Shobhan Gaddameedhi

In vivo investigation of STN1 downregulation in melanoma formation in adult mice following UV irradiation

Knowles, S., Bosland, M. C., Gaddameedhi, S., & Chai, W. (2025, March 21).

In vivo investigation of STN1 downregulation in melanoma formation in adult mice following UV irradiation

Knowles, S., Wang, F., Bosland, M. C., Gaddameedhi, S., & Chai, W. (2025, June 7).

In vivo investigation of STN1 downregulation in melanoma formation in adult mice following UV irradiation

Knowles, S., Wang, F., Bosland, M. C., Gaddameedhi, S., Chai, W., Knowles, S., … Chai, W. (2025, November 14). (R. Jaiswal, Ed.). PLoS ONE.

Long‐term sub‐erythemal UVB exposure does not impact circadian rhythms in mice under standard and rotating shift light conditions

Greer, A. J., Cone, S. J., Bernstein, R., Schuetz, E., Kar, N. P., Koritala, B. S. C., & Gaddameedhi, S. (2025, March 26). Photochemistry and Photobiology.

0096 Simulated Night Shift Schedule Alters Endogenous Temporal Regulation of Glucose and Insulin

Lundholm, K., Skene, D., McDermott, J., Liu, P., Gaddameedhi, S., Dongen, H. V., & Satterfield, B. (2024, April 20). SLEEP, Vol. 47.

Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson

Yan, S., Gaddameedhi, S., & Sobol, R. W. (2024, April 1). Environmental and Molecular Mutagenesis, Vol. 4.

Molecular-Level Dysregulation of Insulin Pathways and Inflammatory Processes in Peripheral Blood Mononuclear Cells by Circadian Misalignment

McDermott, J. E., Jacobs, J. M., Merrill, N. J., Mitchell, H. D., Arshad, O. A., McClure, R., … Dongen, H. P. A. V. (2024, April 15). Journal of Proteome Research, Vol. 4.

A new role of TRPM8 in circadian rhythm and molecular clock

Mishra, S. K., & Gaddameedhi, S. (2023, January 13). Acta Physiologica, Vol. 1.

Telomere dysfunction in Tert knockout mice delays Braf^V600E‐induced melanoma development

Zhang, J., Zhang, F., Porter, K. I., Dakup, P. P., Wang, S., Robertson, G. P., … Zhu, J. (2023, September 20). International Journal of Cancer.

The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study

Koritala, B. S. C., Dakup, P. P., Porter, K. I., & Gaddameedhi, S. (2023, June 28). F1000Research.

The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study

Koritala, B. S. C., Dakup, P. P., Porter, K. I., Gaddameedhi, S., P., D. P., & Koritala, B. S. C. (2023, August 2). (D. P. P., G. Shobhan, B. S. C. Koritala, & K. I. Porter, Eds.) [Version 1;]. F1000Research.

The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study

Koritala, B. S. C., Dakup, P. P., Porter, K. I., & Gaddameedhi, S. (2023, August 17). F1000Research.

CIRCADIAN DYSREGULATION OF HUMAN DNA REPAIR GENES AND ELEVATED DNA DAMAGE IN SIMULATED NIGHT SHIFT SCHEDULE

Sleep. https://publons.com/wos-op/publon/54906417/

Circadian disruption and cisplatin chronotherapy for mammary carcinoma

Koritala, B. S. C., Porter, K. I., Sarkar, S., & Gaddameedhi, S. (2022, January 5). Toxicology and Applied Pharmacology, Vol. 2.

Circadian effects on UV-induced damage and mutations

Goodenow, D., Greer, A. J., Cone, S. J., & Gaddameedhi, S. (2022, January 1). Mutation Research/Reviews in Mutation Research.

Endogenous Diurnal Patterns of Adrenal and Gonadal Hormones During a 24-Hour Constant Routine After Simulated Shift Work

Kelly, M. R., Yuen, F., Satterfield, B. C., Auchus, R. J., Gaddameedhi, S., Dongen, H. P. A. V., & Liu, P. Y. (2022, September 29). Journal of the Endocrine Society, Vol. 10.

Let’s talk about sex: A biological variable in immune response against melanoma

Dakup, P. P., Greer, A. J., & Gaddameedhi, S. (2022, January 25). Pigment Cell & Melanoma Research, Vol. 35, pp. 268–279.

Simulated Night- Shift Schedule Disrupts the Plasma Lipidome and Reveals Early Markers of Cardiovascular Disease Risk

Kyle, J. E., Bramer, L. M., Claborne, D., Stratton, K. G., Bloodsworth, K. J., Teeguarden, J. G., … Dongen, H. P. A. V. (2022, May 1). Nature and Science of Sleep.

