; pressure-controlled flow; biomedical applications
MeSH headings : Acoustics; Drug Delivery Systems; Equipment Design; Fluorocarbons / chemistry; Glycerol / chemistry; Lymphatic System / drug effects; Microfluidic Analytical Techniques; Microfluidics; Microscopy / methods; Microscopy, Electron, Transmission / methods; Nanotechnology / methods; Optics and Photonics / methods; Particle Size; Pressure; Viscosity
TL;DR: A microfluidic approach for the generation of perfluorocarbon nanodroplets as the primary emulsion with diameters as small as 300-400 nm is described, which results in generation of droplets in the sub-micrometer range. (via Semantic Scholar)
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2012 review

Phase-change contrast agents for imaging and therapy

[Review of ]. Current Pharmaceutical Design, 18(15), 2152–2165.

By: P. Sheeran* & P. Dayton*

MeSH headings : Acoustics; Animals; Contrast Media / chemistry; Drug Design; Emulsions; Humans; Microbubbles; Particle Size; Phase Transition; Ultrasonography / methods; Volatilization
TL;DR: The history of PCCAs, physical mechanisms involved, and proposed applications are discussed with a summary of studies demonstrated in vivo and the need for future studies to characterize potential bioeffects for administration in humans and optimization of ultrasound parameters is discussed. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2012 review

Phase-change nanoparticles using highly volatile perfluorocarbons: Toward a platform for extravascular ultrasound imaging

[Review of ]. Theranostics, 2(12), 1185–1198.

By: T. Matsunaga, P. Sheeran, S. Luois, J. Streeter, L. Mullin, B. Banerjee, P. Dayton

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Analysis of Multi-Layer Immiscible Fluid Flow in a Microchannel

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 133(11).

By: J. Li n, P. Sheeran n & C. Kleinstreuer n

author keywords: immiscible fluids; multilayer viscosities; non-newtonian fluids; pressure-driven flow; electroosmotic flow; microchannel entrance effects
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2011 journal article

Formulation and Acoustic Studies of a New Phase-Shift Agent for Diagnostic and Therapeutic Ultrasound

LANGMUIR, 27(17), 10412–10420.

By: P. Sheeran n, S. Luois*, P. Dayton n & T. Matsunaga*

MeSH headings : Acoustics; Contrast Media / chemistry; Contrast Media / therapeutic use; Fluorocarbons / chemistry; Fluorocarbons / therapeutic use; Humans; Particle Size; Surface Properties; Volatilization
TL;DR: This study is the first to the authors' knowledge to demonstrate both a method of generating ADV agents by microbubble condensation and formulation of primarily submicrometer droplets of decafluorobutane that remain stable at physiological temperatures. (via Semantic Scholar)
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2011 journal article

High-speed, clinical-scale microfluidic generation of stable phase-change droplets for gas embolotherapy

LAB ON A CHIP, 11(23), 3990–3998.

By: D. Bardin*, T. Martz*, P. Sheeran*, R. Shih*, P. Dayton* & A. Lee *

MeSH headings : Dimethylpolysiloxanes / chemistry; Fluorocarbons / chemistry; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Particle Size; Phase Transition; Temperature
TL;DR: The opportunity exists to potentiate locoregional cancer therapies such as thermal ablation and percutaneous ethanol injection using thermal or acoustic vaporization of these monodisperse phase-change droplets to intentionally occlude the vessels of a cancer. (via Semantic Scholar)
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2011 journal article

PRECISION MANUFACTURE OF PHASE-CHANGE PERFLUOROCARBON DROPLETS USING MICROFLUIDICS

ULTRASOUND IN MEDICINE AND BIOLOGY, 37(11), 1952–1957.

By: T. Martz*, P. Sheeran n, D. Bardin*, A. Lee * & P. Dayton n

author keywords: Acoustic droplet vaporization; Ultrasound; Monodisperse; Perfluoropentane; Microfluidic
MeSH headings : Acoustics; Contrast Media / chemical synthesis; Fluorocarbons / chemical synthesis; Gases / chemistry; Microfluidics; Particle Size; Temperature; Ultrasonics; Volatilization
TL;DR: Results indicate that microfluidic technology can enable greater manufacturing control of phase-change perfluorocarbons for acousticDroplets of uniform size have very little variability in acoustic vaporization threshold. (via Semantic Scholar)
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