Working around the Clock: Is a Person’s Endogenous Circadian Timing for Optimal Neurobehavioral Functioning Inherently Task-Dependent?

Muck, R. A., Hudson, A. N., Honn, K. A., Gaddameedhi, S., & Dongen, H. P. A. V. (2022, February 11). Clocks & Sleep, Vol. 3.

Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells

Sarkar, S., Porter, K. I., Dakup, P. P., Gajula, R. P., Koritala, B. S. C., Hylton, R., … Gaddameedhi, S. (2021, June 23). Pigment Cell & Melanoma Research, Vol. 34, pp. 955–965.

Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

Hayter, E. A., Wehrens, S. M. T., Dongen, H. P. A. V., Stangherlin, A., Gaddameedhi, S., Crooks, E., … Bechtold, D. A. (2021, April 30). Nature Communications, Vol. 4.

Night shift schedule alters endogenous regulation of circulating cytokines

Liu, P. Y., Irwin, M. R., Krueger, J. M., Gaddameedhi, S., & Dongen, H. P. A. V. (2021, March 7). Neurobiology of Sleep and Circadian Rhythms, Vol. 10, p. 100063.

Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans

Koritala, B. S. C., Porter, K. I., Arshad, O. A., Gajula, R. P., Mitchell, H. D., Arman, T., … Gaddameedhi, S. (2021, February 27). Journal of Pineal Research.

Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene

Xu, T., Cheng, D., Zhao, Y., Zhang, J., Zhu, X., Zhang, F., … Zhu, J. (2021, June 21). Proceedings of the National Academy of Sciences, Vol. 6.

Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues

Khalyfa, A., Gaddameedhi, S., Crooks, E., Zhang, C., Li, Y., Qiao, Z., … Gozal, D. (2020, September 3). International Journal of Molecular Sciences, Vol. 21.

Sex differences in the association between tumor growth and T cell response in a melanoma mouse model

Dakup, P. P., Porter, K. I., Little, A. A., Zhang, H., & Gaddameedhi, S. (2020, June 25). Cancer Immunology Immunotherapy, Vol. 69, pp. 2157–2162.

Solar ultraviolet‐induced DNA damage response: Melanocytes story in transformation to environmental melanomagenesis

Sarkar, S., & Gaddameedhi, S. (2020, April 13). Environmental and Molecular Mutagenesis.

The circadian clock protects against acute radiation-induced dermatitis

Dakup, P. P., Porter, K. I., & Gaddameedhi, S. (2020, May 15). Toxicology and Applied Pharmacology, Vol. 399, p. 115040.

The circadian clock protects against ionizing radiation‐induced cardiotoxicity

Dakup, P. P., Porter, K. I., Gajula, R. P., Goel, P. N., Cheng, Z., & Gaddameedhi, S. (2020, January 10). The FASEB Journal.

It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes

Yale Journal of Biology and Medicine. https://publons.com/wos-op/publon/32413204/

It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes.

The Yale Journal of Biology and Medicine. https://europepmc.org/articles/PMC6585512

Abstract 4159: Circadian clock protects against radiation-induced dermatitis and cardiomyopathy in mice

Dakup, P. P., Porter, K. I., Cheng, Z., & Gaddameedhi, S. (2018, July 1). Cancer Research.

Cardiac autonomic activity during simulated shift work

SKORNYAKOV, E., GADDAMEEDHI, S., PAECH, G. M., SPARROW, A. R., SATTERFIELD, B. C., SHATTUCK, N. L., … DONGEN, H. P. A. V. A. N. (2018, August 7). Industrial Health.

Circulating Plasma Exosomes May Signal Circadian Clock Misalignment to Peripheral Tissues

American Journal of Respiratory and Critical Care Medicine. https://publons.com/wos-op/publon/35726971/

Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism

Skene, D. J., Skornyakov, E., Chowdhury, N. R., Gajula, R. P., Middleton, B., Satterfield, B. C., … Gaddameedhi, S. (2018, July 10). Proceedings of the National Academy of Sciences, Vol. 115, pp. 7825–7830.

The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models

Dakup, P. P., Porter, K. I., Little, A. A., Gajula, R. P., Zhang, H., Skornyakov, E., … Gaddameedhi, S. (2018, February 20). Oncotarget.

UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking

Sarkar, S., & Gaddameedhi, S. (2018, January 19). Journal of Investigative Dermatology.

Abstract 1120: Chronopharmacology of cisplatin: role of the circadian rhythm in modulating cisplatin-induced toxicity in melanoma mouse model

Dakup, P., Porter, K., Gajula, R., & Gaddameedhi, S. (2017, July 1). Cancer Research.

Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being

James, S. M., Honn, K. A., Gaddameedhi, S., & Dongen, H. P. A. V. (2017, April 26). Current Sleep Medicine Reports.

Chronopharmacology of cisplatin: Role of the circadian rhythm in modulating the cisplatin transporters levels

The FASEB Journal. https://publons.com/wos-op/publon/32413213/

Impact of the Circadian Clock on UV‐Induced DNA Damage Response and Photocarcinogenesis

Dakup, P., & Gaddameedhi, S. (2016, November 16). Photochemistry and Photobiology.

Commentary: Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure

Gajula, R. P., & Gaddameedhi, S. (2015, October 6). Frontiers in Physiology.

Development and validation of a new transgenic hairless albino mouse as a mutational model for potential assessment of photocarcinogenicity

Manjanatha, M. G., Shelton, S. D., Chen, Y., Gaddameedhi, S., Howard, P. C., & Boudreau, M. D. (2015, August 8). Mutation Research/Genetic Toxicology and Environmental Mutagenesis.

Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity

Simpson, D., Lemonie, N., Morgan, D., Gaddameedhi, S., & Kaufmann, W. (2015, June 17). Cancers.

Circadian Clock, Cancer, and Chemotherapy

Sancar, A., Lindsey-Boltz, L. A., Gaddameedhi, S., Selby, C. P., Ye, R., Chiou, Y.-Y., … Ozturk, N. (2014, October 10). Biochemistry.

DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair

Kemp, M. G., Gaddameedhi, S., Choi, J.-H., Hu, J., & Sancar, A. (2014, August 9). Journal of Biological Chemistry.

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

Ye, R., Selby, C. P., Chiou, Y.-Y., Ozkan-Dagliyan, I., Gaddameedhi, S., & Sancar, A. (2014, September 15). Genes & Development.

The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin

Gaddameedhi, S., Selby, C. P., Kemp, M. G., Ye, R., & Sancar, A. (2014, November 28). Journal of Investigative Dermatology.

Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells

Choi, J.-H., Gaddameedhi, S., Kim, S.-Y., Hu, J., Kemp, M. G., & Sancar, A. (2013, November 22). Nucleic Acids Research.

Nucleotide Excision Repair in Human Cells

Hu, J., Choi, J.-H., Gaddameedhi, S., Kemp, M. G., Reardon, J. T., & Sancar, A. (2013, June 9). Journal of Biological Chemistry.

DNA Damage–Specific Control of Cell Death by Cryptochrome in p53-Mutant Ras–Transformed Cells

Lee, J. H., Gaddameedhi, S., Ozturk, N., Ye, R., & Sancar, A. (2012, November 14). Cancer Research.

Effect of circadian clock mutations on DNA damage response in mammalian cells

Gaddameedhi, S., Reardon, J. T., Ye, R., Ozturk, N., & Sancar, A. (2012, August 23). Cell Cycle.

Control of skin cancer by the circadian rhythm

Proceedings of the National Academy of Sciences, 108(46), 18790–18795.

Melanoma and DNA damage from a distance (farstander effect)

Gaddameedhi, S., & Sancar, A. (2010, November 12). Pigment Cell & Melanoma Research.

Similar Nucleotide Excision Repair Capacity in Melanocytes and Melanoma Cells

Gaddameedhi, S., Kemp, M. G., Reardon, J. T., Shields, J. M., Smith-Roe, S. L., Kaufmann, W. K., & Sancar, A. (2010, May 26). Cancer Research.

Association between the unfolded protein response, induced by 2-deoxyglucose, and hypersensitivity to cisplatin: A mechanistic study employing molecular genomics

Chatterjee, S., & Gaddameedhi, S. (2009, January 1). Journal of Cancer Research and Therapeutics.

Loss of cryptochrome reduces cancer risk in p53 mutant mice

Ozturk, N., Lee, J. H., Gaddameedhi, S., & Sancar, A. (2009, February 3). Proceedings of the National Academy of Sciences.

Deciphering the association between up-regulation of glucose regulated protein of Mr-78 kDa (GRP78) and hypersensitivity to cisplatin employing comparative genomics

The FASEB Journal. https://publons.com/wos-op/publon/54906423/

Up-regulation of glucose regulated protein of M-r-78KDa (GRP78) followed by cisplatin treatment leads to mitochondrial mediated apoptosis through caspase-2 activation

Cancer Research. https://publons.com/wos-op/publon/54906422/

In-gel precipitation of enzymatically released phosphate

Simonović, A. D., Gaddameedhi, S., & Anderson, M. D. (2004, August 27). Analytical Biochemistry.